BG99736A - Сескитерпени,тяхното получаване и използването им като инхибитори на гамк-бензодиазепиновите рецептори - Google Patents

Сескитерпени,тяхното получаване и използването им като инхибитори на гамк-бензодиазепиновите рецептори Download PDF

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Publication number
BG99736A
BG99736A BG99736A BG9973695A BG99736A BG 99736 A BG99736 A BG 99736A BG 99736 A BG99736 A BG 99736A BG 9973695 A BG9973695 A BG 9973695A BG 99736 A BG99736 A BG 99736A
Authority
BG
Bulgaria
Prior art keywords
formula
sesquiterpenes
compound
fermentation
strain
Prior art date
Application number
BG99736A
Other languages
Bulgarian (bg)
English (en)
Inventor
Didier Renno
Gerard O'beirne
Brent Copp
Original Assignee
Xenova Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenova Limited filed Critical Xenova Limited
Publication of BG99736A publication Critical patent/BG99736A/bg

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/06Peri-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
BG99736A 1992-12-22 1995-06-21 Сескитерпени,тяхното получаване и използването им като инхибитори на гамк-бензодиазепиновите рецептори BG99736A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929226724A GB9226724D0 (en) 1992-12-22 1992-12-22 Pharmaceutical compounds
PCT/GB1993/002632 WO1994014814A1 (en) 1992-12-22 1993-12-22 Sesquiterpenes, their preparation and their use as inhibitors acting on the gaba-benzodiazepine receptor

Publications (1)

Publication Number Publication Date
BG99736A true BG99736A (bg) 1996-04-30

Family

ID=10727034

Family Applications (1)

Application Number Title Priority Date Filing Date
BG99736A BG99736A (bg) 1992-12-22 1995-06-21 Сескитерпени,тяхното получаване и използването им като инхибитори на гамк-бензодиазепиновите рецептори

Country Status (23)

Country Link
US (1) US5565486A (fi)
EP (1) EP0675888A1 (fi)
JP (1) JPH08504804A (fi)
KR (1) KR950704324A (fi)
AU (1) AU677272B2 (fi)
BG (1) BG99736A (fi)
BR (1) BR9307712A (fi)
CA (1) CA2151251A1 (fi)
CZ (1) CZ284121B6 (fi)
FI (1) FI953081A0 (fi)
GB (2) GB9226724D0 (fi)
HU (1) HUT71859A (fi)
IL (1) IL108140A (fi)
MX (1) MX9400174A (fi)
NO (1) NO952483L (fi)
NZ (1) NZ258986A (fi)
PL (1) PL309628A1 (fi)
RU (1) RU95113350A (fi)
SG (1) SG67345A1 (fi)
SK (1) SK77595A3 (fi)
TW (1) TW242141B (fi)
WO (1) WO1994014814A1 (fi)
ZA (1) ZA939626B (fi)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070161095A1 (en) * 2005-01-18 2007-07-12 Gurin Michael H Biomass Fuel Synthesis Methods for Increased Energy Efficiency
CA2797033C (en) 2010-04-22 2021-10-19 Longevity Biotech, Inc. Highly active polypeptides and methods of making and using the same
US9789164B2 (en) 2013-03-15 2017-10-17 Longevity Biotech, Inc. Peptides comprising non-natural amino acids and methods of making and using the same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6348284A (ja) * 1986-08-18 1988-02-29 Yamanouchi Pharmaceut Co Ltd 新抗生物質yp−02908l−aおよびその製造法
EP0301102B1 (en) * 1987-02-06 1991-11-06 Snow Brand Milk Products Co., Ltd. NOVEL 7$g(b)-HYDROXY-4-PREGNENE-3,20-DIONE DERIVATIVES AND PROCESS FOR THEIR PREPARATION
US5120723A (en) * 1987-08-25 1992-06-09 University Of Southern California Method, compositions, and compounds for modulating brain excitability
JP2842613B2 (ja) * 1989-04-28 1999-01-06 塩野義製薬株式会社 フォスフォリパーゼa▲下2▼阻害物質
JPH03108490A (ja) * 1989-06-30 1991-05-08 Shionogi & Co Ltd フォスフォリパーゼa↓2阻害物質
US5130430A (en) * 1990-10-31 1992-07-14 Neurogen Corporation 2-substituted imidazoquinoxaline diones, a new class of gaba brain receptor ligands
US5189050A (en) * 1991-06-03 1993-02-23 Merck & Co., Inc. Fermentation analogs of virginiamycin m1 to treat panic and anxiety disorder

Also Published As

Publication number Publication date
GB9503413D0 (en) 1995-04-12
CZ164695A3 (en) 1995-11-15
IL108140A (en) 1997-06-10
NZ258986A (en) 1996-11-26
GB2284603B (en) 1996-03-27
MX9400174A (es) 1994-07-29
AU5709694A (en) 1994-07-19
HUT71859A (en) 1996-02-28
TW242141B (fi) 1995-03-01
IL108140A0 (en) 1994-04-12
CZ284121B6 (cs) 1998-08-12
BR9307712A (pt) 1999-08-31
EP0675888A1 (en) 1995-10-11
CA2151251A1 (en) 1994-07-07
HU9501840D0 (en) 1995-08-28
NO952483D0 (no) 1995-06-21
JPH08504804A (ja) 1996-05-28
KR950704324A (ko) 1995-11-17
FI953081A (fi) 1995-06-21
US5565486A (en) 1996-10-15
PL309628A1 (en) 1995-10-30
FI953081A0 (fi) 1995-06-21
GB2284603A (en) 1995-06-14
WO1994014814A1 (en) 1994-07-07
NO952483L (no) 1995-08-15
SG67345A1 (en) 1999-09-21
RU95113350A (ru) 1997-06-10
AU677272B2 (en) 1997-04-17
SK77595A3 (en) 1995-12-06
GB9226724D0 (en) 1993-02-17
ZA939626B (en) 1994-08-18

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