BG99729A - Substituted 6-azaandrostenones - Google Patents

Substituted 6-azaandrostenones

Info

Publication number
BG99729A
BG99729A BG99729A BG9972995A BG99729A BG 99729 A BG99729 A BG 99729A BG 99729 A BG99729 A BG 99729A BG 9972995 A BG9972995 A BG 9972995A BG 99729 A BG99729 A BG 99729A
Authority
BG
Bulgaria
Prior art keywords
substituted
hydrogen
lower alkyl
bond
double
Prior art date
Application number
BG99729A
Other languages
Bulgarian (bg)
English (en)
Inventor
Robert Andrews
Cynthia Cribbs
Stephen Frye
Curt Haffner
Patrick Maloney
Original Assignee
Glaxo Wellcome Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Wellcome Inc. filed Critical Glaxo Wellcome Inc.
Publication of BG99729A publication Critical patent/BG99729A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58Radicals substituted by nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/41Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/44Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
    • C07C211/45Monoamines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14Nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D335/00Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/02Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J73/00Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/02Systems containing only non-condensed rings with a three-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/06Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/18Systems containing only non-condensed rings with a ring being at least seven-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/36Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/46Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing nine carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BG99729A 1992-12-18 1995-06-19 Substituted 6-azaandrostenones BG99729A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99393092A 1992-12-18 1992-12-18
US8066593A 1993-06-18 1993-06-18
PCT/US1993/012419 WO1994014833A2 (en) 1992-12-18 1993-12-17 Substituted 6-azaandrostenones

Publications (1)

Publication Number Publication Date
BG99729A true BG99729A (en) 1996-01-31

Family

ID=26763785

Family Applications (1)

Application Number Title Priority Date Filing Date
BG99729A BG99729A (en) 1992-12-18 1995-06-19 Substituted 6-azaandrostenones

Country Status (24)

Country Link
EP (1) EP0674651B1 (sl)
JP (1) JPH08504825A (sl)
CN (1) CN1095383A (sl)
AP (1) AP459A (sl)
AT (1) ATE172738T1 (sl)
AU (1) AU673899B2 (sl)
BG (1) BG99729A (sl)
CA (1) CA2152053A1 (sl)
CZ (1) CZ157695A3 (sl)
DE (1) DE69321849D1 (sl)
FI (1) FI953009A (sl)
HU (1) HUT72083A (sl)
IL (1) IL108073A0 (sl)
IS (1) IS4106A (sl)
LV (1) LV10958B (sl)
MX (1) MX9308015A (sl)
NO (1) NO952402L (sl)
NZ (1) NZ261415A (sl)
OA (1) OA10167A (sl)
PL (1) PL314532A1 (sl)
SI (1) SI9300665A (sl)
SK (1) SK79495A3 (sl)
TW (1) TW293824B (sl)
WO (1) WO1994014833A2 (sl)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW369521B (en) * 1993-09-17 1999-09-11 Smithkline Beecham Corp Androstenone derivative
US5516779A (en) * 1994-06-08 1996-05-14 Merck & Co., Inc. 17β-substituted-6-azasteroid derivatives useful as 5α-reductase inhibitors
US5817818A (en) * 1994-09-16 1998-10-06 Glaxo Wellcome Inc. Androstenones
US5541322A (en) * 1994-10-14 1996-07-30 Glaxo Wellcome Inc. Synthesis of 6-azaandrostenones
US5543417A (en) * 1994-10-21 1996-08-06 Merck & Co., Inc. Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
US5595996A (en) * 1994-10-25 1997-01-21 Merck & Co., Inc. 7-substituted 4-aza cholanic acid derivatives and their use
GB9506678D0 (en) * 1995-03-31 1995-05-24 Glaxo Inc Substituted 6-azacholesten-3-ones
AU704933B2 (en) * 1995-10-19 1999-05-06 Merck & Co., Inc. 16-substituted-6-aza-steroid 5-alpha-reductase inhibitors
US5935968A (en) * 1997-03-17 1999-08-10 Merck & Co., Inc. Methods for treating polycystic ovary syndrome
EP1615866B1 (en) 2003-04-15 2011-02-16 Aquinox Pharmaceuticals Inc. Indene derivatives as pharmaceutical agents
US7790770B2 (en) 2005-11-23 2010-09-07 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
EP2970100A1 (en) 2013-03-14 2016-01-20 Aquinox Pharmaceuticals (Canada) Inc. Ship1 modulators and methods related thereto
US9765085B2 (en) 2013-03-14 2017-09-19 Aquinox Pharmaceuticals (Canada) Inc. SHIP1 modulators and methods related thereto
CA2986790A1 (en) 2015-06-26 2016-12-29 Aquinox Pharmaceuticals (Canada) Inc. Crystalline solid forms of the acetate salt of (1s,3s,4r)-4-((3as,4r,5s,7as)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1h-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol
AU2017209430A1 (en) 2016-01-20 2018-07-12 Aquinox Pharmaceuticals (Canada) Inc. Synthesis of a substituted indene derivative
BR112018072255B1 (pt) * 2016-04-29 2024-02-06 The Research Foundation For The State University Of New York Azasteroides para tratamento de tuberculose

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE165368T1 (de) * 1991-12-20 1998-05-15 Glaxo Wellcome Inc Inhibitoren von testosteron-5-alpha reductase.
US5438061A (en) * 1993-07-16 1995-08-01 Merck & Co., Inc. 7-substituted-δ4-6-azasteroid derivatives as 5α-reductase inhibitors

Also Published As

Publication number Publication date
AU6015094A (en) 1994-07-19
EP0674651A1 (en) 1995-10-04
LV10958A (lv) 1995-12-20
HU9501775D0 (en) 1995-08-28
AU673899B2 (en) 1996-11-28
NZ261415A (en) 1997-03-24
PL314532A1 (en) 1996-09-16
CZ157695A3 (en) 1995-12-13
IS4106A (is) 1994-06-19
EP0674651B1 (en) 1998-10-28
IL108073A0 (en) 1994-04-12
FI953009A (fi) 1995-08-15
CN1095383A (zh) 1994-11-23
WO1994014833A3 (en) 1994-09-29
NO952402D0 (no) 1995-06-16
TW293824B (sl) 1996-12-21
MX9308015A (es) 1994-08-31
FI953009A0 (fi) 1995-06-16
WO1994014833A2 (en) 1994-07-07
JPH08504825A (ja) 1996-05-28
NO952402L (no) 1995-08-16
AP459A (en) 1996-02-14
AP9300599A0 (en) 1994-01-31
LV10958B (en) 1996-10-20
ATE172738T1 (de) 1998-11-15
DE69321849D1 (de) 1998-12-03
CA2152053A1 (en) 1994-07-07
HUT72083A (en) 1996-03-28
SI9300665A (en) 1994-06-30
OA10167A (en) 1996-12-18
SK79495A3 (en) 1995-11-08

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