BG106842A - Сроден на човешката хепараназа полипептид и нуклеинова киселина - Google Patents
Сроден на човешката хепараназа полипептид и нуклеинова киселинаInfo
- Publication number
- BG106842A BG106842A BG106842A BG10684202A BG106842A BG 106842 A BG106842 A BG 106842A BG 106842 A BG106842 A BG 106842A BG 10684202 A BG10684202 A BG 10684202A BG 106842 A BG106842 A BG 106842A
- Authority
- BG
- Bulgaria
- Prior art keywords
- polypeptides
- polynucleotides
- relates
- present
- heparanase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01166—Heparanase (3.2.1.166)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01139—Alpha-glucuronidase (3.2.1.139)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Изобретението се отнася до новоидентифицирани полинуклеотиди и полипептиди, кодирани от тях, до използването на полипептидите и до получаването на тези полинуклеотиди и полипептиди. По-специално полипептидът съгласно изобретението е ендоглюкоронидаза, сродна на хепараназата. Изобретението се отнасясъщо така до вектори и клетки гостоприемници, включващи полинуклеотид от изобретението, както и до антитела, насочени към тези полипептиди, и до фармацевтичен състав и диагностични средства, включващи такива антитела, полипептиди или полинуклеотиди.Изобретението се отнася също така до метод за изменение, модифициране или модулиране по друг начин на нивото на експресията на ендоглюкоронидаза, сродна на хепараназата в клетка или в организъм. Другаспект на изобретението представляват системи, подходящи за идентифициране на модулатори, например агонисти и антагонисти на полипептиди.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99125831 | 1999-12-23 | ||
PCT/EP2000/012909 WO2001048161A2 (en) | 1999-12-23 | 2000-12-18 | Human heparanase-related polypeptide and nucleic acid |
Publications (1)
Publication Number | Publication Date |
---|---|
BG106842A true BG106842A (bg) | 2003-05-30 |
Family
ID=8239724
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG106842A BG106842A (bg) | 1999-12-23 | 2002-06-19 | Сроден на човешката хепараназа полипептид и нуклеинова киселина |
Country Status (20)
Country | Link |
---|---|
US (1) | US20040161745A1 (bg) |
EP (1) | EP1244778A2 (bg) |
JP (1) | JP2003518381A (bg) |
KR (1) | KR20020062375A (bg) |
CN (1) | CN1413249A (bg) |
AU (1) | AU3013901A (bg) |
BG (1) | BG106842A (bg) |
BR (1) | BR0016703A (bg) |
CA (1) | CA2392703A1 (bg) |
CZ (1) | CZ20022147A3 (bg) |
EE (1) | EE200200353A (bg) |
HU (1) | HUP0203724A2 (bg) |
IL (1) | IL149506A0 (bg) |
MX (1) | MXPA02005077A (bg) |
NO (1) | NO20023015L (bg) |
PL (1) | PL362867A1 (bg) |
RU (1) | RU2002119561A (bg) |
SK (1) | SK8882002A3 (bg) |
WO (1) | WO2001048161A2 (bg) |
ZA (1) | ZA200205852B (bg) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001072973A2 (en) * | 2000-02-24 | 2001-10-04 | Bayer Aktiengesellschaft | Regulation of human heparanase-like enzyme |
GB0008912D0 (en) * | 2000-04-11 | 2000-05-31 | Janssen Pharmaceutica Nv | Mammalian heparanase |
EP1276862A2 (en) * | 2000-04-20 | 2003-01-22 | Pharmacia & Upjohn Company | Heparanase ii, a human heparanase paralog |
WO2002004645A2 (en) * | 2000-07-12 | 2002-01-17 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | A second human heparanase, and splice variants thereof, with a predominant expression in skeletal muscle, heart and pancreas |
FR2818131B1 (fr) * | 2000-12-14 | 2005-02-11 | Oreal | Composition cosmetique comprenant de l'heparanase |
CN101311188B (zh) * | 2007-05-21 | 2010-12-29 | 中国人民解放军军事医学科学院生物工程研究所 | 人乙酰肝素酶的小分子多肽抑制剂 |
CN101670115B (zh) * | 2009-07-31 | 2011-07-27 | 中国人民解放军第三军医大学 | 乙酰肝素酶与热休克蛋白的复合物及其制备方法和应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6177545B1 (en) * | 1997-09-02 | 2001-01-23 | Insight Strategy & Marketing Ltd. | Heparanase specific molecular probes and their use in research and medical applications |
IL135823A0 (en) * | 1997-10-28 | 2001-05-20 | Univ Australian | Isolated nucleic acid molecule encoding mammalian endoglucuronidase and uses therefor |
CN1370178A (zh) * | 1999-06-25 | 2002-09-18 | 洞察战略及销售有限公司 | 多核苷酸及其编码的与乙酰肝素酶同源较远的多肽 |
EP1214423A1 (en) * | 1999-09-23 | 2002-06-19 | MERCK PATENT GmbH | Heparanase-2, a member of the heparanase protein family |
-
2000
- 2000-12-18 JP JP2001548674A patent/JP2003518381A/ja active Pending
- 2000-12-18 CN CN00817680A patent/CN1413249A/zh active Pending
- 2000-12-18 BR BR0016703-7A patent/BR0016703A/pt not_active Application Discontinuation
- 2000-12-18 HU HU0203724A patent/HUP0203724A2/hu unknown
- 2000-12-18 MX MXPA02005077A patent/MXPA02005077A/es unknown
- 2000-12-18 EP EP00990789A patent/EP1244778A2/en not_active Withdrawn
- 2000-12-18 IL IL14950600A patent/IL149506A0/xx unknown
- 2000-12-18 CA CA002392703A patent/CA2392703A1/en not_active Abandoned
- 2000-12-18 CZ CZ20022147A patent/CZ20022147A3/cs unknown
- 2000-12-18 US US10/168,795 patent/US20040161745A1/en not_active Abandoned
- 2000-12-18 EE EEP200200353A patent/EE200200353A/xx unknown
- 2000-12-18 PL PL00362867A patent/PL362867A1/xx not_active Application Discontinuation
- 2000-12-18 SK SK888-2002A patent/SK8882002A3/sk unknown
- 2000-12-18 KR KR1020027008186A patent/KR20020062375A/ko not_active Application Discontinuation
- 2000-12-18 RU RU2002119561/13A patent/RU2002119561A/ru unknown
- 2000-12-18 AU AU30139/01A patent/AU3013901A/en not_active Abandoned
- 2000-12-18 WO PCT/EP2000/012909 patent/WO2001048161A2/en not_active Application Discontinuation
-
2002
- 2002-06-19 BG BG106842A patent/BG106842A/bg unknown
- 2002-06-21 NO NO20023015A patent/NO20023015L/no not_active Application Discontinuation
- 2002-07-22 ZA ZA200205852A patent/ZA200205852B/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR20020062375A (ko) | 2002-07-25 |
EP1244778A2 (en) | 2002-10-02 |
WO2001048161A2 (en) | 2001-07-05 |
ZA200205852B (en) | 2003-10-22 |
NO20023015D0 (no) | 2002-06-21 |
EE200200353A (et) | 2003-10-15 |
US20040161745A1 (en) | 2004-08-19 |
MXPA02005077A (es) | 2002-11-07 |
BR0016703A (pt) | 2002-09-24 |
JP2003518381A (ja) | 2003-06-10 |
CZ20022147A3 (cs) | 2002-09-11 |
IL149506A0 (en) | 2002-11-10 |
CA2392703A1 (en) | 2001-07-05 |
NO20023015L (no) | 2002-06-21 |
RU2002119561A (ru) | 2004-02-10 |
SK8882002A3 (en) | 2002-11-06 |
HUP0203724A2 (hu) | 2003-03-28 |
AU3013901A (en) | 2001-07-09 |
CN1413249A (zh) | 2003-04-23 |
WO2001048161A3 (en) | 2002-02-14 |
PL362867A1 (en) | 2004-11-02 |
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