BR0004152A - Micropartìculas lipófilas contendo um medicamento protéico ou antìgeno e preparado compreendendo o mesmo - Google Patents

Micropartìculas lipófilas contendo um medicamento protéico ou antìgeno e preparado compreendendo o mesmo

Info

Publication number
BR0004152A
BR0004152A BR0004152-1A BR0004152A BR0004152A BR 0004152 A BR0004152 A BR 0004152A BR 0004152 A BR0004152 A BR 0004152A BR 0004152 A BR0004152 A BR 0004152A
Authority
BR
Brazil
Prior art keywords
prepared
lipophilic
protein
same
active ingredient
Prior art date
Application number
BR0004152-1A
Other languages
English (en)
Inventor
Myung-Jin Kim
Sun-Jin Kim
Kyu-Chan Kwon
Joon Kim
Original Assignee
Lg Chemichal Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1019990001232A external-priority patent/KR100329336B1/ko
Priority claimed from KR1019990059776A external-priority patent/KR100359252B1/ko
Application filed by Lg Chemichal Ltd filed Critical Lg Chemichal Ltd
Publication of BR0004152A publication Critical patent/BR0004152A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH] (Somatotropin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Abstract

"MICROPARTìCULAS LIPóFILAS CONTENDO UM MEDICAMENTO PROTéICO OU ANTìGENO E PREPARADO COMPREENDENDO O MESMO" Uma micropartícula lipófila tendo um tamanho de partícula médio variando de 0,1 a 200 Ám, compreendendo uma substância lipófila e um ingrediente ativo selecionado do grupo que consiste em um medicamento proteíco ou peptídico e um antígeno, conserva a atividade total do ingrediente ativo, e quando preparada na forma de uma dispersão em óleo ou de uma emulsão de óleo em água, libera em um ambiente in vivo o ingrediente ativo de um modo controlado durante um longo período de tempo.
BR0004152-1A 1999-01-18 2000-01-14 Micropartìculas lipófilas contendo um medicamento protéico ou antìgeno e preparado compreendendo o mesmo BR0004152A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR1019990001232A KR100329336B1 (ko) 1999-01-18 1999-01-18 히아루론산을 이용한 단백질 약물의 서방성 미세 입자 제형
KR1019990059776A KR100359252B1 (ko) 1999-12-21 1999-12-21 항원을 포함하는 고체상 미세입자 및 이를 포함하는 제제
PCT/KR2000/000025 WO2000041682A1 (en) 1999-01-18 2000-01-14 Lipophilic microparticles containing a protein drug or antigen and formulation comprising same

Publications (1)

Publication Number Publication Date
BR0004152A true BR0004152A (pt) 2000-11-21

Family

ID=26634599

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0004152-1A BR0004152A (pt) 1999-01-18 2000-01-14 Micropartìculas lipófilas contendo um medicamento protéico ou antìgeno e preparado compreendendo o mesmo

Country Status (20)

Country Link
EP (2) EP1071407B1 (pt)
JP (1) JP3802348B2 (pt)
CN (1) CN1142772C (pt)
AR (1) AR043272A1 (pt)
AU (1) AU751200B2 (pt)
BG (1) BG65233B1 (pt)
BR (1) BR0004152A (pt)
CA (1) CA2324403C (pt)
DK (1) DK1071407T3 (pt)
ES (1) ES2505696T3 (pt)
HK (1) HK1036415A1 (pt)
HU (1) HUP0101040A3 (pt)
ID (1) ID25592A (pt)
IL (1) IL138468A0 (pt)
MY (1) MY125541A (pt)
NZ (1) NZ506975A (pt)
PL (1) PL200954B1 (pt)
TR (1) TR200002683T1 (pt)
TW (1) TWI260988B (pt)
WO (1) WO2000041682A1 (pt)

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KR100236771B1 (ko) * 1997-04-01 2000-02-01 성재갑 히아루론산을 이용한 약물의 서방성 미세입자 제형
WO2001021154A2 (en) * 1999-09-21 2001-03-29 Rtp Pharma Inc. Surface modified particulate compositions of biologically active substances
AU2006201100B2 (en) * 1999-09-21 2009-09-24 Jagotec Ag Surface modified particulate compositions of biologically active substances
US7582311B1 (en) * 1999-10-15 2009-09-01 Genentech, Inc. Injection vehicle for polymer-based formulations
AU2001264789A1 (en) * 2000-06-08 2001-12-17 Eli Lilly And Company Protein powder for pulmonary delivery
US6998393B2 (en) * 2000-06-23 2006-02-14 Biopharm Solutions, Inc. Aquespheres, their preparation and uses thereof
US7758869B2 (en) * 2001-07-26 2010-07-20 Immune Solutions Limited Immunogenic compositions
EP1595549A4 (en) * 2003-02-19 2010-09-22 Takeda Pharmaceutical DISPERSING AGENT FOR SUSTAINED RELEASE PREPARATIONS
JP4683319B2 (ja) * 2003-02-19 2011-05-18 武田薬品工業株式会社 徐放性製剤用の分散剤
AU2005219372A1 (en) * 2004-02-13 2005-09-15 Safeway Investments Ltd. Therapeutic calcium phosphate particles and methods of making and using same
WO2005120484A1 (ja) * 2004-06-09 2005-12-22 Kurume University グレリンの生理学的機能のレギュレーター
KR100729954B1 (ko) * 2004-12-01 2007-06-20 주식회사 엘지생명과학 Ｓｅｃ１ 변이 단백질의 제형 및 그것의 제형화 방법
WO2007025441A1 (en) 2005-08-29 2007-03-08 Tuo Jin Polysaccharide microparticles containing biological agents: there preparation and applications
JP2009521486A (ja) * 2005-12-23 2009-06-04 アルタス ファーマシューティカルズ インコーポレイテッド ポリカチオン錯化タンパク質結晶を含む組成物およびこれを使用した治療法
FR2904219B1 (fr) * 2006-07-28 2010-08-13 Flamel Tech Sa Microparticules a base de copolymere amphiphile et de principe(s) actif(s) a liberation modifiee et formulations pharmaceutiques en contenant
CN101618213B (zh) * 2008-07-03 2013-01-23 武汉生物制品研究所有限责任公司 麻疹腮腺炎乙型脑炎联合减毒活疫苗及其制备方法
US20120135039A1 (en) * 2008-10-08 2012-05-31 Aldwell Frank E Oral Vaccines for Producing Mucosal Immunity
WO2014206857A1 (en) * 2013-06-28 2014-12-31 Universitat Autonoma De Barcelona Oil-in-water formulations of mycobacterium and uses thereof
CN103923881B (zh) * 2013-08-09 2016-04-06 北京科兴生物制品有限公司 甲肝病毒单克隆抗体及其应用
AU2015241107B2 (en) 2014-04-03 2019-10-03 Boehringer Ingelheim Animal Health USA Inc. Porcine epidemic diarrhea virus vaccine
GB201716419D0 (en) 2017-10-06 2017-11-22 Univ Central Lancashire Solid composition
BR112022005354A2 (pt) 2019-09-23 2022-08-23 Dds Res Inc Composições de vesícula lipídica com agentes potencializadores de penetração
CN112933044A (zh) * 2020-12-17 2021-06-11 太阳雨林（厦门）生物医药有限公司 一种用于恶性肿瘤治疗的载药油制剂及制备方法和应用
CN112961221B (zh) * 2021-02-28 2022-05-17 长春祈健生物制品有限公司 一种水痘-带状疱疹病毒糖蛋白e胞外区蛋白的制备方法

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Also Published As

Publication number Publication date
EP2481401A1 (en) 2012-08-01
ID25592A (id) 2000-10-19
ES2505696T3 (es) 2014-10-10
WO2000041682A1 (en) 2000-07-20
BG104742A (en) 2001-07-31
EP1071407A1 (en) 2001-01-31
HK1036415A1 (en) 2002-01-04
CN1293568A (zh) 2001-05-02
EP1071407B1 (en) 2014-07-23
MY125541A (en) 2006-08-31
CN1142772C (zh) 2004-03-24
AR043272A1 (es) 2005-07-27
AU3080500A (en) 2000-08-01
TR200002683T1 (tr) 2000-12-21
JP3802348B2 (ja) 2006-07-26
PL342967A1 (en) 2001-07-16
HUP0101040A2 (hu) 2001-08-28
CA2324403C (en) 2005-12-13
CA2324403A1 (en) 2000-07-20
EP1071407A4 (en) 2009-05-20
NZ506975A (en) 2004-01-30
HUP0101040A3 (en) 2005-11-28
TWI260988B (en) 2006-09-01
IL138468A0 (en) 2001-10-31
PL200954B1 (pl) 2009-02-27
AU751200B2 (en) 2002-08-08
BG65233B1 (bg) 2007-09-28
DK1071407T3 (da) 2014-10-20
JP2002534459A (ja) 2002-10-15

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Legal Events

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B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFERIDO O PEDIDO COM BASE NOS ARTIGOS 8O, 11 E 13 DA LPI.

B12B Appeal against refusal [chapter 12.2 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE. PAGAR RESTAURACAO.

B08H Application fees: decision cancelled [chapter 8.8 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 NA RPI 2256 NA DATA 01/04/2014.