ES2247736T3 - Microparticulas para el transporte de sustancias farmaceuticas a traves de la mucosa y la barrera hematoencefalica. - Google Patents
Microparticulas para el transporte de sustancias farmaceuticas a traves de la mucosa y la barrera hematoencefalica.Info
- Publication number
- ES2247736T3 ES2247736T3 ES98965704T ES98965704T ES2247736T3 ES 2247736 T3 ES2247736 T3 ES 2247736T3 ES 98965704 T ES98965704 T ES 98965704T ES 98965704 T ES98965704 T ES 98965704T ES 2247736 T3 ES2247736 T3 ES 2247736T3
- Authority
- ES
- Spain
- Prior art keywords
- microparticles
- mucosa
- transport
- water
- pharmaceutical substances
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/924—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis using nanostructure as support of dna analysis
Abstract
Utilización de micropartículas compuestas de un lípido o varios lípidos y una sustancia farmacéutica seleccionada de entre péptidos, antibióticos, citoestáticos para el tratamiento de linfomas, y, opcionalmente, de un agente estabilizante seleccionado de entre el grupo formado por dipalmitoilfosfatidiletanolamina-PEG, PEG- estearato, esteres de ácidos grasos de ácido mirístico hasta ácido docosanoico con metiléter-PEG, diacilfosfatidiletanolaminas esterificadas con metiléter-PEG, y polilactatos y lactatos poliglicólicos esterificados con metiléter-PEG, para la preparación de composiciones apropiadas para ser administradas por vía oral para la absorción transmucosa de citoestáticos utilizados para el tratamiento de linfomas, y de antibióticos y péptidos con efectos sobre el sistema linfático.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT97MI002663A IT1296914B1 (it) | 1997-12-01 | 1997-12-01 | Composizione farmaceutica comprendente microparticelle atte al passaggio transmucosale ed al superamento della barriera |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2247736T3 true ES2247736T3 (es) | 2006-03-01 |
Family
ID=11378297
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES98965704T Expired - Lifetime ES2247736T3 (es) | 1997-12-01 | 1998-11-27 | Microparticulas para el transporte de sustancias farmaceuticas a traves de la mucosa y la barrera hematoencefalica. |
Country Status (8)
Country | Link |
---|---|
US (1) | US6419949B1 (es) |
EP (1) | EP1071408B1 (es) |
AT (1) | ATE303799T1 (es) |
AU (1) | AU2155199A (es) |
DE (1) | DE69831511T2 (es) |
ES (1) | ES2247736T3 (es) |
IT (1) | IT1296914B1 (es) |
WO (1) | WO1999027918A1 (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1296914B1 (it) | 1997-12-01 | 1999-08-03 | Maria Rosa Gasco | Composizione farmaceutica comprendente microparticelle atte al passaggio transmucosale ed al superamento della barriera |
US7153525B1 (en) | 2000-03-22 | 2006-12-26 | The University Of Kentucky Research Foundation | Microemulsions as precursors to solid nanoparticles |
AU784191B2 (en) * | 2000-04-11 | 2006-02-16 | Ibergesfer, S.L. | Structure for a washbasin |
EP1345597B1 (en) * | 2000-12-27 | 2007-10-03 | Ares Trading S.A. | Amphiphilic lipid nanoparticles for peptide and/or protein incorporation |
US7763663B2 (en) | 2001-12-19 | 2010-07-27 | University Of Massachusetts | Polysaccharide-containing block copolymer particles and uses thereof |
NZ534377A (en) * | 2002-03-13 | 2008-04-30 | Collagenex Pharm Inc | Water-based topical delivery system consisting of cholesterol, fatty acids water and a phospholipid/ceramide portion. |
JP2006518701A (ja) * | 2002-05-24 | 2006-08-17 | ネオファーム、インコーポレイティッド | カルジオリピン組成物、その製造方法及び使用 |
EA200401565A1 (ru) * | 2002-05-24 | 2005-04-28 | Неофарм, Инк. | Способ получения кардиолипина или аналога кардиолипина (варианты), способ получения липосомы и композиция кардиолипина для лечения заболеваний (варианты) |
US20050277611A1 (en) * | 2002-10-16 | 2005-12-15 | Neopharm, Inc. | Cationic cardiolipin analoges and its use thereof |
ITMI20022323A1 (it) * | 2002-10-31 | 2004-05-01 | Maria Rosa Gasco | Composizioni farmaceutiche atte al trattamento di malattie oftalmiche. |
US20050101605A1 (en) * | 2003-11-07 | 2005-05-12 | Ahmed Salah U. | Oral liquid formulations of methotrexate |
US20070219131A1 (en) * | 2004-04-15 | 2007-09-20 | Ben-Sasson Shmuel A | Compositions capable of facilitating penetration across a biological barrier |
WO2006097793A2 (en) * | 2004-04-15 | 2006-09-21 | Chiasma, Ltd. | Compositions capable of facilitating penetration across a biological barrier |
ITMI20041151A1 (it) * | 2004-06-09 | 2004-09-09 | Maria Rosa Gasco | Nanoparticelle lipidiche come agenti veicolanti per acidi nucleici procedimento per la loro preparazione e loro uso |
US20090180964A1 (en) * | 2005-06-24 | 2009-07-16 | Rao Papineni | Transmucosal delivery of optical, spect, multimodal,drug or biological cargo laden nanoparticle(s) in small animals or humans |
US9486408B2 (en) | 2005-12-01 | 2016-11-08 | University Of Massachusetts Lowell | Botulinum nanoemulsions |
US20070154403A1 (en) * | 2006-01-05 | 2007-07-05 | Thomas Skold | Oral, Pulmonary and Transmucosal Delivery Composition |
US7914988B1 (en) * | 2006-03-31 | 2011-03-29 | Illumina, Inc. | Gene expression profiles to predict relapse of prostate cancer |
EP1867323A1 (en) * | 2006-06-13 | 2007-12-19 | Farmatron Ltd. | Pharmaceutical compositions with biological barriers permeation enhancing properties |
CA2687106A1 (en) * | 2007-05-16 | 2008-11-20 | Yeda Research And Development Co. Ltd. | Assessment of blood-brain barrier disruption |
WO2009105792A1 (en) * | 2008-02-18 | 2009-08-27 | Csir | Nanoparticle carriers for drug administration and process for producing same |
EP2123262A1 (en) | 2008-05-20 | 2009-11-25 | Consorzio per il Centro di Biomedica Moleculare Scrl | Polyelectrolyte-encapsulated gold nanoparticles capable of crossing blood-brain barrier |
CA2730760A1 (en) * | 2008-07-16 | 2010-01-21 | Surmodics Pharmaceuticals, Inc. | Process for preparing microparticles containing bioactive peptides |
CA2963659C (en) | 2008-09-17 | 2020-06-23 | Chiasma Inc. | Use of oral octreotride compositions |
JP2013502263A (ja) | 2009-08-18 | 2013-01-24 | ベン‐グリオン ユニバーシティ オブ ザ ネゲヴ リサーチ アンド デベロップメント オーソリティ | 撮像データを解析するためのシステムおよび方法 |
US10275680B2 (en) | 2011-10-19 | 2019-04-30 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Magnetic resonance maps for analyzing tissue |
EP2645099A1 (en) * | 2012-03-30 | 2013-10-02 | Phares Pharmaceutical Research N.V. | Biorelevant compositions |
EP2988668B1 (en) | 2013-04-24 | 2019-07-24 | Tel HaShomer Medical Research Infrastructure and Services Ltd. | Magnetic resonance maps for analyzing tissue |
JP6091721B2 (ja) | 2014-12-19 | 2017-03-08 | 積水化学工業株式会社 | 製剤 |
CN107405305B (zh) | 2015-01-20 | 2020-12-25 | 泰特拉德姆集团有限责任公司 | 提供粘膜和皮肤屏障恢复的通用局部药物递送载体和多因子组织保湿剂 |
EP3253401A4 (en) | 2015-02-03 | 2018-11-21 | Chiasma Inc. | Method of treating diseases |
CN110198703A (zh) | 2016-11-21 | 2019-09-03 | 艾里奥治疗公司 | 大试剂的透皮递送 |
EP3888635A4 (en) * | 2019-01-07 | 2022-08-03 | Pusan National University Industry-University Cooperation Foundation | DRUG DELIVERY PLATFORM USING W/O/W TRIOLEIN EMULSION TO PROMOTE OPENING OF THE BLOOD-BRAIN BARRIER |
US11141457B1 (en) | 2020-12-28 | 2021-10-12 | Amryt Endo, Inc. | Oral octreotide therapy and contraceptive methods |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3421468A1 (de) | 1984-06-08 | 1985-12-19 | Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim | Lipidnanopellets als traegersystem fuer arzneimittel zur peroralen anwendung |
US5250236A (en) | 1991-08-05 | 1993-10-05 | Gasco Maria R | Method for producing solid lipid microspheres having a narrow size distribution |
DE4131562A1 (de) * | 1991-09-18 | 1993-03-25 | Medac Klinische Spezialpraep | Arzneistofftraeger aus festen lipidteilchen-feste lipidnanosphaeren (sln) |
DE4327063A1 (de) | 1993-08-12 | 1995-02-16 | Kirsten Dr Westesen | Ubidecarenon-Partikel mit modifizierten physikochemischen Eigenschaften |
US5858398A (en) * | 1994-11-03 | 1999-01-12 | Isomed Inc. | Microparticular pharmaceutical compositions |
IT1292142B1 (it) * | 1997-06-12 | 1999-01-25 | Maria Rosa Gasco | Composizione farmaceutica in forma di microparticelle lipidiche solide atte alla somministrazione parenterale |
IT1296914B1 (it) | 1997-12-01 | 1999-08-03 | Maria Rosa Gasco | Composizione farmaceutica comprendente microparticelle atte al passaggio transmucosale ed al superamento della barriera |
-
1997
- 1997-12-01 IT IT97MI002663A patent/IT1296914B1/it active IP Right Grant
-
1998
- 1998-11-27 ES ES98965704T patent/ES2247736T3/es not_active Expired - Lifetime
- 1998-11-27 EP EP98965704A patent/EP1071408B1/en not_active Expired - Lifetime
- 1998-11-27 US US09/555,828 patent/US6419949B1/en not_active Expired - Fee Related
- 1998-11-27 DE DE69831511T patent/DE69831511T2/de not_active Expired - Lifetime
- 1998-11-27 AU AU21551/99A patent/AU2155199A/en not_active Abandoned
- 1998-11-27 AT AT98965704T patent/ATE303799T1/de not_active IP Right Cessation
- 1998-11-27 WO PCT/EP1998/007664 patent/WO1999027918A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
EP1071408B1 (en) | 2005-09-07 |
WO1999027918A1 (en) | 1999-06-10 |
AU2155199A (en) | 1999-06-16 |
EP1071408A1 (en) | 2001-01-31 |
DE69831511T2 (de) | 2006-06-14 |
IT1296914B1 (it) | 1999-08-03 |
US6419949B1 (en) | 2002-07-16 |
ATE303799T1 (de) | 2005-09-15 |
ITMI972663A1 (it) | 1999-06-01 |
DE69831511D1 (de) | 2005-10-13 |
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