BR0008759A - Métodos para a produção de proteinas contendo resìduos de cisteina livre - Google Patents
Métodos para a produção de proteinas contendo resìduos de cisteina livreInfo
- Publication number
- BR0008759A BR0008759A BR0008759-9A BR0008759A BR0008759A BR 0008759 A BR0008759 A BR 0008759A BR 0008759 A BR0008759 A BR 0008759A BR 0008759 A BR0008759 A BR 0008759A
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- production
- cysteine residues
- proteins containing
- containing free
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 235000018102 proteins Nutrition 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical group SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 title 1
- 235000018417 cysteine Nutrition 0.000 abstract 2
- 108091006006 PEGylated Proteins Proteins 0.000 abstract 1
- 239000002981 blocking agent Substances 0.000 abstract 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
- 150000001945 cysteines Chemical class 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Wood Science & Technology (AREA)
- Diabetes (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
"MéTODOS PARA A PRODUçãO DE PROTEìNAS CONTENDO RESìDUOS DE CISTEìNA LIVRE".A presente invenção se refere a novos métodos de fabricação de proteínas solúveis dotadas de cisteínas livres, nas quais uma célula hospedeira é exposta a um agente bloqueador de cisteína. As proteínas solúveis produzidas por esses métodos podem então ser modificadas. para aumentarem suas efetividades. Essas modificações incluem a ligação de uma metade PEG para a formação de proteínas peguiladas.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11604199P | 1999-01-14 | 1999-01-14 | |
US60/116,041 | 1999-01-14 | ||
PCT/US2000/000931 WO2000042175A1 (en) | 1999-01-14 | 2000-01-14 | Methods for making proteins containing free cysteine residues |
Publications (2)
Publication Number | Publication Date |
---|---|
BR0008759A true BR0008759A (pt) | 2002-08-06 |
BR0008759B1 BR0008759B1 (pt) | 2014-03-11 |
Family
ID=22364893
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR122013003013A BR122013003013B8 (pt) | 1999-01-14 | 2000-01-14 | proteína isolada monopeguilada do hormônio do crescimento e método para sua obtenção |
BRPI0008759-9A BR0008759B1 (pt) | 1999-01-14 | 2000-01-14 | Métodos para a produção de proteinas contendo resíduos de cisteina livre |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR122013003013A BR122013003013B8 (pt) | 1999-01-14 | 2000-01-14 | proteína isolada monopeguilada do hormônio do crescimento e método para sua obtenção |
Country Status (12)
Country | Link |
---|---|
EP (2) | EP1144613B2 (pt) |
JP (3) | JP2002534119A (pt) |
KR (1) | KR100731826B1 (pt) |
CN (1) | CN1210400C (pt) |
AT (1) | ATE526401T1 (pt) |
AU (2) | AU775937B2 (pt) |
BR (2) | BR122013003013B8 (pt) |
CA (1) | CA2359345A1 (pt) |
ES (1) | ES2373093T3 (pt) |
IL (3) | IL144259A0 (pt) |
NZ (1) | NZ513077A (pt) |
WO (1) | WO2000042175A1 (pt) |
Families Citing this family (53)
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WO1999003887A1 (en) | 1997-07-14 | 1999-01-28 | Bolder Biotechnology, Inc. | Derivatives of growth hormone and related proteins |
US6753165B1 (en) | 1999-01-14 | 2004-06-22 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
US20080076706A1 (en) | 1997-07-14 | 2008-03-27 | Bolder Biotechnology, Inc. | Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof |
US7270809B2 (en) | 1997-07-14 | 2007-09-18 | Bolder Biotechnology, Inc. | Cysteine variants of alpha interferon-2 |
US8288126B2 (en) | 1999-01-14 | 2012-10-16 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
IL144259A0 (en) | 1999-01-14 | 2002-05-23 | Bolder Biotechnology Inc | Methods for making proteins containing free cysteine residues |
DE60129432T2 (de) | 2000-05-16 | 2008-04-17 | Bolder Biotechnology, Inc., Louisville | Verfahren zur rückfaltung von proteinen mit freien cysteinresten |
EP1333036B1 (en) * | 2000-10-16 | 2009-01-21 | Chugai Seiyaku Kabushiki Kaisha | Peg-modified erythropoietin |
ATE505204T1 (de) | 2000-12-20 | 2011-04-15 | Hoffmann La Roche | Konjugate von erythropoietin (epo) mit polyethylenglykol (peg) |
JP4656814B2 (ja) | 2000-12-20 | 2011-03-23 | エフ.ホフマン−ラ ロシュ アーゲー | エリスロポエチンコンジュゲート |
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KR20100014215A (ko) | 2006-07-07 | 2010-02-10 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | 신규 단백질 접합체 및 그것의 제조 방법 |
CN105963710A (zh) | 2009-08-06 | 2016-09-28 | 诺沃—诺迪斯克保健股份有限公司 | 具有延长的体内功效的生长激素 |
CN105593242B (zh) | 2013-07-11 | 2020-11-06 | 斯克利普斯研究所 | 卷曲螺旋免疫球蛋白融合蛋白及其组合物 |
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2000
- 2000-01-14 IL IL14425900A patent/IL144259A0/xx unknown
- 2000-01-14 ES ES00902412T patent/ES2373093T3/es not_active Expired - Lifetime
- 2000-01-14 EP EP00902412.6A patent/EP1144613B2/en not_active Expired - Lifetime
- 2000-01-14 AT AT00902412T patent/ATE526401T1/de not_active IP Right Cessation
- 2000-01-14 KR KR1020017008951A patent/KR100731826B1/ko active IP Right Grant
- 2000-01-14 EP EP20100012486 patent/EP2305804B1/en not_active Revoked
- 2000-01-14 BR BR122013003013A patent/BR122013003013B8/pt not_active IP Right Cessation
- 2000-01-14 JP JP2000593732A patent/JP2002534119A/ja active Pending
- 2000-01-14 AU AU24133/00A patent/AU775937B2/en not_active Ceased
- 2000-01-14 WO PCT/US2000/000931 patent/WO2000042175A1/en active Application Filing
- 2000-01-14 CN CNB008088411A patent/CN1210400C/zh not_active Expired - Fee Related
- 2000-01-14 CA CA002359345A patent/CA2359345A1/en not_active Abandoned
- 2000-01-14 NZ NZ513077A patent/NZ513077A/xx not_active IP Right Cessation
- 2000-01-14 BR BRPI0008759-9A patent/BR0008759B1/pt not_active IP Right Cessation
-
2001
- 2001-07-11 IL IL144259A patent/IL144259A/en not_active IP Right Cessation
-
2004
- 2004-11-19 AU AU2004231217A patent/AU2004231217B2/en not_active Ceased
-
2008
- 2008-10-02 IL IL194483A patent/IL194483A0/en unknown
-
2010
- 2010-09-02 JP JP2010196790A patent/JP5517844B2/ja not_active Expired - Fee Related
-
2014
- 2014-01-20 JP JP2014007656A patent/JP2014064594A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2010280714A (ja) | 2010-12-16 |
CA2359345A1 (en) | 2000-07-20 |
EP1144613A4 (en) | 2002-10-29 |
IL144259A (en) | 2009-06-15 |
AU2004231217A1 (en) | 2004-12-23 |
WO2000042175A1 (en) | 2000-07-20 |
EP2305804B1 (en) | 2015-05-06 |
ES2373093T3 (es) | 2012-01-31 |
EP2305804A1 (en) | 2011-04-06 |
CN1210400C (zh) | 2005-07-13 |
EP1144613A1 (en) | 2001-10-17 |
BR0008759B1 (pt) | 2014-03-11 |
JP5517844B2 (ja) | 2014-06-11 |
BR122013003013B1 (pt) | 2015-06-30 |
NZ513077A (en) | 2004-03-26 |
KR100731826B1 (ko) | 2007-06-22 |
AU2413300A (en) | 2000-08-01 |
IL144259A0 (en) | 2002-05-23 |
KR20020011364A (ko) | 2002-02-08 |
JP2014064594A (ja) | 2014-04-17 |
BR122013003013B8 (pt) | 2021-07-06 |
JP2002534119A (ja) | 2002-10-15 |
EP1144613B2 (en) | 2020-05-06 |
AU775937B2 (en) | 2004-08-19 |
EP1144613B1 (en) | 2011-09-28 |
IL194483A0 (en) | 2011-08-01 |
ATE526401T1 (de) | 2011-10-15 |
CN1355842A (zh) | 2002-06-26 |
AU2004231217B2 (en) | 2008-02-28 |
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