BR0011246A - Processos para o preparo de novos derivados de propenona substituìda - Google Patents

Processos para o preparo de novos derivados de propenona substituìda

Info

Publication number
BR0011246A
BR0011246A BR0011246-1A BR0011246A BR0011246A BR 0011246 A BR0011246 A BR 0011246A BR 0011246 A BR0011246 A BR 0011246A BR 0011246 A BR0011246 A BR 0011246A
Authority
BR
Brazil
Prior art keywords
preparation
processes
derivatives
new substituted
propenone derivatives
Prior art date
Application number
BR0011246-1A
Other languages
English (en)
Inventor
Masaaki Uenaka
Kyozo Kawata
Masahiko Nagai
Takeshi Endoh
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of BR0011246A publication Critical patent/BR0011246A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Patente de Invenção: "PROCESSOS PARA O PREPARO DE NOVOS DERIVADOS DE PROPENONA SUBSTITUIDA". A presente invenção proporciona processos industriais e comerciais para o preparo de derivados de 2-acil-5-benzilfurano, derivados de éster de ácido 1,2,4-triazola-3-carboxílico e derivados de propenona tendo atividades anti-HIV e cristais úteis dos mesmos. em que R^ 1^, R^ 2^ e R^ 4^ são, cada um, independentemente, hidrogênio ou semelhantes; A é CR^ 6^ ou N; R^ 6^ é hidrogênio ou semelhantes; Q é um grupo de proteção; e L é um grupo de condução.
BR0011246-1A 1999-06-02 2000-05-29 Processos para o preparo de novos derivados de propenona substituìda BR0011246A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP15550399 1999-06-02
JP23030599 1999-08-17
PCT/JP2000/003456 WO2000075122A1 (fr) 1999-06-02 2000-05-29 Nouveau procede de preparation de derives de propenone a substitution

Publications (1)

Publication Number Publication Date
BR0011246A true BR0011246A (pt) 2002-03-05

Family

ID=26483489

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0011246-1A BR0011246A (pt) 1999-06-02 2000-05-29 Processos para o preparo de novos derivados de propenona substituìda

Country Status (10)

Country Link
US (1) US6831177B1 (pt)
EP (1) EP1186599A4 (pt)
KR (1) KR100423781B1 (pt)
CN (1) CN1367784A (pt)
AU (1) AU763231B2 (pt)
BR (1) BR0011246A (pt)
CA (1) CA2376043A1 (pt)
MX (1) MXPA01012299A (pt)
TR (2) TR200103801T2 (pt)
WO (1) WO2000075122A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003503386A (ja) * 1999-06-25 2003-01-28 メルク エンド カムパニー インコーポレーテッド １−（芳香族またはヘテロ芳香族置換）−３−（ヘテロ芳香族置換）−１，３−プロパンジオン類およびそれの使用
MXPA02012160A (es) * 2000-06-13 2003-04-25 Shionogi & Co Composiciones medicinales las cuales contienen derivados de propenona.
WO2004035577A2 (en) 2002-10-16 2004-04-29 Gilead Sciences, Inc. Pre-organized tricyclic integrase inhibitor compounds
CA2537325A1 (en) 2003-09-19 2005-03-31 Gilead Sciences, Inc. Aza-quinolinol phosphonate integrase inhibitor compounds
JP2009515840A (ja) * 2005-11-14 2009-04-16 ハー・ルンドベック・アクチエゼルスカベット エスシタロプラムの製造方法
AU2007254190A1 (en) 2006-05-16 2007-11-29 Gilead Sciences, Inc. Integrase inhibitors
CN102670628B (zh) 2008-01-25 2015-11-25 奇默里克斯公司 治疗病毒感染的方法
CN102482249B (zh) 2009-07-08 2016-06-08 德米拉(加拿大)公司 用于治疗皮肤病症或疾病状态的tofa类似物
EP2534150B1 (en) 2010-02-12 2017-04-05 Chimerix, Inc. Methods of treating viral infection
BR112013000925A2 (pt) 2010-07-15 2020-12-01 Bayer Intellectual Property Gmbh compostos heterocíclicos como pesticidas
US9572816B2 (en) 2012-10-25 2017-02-21 Technion Research And Development Foundation Ltd. Method of treatment of disease

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1481990A (en) * 1974-12-23 1977-08-03 May & Baker Ltd Herbicidal 3-benzyl-pyridazine derivatives
JPS5268182A (en) 1975-11-29 1977-06-06 Sumitomo Chem Co Ltd Preparation of novel triazole derivatives
JPS6153275A (ja) 1984-08-23 1986-03-17 Arakawa Chem Ind Co Ltd ２−アシルフラン系化合物の製法
GB2271566A (en) * 1992-10-14 1994-04-20 Merck & Co Inc HIV integrase inhibitors
JP2530102B2 (ja) 1993-07-14 1996-09-04 株式会社東芝 半導体ディスク装置およびその制御方法
JPH0778057A (ja) 1993-06-25 1995-03-20 Casio Comput Co Ltd プリンタ制御システム
AU6039296A (en) 1995-06-07 1996-12-30 G.D. Searle & Co. Method to treat cardiofibrosis with a combination therapy of an angiotensin ii antagonist and an epoxy-steroidal aldoste rone antagonist
GB2306476A (en) * 1995-10-27 1997-05-07 Merck & Co Inc Hiv integrase inhibitors
US5759842A (en) * 1996-10-24 1998-06-02 Merck & Co., Inc. In vitro HIV integrase inhibitors
AU6271098A (en) * 1997-02-06 1998-08-26 Merck & Co., Inc. Hiv integrase inhibitors
EP1069111A4 (en) 1998-03-26 2001-06-06 Shionogi & Co INDOLE DERIVATIVES EXER ANT ANTIVIRAL ACTIVITY
DE69939749D1 (de) * 1998-12-25 2008-11-27 Shionogi & Co Aromatische heterocyclen mit hiv integrase inhibierenden eigenschaften

Also Published As

Publication number Publication date
US6831177B1 (en) 2004-12-14
WO2000075122A1 (fr) 2000-12-14
TR200103801T2 (tr) 2002-04-22
TR200202129T2 (tr) 2003-03-21
EP1186599A4 (en) 2003-02-26
AU763231B2 (en) 2003-07-17
AU4782700A (en) 2000-12-28
CA2376043A1 (en) 2000-12-14
EP1186599A1 (en) 2002-03-13
KR20020020718A (ko) 2002-03-15
MXPA01012299A (es) 2002-07-30
CN1367784A (zh) 2002-09-04
KR100423781B1 (ko) 2004-03-22

Similar Documents

Publication Publication Date Title
BR9713465A (pt) Inibidores metalotprotease de amina cìclica sibstituìda
WO1998045276A3 (en) 4,4-disubstituted-3,4-dihydro-2(1h)-quinazolinones useful as hiv reverse transcriptase inhibitors
NO941937D0 (no) Sakarinderivater som inhiberer proteolytiske enzymer
NO2006003I1 (no) ÄR-(R*R*)-N-Ä3-Ä1-Ä5,6-dihydro-4-hydroksy-2-okso-6-(2-fenyletyl)-6-propyl-2H-pyran-3-yl)ÜpropylÜfenylÜ5-(trifluormetyl)-2-pyridinsulfonamid eller et farmasoytisk salt derav = tipranavir eller et farmasoytisk salt derav
NO992821L (no) Ketobenzamider som calpain-inhibitorer
DK0656887T3 (da) Hydroxyethylaminosulfonamider til anvendelse som inhibitorer af retrovirale proteaser
WO2003006425A3 (en) Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
CA2305313A1 (en) Acylsulfamoylbenzamides, crop protection compositions comprising them, and processes for their preparation
AU4700896A (en) Bis-sulfonamide hydroxyethylamino retroviral protease inhibitors
DK0816376T3 (da) Thrombininhibitorer som antikoagulante midler
DK0727419T3 (da) Mellemprodukter til fremstilling af forbindelser, som inhiberer retroviral protease
WO2000010965A3 (en) Quaternary ammonium salts and their use as anti-hiv agents
TR199902606T2 (xx) Farnesil transferaz� engelleyici kinazolinonlar.
BR0011246A (pt) Processos para o preparo de novos derivados de propenona substituìda
CA2183315A1 (en) Novel Mercaptoacetylamido 1,3,4,5-Tetrahydro-Benzo[c]azepin-3-One Disulfide Derivatives Useful as Inhibitors of Enkephalinase and Ace
BR0015836A (pt) Cristal de 4-carboxiamino-2-etil-1,2,3,4-tetra-hidroquinolina como inibidor de cetp
BR9810657A (pt) "processo de preparação de um per-hidroisoindol substituìdo"
ES551522A0 (es) Procedimiento para preparar 5h, 11h-pirrolo-2,1-c-1,4 benzoxazepinas sustituidas en posicion 11
BR0215067A (pt) Piridoquinoxalinas antivirais
BR0314966A (pt) Processo para preparar um composto, e, composto
DK0589322T3 (da) 5-Oxo-dibenzo a,d cyclohepta-1,4-diener samt deres anvendelse som retrovirale midler.
BR9811579A (pt) Processo para preparação de ácidos 3-ciano-2,4-dialógeno-5-fluorobenzóicos
BR9909029A (pt) Estabilização de poliisocianatos orgânicos
BR9902525A (pt) Processo para compostos de ácido pirrolidinil-hidroxâmico
NO972905L (no) Tienoksasinon-derivater anvendelige som antivirusmidler

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A, 7A 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1962 DE 12/08/2008.