BR0112715A - Motif com base em leucina e neurotoxinas clostridiais - Google Patents

Motif com base em leucina e neurotoxinas clostridiais

Info

Publication number
BR0112715A
BR0112715A BR0112715-2A BR0112715A BR0112715A BR 0112715 A BR0112715 A BR 0112715A BR 0112715 A BR0112715 A BR 0112715A BR 0112715 A BR0112715 A BR 0112715A
Authority
BR
Brazil
Prior art keywords
leucine
region
clostridial neurotoxins
motif based
modified neurotoxin
Prior art date
Application number
BR0112715-2A
Other languages
English (en)
Inventor
Lance E Steward
Ester Fernandez-Salas
Todd M Herrington
Kei Roger Aoki
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24487624&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0112715(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of BR0112715A publication Critical patent/BR0112715A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/825—Bacteria

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

"MOTIF COM BASE EM LEUCINA E NEUROTOXINAS CLOSTRIDIAIS". Neurotoxina modificada compreendendo neurotoxina incluindo modificação estrutural, em que a modificação estrutural altera a persistência biológica, tal como a meia-vida biológica e/ou uma atividade biológica da neurotoxina modificada referente a uma neurotoxina idêntica sem a modificação estrutural. Em uma certa modalidade, métodos de preparo da neurotoxina modificada incluem o emprego de técnicas recombinantes. Em outra modalidade, métodos de emprego da neurotoxina modificada para tratar condições incluem o tratamento de vários distúrbios, alimentação neuromuscular e dor.
BR0112715-2A 2000-07-21 2001-07-20 Motif com base em leucina e neurotoxinas clostridiais BR0112715A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/620,840 US6903187B1 (en) 2000-07-21 2000-07-21 Leucine-based motif and clostridial neurotoxins
PCT/US2001/023122 WO2002008268A2 (en) 2000-07-21 2001-07-20 Leucine-based motif and clostridial neurotoxins

Publications (1)

Publication Number Publication Date
BR0112715A true BR0112715A (pt) 2003-05-20

Family

ID=24487624

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0112715-2A BR0112715A (pt) 2000-07-21 2001-07-20 Motif com base em leucina e neurotoxinas clostridiais

Country Status (14)

Country Link
US (11) US6903187B1 (pt)
EP (3) EP1849801A1 (pt)
JP (1) JP4818565B2 (pt)
KR (1) KR20030033000A (pt)
CN (1) CN100457777C (pt)
AT (1) ATE380824T1 (pt)
AU (2) AU2001280703B2 (pt)
BR (1) BR0112715A (pt)
CA (1) CA2416988C (pt)
DE (1) DE60131856T2 (pt)
ES (1) ES2296782T3 (pt)
MX (1) MXPA03000576A (pt)
NZ (1) NZ523662A (pt)
WO (1) WO2002008268A2 (pt)

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US20080177042A1 (en) 2008-07-24
US7691974B2 (en) 2010-04-06
US20030027752A1 (en) 2003-02-06
US6903187B1 (en) 2005-06-07
US8206723B2 (en) 2012-06-26
US7705125B2 (en) 2010-04-27
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US7705124B2 (en) 2010-04-27
US20080194797A1 (en) 2008-08-14
US7393925B2 (en) 2008-07-01
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