BR0206193A - Compostos, método de preparação dos compostos, e, agentes hipocolesterolêmicos no soro - Google Patents
Compostos, método de preparação dos compostos, e, agentes hipocolesterolêmicos no soroInfo
- Publication number
- BR0206193A BR0206193A BR0206193-7A BR0206193A BR0206193A BR 0206193 A BR0206193 A BR 0206193A BR 0206193 A BR0206193 A BR 0206193A BR 0206193 A BR0206193 A BR 0206193A
- Authority
- BR
- Brazil
- Prior art keywords
- group
- carbon atoms
- compounds
- chain
- chem
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cephalosporin Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
"COMPOSTOS, MéTODO DE PREPARAçãO DOS COMPOSTOS, E, AGENTES HIPOCOLESTEROLêMICOS NO SORO". Novos compostos de <225>-lactama apresentados pela seguinte fórmula geral (I) ou ou seus sais farmaceuticamente aceitáveis que são aceitáveis como agentes de abaixamento do colesterol do soro (I) em que: A~ 1~, A~ 3~ e A~ 4~ representam, cada um, hidrogênio, halogênio, alquila C~ 1-5~, alcóxi a C~ 1-5~, , -COOR~ 1~, um grupo representado pela seguinte fpormula geral (b): (b) (em que: R~ 1~ é átomo de hidrogênio ou alquila C~ 1-5~,) ou um grupo representado pela seguinte fórmula geral (a): (a) [em que: R~ 2~ representa -CH~ 2~OH, -CH~ 2~OC(O)-R~ 1~ ou -CO~ 2~-R~ 1~; R~ 3~ representa -OH ou -OC(O)-R~ 1~; R~ 4~ representa -(CH~ 2~)~ k~R~ 5~(CH~ 2~)~ 1~-(em que k e 1 são, cada um 0 ou inteiro de 1 ou acima desde que k+1 seja um inteiro de não mais do que 10; e R~ 5~ representa uma ligação simples (-), -CH=CH-, -OCH~ 2~-, carbonila ou -CH(OH)-). desde que pelo menos um dentre A~ 1~, A~ 3~ e A~ 4~ seja um grupo representado pela fórmula (a); A~ 2~ representa alquila C~ 1-5~, alcóxi C~ 1-5~, alquenila C~ 1-5~, hidroxialquila C~ 1-5~, ou carbonilalquila C~ 1-5~, e. n, p, q ou r são, cada um, um inteiro de 0, 1 ou 2.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001048202 | 2001-02-23 | ||
| JP2001128031 | 2001-04-25 | ||
| PCT/JP2002/001481 WO2002066464A1 (en) | 2001-02-23 | 2002-02-20 | β-LACTAM COMPOUNDS, PROCESS FOR REPODUCING THE SAME AND SERUM CHOLESTEROL-LOWERING AGENTS CONTAINING THE SAME |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR0206193A true BR0206193A (pt) | 2004-02-03 |
| BRPI0206193B1 BRPI0206193B1 (pt) | 2016-05-24 |
Family
ID=26609978
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0206193A BRPI0206193B1 (pt) | 2001-02-23 | 2002-02-20 | compostos, método de preparação dos compostos, e, agentes hipocolesterolêmicos no soro |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7045515B2 (pt) |
| EP (1) | EP1362855B1 (pt) |
| JP (1) | JP4229701B2 (pt) |
| KR (1) | KR100721639B1 (pt) |
| CN (1) | CN1273467C (pt) |
| AT (1) | ATE374769T1 (pt) |
| AU (1) | AU2002237522B2 (pt) |
| BR (1) | BRPI0206193B1 (pt) |
| CA (1) | CA2438961C (pt) |
| DE (1) | DE60222742T2 (pt) |
| DK (1) | DK1362855T3 (pt) |
| ES (1) | ES2294101T3 (pt) |
| HK (1) | HK1060357A1 (pt) |
| MX (1) | MXPA03005073A (pt) |
| PT (1) | PT1362855E (pt) |
| RU (1) | RU2301799C2 (pt) |
| TW (1) | TWI291957B (pt) |
| WO (1) | WO2002066464A1 (pt) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EE05453B1 (et) | 2001-03-28 | 2011-08-15 | Schering Corporation | Protsess asetidinoonvahehendite valmistamiseks |
| GB0215579D0 (en) * | 2002-07-05 | 2002-08-14 | Astrazeneca Ab | Chemical compounds |
| JP2005015434A (ja) * | 2003-06-27 | 2005-01-20 | Kotobuki Seiyaku Kk | 血清コレステロール低下剤或はアテローム性硬化症の予防又は治療剤 |
| EP1682117A1 (en) * | 2003-10-30 | 2006-07-26 | Merck & Co., Inc. | 2-azetidinones as anti-hypercholesterolemic agents |
| EP1918000A2 (en) | 2003-11-05 | 2008-05-07 | Schering Corporation | Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions |
| SI1682499T1 (sl) * | 2003-11-10 | 2008-02-29 | Microbia Inc | 4-biarilil-1-fenilazetidin-2-oni |
| PT1682499E (pt) * | 2003-11-10 | 2007-11-05 | Microbia Inc | 4-biarilil-1-fenilazetidin-2-onas |
| EP1699759B1 (en) | 2003-12-23 | 2010-10-20 | AstraZeneca AB | Diphenylazetidinone derivates possessing cholesterol absorption inhibitory activity |
| AU2004308332B2 (en) | 2003-12-23 | 2008-04-10 | Merck Sharp & Dohme Corp. | Anti-hypercholesterolemic compounds |
| PT1756049E (pt) | 2004-05-21 | 2007-12-17 | Sanofi Aventis Deutschland | Processo para a preparação de derivados de 1,4-difenilazetidinona |
| WO2006039334A1 (en) * | 2004-09-29 | 2006-04-13 | Schering Corporation | Combinations of substituted azetidonones and cb1 antagonists |
| MX2007006695A (es) | 2004-12-03 | 2007-08-14 | Schering Corp | Piperazinas sustituidas como antagonistas de cb1. |
| TW200726746A (en) | 2005-05-06 | 2007-07-16 | Microbia Inc | Processes for production of 4-biphenylylazetidin-2-ones |
| MX2007014172A (es) * | 2005-05-11 | 2008-04-02 | Microbia Inc | Procedimiento para la produccion de 4-bifenililacetidina-2-onas fenolicos. |
| US7737155B2 (en) | 2005-05-17 | 2010-06-15 | Schering Corporation | Nitrogen-containing heterocyclic compounds and methods of use thereof |
| AU2006249905A1 (en) * | 2005-05-25 | 2006-11-30 | Microbia, Inc. | Processes for production of 4-(biphenylyl)azetidin-2-one phosphonic acids |
| CN101198338A (zh) * | 2005-06-15 | 2008-06-11 | 默克公司 | 抗高胆固醇血化合物 |
| KR20080021082A (ko) | 2005-06-20 | 2008-03-06 | 쉐링 코포레이션 | 히스타민 ｈ3 길항제로서 유용한 피페리딘 유도체 |
| UY29607A1 (es) | 2005-06-20 | 2007-01-31 | Astrazeneca Ab | Compuestos quimicos |
| AR057072A1 (es) | 2005-06-22 | 2007-11-14 | Astrazeneca Ab | Compuestos quimicos derivados de 2-azetidinona, formulacion farmaceutica y un proceso de preparacion del compuesto |
| SA06270191B1 (ar) | 2005-06-22 | 2010-03-29 | استرازينيكا ايه بي | مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم |
| NZ566877A (en) | 2005-09-29 | 2010-05-28 | Sanofi Aventis | Phenyl-1,2,4-oxadiazolone derivatives, processes for their preparation and their use as pharmaceuticals |
| TW200806623A (en) * | 2005-10-05 | 2008-02-01 | Merck & Co Inc | Anti-hypercholesterolemic compounds |
| NZ569814A (en) * | 2006-01-18 | 2011-10-28 | Schering Corp | Cannibinoid receptor modulators |
| JP4880348B2 (ja) * | 2006-04-25 | 2012-02-22 | 壽製薬株式会社 | アズレン誘導体及びそれを有効成分とする血清コレステロール低下剤 |
| AR060623A1 (es) | 2006-04-27 | 2008-07-02 | Astrazeneca Ab | Compuestos derivados de 2-azetidinona y un metodo de preparacion |
| BRPI0715160A2 (pt) | 2006-08-08 | 2013-06-11 | Sanofi Aventis | imidazolidina-2,4-dionas substituÍdas por arilamimoaril-alquil-, processo para preparÁ-las, medicamentos compeendendo estes compostos, e seu uso |
| CA2663500A1 (en) * | 2006-09-15 | 2008-03-20 | Schering Corporation | Spiro-condensed azetidine derivatives useful in treating pain, diabetes and disorders of lipid metabolism |
| CN101541805A (zh) | 2006-09-15 | 2009-09-23 | 先灵公司 | 用于治疗疼痛和脂代射紊乱的氮杂环丁烷和氮杂环丁酮衍生物 |
| JP2010503677A (ja) | 2006-09-15 | 2010-02-04 | シェーリング コーポレイション | 脂質代謝の障害を治療するためのアゼチジノン誘導体 |
| US20080070890A1 (en) * | 2006-09-15 | 2008-03-20 | Burnett Duane A | Spirocyclic Azetidinone Compounds and Methods of Use Thereof |
| EP2124549A4 (en) * | 2006-12-20 | 2010-01-20 | Merck & Co Inc | ANTIHYPERCHOLESTERINAMIC COMPOUNDS |
| DE102007005045B4 (de) | 2007-01-26 | 2008-12-18 | Sanofi-Aventis | Phenothiazin Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US20100197564A1 (en) * | 2007-04-19 | 2010-08-05 | Schering Corporation | Diaryl morpholines as cb1 modulators |
| MX2010000334A (es) * | 2007-06-28 | 2010-04-22 | Intervet Int Bv | Piperazinas sustituidas como antagonistas de cannabinoides 1. |
| CA2694264A1 (en) * | 2007-06-28 | 2009-01-08 | Intervet International B.V. | Substituted piperazines as cb1 antagonists |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE102007054497B3 (de) | 2007-11-13 | 2009-07-23 | Sanofi-Aventis Deutschland Gmbh | Neue kristalline Diphenylazetidinonhydrate und Verfahren zu deren Herstellung |
| UY31968A (es) | 2008-07-09 | 2010-01-29 | Sanofi Aventis | Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos |
| WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
| EP2379562A1 (en) | 2008-12-16 | 2011-10-26 | Schering Corporation | Bicyclic pyranone derivatives as nicotinic acid receptor agonists |
| EP2379547A1 (en) | 2008-12-16 | 2011-10-26 | Schering Corporation | Pyridopyrimidine derivatives and methods of use thereof |
| CA2754384A1 (en) | 2009-03-06 | 2010-09-10 | Lipideon Biotechnology Ag | Pharmaceutical hypocholesterolemic compositions |
| CN101993403B (zh) * | 2009-08-11 | 2012-07-11 | 浙江海正药业股份有限公司 | 氮杂环丁酮类化合物及医药应用 |
| US8785608B2 (en) | 2009-08-26 | 2014-07-22 | Sanofi | Crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| WO2012120052A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2012120058A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8895547B2 (en) | 2011-03-08 | 2014-11-25 | Sanofi | Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof |
| US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
| WO2012120055A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683698B1 (de) | 2011-03-08 | 2017-10-04 | Sanofi | Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8809324B2 (en) | 2011-03-08 | 2014-08-19 | Sanofi | Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof |
| WO2012120053A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683705B1 (de) | 2011-03-08 | 2015-04-22 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| CN104860980B (zh) * | 2015-04-23 | 2018-06-19 | 上海弈柯莱生物医药科技有限公司 | 一种用于合成依折麦布的中间体及其制备方法和应用 |
| US11504390B2 (en) | 2019-03-20 | 2022-11-22 | Regeneron Pharmaceuticals, Inc. | Treatment of increased lipid levels with sterol regulatory element binding transcription factor 1 (SREBF1) inhibitors |
| WO2020191163A1 (en) | 2019-03-20 | 2020-09-24 | Regeneron Pharmaceuticals, Inc. | Treatment of increased lipid levels with sterol regulatory element binding protein cleavage-activating protein (scap) inhibitors |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5857360A (ja) * | 1981-10-01 | 1983-04-05 | Ajinomoto Co Inc | アゼチジノン誘導体 |
| HUT67341A (en) * | 1991-07-23 | 1995-03-28 | Schering Corp | Substituted beta-lactam compounds useful as hypocholesterolemic agents, pharmaceutical compositions containing the same and process for the production thereof |
| US5412092A (en) * | 1993-04-23 | 1995-05-02 | Bristol-Myers Squibb Company | N-substituted 2-azetidinones |
| US5631365A (en) | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
| TW448181B (en) * | 1995-10-31 | 2001-08-01 | Schering Corp | Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents |
| AU7472896A (en) * | 1995-11-02 | 1997-05-22 | Schering Corporation | Process for preparing 1-(4-fluorophenyl)-3(r)-(3(s)-hydroxy-3-({phenyl or 4-fluorophenyl})-propyl)-4(s)-(4-hydroxyphenyl)-2-azetidinon |
| CZ20031733A3 (cs) * | 2000-12-21 | 2003-09-17 | Aventis Pharma Deutschland Gmbh | Difenylazetidinonové deriváty a farmaceutické prostředky s jejich obsahem |
-
2002
- 2002-02-08 TW TW091102310A patent/TWI291957B/zh not_active IP Right Cessation
- 2002-02-20 JP JP2002565979A patent/JP4229701B2/ja not_active Expired - Lifetime
- 2002-02-20 RU RU2003128424/04A patent/RU2301799C2/ru not_active IP Right Cessation
- 2002-02-20 EP EP02703861A patent/EP1362855B1/en not_active Expired - Lifetime
- 2002-02-20 AU AU2002237522A patent/AU2002237522B2/en not_active Ceased
- 2002-02-20 DE DE60222742T patent/DE60222742T2/de not_active Expired - Lifetime
- 2002-02-20 AT AT02703861T patent/ATE374769T1/de active
- 2002-02-20 US US10/450,171 patent/US7045515B2/en not_active Expired - Lifetime
- 2002-02-20 DK DK02703861T patent/DK1362855T3/da active
- 2002-02-20 KR KR1020037010927A patent/KR100721639B1/ko not_active IP Right Cessation
- 2002-02-20 CA CA2438961A patent/CA2438961C/en not_active Expired - Fee Related
- 2002-02-20 MX MXPA03005073A patent/MXPA03005073A/es active IP Right Grant
- 2002-02-20 WO PCT/JP2002/001481 patent/WO2002066464A1/ja active IP Right Grant
- 2002-02-20 CN CNB028052013A patent/CN1273467C/zh not_active Expired - Fee Related
- 2002-02-20 ES ES02703861T patent/ES2294101T3/es not_active Expired - Lifetime
- 2002-02-20 BR BRPI0206193A patent/BRPI0206193B1/pt not_active IP Right Cessation
- 2002-02-20 PT PT02703861T patent/PT1362855E/pt unknown
-
2004
- 2004-05-12 HK HK04103348A patent/HK1060357A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2301799C2 (ru) | 2007-06-27 |
| ATE374769T1 (de) | 2007-10-15 |
| JPWO2002066464A1 (ja) | 2004-06-17 |
| HK1060357A1 (en) | 2004-08-06 |
| DK1362855T3 (da) | 2008-01-28 |
| DE60222742T2 (de) | 2008-07-17 |
| US20040063929A1 (en) | 2004-04-01 |
| RU2003128424A (ru) | 2005-01-27 |
| CA2438961C (en) | 2010-02-16 |
| AU2002237522B2 (en) | 2007-08-02 |
| JP4229701B2 (ja) | 2009-02-25 |
| DE60222742D1 (de) | 2007-11-15 |
| CN1273467C (zh) | 2006-09-06 |
| EP1362855A4 (en) | 2005-02-23 |
| US7045515B2 (en) | 2006-05-16 |
| EP1362855B1 (en) | 2007-10-03 |
| KR100721639B1 (ko) | 2007-05-23 |
| EP1362855A1 (en) | 2003-11-19 |
| CN1492865A (zh) | 2004-04-28 |
| ES2294101T3 (es) | 2008-04-01 |
| CA2438961A1 (en) | 2002-08-29 |
| KR20030076690A (ko) | 2003-09-26 |
| PT1362855E (pt) | 2007-12-04 |
| BRPI0206193B1 (pt) | 2016-05-24 |
| TWI291957B (en) | 2008-01-01 |
| WO2002066464A1 (en) | 2002-08-29 |
| MXPA03005073A (es) | 2003-09-05 |
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