BG27546A4 - Method of obtaining of n- tetrahydrofurfuril- horohymorphones and their salts - Google Patents

Method of obtaining of n- tetrahydrofurfuril- horohymorphones and their salts

Info

Publication number
BG27546A4
BG27546A4 BG034743A BG3474376A BG27546A4 BG 27546 A4 BG27546 A4 BG 27546A4 BG 034743 A BG034743 A BG 034743A BG 3474376 A BG3474376 A BG 3474376A BG 27546 A4 BG27546 A4 BG 27546A4
Authority
BG
Bulgaria
Prior art keywords
tetrahydrofurfuril
horohymorphones
salts
obtaining
Prior art date
Application number
BG034743A
Other languages
Bulgarian (bg)
English (en)
Inventor
Herbert Merz
Gerhard Walter
Adolf Langbein
Klaus Stackhaus
Helmut Wiek
Original Assignee
Неизвестен
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Неизвестен filed Critical Неизвестен
Publication of BG27546A4 publication Critical patent/BG27546A4/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BG034743A 1975-08-27 1976-08-25 Method of obtaining of n- tetrahydrofurfuril- horohymorphones and their salts BG27546A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19752538075 DE2538075A1 (de) 1975-08-27 1975-08-27 N-tetrahydrofurfuryl-noroxymorphone, deren saeureadditionssalze, diese enthaltende arzneimittel sowie verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
BG27546A4 true BG27546A4 (en) 1979-11-12

Family

ID=5954931

Family Applications (2)

Application Number Title Priority Date Filing Date
BG034062A BG27545A3 (en) 1975-08-27 1976-08-25 Method of obtaining of n- tetrahydrofurfuril- noroxymorphones and their salts
BG034743A BG27546A4 (en) 1975-08-27 1976-08-25 Method of obtaining of n- tetrahydrofurfuril- horohymorphones and their salts

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BG034062A BG27545A3 (en) 1975-08-27 1976-08-25 Method of obtaining of n- tetrahydrofurfuril- noroxymorphones and their salts

Country Status (33)

Country Link
US (1) US4100288A (ro)
JP (1) JPS5231100A (ro)
AT (1) AT350737B (ro)
AU (1) AU499926B2 (ro)
BE (1) BE845563A (ro)
BG (2) BG27545A3 (ro)
CA (1) CA1068266A (ro)
CH (5) CH622521A5 (ro)
CS (2) CS192564B2 (ro)
DD (1) DD127145A5 (ro)
DE (1) DE2538075A1 (ro)
DK (1) DK143278C (ro)
ES (5) ES450897A1 (ro)
FI (1) FI762430A (ro)
FR (1) FR2321888A1 (ro)
GB (1) GB1519719A (ro)
GR (1) GR61158B (ro)
HU (1) HU176929B (ro)
IE (1) IE44069B1 (ro)
IL (1) IL50355A (ro)
LU (1) LU75667A1 (ro)
MX (1) MX4133E (ro)
NL (1) NL7609485A (ro)
NO (1) NO145793C (ro)
NZ (1) NZ181864A (ro)
PH (1) PH13780A (ro)
PL (2) PL109091B1 (ro)
PT (1) PT65521B (ro)
RO (1) RO69457A (ro)
SE (1) SE7609495L (ro)
SU (2) SU612631A3 (ro)
YU (1) YU208176A (ro)
ZA (1) ZA765120B (ro)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4272541A (en) * 1978-06-02 1981-06-09 Miles Laboratories, Inc. 7,8 and 7-8 Substituted 4,5α-epoxymorphinan-6-one compounds, and methods of treating pain and drug dependence with them
US4272540A (en) * 1979-04-24 1981-06-09 Sisa, Incorporated 14-Methoxymorphinan-6-one compounds and therapeutic methods of treating pain and drug dependence with them
DE3220831A1 (de) * 1982-06-03 1983-12-08 Boehringer Ingelheim KG, 6507 Ingelheim N-(2-methoxyethyl)-noroxymorphon, dessen saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung
AU2007240680B2 (en) * 2006-04-21 2013-05-02 Nektar Therapeutics Stereoselective reduction of a morphinone
US20120010412A1 (en) 2010-07-08 2012-01-12 Alkermes, Inc. Process for the Synthesis of Substituted Morphinans
US9211293B2 (en) 2011-12-15 2015-12-15 Alkermes Pharma Ireland Limited Opioid agonist antagonist combinations
EP3003311A2 (en) 2013-05-24 2016-04-13 Alkermes Pharma Ireland Limited Methods for treating depressive symptoms
EP3004114B1 (en) 2013-05-24 2019-12-25 Alkermes Pharma Ireland Limited Morphan and morphinan analogues, and methods of use
AU2019224127B2 (en) * 2018-02-23 2021-12-09 Rhodes Technologies Novel opioid compounds and uses thereof
EP4243768A1 (en) 2020-11-12 2023-09-20 Alkermes Pharma Ireland Limited Immediate release multilayer tablet

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH446370A (de) 1964-03-05 1967-11-15 Hoffmann La Roche Verfahren zur Herstellung von Phenanthren-Derivaten
DE2238839A1 (de) * 1972-08-07 1974-02-14 Boehringer Sohn Ingelheim Neue morphinon-derivate, deren saeureadditionssalze, verfahren zu ihrer herstellung sowie ihre verwendung zur herstellung von arzneimitteln

Also Published As

Publication number Publication date
YU208176A (en) 1982-08-31
DE2538075A1 (de) 1977-03-17
IL50355A (en) 1979-11-30
AU1720176A (en) 1978-03-02
IL50355A0 (en) 1976-10-31
CA1068266A (en) 1979-12-18
AU499926B2 (en) 1979-05-03
ES454085A1 (es) 1977-11-16
JPS5231100A (en) 1977-03-09
ES454087A2 (es) 1977-11-16
CS192564B2 (en) 1979-08-31
DK143278B (da) 1981-08-03
IE44069L (en) 1977-02-27
DK386876A (da) 1977-02-28
FI762430A (ro) 1977-02-28
CH624115A5 (ro) 1981-07-15
DD127145A5 (ro) 1977-09-07
NO145793B (no) 1982-02-22
ZA765120B (en) 1978-05-30
SU612631A3 (ru) 1978-06-25
BG27545A3 (en) 1979-11-12
DK143278C (da) 1981-12-07
NZ181864A (en) 1978-06-20
GB1519719A (en) 1978-08-02
HU176929B (hu) 1981-06-28
CS192599B2 (en) 1979-08-31
CH624117A5 (ro) 1981-07-15
SU638262A3 (ru) 1978-12-15
AT350737B (de) 1979-06-11
PH13780A (en) 1980-09-26
SE7609495L (sv) 1977-02-28
CH624114A5 (ro) 1981-07-15
US4100288A (en) 1978-07-11
NL7609485A (nl) 1977-03-01
ES450897A1 (es) 1977-12-01
PT65521A (de) 1976-09-01
PT65521B (de) 1978-07-04
NO145793C (no) 1982-06-02
ATA553976A (de) 1978-11-15
PL109091B1 (en) 1980-05-31
ES454084A1 (es) 1977-11-16
NO762932L (ro) 1977-03-01
CH622521A5 (ro) 1981-04-15
IE44069B1 (en) 1981-08-12
PL110724B1 (en) 1980-07-31
ES454086A1 (es) 1977-11-16
PL192020A1 (pl) 1979-03-12
FR2321888B1 (ro) 1980-01-11
FR2321888A1 (fr) 1977-03-25
GR61158B (en) 1978-09-30
LU75667A1 (ro) 1977-09-13
RO69457A (ro) 1981-04-30
CH624116A5 (ro) 1981-07-15
MX4133E (es) 1982-01-06
BE845563A (fr) 1977-02-28

Similar Documents

Publication Publication Date Title
BG27553A3 (en) Method of obtaining of 2- phenyl- 3- aroylxenzothiophenes
JPS5215955A (en) Multiivvpulley and method of producing same
BG24673A3 (en) Method of obtaining quinazone derivatives
BG27380A3 (en) Method of obtaining of erythromycilamine derivaties
BG27362A3 (en) Method of obtaining n- phenyl- n- benzoyl carbamides
BG27548A3 (en) Method of obtaining of carbonylsubstituated 1- sulphanylbenzimidazoles
BG27554A3 (en) Method of obtaining of derivatives of 2- aroyl- 3- phenyl- bewzothiophenes
JPS51119305A (en) Bricket and method of producing same
ZA76460B (en) Substituted benzodiazepin-10-ones and method of use
BG24799A3 (en) Method of obtaining benzoylureidediphenyl-esters
BG27355A3 (en) Method of obtaining of 11- desoxy- 16- ariloxy- w- tetranoprostaglandines
BG27545A3 (en) Method of obtaining of n- tetrahydrofurfuril- noroxymorphones and their salts
BG27543A3 (en) Method of obtaining of n- aryl- n- (1- l- 4- piperidinyj)- arylacetamides
BG24801A3 (en) Method of obtaining l-pyroglutamyl-l-prolineamide
JPS5280397A (en) Popymerization method of epsilonncaprolactam
BG27360A3 (en) Method of obtaining benzamides
BG27558A3 (en) Method of obtaining of 7- beta- (d- 2- amino- 2- (methylsulphonyl- aminorhenyl)- acetyl- amino)- 3- r- 3- cephem- 4- carbonic acios and their salts
JPS5219623A (en) Nitryle and method of its preparation
PH12074A (en) Diarylbutanolamines and method of use thereof
BG27732A3 (en) Method of obtaining of di- substituated phenolethers of 3- amino- 2-hydroxipropane
JPS5277415A (en) Fixed anchor and method of making same
JPS5283326A (en) Perflvoroalkyllacetyllchloride and method of manufacturing
BG27555A3 (en) Method of obtaining of derivatives of aroyl- phenilnaphtalenes
BG27378A3 (en) Method of obtaining eszine and its salts
JPS5218757A (en) Compound and method of cohting