BR0117171A - Composição farmacêutica para liberação controlada de um antibiótico do tipo beta-lactama - Google Patents
Composição farmacêutica para liberação controlada de um antibiótico do tipo beta-lactamaInfo
- Publication number
- BR0117171A BR0117171A BR0117171-2A BR0117171A BR0117171A BR 0117171 A BR0117171 A BR 0117171A BR 0117171 A BR0117171 A BR 0117171A BR 0117171 A BR0117171 A BR 0117171A
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical composition
- water
- controlled release
- active ingredient
- beta
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 4
- 238000013270 controlled release Methods 0.000 title abstract 3
- 239000003782 beta lactam antibiotic agent Substances 0.000 title 1
- 239000002132 β-lactam antibiotic Substances 0.000 title 1
- 229940124586 β-lactam antibiotics Drugs 0.000 title 1
- 239000004480 active ingredient Substances 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 230000003115 biocidal effect Effects 0.000 abstract 2
- 239000003085 diluting agent Substances 0.000 abstract 2
- 229920001477 hydrophilic polymer Polymers 0.000 abstract 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 abstract 1
- 159000000007 calcium salts Chemical class 0.000 abstract 1
- QYIYFLOTGYLRGG-GPCCPHFNSA-N cefaclor Chemical compound C1([C@H](C(=O)N[C@@H]2C(N3C(=C(Cl)CS[C@@H]32)C(O)=O)=O)N)=CC=CC=C1 QYIYFLOTGYLRGG-GPCCPHFNSA-N 0.000 abstract 1
- 229960005361 cefaclor Drugs 0.000 abstract 1
- 229940106164 cephalexin Drugs 0.000 abstract 1
- AVGYWQBCYZHHPN-CYJZLJNKSA-N cephalexin monohydrate Chemical compound O.C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CC=CC=C1 AVGYWQBCYZHHPN-CYJZLJNKSA-N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 abstract 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 abstract 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 abstract 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 abstract 1
- DBABZHXKTCFAPX-UHFFFAOYSA-N probenecid Chemical compound CCCN(CCC)S(=O)(=O)C1=CC=C(C(O)=O)C=C1 DBABZHXKTCFAPX-UHFFFAOYSA-N 0.000 abstract 1
- 229960003081 probenecid Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000661 sodium alginate Substances 0.000 abstract 1
- 235000010413 sodium alginate Nutrition 0.000 abstract 1
- 229940005550 sodium alginate Drugs 0.000 abstract 1
- 239000000230 xanthan gum Substances 0.000 abstract 1
- 235000010493 xanthan gum Nutrition 0.000 abstract 1
- 229920001285 xanthan gum Polymers 0.000 abstract 1
- 229940082509 xanthan gum Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Cephalosporin Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
"COMPOSIçãO FARMACêUTICA PARA LIBERAçãO CONTROLADA DE UM ANTIBIóTICO DO TIPO BETA-LACTAMA". Que e uma composição farmacêutica estável e melhorada para liberação controlada de um ingrediente ativo compreende um antibiótico do tipo betalactama tal como cefalexina, cefaclor ou seus hidratos, sais ou ésteres farmaceuticamente aceitáveis como ingrediente ativo, um sal de cálcio e uma mistura de polímeros hidrófilos selecionados do grupo que consiste de pelo menos um alginato de sódio e uma goma xantana e com ou sem hidroxipropil metilcelulose, a referida composição opcionalmente contendo probenecida. A composição também pode conter um ou mais de um diluente solúvel em água e/ou dispersível em água, onde as quantidades dos polímeros hidrófilos e dos diluentes solúveis em água e/ou dispersíveis em água são tais que o ingrediente ativo terapeuticamente eficaz e liberado a uma taxa adequada para administração da composição farmacêutica uma ou duas vezes ao
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IN2001/000204 WO2003043607A1 (en) | 2001-11-19 | 2001-11-19 | A pharmaceutical composition for controlled release of a beta-lactam antibiotic |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0117171A true BR0117171A (pt) | 2004-10-26 |
Family
ID=11076411
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0117171-2A BR0117171A (pt) | 2001-11-19 | 2001-11-19 | Composição farmacêutica para liberação controlada de um antibiótico do tipo beta-lactama |
Country Status (11)
Country | Link |
---|---|
US (1) | US8192755B2 (pt) |
EP (1) | EP1461017B1 (pt) |
AT (1) | ATE319434T1 (pt) |
AU (1) | AU2002224011B2 (pt) |
BR (1) | BR0117171A (pt) |
CY (1) | CY1105365T1 (pt) |
DE (1) | DE60117712T2 (pt) |
DK (1) | DK1461017T3 (pt) |
ES (1) | ES2259011T3 (pt) |
PT (1) | PT1461017E (pt) |
WO (1) | WO2003043607A1 (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6544555B2 (en) * | 2000-02-24 | 2003-04-08 | Advancis Pharmaceutical Corp. | Antibiotic product, use and formulation thereof |
US20020068078A1 (en) * | 2000-10-13 | 2002-06-06 | Rudnic Edward M. | Antifungal product, use and formulation thereof |
EP1680089B1 (en) | 2003-10-22 | 2013-09-11 | Lidds AB | Composition comprising biodegradable hydrating ceramics for controlled drug delivery |
US7807715B2 (en) | 2006-06-09 | 2010-10-05 | Ucb Pharma Gmbh | Pharmaceutical compositions comprising fesoterodine |
US9050357B2 (en) * | 2010-03-08 | 2015-06-09 | Cp Kelco U.S., Inc. | Compositions and methods for producing consumables for patients with dysphagia |
RU2470671C1 (ru) * | 2011-07-06 | 2012-12-27 | Государственное образовательное учреждение высшего профессионального образования "Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова Федерального агентства по здравоохранению и социальному развитию" | Способ обработки текстильных изделий для сердечно-сосудистой хирургии |
CN107661507A (zh) * | 2017-10-30 | 2018-02-06 | 四川飞扬动物药业有限公司 | 兽用肠溶长效复方阿莫西林粉及其制备方法 |
US11554112B2 (en) * | 2018-06-07 | 2023-01-17 | Herum Therapeutics International Limited | Combinations of β-lactam compounds and probenecid and uses thereof |
CA3129337A1 (en) * | 2019-02-13 | 2020-08-20 | Iterum Therapeutics International Limited | Combinations of beta-lactam compounds and probenecid and uses thereof |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6055486B2 (ja) | 1976-02-28 | 1985-12-05 | 富山化学工業株式会社 | β−ラクタム環を有する化合物の直腸投与用組成物 |
GB8601204D0 (en) | 1986-01-18 | 1986-02-19 | Boots Co Plc | Therapeutic agents |
US5419917A (en) * | 1994-02-14 | 1995-05-30 | Andrx Pharmaceuticals, Inc. | Controlled release hydrogel formulation |
IL119627A (en) * | 1996-11-17 | 2002-03-10 | Yissum Res Dev Co | PHARMACEUTICAL PREPARATIONS FOR THE CONTROLLED-RELEASE OF AN ACTIVE AGENT COMPRISING AT LEAST ONE β-LACTAM ANTIBIOTIC AGENT |
US5948440A (en) * | 1997-12-17 | 1999-09-07 | Ranbaxy Laboratories Limited | Modified release matrix formulation of cefaclor and cephalexin |
CZ2001901A3 (cs) | 1998-09-14 | 2001-08-15 | Ranbaxy Laboratories Limited | Farmaceutická kompozice představující systém řízeného dodávání léku pro orální podání, poskytující časovou a místní kontrolu |
US6267986B1 (en) * | 1999-09-24 | 2001-07-31 | Ranbaxy Laboratories Limited | Process for the preparation of a controlled drug delivery system containing pseudoephedrine and a long acting antihistamine |
CA2473503C (en) | 2002-01-14 | 2010-01-05 | The Board Of Trustees Of The University Of Illinois | Use of modified pyrimidine compounds to promote stem cell migration and proliferation |
-
2001
- 2001-11-19 AU AU2002224011A patent/AU2002224011B2/en not_active Ceased
- 2001-11-19 DK DK01274758T patent/DK1461017T3/da active
- 2001-11-19 ES ES01274758T patent/ES2259011T3/es not_active Expired - Lifetime
- 2001-11-19 BR BR0117171-2A patent/BR0117171A/pt not_active Application Discontinuation
- 2001-11-19 PT PT01274758T patent/PT1461017E/pt unknown
- 2001-11-19 EP EP01274758A patent/EP1461017B1/en not_active Expired - Lifetime
- 2001-11-19 WO PCT/IN2001/000204 patent/WO2003043607A1/en active IP Right Grant
- 2001-11-19 DE DE60117712T patent/DE60117712T2/de not_active Expired - Fee Related
- 2001-11-19 AT AT01274758T patent/ATE319434T1/de not_active IP Right Cessation
- 2001-11-19 US US10/495,961 patent/US8192755B2/en not_active Expired - Fee Related
-
2006
- 2006-06-05 CY CY20061100721T patent/CY1105365T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
ES2259011T3 (es) | 2006-09-16 |
EP1461017B1 (en) | 2006-03-08 |
EP1461017A1 (en) | 2004-09-29 |
PT1461017E (pt) | 2006-07-31 |
DE60117712T2 (de) | 2006-11-16 |
US20050031685A1 (en) | 2005-02-10 |
WO2003043607A1 (en) | 2003-05-30 |
ATE319434T1 (de) | 2006-03-15 |
CY1105365T1 (el) | 2010-03-03 |
AU2002224011B2 (en) | 2008-05-01 |
DE60117712D1 (de) | 2006-05-04 |
AU2002224011A1 (en) | 2003-06-10 |
US8192755B2 (en) | 2012-06-05 |
DK1461017T3 (da) | 2006-06-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08E | Application fees: payment of additional fee required [chapter 8.5 patent gazette] |
Free format text: COMPLEMENTAR A 3A ANUIDADE DE ACORDO COM A TABELA VIGENTE,CUJA GUIA ( 220401090201 ) |
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B08G | Application fees: restoration [chapter 8.7 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] |
Free format text: DE ACORDO COM ART. 34 " II " DA LPI ( LEI 9279, DE 14/05/96 ) , O EXAME FICA SUSPENSO PARA QUE O REQUERENTE APRESENTE DOCUMENTOS NECESSARIOS A REGULARIZACAO DO PROCESSO E EXAME DO PEDIDO. |
|
B11E | Dismissal acc. art. 34 of ipl - requirements for examination incomplete | ||
B11T | Dismissal of application maintained [chapter 11.20 patent gazette] |