HUP0101040A2 - Protein gyógyszer hatóanyagot vagy antigént tartalmazó lipofil mikrorészecskék és az azokat tartalmazó készítmények - Google Patents
Protein gyógyszer hatóanyagot vagy antigént tartalmazó lipofil mikrorészecskék és az azokat tartalmazó készítményekInfo
- Publication number
- HUP0101040A2 HUP0101040A2 HU0101040A HUP0101040A HUP0101040A2 HU P0101040 A2 HUP0101040 A2 HU P0101040A2 HU 0101040 A HU0101040 A HU 0101040A HU P0101040 A HUP0101040 A HU P0101040A HU P0101040 A2 HUP0101040 A2 HU P0101040A2
- Authority
- HU
- Hungary
- Prior art keywords
- antigen
- formulation
- same
- lipophilic
- protein drug
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 2
- 102000036639 antigens Human genes 0.000 title abstract 2
- 108091007433 antigens Proteins 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- 239000011859 microparticle Substances 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 238000009472 formulation Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 239000013543 active substance Substances 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000006185 dispersion Substances 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000007764 o/w emulsion Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dispersion Chemistry (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Mycology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
A találmány tárgya egy 0,1-200 mm részecskeméretű lipofilmikrorészecske, amely egy lipofil anyagot és egy protein vagy peptidgyógyszer vagy antigén közül választott hatóanyagot tartalmaz, megőrzia hatóanyag teljes aktivitását, és amikor olajos diszperzió vagyolajavízben emulzió alakjában formulázzák, in vivo környezetbenszabályozottan, hosszú időn át szabadítja fel a hatóanyagot. Ó
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019990001232A KR100329336B1 (ko) | 1999-01-18 | 1999-01-18 | 히아루론산을 이용한 단백질 약물의 서방성 미세 입자 제형 |
KR1019990059776A KR100359252B1 (ko) | 1999-12-21 | 1999-12-21 | 항원을 포함하는 고체상 미세입자 및 이를 포함하는 제제 |
PCT/KR2000/000025 WO2000041682A1 (en) | 1999-01-18 | 2000-01-14 | Lipophilic microparticles containing a protein drug or antigen and formulation comprising same |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0101040A2 true HUP0101040A2 (hu) | 2001-08-28 |
HUP0101040A3 HUP0101040A3 (en) | 2005-11-28 |
Family
ID=26634599
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0101040A HUP0101040A3 (en) | 1999-01-18 | 2000-01-14 | Lipophilic microparticles containing a protein drug or antigen and formulation comprising same |
Country Status (20)
Country | Link |
---|---|
EP (2) | EP1071407B1 (hu) |
JP (1) | JP3802348B2 (hu) |
CN (1) | CN1142772C (hu) |
AR (1) | AR043272A1 (hu) |
AU (1) | AU751200B2 (hu) |
BG (1) | BG65233B1 (hu) |
BR (1) | BR0004152A (hu) |
CA (1) | CA2324403C (hu) |
DK (1) | DK1071407T3 (hu) |
ES (1) | ES2505696T3 (hu) |
HK (1) | HK1036415A1 (hu) |
HU (1) | HUP0101040A3 (hu) |
ID (1) | ID25592A (hu) |
IL (1) | IL138468A0 (hu) |
MY (1) | MY125541A (hu) |
NZ (1) | NZ506975A (hu) |
PL (1) | PL200954B1 (hu) |
TR (1) | TR200002683T1 (hu) |
TW (1) | TWI260988B (hu) |
WO (1) | WO2000041682A1 (hu) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100236771B1 (ko) * | 1997-04-01 | 2000-02-01 | 성재갑 | 히아루론산을 이용한 약물의 서방성 미세입자 제형 |
CN1174741C (zh) * | 1999-09-21 | 2004-11-10 | Rtp药品公司 | 生物活性物质的表面改性微粒组合物 |
AU2006201100B2 (en) * | 1999-09-21 | 2009-09-24 | Jagotec Ag | Surface modified particulate compositions of biologically active substances |
US7582311B1 (en) * | 1999-10-15 | 2009-09-01 | Genentech, Inc. | Injection vehicle for polymer-based formulations |
AU2001264789A1 (en) * | 2000-06-08 | 2001-12-17 | Eli Lilly And Company | Protein powder for pulmonary delivery |
US6998393B2 (en) * | 2000-06-23 | 2006-02-14 | Biopharm Solutions, Inc. | Aquespheres, their preparation and uses thereof |
JP4685350B2 (ja) * | 2001-07-26 | 2011-05-18 | オタゴ イノベイション リミティド | 抗原性組成物 |
JP4683319B2 (ja) * | 2003-02-19 | 2011-05-18 | 武田薬品工業株式会社 | 徐放性製剤用の分散剤 |
EP1595549A4 (en) * | 2003-02-19 | 2010-09-22 | Takeda Pharmaceutical | DISPERSING AGENT FOR SUSTAINED RELEASE PREPARATIONS |
CA2555921A1 (en) * | 2004-02-13 | 2005-09-15 | Nod Pharmaceuticals, Inc. | Therapeutic calcium phosphate particles and methods of making and using same |
WO2005120484A1 (ja) * | 2004-06-09 | 2005-12-22 | Kurume University | グレリンの生理学的機能のレギュレーター |
KR100729954B1 (ko) * | 2004-12-01 | 2007-06-20 | 주식회사 엘지생명과학 | Sec1 변이 단백질의 제형 및 그것의 제형화 방법 |
WO2007025441A1 (en) | 2005-08-29 | 2007-03-08 | Tuo Jin | Polysaccharide microparticles containing biological agents: there preparation and applications |
US20090023629A1 (en) * | 2005-12-23 | 2009-01-22 | Altus Pharmaceuticals Inc. | Compositions comprising polycation-complexed protein crystals and methods of treatment using them |
FR2904219B1 (fr) * | 2006-07-28 | 2010-08-13 | Flamel Tech Sa | Microparticules a base de copolymere amphiphile et de principe(s) actif(s) a liberation modifiee et formulations pharmaceutiques en contenant |
CN101618213B (zh) * | 2008-07-03 | 2013-01-23 | 武汉生物制品研究所有限责任公司 | 麻疹腮腺炎乙型脑炎联合减毒活疫苗及其制备方法 |
US20120135039A1 (en) * | 2008-10-08 | 2012-05-31 | Aldwell Frank E | Oral Vaccines for Producing Mucosal Immunity |
WO2014206857A1 (en) * | 2013-06-28 | 2014-12-31 | Universitat Autonoma De Barcelona | Oil-in-water formulations of mycobacterium and uses thereof |
CN103923881B (zh) * | 2013-08-09 | 2016-04-06 | 北京科兴生物制品有限公司 | 甲肝病毒单克隆抗体及其应用 |
EP3125932A1 (en) | 2014-04-03 | 2017-02-08 | Boehringer Ingelheim Vetmedica, Inc. | Porcine epidemic diarrhea virus vaccine |
GB201716419D0 (en) | 2017-10-06 | 2017-11-22 | Univ Central Lancashire | Solid composition |
MX2022003446A (es) | 2019-09-23 | 2022-07-13 | Dds Res Inc | Composiciones de vesiculas lipidicas con agentes potenciadores de la penetracion. |
CN112933044A (zh) * | 2020-12-17 | 2021-06-11 | 太阳雨林(厦门)生物医药有限公司 | 一种用于恶性肿瘤治疗的载药油制剂及制备方法和应用 |
CN112961221B (zh) * | 2021-02-28 | 2022-05-17 | 长春祈健生物制品有限公司 | 一种水痘-带状疱疹病毒糖蛋白e胞外区蛋白的制备方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5059421A (en) * | 1985-07-26 | 1991-10-22 | The Liposome Company, Inc. | Preparation of targeted liposome systems of a defined size distribution |
JPH01287041A (ja) | 1988-05-13 | 1989-11-17 | Rooman Kogyo:Kk | 徐放性製剤 |
JP2513276B2 (ja) | 1988-06-10 | 1996-07-03 | 日本電気株式会社 | 位相同期ル―プ |
US5416017A (en) | 1990-05-18 | 1995-05-16 | The Scripps Research Institute | Cholera toxin gene regulated by tissue-specific promoters |
DE4107153A1 (de) | 1991-03-06 | 1992-09-10 | Gregor Cevc | Praeparat zur wirkstoffapplikation in kleinsttroepfchenform |
DE69128455T2 (de) | 1990-11-06 | 1998-06-18 | Inst Nacional De Engenharia E | Liposomale Mittel sowie Verfahren zu deren Herstellung |
WO1992014449A1 (en) * | 1991-02-20 | 1992-09-03 | Nova Pharmaceutical Corporation | Controlled release microparticulate delivery system for proteins |
DE69426570T2 (de) * | 1993-11-03 | 2001-08-23 | Isomed Inc | Mizelleförmige feinteilige pharmazeutische zusammensetzungen |
US5858398A (en) * | 1994-11-03 | 1999-01-12 | Isomed Inc. | Microparticular pharmaceutical compositions |
KR100201352B1 (ko) | 1995-03-16 | 1999-06-15 | 성재갑 | 단일주사 백신 제형 |
KR100236771B1 (ko) * | 1997-04-01 | 2000-02-01 | 성재갑 | 히아루론산을 이용한 약물의 서방성 미세입자 제형 |
AU740111B2 (en) * | 1996-09-27 | 2001-11-01 | Jagotec Ag | Hyaluronic drug delivery system |
US6096291A (en) | 1996-12-27 | 2000-08-01 | Biovector Therapeutics, S.A. | Mucosal administration of substances to mammals |
AU2001280934A1 (en) * | 2000-07-28 | 2002-02-13 | Alliance Pharmaceutical Corp. | Methods and compositions to upregulate, redirect or limit immune responses to bioactive compounds |
-
2000
- 2000-01-14 TR TR2000/02683T patent/TR200002683T1/xx unknown
- 2000-01-14 CN CNB008000433A patent/CN1142772C/zh not_active Expired - Lifetime
- 2000-01-14 EP EP00900954.9A patent/EP1071407B1/en not_active Expired - Lifetime
- 2000-01-14 WO PCT/KR2000/000025 patent/WO2000041682A1/en active IP Right Grant
- 2000-01-14 IL IL13846800A patent/IL138468A0/xx not_active IP Right Cessation
- 2000-01-14 PL PL342967A patent/PL200954B1/pl not_active IP Right Cessation
- 2000-01-14 EP EP11176647A patent/EP2481401A1/en not_active Withdrawn
- 2000-01-14 CA CA002324403A patent/CA2324403C/en not_active Expired - Lifetime
- 2000-01-14 HU HU0101040A patent/HUP0101040A3/hu unknown
- 2000-01-14 DK DK00900954.9T patent/DK1071407T3/da active
- 2000-01-14 NZ NZ506975A patent/NZ506975A/en not_active IP Right Cessation
- 2000-01-14 AU AU30805/00A patent/AU751200B2/en not_active Expired
- 2000-01-14 BR BR0004152-1A patent/BR0004152A/pt not_active Application Discontinuation
- 2000-01-14 JP JP2000593294A patent/JP3802348B2/ja not_active Expired - Lifetime
- 2000-01-14 ES ES00900954.9T patent/ES2505696T3/es not_active Expired - Lifetime
- 2000-01-14 ID IDW20001816A patent/ID25592A/id unknown
- 2000-01-17 MY MYPI20000141A patent/MY125541A/en unknown
- 2000-01-18 TW TW089100737A patent/TWI260988B/zh not_active IP Right Cessation
- 2000-01-18 AR ARP000100211A patent/AR043272A1/es active IP Right Grant
- 2000-09-01 BG BG104742A patent/BG65233B1/bg unknown
-
2001
- 2001-10-26 HK HK01107474A patent/HK1036415A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP3802348B2 (ja) | 2006-07-26 |
ES2505696T3 (es) | 2014-10-10 |
EP1071407A1 (en) | 2001-01-31 |
CN1293568A (zh) | 2001-05-02 |
EP1071407B1 (en) | 2014-07-23 |
PL342967A1 (en) | 2001-07-16 |
TWI260988B (en) | 2006-09-01 |
WO2000041682A1 (en) | 2000-07-20 |
BR0004152A (pt) | 2000-11-21 |
CA2324403A1 (en) | 2000-07-20 |
DK1071407T3 (da) | 2014-10-20 |
CN1142772C (zh) | 2004-03-24 |
EP2481401A1 (en) | 2012-08-01 |
PL200954B1 (pl) | 2009-02-27 |
MY125541A (en) | 2006-08-31 |
NZ506975A (en) | 2004-01-30 |
HK1036415A1 (en) | 2002-01-04 |
AU751200B2 (en) | 2002-08-08 |
JP2002534459A (ja) | 2002-10-15 |
EP1071407A4 (en) | 2009-05-20 |
BG65233B1 (bg) | 2007-09-28 |
IL138468A0 (en) | 2001-10-31 |
BG104742A (en) | 2001-07-31 |
CA2324403C (en) | 2005-12-13 |
AR043272A1 (es) | 2005-07-27 |
AU3080500A (en) | 2000-08-01 |
ID25592A (id) | 2000-10-19 |
HUP0101040A3 (en) | 2005-11-28 |
TR200002683T1 (tr) | 2000-12-21 |
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