BG108035A - 3,7-диазабицикло[3.3.0] октани и тяхното използване при лечение на сърдечни аритмии - Google Patents

3,7-диазабицикло[3.3.0] октани и тяхното използване при лечение на сърдечни аритмии Download PDF

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Publication number
BG108035A
BG108035A BG108035A BG10803503A BG108035A BG 108035 A BG108035 A BG 108035A BG 108035 A BG108035 A BG 108035A BG 10803503 A BG10803503 A BG 10803503A BG 108035 A BG108035 A BG 108035A
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BG
Bulgaria
Prior art keywords
formula
alkyl
compound
het
aryl
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Application number
BG108035A
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Bulgarian (bg)
English (en)
Inventor
Magnus Bjorsne
Fritiof Ponten
Gert Strandlund
Peder Svensson
Michael Wilstermann
Original Assignee
Astrazeneca Ab
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Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BG108035A publication Critical patent/BG108035A/bg

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BG108035A 2001-02-02 2003-07-28 3,7-диазабицикло[3.3.0] октани и тяхното използване при лечение на сърдечни аритмии BG108035A (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0100326A SE0100326D0 (sv) 2001-02-02 2001-02-02 New compounds

Publications (1)

Publication Number Publication Date
BG108035A true BG108035A (bg) 2003-07-28

Family

ID=20282824

Family Applications (1)

Application Number Title Priority Date Filing Date
BG108035A BG108035A (bg) 2001-02-02 2003-07-28 3,7-диазабицикло[3.3.0] октани и тяхното използване при лечение на сърдечни аритмии

Country Status (30)

Country Link
US (1) US7144914B2 (ru)
EP (1) EP1360187B1 (ru)
JP (1) JP2004522749A (ru)
KR (1) KR20030074764A (ru)
CN (2) CN1263758C (ru)
AR (1) AR035423A1 (ru)
AT (1) ATE298339T1 (ru)
BG (1) BG108035A (ru)
BR (1) BR0206791A (ru)
CA (1) CA2434970A1 (ru)
CZ (1) CZ20032061A3 (ru)
DE (1) DE60204755T2 (ru)
EE (1) EE200300364A (ru)
ES (1) ES2243706T3 (ru)
HK (1) HK1063629A1 (ru)
HU (1) HUP0302538A3 (ru)
IL (1) IL156734A0 (ru)
IS (1) IS6874A (ru)
MX (1) MXPA03006579A (ru)
MY (1) MY136788A (ru)
NO (1) NO20033434L (ru)
NZ (1) NZ526992A (ru)
PL (1) PL363454A1 (ru)
PT (1) PT1360187E (ru)
RU (1) RU2293085C2 (ru)
SE (1) SE0100326D0 (ru)
SK (1) SK9702003A3 (ru)
UA (1) UA75382C2 (ru)
WO (1) WO2002060902A1 (ru)
ZA (1) ZA200305345B (ru)

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EP1368354A1 (en) * 2001-03-07 2003-12-10 Pfizer Products Inc. Modulators of chemokine receptor activity
EP1761542B1 (en) * 2004-06-09 2008-01-02 F.Hoffmann-La Roche Ag Octahydropyrrolo[3,4-c]pyrrole derivatives an their use as antiviral agents
US7665658B2 (en) 2005-06-07 2010-02-23 First Data Corporation Dynamic aggregation of payment transactions
GB0514018D0 (en) * 2005-07-07 2005-08-17 Ionix Pharmaceuticals Ltd Chemical compounds
DK2491038T3 (da) 2009-10-23 2016-07-18 Janssen Pharmaceutica Nv Disubstituerede octahydropyrrolo [3,4-c]pyrroler som orexin receptormodulatorer
CN102718695B (zh) * 2012-06-25 2014-04-02 华东师范大学 一种氮杂双环[3.3.0]辛烷衍生物的合成方法
PE20161035A1 (es) 2013-03-15 2016-11-13 Global Blood Therapeutics Inc Compuestos y usos de estos para la modulacion de la hemoglobina
CA2917050A1 (en) * 2013-07-03 2015-01-08 Todd K. Jones Pyrrolo-pyrrole carbamate and related organic compounds, pharmaceutical compositions, and medical uses thereof
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
CA3016706A1 (en) 2016-03-10 2017-09-14 Janssen Pharmaceutica Nv Methods of treating depression using orexin-2 receptor antagonists
WO2017212423A1 (en) 2016-06-08 2017-12-14 Glaxosmithkline Intellectual Property Development Limited Chemcical compounds
NZ763766A (en) 2017-03-20 2023-07-28 Novo Nordisk Healthcare Ag Pyrrolopyrrole compositions as pyruvate kinase (pkr) activators
EP3852791B1 (en) 2018-09-19 2024-07-03 Novo Nordisk Health Care AG Activating pyruvate kinase r
BR112021005188A2 (pt) 2018-09-19 2021-06-08 Forma Therapeutics, Inc. tratamento de anemia falciforme com um composto de ativação de piruvato cinase r
RU2726120C1 (ru) * 2019-09-24 2020-07-09 Федеральное государственное бюджетное научное учреждение Уфимский федеральный исследовательский центр Российской академии наук N-алкил-n-{ [3-алкил-3,8-диазабицикло[3.2.1]окта-1(7),5-диен-8-ил]метил} амины, обладающие цитотоксической активностью в отношении клеточной линии нек 293

Family Cites Families (24)

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DE2428792A1 (de) 1974-06-14 1976-01-02 Knoll Ag Neue antiarrhythmika
DE3112055A1 (de) 1981-03-27 1982-10-07 Basf Ag, 6700 Ludwigshafen Bispidinderivate, ihre herstellung und diese enthaltende arzneimittel
DE3234697A1 (de) 1982-09-18 1984-03-22 Kali-Chemie Pharma Gmbh, 3000 Hannover Neue diazabicyclo-(3,3,1)-nonane
PT88381B (pt) 1987-09-09 1995-07-06 Kali Chemie Pharma Gmbh Processo para a preparacao de novos compostos 3,7-diazabiciclo{3,3,1} nonano, e de composicoes farmaceuticas que contem estes compostos
DE3732094A1 (de) 1987-09-24 1989-04-06 Basf Ag Bispidinderivate als klasse iii-antiarrhythmika
DE3930266A1 (de) * 1989-09-11 1991-03-14 Thomae Gmbh Dr K Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US5110933A (en) 1989-11-13 1992-05-05 Board Of Regents Of Oklahoma State University Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof
US5468858A (en) 1993-10-28 1995-11-21 The Board Of Regents Of Oklahoma State University Physical Sciences N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents
DE4338396A1 (de) 1993-11-10 1995-05-11 Basf Ag N-Substituierte Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
DE4341403A1 (de) 1993-12-04 1995-06-08 Basf Ag N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
DE4402931A1 (de) 1994-02-01 1995-08-03 Kali Chemie Pharma Gmbh Neue 3-Phenylsulfonyl-3,7-diazabicyclo[3,3,1] nonan-Verbindungen enthaltende Arzneimittel
US5457121A (en) 1994-09-02 1995-10-10 Eli Lilly And Company Cis-hexahydro-5-(1,2,3,4-tetrahydro-2-naphthalenyl)pyrrolo<3,4-c>pyrroles as inhibitors of serotonin reuptake
DK0728758T3 (da) * 1995-02-27 2004-02-23 Hoffmann La Roche Dioxopyrrolo-pyrrolderivater
AU702752B2 (en) 1995-05-11 1999-03-04 Pharmacia & Upjohn Company Spirocyclic and bicyclic diazinyl and carbazinyl oxazolidinones
CA2222322A1 (en) * 1995-06-06 1996-12-12 Abbott Laboratories Quinolizinone type compounds
ATE257829T1 (de) 1995-09-15 2004-01-15 Upjohn Co Aminoaryl oxazolidinone n-oxide
GB9519563D0 (en) * 1995-09-26 1995-11-29 Merck Sharp & Dohme Therapeutic agents
WO1998006725A1 (en) 1996-08-13 1998-02-19 Merck & Co., Inc. Palladium catalyzed indolization
US5808064A (en) * 1996-08-13 1998-09-15 Merck & Co., Inc. Palladium catalyzed indolization
SE9704709D0 (sv) 1997-12-17 1997-12-17 Astra Ab Pharmaceutically active compounds
US6355641B1 (en) * 1999-03-17 2002-03-12 Syntex (U.S.A.) Llc Oxazolone derivatives and uses thereof
DE19932621A1 (de) * 1999-07-13 2001-04-26 Bayer Ag Neue substituerte alpha, beta-anellierte Butyrolactone
MY145722A (en) * 2000-04-27 2012-03-30 Abbott Lab Diazabicyclic central nervous system active agents
CA2429382A1 (en) * 2000-11-20 2002-06-06 Scios Inc. Indole-type inhibitors of p38 kinase

Also Published As

Publication number Publication date
ZA200305345B (en) 2004-10-11
HK1063629A1 (en) 2005-01-07
HUP0302538A3 (en) 2006-05-29
US7144914B2 (en) 2006-12-05
ES2243706T3 (es) 2005-12-01
DE60204755T2 (de) 2006-05-18
HUP0302538A2 (hu) 2003-11-28
KR20030074764A (ko) 2003-09-19
SK9702003A3 (en) 2004-01-08
EP1360187A1 (en) 2003-11-12
RU2003121308A (ru) 2005-03-10
CZ20032061A3 (cs) 2003-10-15
JP2004522749A (ja) 2004-07-29
PL363454A1 (en) 2004-11-15
IL156734A0 (en) 2004-02-08
SE0100326D0 (sv) 2001-02-02
NZ526992A (en) 2005-01-28
NO20033434L (no) 2003-09-23
DE60204755D1 (de) 2005-07-28
IS6874A (is) 2004-07-11
US20040053986A1 (en) 2004-03-18
MY136788A (en) 2008-11-28
MXPA03006579A (es) 2003-09-22
AR035423A1 (es) 2004-05-26
RU2293085C2 (ru) 2007-02-10
UA75382C2 (en) 2006-04-17
EP1360187B1 (en) 2005-06-22
BR0206791A (pt) 2004-01-27
CN1854138A (zh) 2006-11-01
PT1360187E (pt) 2005-10-31
CN1263758C (zh) 2006-07-12
NO20033434D0 (no) 2003-08-01
CA2434970A1 (en) 2002-08-08
EE200300364A (et) 2003-10-15
ATE298339T1 (de) 2005-07-15
WO2002060902A1 (en) 2002-08-08
CN1489592A (zh) 2004-04-14

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