BG99736A - Сескитерпени,тяхното получаване и използването им като инхибитори на гамк-бензодиазепиновите рецептори - Google Patents

Сескитерпени,тяхното получаване и използването им като инхибитори на гамк-бензодиазепиновите рецептори Download PDF

Info

Publication number
BG99736A
BG99736A BG99736A BG9973695A BG99736A BG 99736 A BG99736 A BG 99736A BG 99736 A BG99736 A BG 99736A BG 9973695 A BG9973695 A BG 9973695A BG 99736 A BG99736 A BG 99736A
Authority
BG
Bulgaria
Prior art keywords
formula
sesquiterpenes
compound
fermentation
strain
Prior art date
Application number
BG99736A
Other languages
Bulgarian (bg)
English (en)
Inventor
Didier Renno
Gerard O'beirne
Brent Copp
Original Assignee
Xenova Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenova Limited filed Critical Xenova Limited
Publication of BG99736A publication Critical patent/BG99736A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
BG99736A 1992-12-22 1995-06-21 Сескитерпени,тяхното получаване и използването им като инхибитори на гамк-бензодиазепиновите рецептори BG99736A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929226724A GB9226724D0 (en) 1992-12-22 1992-12-22 Pharmaceutical compounds
PCT/GB1993/002632 WO1994014814A1 (en) 1992-12-22 1993-12-22 Sesquiterpenes, their preparation and their use as inhibitors acting on the gaba-benzodiazepine receptor

Publications (1)

Publication Number Publication Date
BG99736A true BG99736A (bg) 1996-04-30

Family

ID=10727034

Family Applications (1)

Application Number Title Priority Date Filing Date
BG99736A BG99736A (bg) 1992-12-22 1995-06-21 Сескитерпени,тяхното получаване и използването им като инхибитори на гамк-бензодиазепиновите рецептори

Country Status (23)

Country Link
US (1) US5565486A (no)
EP (1) EP0675888A1 (no)
JP (1) JPH08504804A (no)
KR (1) KR950704324A (no)
AU (1) AU677272B2 (no)
BG (1) BG99736A (no)
BR (1) BR9307712A (no)
CA (1) CA2151251A1 (no)
CZ (1) CZ284121B6 (no)
FI (1) FI953081A0 (no)
GB (2) GB9226724D0 (no)
HU (1) HUT71859A (no)
IL (1) IL108140A (no)
MX (1) MX9400174A (no)
NO (1) NO952483L (no)
NZ (1) NZ258986A (no)
PL (1) PL309628A1 (no)
RU (1) RU95113350A (no)
SG (1) SG67345A1 (no)
SK (1) SK77595A3 (no)
TW (1) TW242141B (no)
WO (1) WO1994014814A1 (no)
ZA (1) ZA939626B (no)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070161095A1 (en) * 2005-01-18 2007-07-12 Gurin Michael H Biomass Fuel Synthesis Methods for Increased Energy Efficiency
CA2797033C (en) 2010-04-22 2021-10-19 Longevity Biotech, Inc. Highly active polypeptides and methods of making and using the same
US9789164B2 (en) 2013-03-15 2017-10-17 Longevity Biotech, Inc. Peptides comprising non-natural amino acids and methods of making and using the same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6348284A (ja) * 1986-08-18 1988-02-29 Yamanouchi Pharmaceut Co Ltd 新抗生物質ｙｐ−０２９０８ｌ−ａおよびその製造法
US5028722A (en) * 1987-02-06 1991-07-02 Snow Brand Milk Products Co., Ltd. Novel 7 β-hydroxy-4-pregnene-3,20-dione derivatives and method for preparing same
US5120723A (en) * 1987-08-25 1992-06-09 University Of Southern California Method, compositions, and compounds for modulating brain excitability
JP2842613B2 (ja) * 1989-04-28 1999-01-06 塩野義製薬株式会社 フォスフォリパーゼａ▲下２▼阻害物質
JPH03108490A (ja) * 1989-06-30 1991-05-08 Shionogi & Co Ltd フォスフォリパーゼａ↓２阻害物質
US5130430A (en) * 1990-10-31 1992-07-14 Neurogen Corporation 2-substituted imidazoquinoxaline diones, a new class of gaba brain receptor ligands
US5189050A (en) * 1991-06-03 1993-02-23 Merck & Co., Inc. Fermentation analogs of virginiamycin m1 to treat panic and anxiety disorder

Also Published As

Publication number Publication date
CZ164695A3 (en) 1995-11-15
IL108140A (en) 1997-06-10
ZA939626B (en) 1994-08-18
HU9501840D0 (en) 1995-08-28
GB2284603A (en) 1995-06-14
JPH08504804A (ja) 1996-05-28
US5565486A (en) 1996-10-15
EP0675888A1 (en) 1995-10-11
TW242141B (no) 1995-03-01
NO952483D0 (no) 1995-06-21
NZ258986A (en) 1996-11-26
RU95113350A (ru) 1997-06-10
GB9503413D0 (en) 1995-04-12
SK77595A3 (en) 1995-12-06
CZ284121B6 (cs) 1998-08-12
IL108140A0 (en) 1994-04-12
AU5709694A (en) 1994-07-19
WO1994014814A1 (en) 1994-07-07
AU677272B2 (en) 1997-04-17
MX9400174A (es) 1994-07-29
KR950704324A (ko) 1995-11-17
FI953081A (fi) 1995-06-21
PL309628A1 (en) 1995-10-30
SG67345A1 (en) 1999-09-21
CA2151251A1 (en) 1994-07-07
BR9307712A (pt) 1999-08-31
NO952483L (no) 1995-08-15
FI953081A0 (fi) 1995-06-21
GB9226724D0 (en) 1993-02-17
HUT71859A (en) 1996-02-28
GB2284603B (en) 1996-03-27

Similar Documents

Publication Publication Date Title
CA2494742C (en) Tiacumicin production
FI110871B (fi) Menetelmä polysyklisten antiparasiittisten aineiden valmistamiseksi ja menetelmässä käytettävä mikro-organismi
US20070191415A1 (en) Production of tacrolimus (fk-506) using new streptomyces species
US5468849A (en) Rebeccamycin analogs by tryptophan analogs feeding
BG99736A (bg) Сескитерпени,тяхното получаване и използването им като инхибитори на гамк-бензодиазепиновите рецептори
EP0722940B1 (en) Physiologically active substances PF1092A, PF1092B and PF1092C, process for the production thereof, and contraceptives and anticancer drugs containing the same as active ingredients
EP0504711B1 (en) Compound UCA1064-B
CN115925782A (zh) 一种天然Rakicidins类化合物Rakicidin K及其发酵提取方法
CA2037783C (en) Rebeccamycin analogs by tryptophan analogs feeding
JPS59161396A (ja) 新規抗生物質スピカマイシン
JPH09202797A (ja) ５α−還元酵素阻害化合物ｄ１０６７３３１
JPH02193940A (ja) 化合物ｔａｎ―１１４０およびその製造法