DE69831511D1 - Mikropartikel zum transport von arzneistoffen durch die schleimhaut und die blut-hirn-schranke - Google Patents
Mikropartikel zum transport von arzneistoffen durch die schleimhaut und die blut-hirn-schrankeInfo
- Publication number
- DE69831511D1 DE69831511D1 DE69831511T DE69831511T DE69831511D1 DE 69831511 D1 DE69831511 D1 DE 69831511D1 DE 69831511 T DE69831511 T DE 69831511T DE 69831511 T DE69831511 T DE 69831511T DE 69831511 D1 DE69831511 D1 DE 69831511D1
- Authority
- DE
- Germany
- Prior art keywords
- microparticles
- tip
- blood brain
- medicinal products
- brain disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/924—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis using nanostructure as support of dna analysis
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT97MI002663A IT1296914B1 (it) | 1997-12-01 | 1997-12-01 | Composizione farmaceutica comprendente microparticelle atte al passaggio transmucosale ed al superamento della barriera |
PCT/EP1998/007664 WO1999027918A1 (en) | 1997-12-01 | 1998-11-27 | Microparticles for drug delivery across mucosa and the blood-brain barrier |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69831511D1 true DE69831511D1 (de) | 2005-10-13 |
DE69831511T2 DE69831511T2 (de) | 2006-06-14 |
Family
ID=11378297
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69831511T Expired - Lifetime DE69831511T2 (de) | 1997-12-01 | 1998-11-27 | Mikropartikel zum transport von arzneistoffen durch die schleimhaut und die blut-hirn-schranke |
Country Status (8)
Country | Link |
---|---|
US (1) | US6419949B1 (de) |
EP (1) | EP1071408B1 (de) |
AT (1) | ATE303799T1 (de) |
AU (1) | AU2155199A (de) |
DE (1) | DE69831511T2 (de) |
ES (1) | ES2247736T3 (de) |
IT (1) | IT1296914B1 (de) |
WO (1) | WO1999027918A1 (de) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1296914B1 (it) | 1997-12-01 | 1999-08-03 | Maria Rosa Gasco | Composizione farmaceutica comprendente microparticelle atte al passaggio transmucosale ed al superamento della barriera |
US7153525B1 (en) | 2000-03-22 | 2006-12-26 | The University Of Kentucky Research Foundation | Microemulsions as precursors to solid nanoparticles |
AU784191B2 (en) * | 2000-04-11 | 2006-02-16 | Ibergesfer, S.L. | Structure for a washbasin |
ES2291379T3 (es) * | 2000-12-27 | 2008-03-01 | Ares Trading S.A. | Nanoparticulas lipidicas anfifilicas para la incorporacion de peptidos y/o proteinas. |
US7763663B2 (en) | 2001-12-19 | 2010-07-27 | University Of Massachusetts | Polysaccharide-containing block copolymer particles and uses thereof |
WO2003077861A2 (en) * | 2002-03-13 | 2003-09-25 | Collagenex Pharmaceuticals, Inc. | Water-based delivery systems |
EA200401565A1 (ru) * | 2002-05-24 | 2005-04-28 | Неофарм, Инк. | Способ получения кардиолипина или аналога кардиолипина (варианты), способ получения липосомы и композиция кардиолипина для лечения заболеваний (варианты) |
JP2006518701A (ja) * | 2002-05-24 | 2006-08-17 | ネオファーム、インコーポレイティッド | カルジオリピン組成物、その製造方法及び使用 |
US20050277611A1 (en) * | 2002-10-16 | 2005-12-15 | Neopharm, Inc. | Cationic cardiolipin analoges and its use thereof |
ITMI20022323A1 (it) * | 2002-10-31 | 2004-05-01 | Maria Rosa Gasco | Composizioni farmaceutiche atte al trattamento di malattie oftalmiche. |
US20050101605A1 (en) * | 2003-11-07 | 2005-05-12 | Ahmed Salah U. | Oral liquid formulations of methotrexate |
US20070219131A1 (en) * | 2004-04-15 | 2007-09-20 | Ben-Sasson Shmuel A | Compositions capable of facilitating penetration across a biological barrier |
CN101084016A (zh) * | 2004-04-15 | 2007-12-05 | 克艾思马有限公司 | 能够容易穿透生物学障碍的组合物 |
ITMI20041151A1 (it) * | 2004-06-09 | 2004-09-09 | Maria Rosa Gasco | Nanoparticelle lipidiche come agenti veicolanti per acidi nucleici procedimento per la loro preparazione e loro uso |
US20090180964A1 (en) * | 2005-06-24 | 2009-07-16 | Rao Papineni | Transmucosal delivery of optical, spect, multimodal,drug or biological cargo laden nanoparticle(s) in small animals or humans |
US9486408B2 (en) | 2005-12-01 | 2016-11-08 | University Of Massachusetts Lowell | Botulinum nanoemulsions |
US20070154403A1 (en) * | 2006-01-05 | 2007-07-05 | Thomas Skold | Oral, Pulmonary and Transmucosal Delivery Composition |
US7914988B1 (en) | 2006-03-31 | 2011-03-29 | Illumina, Inc. | Gene expression profiles to predict relapse of prostate cancer |
EP1867323A1 (de) * | 2006-06-13 | 2007-12-19 | Farmatron Ltd. | Pharmazeutische Zusammensetzungen mit verbesserter Permeation durch biologische Barrieren |
US20100172842A1 (en) * | 2007-05-16 | 2010-07-08 | Yeda Research And Development Co., Ltd. At The Weizmann Institute Of Science | Assessment of blood-brain barrier disruption |
EP2249817B8 (de) * | 2008-02-18 | 2012-03-21 | Csir | Nanoteilchen-träger zur verabreichung von arzneimitteln und verfahren zu ihrer herstellung |
EP2123262A1 (de) | 2008-05-20 | 2009-11-25 | Consorzio per il Centro di Biomedica Moleculare Scrl | Zum Überschreiten der Blut-Hirn-Schranke fähige Polyelektrolyt-gekapselte Gold-Nanopartikel |
US20100015240A1 (en) * | 2008-07-16 | 2010-01-21 | Danielle Biggs | Process for preparing microparticles containing bioactive peptides |
SI2343982T1 (sl) * | 2008-09-17 | 2017-08-31 | Chiasma Inc. | Farmacevtski sestavki in metode povezane z dostavo |
CA2772023A1 (en) | 2009-08-18 | 2011-02-24 | Ben Gurion University Of The Negev Research And Development Authority | System and method for analyzing imaging data |
WO2013057697A1 (en) | 2011-10-19 | 2013-04-25 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Magnetic resonance maps for analyzing tissue |
EP2645099A1 (de) * | 2012-03-30 | 2013-10-02 | Phares Pharmaceutical Research N.V. | Biorelevante Zusammensetzungen |
WO2014174480A1 (en) | 2013-04-24 | 2014-10-30 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Magnetic resonance maps for analyzing tissue |
JP6091721B2 (ja) * | 2014-12-19 | 2017-03-08 | 積水化学工業株式会社 | 製剤 |
CA2974196C (en) | 2015-01-20 | 2023-12-12 | TetraDerm Group LLC | Versatile topical drug delivery vehicle and multifactorial tissue moisturizer that provides mucosal and skin barrier restoration |
WO2016126830A1 (en) | 2015-02-03 | 2016-08-11 | Chiasma Inc. | Method of treating diseases |
BR112019010131A2 (pt) | 2016-11-21 | 2019-10-08 | Eirion Therapeutics Inc | entrega transdérmica de agentes grandes |
CN113271925B (zh) * | 2019-01-07 | 2023-11-10 | 釜山大学校产学协力团 | 使用w/o/w型三油酸甘油酯乳液促进血脑屏障开放的药物递送平台 |
US11141457B1 (en) | 2020-12-28 | 2021-10-12 | Amryt Endo, Inc. | Oral octreotide therapy and contraceptive methods |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3421468A1 (de) | 1984-06-08 | 1985-12-19 | Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim | Lipidnanopellets als traegersystem fuer arzneimittel zur peroralen anwendung |
US5250236A (en) * | 1991-08-05 | 1993-10-05 | Gasco Maria R | Method for producing solid lipid microspheres having a narrow size distribution |
DE4131562A1 (de) | 1991-09-18 | 1993-03-25 | Medac Klinische Spezialpraep | Arzneistofftraeger aus festen lipidteilchen-feste lipidnanosphaeren (sln) |
DE4327063A1 (de) * | 1993-08-12 | 1995-02-16 | Kirsten Dr Westesen | Ubidecarenon-Partikel mit modifizierten physikochemischen Eigenschaften |
US5858398A (en) * | 1994-11-03 | 1999-01-12 | Isomed Inc. | Microparticular pharmaceutical compositions |
IT1292142B1 (it) * | 1997-06-12 | 1999-01-25 | Maria Rosa Gasco | Composizione farmaceutica in forma di microparticelle lipidiche solide atte alla somministrazione parenterale |
IT1296914B1 (it) | 1997-12-01 | 1999-08-03 | Maria Rosa Gasco | Composizione farmaceutica comprendente microparticelle atte al passaggio transmucosale ed al superamento della barriera |
-
1997
- 1997-12-01 IT IT97MI002663A patent/IT1296914B1/it active IP Right Grant
-
1998
- 1998-11-27 EP EP98965704A patent/EP1071408B1/de not_active Expired - Lifetime
- 1998-11-27 WO PCT/EP1998/007664 patent/WO1999027918A1/en active IP Right Grant
- 1998-11-27 DE DE69831511T patent/DE69831511T2/de not_active Expired - Lifetime
- 1998-11-27 US US09/555,828 patent/US6419949B1/en not_active Expired - Fee Related
- 1998-11-27 AT AT98965704T patent/ATE303799T1/de not_active IP Right Cessation
- 1998-11-27 ES ES98965704T patent/ES2247736T3/es not_active Expired - Lifetime
- 1998-11-27 AU AU21551/99A patent/AU2155199A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ATE303799T1 (de) | 2005-09-15 |
EP1071408B1 (de) | 2005-09-07 |
ITMI972663A1 (it) | 1999-06-01 |
IT1296914B1 (it) | 1999-08-03 |
ES2247736T3 (es) | 2006-03-01 |
WO1999027918A1 (en) | 1999-06-10 |
DE69831511T2 (de) | 2006-06-14 |
EP1071408A1 (de) | 2001-01-31 |
AU2155199A (en) | 1999-06-16 |
US6419949B1 (en) | 2002-07-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |