BR0110110A - Derivados de ácido poliamida nucléico, agentes e processo para sua preparação - Google Patents

Derivados de ácido poliamida nucléico, agentes e processo para sua preparação

Info

Publication number
BR0110110A
BR0110110A BR0110110-2A BR0110110A BR0110110A BR 0110110 A BR0110110 A BR 0110110A BR 0110110 A BR0110110 A BR 0110110A BR 0110110 A BR0110110 A BR 0110110A
Authority
BR
Brazil
Prior art keywords
agents
groups
preparation
nucleic acid
pna
Prior art date
Application number
BR0110110-2A
Other languages
English (en)
Inventor
Eugen Uhlmann
Gerhard Breipohl
David William Will
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of BR0110110A publication Critical patent/BR0110110A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003—Peptide-nucleic acids (PNAs)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Polyamides (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

"DERIVADOS DE áCIDO POLIAMIDA NUCLéICO, AGENTES E PROCESSO PARA SUA PREPARAçãO". Objeto da presente invenção são derivados de PNA, que portam na terminação C ou na terminação N da cadeia principal do PNA um ou mais radicais fosforila, que opcionalmente favorecem um ou mais grupos marcadores, ou grupos para a reticulação transversal, ou grupos que favorecem a absorção intracelular, ou grupos que aumentam a afinidade de ligação do derivado de PNA nos ácidos nucléicos. Objeto da invenção é, além disso, um processo para preparação dos derivados de PNA supra citados e seu emprego como medicamento ou diagnóstico.
BR0110110-2A 2000-04-18 2001-04-07 Derivados de ácido poliamida nucléico, agentes e processo para sua preparação BR0110110A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10019135A DE10019135A1 (de) 2000-04-18 2000-04-18 Polyamidnukleinsäure-Derivate, Mittel und Verfahren zu ihrer Herstellung
PCT/EP2001/004030 WO2001079216A2 (de) 2000-04-18 2001-04-07 Polyamidnukleinsäure-derivate, mittel und verfahren zur ihrer herstellung

Publications (1)

Publication Number Publication Date
BR0110110A true BR0110110A (pt) 2003-02-11

Family

ID=7639143

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0110110-2A BR0110110A (pt) 2000-04-18 2001-04-07 Derivados de ácido poliamida nucléico, agentes e processo para sua preparação

Country Status (21)

Country Link
US (5) US6905820B2 (pt)
EP (1) EP1276760B1 (pt)
JP (1) JP4908714B2 (pt)
KR (1) KR100842723B1 (pt)
AR (1) AR032153A1 (pt)
AT (1) ATE344276T1 (pt)
AU (1) AU5479501A (pt)
BR (1) BR0110110A (pt)
CA (1) CA2406169C (pt)
CY (1) CY1105958T1 (pt)
DE (2) DE10019135A1 (pt)
DK (1) DK1276760T3 (pt)
ES (1) ES2275677T3 (pt)
IL (2) IL152288A0 (pt)
MX (1) MXPA02009953A (pt)
NO (1) NO333193B1 (pt)
NZ (1) NZ521988A (pt)
PT (1) PT1276760E (pt)
TW (1) TWI298328B (pt)
WO (1) WO2001079216A2 (pt)
ZA (1) ZA200208344B (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6518017B1 (en) * 1997-10-02 2003-02-11 Oasis Biosciences Incorporated Combinatorial antisense library
US20030165888A1 (en) 2001-07-18 2003-09-04 Brown Bob D. Oligonucleotide probes and primers comprising universal bases for diagnostic purposes
KR20020007359A (ko) * 1999-04-08 2002-01-26 추후제출 프라이머 쌍들의 증폭 및 시퀀싱 및 그 이용
DE10019135A1 (de) * 2000-04-18 2001-10-31 Aventis Pharma Gmbh Polyamidnukleinsäure-Derivate, Mittel und Verfahren zu ihrer Herstellung
TWI286849B (en) * 2003-03-25 2007-09-11 Nichia Corp Positive electrode active material for nonaqueous electrolyte secondary battery and nonaqueous electrolyte secondary battery
JP2010528615A (ja) * 2007-05-31 2010-08-26 サノフィ−アベンティス ＮＡＰＥ−ＰＬＤ又はＡｂｈ４の活性を修飾する薬剤を同定するためのアッセイ方法
US8703119B2 (en) * 2007-10-05 2014-04-22 Polygene Ltd. Injectable biodegradable polymer compositions for soft tissue repair and augmentation
US20090276855A1 (en) * 2008-04-30 2009-11-05 Nokia Corporation Method, apparatus, and computer program product that provide for presentation of event items
US20090276436A1 (en) * 2008-04-30 2009-11-05 Nokia Corporation Method, apparatus, and computer program product for providing service invitations
US20090276700A1 (en) * 2008-04-30 2009-11-05 Nokia Corporation Method, apparatus, and computer program product for determining user status indicators
US20090276412A1 (en) * 2008-04-30 2009-11-05 Nokia Corporation Method, apparatus, and computer program product for providing usage analysis
US20090292762A1 (en) * 2008-05-20 2009-11-26 Nokia Corporation Method, Apparatus, and Computer Program Product for Publishing Content
US20090327434A1 (en) * 2008-06-30 2009-12-31 Nokia Corporation Method, Apparatus, and Computer Program Product for Anonymous Polling
JP5990987B2 (ja) * 2012-04-11 2016-09-14 株式会社Ihi 微生物固定方法、および微生物検出方法
JP2015172904A (ja) * 2014-03-12 2015-10-01 株式会社東芝 Ｌｄｏ型電圧レギュレータ、及び、受電装置
US20180030065A1 (en) * 2015-01-27 2018-02-01 Isi Life Sciences, Inc. Fluorescein polymer conjugates
KR102659194B1 (ko) * 2016-07-26 2024-04-19 삼성전자주식회사 홀로그래픽 디스플레이 장치용 박형 백라이트 유닛 및 이를 포함하는 홀로그래픽 디스플레이 장치

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2597698B2 (ja) * 1987-10-28 1997-04-09 ハワード・フローレイ・インスティテュト・オブ・イクスペリメンタル・フィジオロジー・アンド・メディシン オリゴヌクレオチド‐ポリアミド コンジュゲート
DK51092D0 (da) 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
IL128775A (en) * 1994-03-07 2001-05-20 Dow Chemical Co A preparation containing a dendritic polymer in a complex with at least one unit of biological reaction sub
DE4408528A1 (de) * 1994-03-14 1995-09-28 Hoechst Ag Peptid-Oligonucleotid-Derivate, deren Herstellung und Verwendung
DE4408531A1 (de) * 1994-03-14 1995-09-28 Hoechst Ag PNA-Synthese unter Verwendung einer gegen schwache Säuren labilen Amino-Schutzgruppe
ATE222589T1 (de) * 1994-10-06 2002-09-15 Isis Pharmaceuticals Inc Peptid-nukleinsäure-konjugate
DE19508923A1 (de) * 1995-03-13 1996-09-19 Hoechst Ag Phosphonomonoesternukleinsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung
DE59607750D1 (de) * 1995-03-13 2001-10-31 Aventis Pharma Gmbh Phosphonomonoesternnukleinsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung
DE19640974A1 (de) 1996-10-04 1998-04-16 Bayer Ag Bausteine für DNA/PNA-Cooligomere
DE19757516A1 (de) * 1997-12-23 1999-06-24 Roche Diagnostics Gmbh Modifizierte Nukleinsäureanaloga
US6326479B1 (en) * 1998-01-27 2001-12-04 Boston Probes, Inc. Synthetic polymers and methods, kits or compositions for modulating the solubility of same
US6043352A (en) * 1998-08-07 2000-03-28 Isis Pharmaceuticals, Inc. 2'-O-Dimethylaminoethyloxyethyl-modified oligonucleotides
DE10019136A1 (de) * 2000-04-18 2001-10-31 Aventis Pharma Gmbh Polyamidnukleinsäure-Derivate, Mittel und Verfahren zu ihrer Herstellung
DE10019135A1 (de) * 2000-04-18 2001-10-31 Aventis Pharma Gmbh Polyamidnukleinsäure-Derivate, Mittel und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
US20100022016A1 (en) 2010-01-28
US20020187473A1 (en) 2002-12-12
US20050009073A1 (en) 2005-01-13
ATE344276T1 (de) 2006-11-15
CA2406169C (en) 2012-06-19
US7550582B2 (en) 2009-06-23
NO20024959D0 (no) 2002-10-15
DK1276760T3 (da) 2007-03-19
AU5479501A (en) 2001-10-30
JP2004501211A (ja) 2004-01-15
US6905820B2 (en) 2005-06-14
NO333193B1 (no) 2013-04-02
ZA200208344B (en) 2003-08-21
ES2275677T3 (es) 2007-06-16
EP1276760B1 (de) 2006-11-02
CY1105958T1 (el) 2011-04-06
JP4908714B2 (ja) 2012-04-04
DE10019135A1 (de) 2001-10-31
TWI298328B (en) 2008-07-01
US20080070258A1 (en) 2008-03-20
NZ521988A (en) 2004-12-24
EP1276760A2 (de) 2003-01-22
CA2406169A1 (en) 2001-10-25
NO20024959L (no) 2002-10-15
US7897346B2 (en) 2011-03-01
US20110117569A1 (en) 2011-05-19
IL152288A (en) 2010-11-30
KR20030036166A (ko) 2003-05-09
DE50111371D1 (de) 2006-12-14
IL152288A0 (en) 2003-05-29
MXPA02009953A (es) 2003-02-12
AR032153A1 (es) 2003-10-29
PT1276760E (pt) 2007-02-28
WO2001079216A2 (de) 2001-10-25
US8268560B2 (en) 2012-09-18
KR100842723B1 (ko) 2008-07-01
WO2001079216A3 (de) 2002-02-28

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH (DE)

Free format text: ALTERADO DE: AVENTIS PHARMA DEUTSCHLAND GMBH

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 14A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2307 DE 24/03/2015.