BR0011520A - Polìmeros aniÈnicos usados como ligantes de toxinas e agentes antibacterianos - Google Patents
Polìmeros aniÈnicos usados como ligantes de toxinas e agentes antibacterianosInfo
- Publication number
- BR0011520A BR0011520A BR0011520-7A BR0011520A BR0011520A BR 0011520 A BR0011520 A BR 0011520A BR 0011520 A BR0011520 A BR 0011520A BR 0011520 A BR0011520 A BR 0011520A
- Authority
- BR
- Brazil
- Prior art keywords
- toxin
- antibacterial agents
- polymers used
- anionic polymers
- animal
- Prior art date
Links
- 239000003053 toxin Substances 0.000 title abstract 4
- 231100000765 toxin Toxicity 0.000 title abstract 4
- 239000003242 anti bacterial agent Substances 0.000 title abstract 2
- 229920006318 anionic polymer Polymers 0.000 title 1
- 239000011230 binding agent Substances 0.000 title 1
- 229920000642 polymer Polymers 0.000 abstract 4
- 125000006850 spacer group Chemical group 0.000 abstract 2
- OTLLEIBWKHEHGU-UHFFFAOYSA-N 2-[5-[[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy]-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-4-phosphonooxyhexanedioic acid Chemical compound C1=NC=2C(N)=NC=NC=2N1C(C(C1O)O)OC1COC1C(CO)OC(OC(C(O)C(OP(O)(O)=O)C(O)C(O)=O)C(O)=O)C(O)C1O OTLLEIBWKHEHGU-UHFFFAOYSA-N 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 231100000776 exotoxin Toxicity 0.000 abstract 1
- 239000002095 exotoxin Substances 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
- 230000001717 pathogenic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/795—Polymers containing sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Detergent Compositions (AREA)
- Absorbent Articles And Supports Therefor (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Abstract
"POLìMEROS ANIÈNICOS USADOS COMO LIGANTES DE TOXINAS E AGENTES ANTIBACTERIANOS". A presente invenção refere-se a um método para inibir uma toxina, em um animal, tal como um ser humano, através da administração ao animal de uma quantidade terapeuticamente efetiva de um polímero tendo uma pluralidade de grupos funcionais ácido pendente os quais são diretamente ligados a cadeia polimérica principal ou ligados a cadeia polimérica principal através de um grupo espaçador. O grupo espaçador pode Ter um comprimento em torno de o a aproximadamente 20 átomos. A toxina é, tipicamente, uma exotoxina secretada por um microrganismo patógeno, tal como uma bactéria.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13397599P | 1999-05-13 | 1999-05-13 | |
US09/541,268 US6270755B1 (en) | 1999-05-13 | 2000-04-03 | Anionic polymers as toxin binders |
PCT/US2000/012943 WO2000069428A2 (en) | 1999-05-13 | 2000-05-11 | Anionic polymers as toxin binders and antibacterial agents |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0011520A true BR0011520A (pt) | 2003-06-24 |
Family
ID=26831853
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0011520-7A BR0011520A (pt) | 1999-05-13 | 2000-05-11 | Polìmeros aniÈnicos usados como ligantes de toxinas e agentes antibacterianos |
Country Status (23)
Country | Link |
---|---|
US (2) | US6270755B1 (pt) |
EP (1) | EP1189622B1 (pt) |
JP (1) | JP2002544226A (pt) |
KR (1) | KR100742433B1 (pt) |
CN (1) | CN100435806C (pt) |
AT (1) | ATE367818T1 (pt) |
AU (1) | AU768592B2 (pt) |
BR (1) | BR0011520A (pt) |
CA (1) | CA2374108A1 (pt) |
DE (1) | DE60035689T2 (pt) |
DK (1) | DK1189622T3 (pt) |
ES (1) | ES2288855T3 (pt) |
HK (1) | HK1044490A1 (pt) |
HU (1) | HUP0201114A3 (pt) |
IL (2) | IL146211A0 (pt) |
MY (1) | MY132695A (pt) |
NO (1) | NO329497B1 (pt) |
NZ (1) | NZ515226A (pt) |
PL (1) | PL197157B1 (pt) |
PT (1) | PT1189622E (pt) |
RU (1) | RU2246938C2 (pt) |
TW (1) | TW592704B (pt) |
WO (1) | WO2000069428A2 (pt) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6270755B1 (en) * | 1999-05-13 | 2001-08-07 | Geltex Pharmaceuticals, Inc. | Anionic polymers as toxin binders |
US6290946B1 (en) * | 1999-05-13 | 2001-09-18 | Geltex Pharmaceuticals, Inc. | Anionic polymers as toxin binders and antibacterial agents |
US6805857B2 (en) * | 2000-03-06 | 2004-10-19 | Kumarpal A. Shah | Method of modulating factor D, factor H and CD4 cell immune response with a polystyrene sulfonate, alginate, and saline infusion solution |
CA2314494A1 (en) * | 2000-05-02 | 2001-11-02 | Geltex Pharmaceuticals, Inc. | Anionic polymers as species specific antibacterial agents |
US6537538B2 (en) * | 2000-12-18 | 2003-03-25 | Rush-Presbyterian-St. Luke's Medical Center | Method for the prevention, inhibition, or treatment of vaginitis and/or bacterial vaginosis using polystyrene sulfonate |
CA2492211A1 (en) * | 2002-07-22 | 2004-01-29 | Genzyme Corporation | Poly(potassium and sodium styrene sulfonate), its manufacture and its uses |
ATE448775T1 (de) * | 2002-08-29 | 2009-12-15 | Activbiotics Pharma Llc | Rifalazil zur behandlung von infektionen mit clostridium difficile |
US7682631B2 (en) * | 2003-10-01 | 2010-03-23 | Clemson University | Adhesin-specific nanoparticles and process for using same |
CA2542968C (en) | 2003-10-20 | 2013-06-04 | Framework Therapeutics, L.L.C. | Zeolite molecular sieves for the removal of toxins |
EP1802349A1 (en) * | 2004-10-13 | 2007-07-04 | Ilypsa, Inc. | Pharmaceutical compositions comprising a toxin-binding oligosaccharide and a polymeric particle |
US20060078534A1 (en) * | 2004-10-13 | 2006-04-13 | Dominique Charmot | Toxin binding compositions |
WO2007024973A1 (en) * | 2005-08-22 | 2007-03-01 | Quick-Med Technologies, Inc. | Disinfectant with quaternary ammonium polymers and copolymers |
KR20080088587A (ko) * | 2005-11-02 | 2008-10-02 | 슈어 인터내셔날 벤쳐스 비.브이. | 세포 사멸을 위한 조성물 및 방법 |
TW200829286A (en) * | 2006-09-06 | 2008-07-16 | Genzyme Corp | Polystyrene sulfonate polymer tablets, their preparation and use |
US8809444B2 (en) * | 2009-12-23 | 2014-08-19 | Momentive Performance Materials Inc. | Network copolymer crosslinked emulsions and demulsifying compositions comprising the same |
JP5820112B2 (ja) * | 2010-12-15 | 2015-11-24 | 積水化学工業株式会社 | インフルエンザウイルス感染阻止剤、インフルエンザウイルス感染阻止塗料及びインフルエンザウイルス感染阻止製品 |
CN102160870B (zh) * | 2011-03-18 | 2013-04-24 | 南京欧睿医药科技有限公司 | 聚(4-苯乙烯磺酸-共聚-马来酸)钠盐的用途及其药物组合物 |
CA2845091A1 (en) * | 2011-09-08 | 2013-03-14 | Safe Bt, Inc. | Use of modified hollow fiber materials for removing exotoxins produced by escherichia coli from liquids, preferably from blood and plasma as well as their use for treating concomitant diseases |
RU2482883C1 (ru) * | 2012-03-12 | 2013-05-27 | Федеральное государственное бюджетное учреждение науки Институт высокомолекулярных соединений Российской академии наук | Способ получения полимерно-композиционных волокнистых материалов с антимикробной активностью |
CA2971725C (en) * | 2014-12-23 | 2024-05-14 | Ardelyx, Inc. | Compositions and methods for treating hyperkalemia |
KR101720053B1 (ko) | 2015-04-30 | 2017-03-27 | 이현국 | 고주파 열처리 장치 및 고주파 열처리 방법 |
Family Cites Families (41)
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US3224941A (en) | 1963-01-21 | 1965-12-21 | Lilly Co Eli | Resin compositions and method for controlling diarrhea |
US3466365A (en) | 1967-07-24 | 1969-09-09 | White Lab Inc | Antiviral compositions and method of use |
GB1466702A (en) * | 1973-02-09 | 1977-03-09 | Sandoz Ltd | Polymer encapsulated-activated carbon |
IE44690B1 (en) | 1976-02-04 | 1982-02-24 | Rohm & Haas | Pharmaceutical compositions containing polyvinylbenzenosulfonic acids |
US4395392A (en) | 1980-06-24 | 1983-07-26 | Adria Laboratories Inc. | Method for treating kidney stones |
US4362711A (en) | 1980-07-11 | 1982-12-07 | Evreka Inc. | Blood cholesterol level reducing agent and method |
US5171738A (en) | 1982-10-04 | 1992-12-15 | Toray Industries, Inc. | Method of treating malignant tumors |
US5435821A (en) | 1985-12-12 | 1995-07-25 | Exxon Research & Engineering Co. | Controlled release vegetation enhancement agents coated with sulfonated polymers, method of production and prcesses of use |
US5071759A (en) | 1986-05-30 | 1991-12-10 | The United States Of America As Represented By The Secretary Of The Army | Hybridoma cell lines and monoclonal antibodies to clostridum difficile toxins A and B |
US5091171B2 (en) * | 1986-12-23 | 1997-07-15 | Tristrata Inc | Amphoteric compositions and polymeric forms of alpha hydroxyacids and their therapeutic use |
JPS6422551A (en) * | 1987-07-16 | 1989-01-25 | Dainippon Ink & Chemicals | Composite film for lid |
JPH0219319A (ja) | 1988-05-26 | 1990-01-23 | Duphar Internatl Res Bv | ラクツロースシロップから単離したフラクション及びこれを有効成分とする抗内毒素作用を有する医薬組成物 |
JPH02176351A (ja) | 1988-12-27 | 1990-07-09 | Matsushita Electric Ind Co Ltd | 給湯器 |
US5149523A (en) | 1989-06-20 | 1992-09-22 | Aktiebolaget Hassle | Polystyrenesulfonate-drug complex and solid dosage forms thereof |
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US5231003A (en) | 1990-05-11 | 1993-07-27 | Cambridge Bioscience Corporation | Monoclonal antibodies specific for toxin b of clostridium difficile |
US5149543A (en) | 1990-10-05 | 1992-09-22 | Massachusetts Institute Of Technology | Ionically cross-linked polymeric microcapsules |
FR2669535A1 (fr) * | 1990-11-26 | 1992-05-29 | Medgenix Group Sa | Utilisation a titre de medicament de macromolecules polysulfonees. |
ATE162081T1 (de) * | 1991-09-17 | 1998-01-15 | Alcon Lab Inc | Chinolan-antibiotika und polystyrolsulfonat enthaltende zusammensetzungen |
US5424063A (en) | 1992-01-09 | 1995-06-13 | The Dow Chemical Company | Narrow poly- and mono-dispersed anionic oligomers, and their uses, formulations and process |
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EP0800862B1 (en) | 1994-12-26 | 2002-02-27 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Adsorbent for endotoxin, tumor necrosis factor-alpha or interleukins, method for removal via adsorption, and adsorber |
US5610023A (en) | 1995-03-31 | 1997-03-11 | Lee Laboratories, Inc. | Method of purification of clostridium difficile toxin A and production of mono-specific antibodies |
DE19549420A1 (de) | 1995-04-27 | 1997-09-18 | Braun Melsungen Ag | Verfahren zur simultanen extrakorporalen Elimination von Tumor-Nekrose Faktor alpha (TNF alpha) und bakteriellen Lipopolysacchariden (LPS) aus Vollblut oder/und Blutplasma |
AUPN327695A0 (en) * | 1995-05-30 | 1995-06-22 | Chemeq Pty. Limited | Chemotherapeutic compositions |
US5700458A (en) * | 1996-09-20 | 1997-12-23 | Geltex Pharmaceuticals Inc. | Acid-functionalized saccharides as polyvalent anti-infectives |
US5800803A (en) | 1997-02-10 | 1998-09-01 | Colgate-Palmolive Company | Oral composition exhibiting enhanced uptake by dental tissue of noncationic antibacterial agents |
US6007803A (en) * | 1997-09-19 | 1999-12-28 | Geltex Pharmaceuticals, Inc. | Ionic polymers as toxin binding agents |
US6060235A (en) | 1997-09-19 | 2000-05-09 | Geltex Pharmaceuticals, Inc. | Antiviral polymers comprising acid functional groups and hydrophobic groups |
WO1999020285A1 (fr) | 1997-10-16 | 1999-04-29 | Sanwa Kagaku Kenkyusho Co., Ltd. | Preparations de gels contenant un polystyrenesulfonate |
US6270755B1 (en) * | 1999-05-13 | 2001-08-07 | Geltex Pharmaceuticals, Inc. | Anionic polymers as toxin binders |
-
2000
- 2000-04-03 US US09/541,268 patent/US6270755B1/en not_active Expired - Lifetime
- 2000-05-09 MY MYPI20001992A patent/MY132695A/en unknown
- 2000-05-10 TW TW089108898A patent/TW592704B/zh not_active IP Right Cessation
- 2000-05-11 JP JP2000617887A patent/JP2002544226A/ja active Pending
- 2000-05-11 NZ NZ515226A patent/NZ515226A/en not_active IP Right Cessation
- 2000-05-11 PL PL352411A patent/PL197157B1/pl not_active IP Right Cessation
- 2000-05-11 IL IL14621100A patent/IL146211A0/xx active IP Right Grant
- 2000-05-11 ES ES00930620T patent/ES2288855T3/es not_active Expired - Lifetime
- 2000-05-11 DE DE60035689T patent/DE60035689T2/de not_active Expired - Lifetime
- 2000-05-11 RU RU2001133465/15A patent/RU2246938C2/ru not_active IP Right Cessation
- 2000-05-11 HU HU0201114A patent/HUP0201114A3/hu unknown
- 2000-05-11 KR KR1020017014459A patent/KR100742433B1/ko not_active IP Right Cessation
- 2000-05-11 CN CNB008075360A patent/CN100435806C/zh not_active Expired - Fee Related
- 2000-05-11 AU AU48409/00A patent/AU768592B2/en not_active Ceased
- 2000-05-11 CA CA002374108A patent/CA2374108A1/en not_active Abandoned
- 2000-05-11 DK DK00930620T patent/DK1189622T3/da active
- 2000-05-11 WO PCT/US2000/012943 patent/WO2000069428A2/en active IP Right Grant
- 2000-05-11 AT AT00930620T patent/ATE367818T1/de not_active IP Right Cessation
- 2000-05-11 EP EP00930620A patent/EP1189622B1/en not_active Expired - Lifetime
- 2000-05-11 BR BR0011520-7A patent/BR0011520A/pt not_active Application Discontinuation
- 2000-05-11 PT PT00930620T patent/PT1189622E/pt unknown
-
2001
- 2001-06-11 US US09/878,843 patent/US6419914B2/en not_active Expired - Fee Related
- 2001-10-28 IL IL146211A patent/IL146211A/en not_active IP Right Cessation
- 2001-11-12 NO NO20015524A patent/NO329497B1/no not_active IP Right Cessation
-
2002
- 2002-08-28 HK HK02106350.9A patent/HK1044490A1/zh unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25A | Requested transfer of rights approved |
Owner name: GENZYME CORPORATION (US) Free format text: TRANSFERIDO POR FUSAO DE: GELTEX PHARMACEUTICALS, INC. |
|
B25G | Requested change of headquarter approved |
Owner name: GENZYME CORPORATION (US) Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 018080029522/SP DE 14/05/2008. |
|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
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