BR0013366A - Métodos para tratar um distúrbio comportamental, um paciente humano, doença de próstata, distúrbios de ansiedade e cognitivos em um paciente humano afligido com uma condição ou disposto ao desenvolvimento de uma condição distinguida pelo menos em parte pela concentração de glutamato extracelular anormal no cérebro ou em outro tecido nervoso, distúrbio comportamental nas espécies humana, canina, felina e equina e um paciente afligido com ou disposto a desenvolver uma doença compreendendo concentrações de glutamato anormalmente elevadas em tecido neuronal ou nìveis de naaladase elevados em tecido prostático e com esclerose múltipla e para realçar a função cognitiva, formulação farmacêutica e usos de um inibidor da atividade de peptidase de uma dipeptidase ácida ligada em alfa n-acetilada e de um composto de beta-lactama - Google Patents

Métodos para tratar um distúrbio comportamental, um paciente humano, doença de próstata, distúrbios de ansiedade e cognitivos em um paciente humano afligido com uma condição ou disposto ao desenvolvimento de uma condição distinguida pelo menos em parte pela concentração de glutamato extracelular anormal no cérebro ou em outro tecido nervoso, distúrbio comportamental nas espécies humana, canina, felina e equina e um paciente afligido com ou disposto a desenvolver uma doença compreendendo concentrações de glutamato anormalmente elevadas em tecido neuronal ou nìveis de naaladase elevados em tecido prostático e com esclerose múltipla e para realçar a função cognitiva, formulação farmacêutica e usos de um inibidor da atividade de peptidase de uma dipeptidase ácida ligada em alfa n-acetilada e de um composto de beta-lactama

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Publication number
BR0013366A
BR0013366A BR0013366-3A BR0013366A BR0013366A BR 0013366 A BR0013366 A BR 0013366A BR 0013366 A BR0013366 A BR 0013366A BR 0013366 A BR0013366 A BR 0013366A
Authority
BR
Brazil
Prior art keywords
tissue
willing
develop
disease
human
Prior art date
Application number
BR0013366-3A
Other languages
English (en)
Inventor
Gary A Koppel
Original Assignee
Revaax Pharmaceuticals Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Revaax Pharmaceuticals Llc filed Critical Revaax Pharmaceuticals Llc
Publication of BR0013366A publication Critical patent/BR0013366A/pt

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
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Abstract

"MéTODOS PARA TRATAR UM DISTúRBIO COMPORTAMENTAL, UM PACIENTE HUMANO, DOENçA DE PRóSTATA, DISTúRBIOS DE ANSIEDADE E COGNITIVOS EM UM PACIENTE HUMANO AFLIGIDO COM UMA CONDIçãO OU DISPOSTO AO DESENVOLVIMENTO DE UMA CONDIçãO DISTINGUIDA PELO MENOS EM PARTE PELA CONCENTRAçãO DE GLUTAMATO EXTRACELULAR ANORMAL NO CéREBRO OU EM OUTRO TECIDO NERVOSO, DISTúRBIO COMPORTAMENTAL NAS ESPéCIES HUMANA, CANINA, FELINA E EQuINA E UM PACIENTE AFLIGIDO COM OU DISPOSTO A DESENVOLVER UMA DOENçA COMPREENDENDO CONCENTRAçõES DE GLUTAMATO ANORMALMENTE ELEVADAS EM TECIDO NEURONAL OU NìVEIS DE NAALADASE ELEVADOS EM TECIDO PROSTáTICO E COM ESCLEROSE MúLTIPLA E PARA REALçAR A FUNçãO COGNITIVA, FORMULAçãO FARMACêUTICA E USOS DE UM INIBIDOR DA ATIVIDADE DE PEPTIDASE DE UMA DIPEPTIDASE áCIDA LIGADA EM ALFA N-ACETILADA E DE UM COMPOSTO DE BETA-LACTAMA". Verificou-se que a administração de compostos de <225>-lactama, incluindo os inibidores de certas peptidases bacterianas produz efeitos neurotrópicos significantes em vertebrados de sangue quente evidenciados, inter alia, pelo comportamento anxiolítico e anti-agressivo e acredita-se que a cognição realçada seja mediada pela inibição de NAALADase neurogênica e de atividade enzimática relacionada. Verificou-se que os antibióticos de <225>lactama e os inibidores de <225>-lactamase exibem inibição de NAALADase potente e estes compostos com transporte de barreira hematoencefálica são inibidores eficazes de NAALADase neurogênica com efeitos neuroterapêuticos significantes. Os compostos de <225>-lactama são úteis para o tratamento de numerosos estados de doença associados com as anormalidades de glutamato. Os método terapêuticos para o uso de tais compostos e suas formulações farmacêuticas são descritos.
BR0013366-3A 1999-08-16 2000-08-16 Métodos para tratar um distúrbio comportamental, um paciente humano, doença de próstata, distúrbios de ansiedade e cognitivos em um paciente humano afligido com uma condição ou disposto ao desenvolvimento de uma condição distinguida pelo menos em parte pela concentração de glutamato extracelular anormal no cérebro ou em outro tecido nervoso, distúrbio comportamental nas espécies humana, canina, felina e equina e um paciente afligido com ou disposto a desenvolver uma doença compreendendo concentrações de glutamato anormalmente elevadas em tecido neuronal ou nìveis de naaladase elevados em tecido prostático e com esclerose múltipla e para realçar a função cognitiva, formulação farmacêutica e usos de um inibidor da atividade de peptidase de uma dipeptidase ácida ligada em alfa n-acetilada e de um composto de beta-lactama BR0013366A (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US14911599P 1999-08-16 1999-08-16
US17245299P 1999-12-17 1999-12-17
US17657000P 2000-01-18 2000-01-18
US19453400P 2000-04-04 2000-04-04
PCT/US2000/022450 WO2001012184A1 (en) 1999-08-16 2000-08-16 Neurotherapeutic composition and method

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BR0013366A true BR0013366A (pt) 2002-07-23

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