BG106394A - A medicament and method for the production thereof - Google Patents
A medicament and method for the production thereofInfo
- Publication number
- BG106394A BG106394A BG106394A BG10639402A BG106394A BG 106394 A BG106394 A BG 106394A BG 106394 A BG106394 A BG 106394A BG 10639402 A BG10639402 A BG 10639402A BG 106394 A BG106394 A BG 106394A
- Authority
- BG
- Bulgaria
- Prior art keywords
- dihydrophthalazine
- medicament
- dione
- amino
- produced
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- 239000000543 intermediate Substances 0.000 abstract 2
- 159000000000 sodium salts Chemical class 0.000 abstract 2
- YVOBBFQJMOGQOU-UHFFFAOYSA-N 5-nitro-2,3-dihydrophthalazine-1,4-dione Chemical compound O=C1NNC(=O)C2=C1C([N+](=O)[O-])=CC=C2 YVOBBFQJMOGQOU-UHFFFAOYSA-N 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 230000002519 immonomodulatory effect Effects 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- HWYHZTIRURJOHG-UHFFFAOYSA-N luminol Chemical compound O=C1NNC(=O)C2=C1C(N)=CC=C2 HWYHZTIRURJOHG-UHFFFAOYSA-N 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biochemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2000107351A RU2155043C1 (ru) | 2000-03-28 | 2000-03-28 | Способ получения лекарственного препарата |
RU2000120270A RU2163122C1 (ru) | 2000-08-01 | 2000-08-01 | Лекарственное средство |
PCT/RU2001/000086 WO2001072305A1 (fr) | 2000-03-28 | 2001-02-28 | Composition médicamenteuse et procédé de fabrication correspondant |
Publications (1)
Publication Number | Publication Date |
---|---|
BG106394A true BG106394A (en) | 2002-12-29 |
Family
ID=26654045
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG106394A BG106394A (en) | 2000-03-28 | 2002-02-06 | A medicament and method for the production thereof |
Country Status (9)
Country | Link |
---|---|
US (1) | US6489326B1 (ru) |
EP (1) | EP1203587B1 (ru) |
AT (1) | ATE473743T1 (ru) |
AU (1) | AU4291201A (ru) |
BG (1) | BG106394A (ru) |
CZ (1) | CZ2002235A3 (ru) |
DE (1) | DE60142541D1 (ru) |
EA (1) | EA004056B1 (ru) |
WO (1) | WO2001072305A1 (ru) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2167659C1 (ru) * | 2000-08-02 | 2001-05-27 | Закрытое акционерное общество "Центр современной медицины "Медикор" | Способ коррекции иммунной системы живого организма |
US7326690B2 (en) * | 2002-10-30 | 2008-02-05 | Bach Pharma, Inc. | Modulation of cell fates and activities by phthalazinediones |
AU2003301513A1 (en) * | 2003-08-04 | 2005-02-15 | Valery Khazhmuratovich Zhilov | Cyclic bioisosters of purine system derivatives and a pharmaceutical composition based thereon |
BRPI0307864B1 (pt) * | 2003-11-25 | 2016-01-12 | Univ Rio De Janeiro | processo para formação de hidrazidas a partir de hidrazinas e ácido dicarboxílicos |
PL231885B1 (pl) | 2009-01-16 | 2019-04-30 | Abidopharma Spolka Z Ograniczona Odpowiedzialnoscia | Sposób wytwarzania soli 5-amino-2,3-dihydroftalazyno-1,4-di onu z metalami alkalicznymi, ich kompozycje farmaceutyczne i ich zastosowanie |
EP2393361B1 (en) * | 2009-02-06 | 2016-12-07 | Bach Pharma, Inc. | Pharmaceutical grade phthalazinediones, process for their preparation and pharmaceutical compositions containing them |
CN102971300B (zh) * | 2010-03-01 | 2016-03-02 | 梅特里奥药品股份公司 | 5-氨基-2,3-二氢-(2,3-二氮杂萘)-1,4-二酮钠盐的晶型、含有它们的药物制剂以及所述晶型的生产方法 |
WO2016096143A1 (de) | 2014-12-18 | 2016-06-23 | Metriopharm Ag | Kristalline form von 5-amino-2,3-dihydrophthalazin-1,4-dion natriumsalz, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung |
RU2625267C1 (ru) * | 2016-09-22 | 2017-07-12 | Общество с ограниченной ответственностью "АБИДАФАРМА" | Способ производства нестерильных субстанций безводного "тамерита" и/или двухводного "галавита" - натриевых солей 5-амино-2,3-дигидрофталазин-1,4-диона (варианты) и способы дальнейшей их переработки в стерильные лекарственные препараты |
WO2020084348A1 (en) * | 2018-10-26 | 2020-04-30 | Immunopharma Plus D.O.O. | Oral aminodihydrophthalazinedione compositions and their use the treatment of non-viral hepatitis |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU130903A1 (ru) * | 1959-11-21 | 1959-11-30 | Е.П. Крысин | Способ получени 5-амино-2,3-дигидрофталазиндиона-1,4 (люминола) |
GB1480591A (en) * | 1973-10-31 | 1977-07-20 | Boots Co Ltd | Substituted phthalazines and their use as therapeutic agents |
US4226993A (en) * | 1978-07-24 | 1980-10-07 | Miles Laboratories, Inc. | Amino-functionalized phthalhydrazides |
CH683965A5 (it) * | 1993-02-19 | 1994-06-30 | Limad Marketing Exp & Imp | Composti della classe dei ftalidrazidici come sostanza attiva in agenti antinfiammatori ed antitossici. |
CH683966A5 (it) | 1993-02-19 | 1994-06-30 | Limad Marketing Exp & Imp | Composti della classe dei ftalidrazidici come sostanze attive in agenti anti-ipossici e di difesa. |
RU2113222C1 (ru) * | 1997-09-30 | 1998-06-20 | Закрытое акционерное общество "Центр современной медицины "Медикор" | Иммуномодулирующее средство |
RU2138264C1 (ru) * | 1999-05-06 | 1999-09-27 | Абидов Муса Тажудинович | Способ получения лекарственного препарата галавит |
RU2155043C1 (ru) * | 2000-03-28 | 2000-08-27 | Абидов Муса Тажудинович | Способ получения лекарственного препарата |
RU2167659C1 (ru) * | 2000-08-02 | 2001-05-27 | Закрытое акционерное общество "Центр современной медицины "Медикор" | Способ коррекции иммунной системы живого организма |
-
2001
- 2001-02-28 WO PCT/RU2001/000086 patent/WO2001072305A1/ru active Application Filing
- 2001-02-28 AU AU42912/01A patent/AU4291201A/en not_active Abandoned
- 2001-02-28 CZ CZ2002235A patent/CZ2002235A3/cs unknown
- 2001-02-28 EA EA200101261A patent/EA004056B1/ru not_active IP Right Cessation
- 2001-02-28 DE DE60142541T patent/DE60142541D1/de not_active Expired - Lifetime
- 2001-02-28 AT AT01915966T patent/ATE473743T1/de not_active IP Right Cessation
- 2001-02-28 EP EP01915966A patent/EP1203587B1/en not_active Revoked
- 2001-02-28 US US09/979,846 patent/US6489326B1/en not_active Expired - Lifetime
-
2002
- 2002-02-06 BG BG106394A patent/BG106394A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EA200101261A1 (ru) | 2002-06-27 |
CZ2002235A3 (cs) | 2002-05-15 |
EA004056B1 (ru) | 2003-12-25 |
AU4291201A (en) | 2001-10-08 |
ATE473743T1 (de) | 2010-07-15 |
DE60142541D1 (de) | 2010-08-26 |
US20020198208A1 (en) | 2002-12-26 |
EP1203587A1 (en) | 2002-05-08 |
US6489326B1 (en) | 2002-12-03 |
EP1203587B1 (en) | 2010-07-14 |
EP1203587A4 (en) | 2006-11-08 |
WO2001072305A1 (fr) | 2001-10-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
YU84703A (sh) | Oralni rastvor aripiprazola | |
NZ516347A (en) | Indanyl-substituted benzenecarboxamides, process for their preparation, their use as a medicament and pharmaceutical formulations containing them | |
AU2002360949A1 (en) | 17Alpha-ALKYL-17Beta-OXY-ESTRATRIENES AND INTERMEDIATES FOR THE PRODUCTION THEREOF, AND USE OF SAID 17Alpha-ALKYL-17Beta-OXY-ESTRATRIENES FOR PRODUCING MEDICAMENTS AND PHARMACEUTICAL PREPARATIONS | |
HUP0400200A3 (en) | Pharmaceutical formulation for the efficient administration of apomorphine, 6ar-(-)-n-propyl-norapomorphine and their derivatives and pro-drugs thereof | |
ZA95631B (en) | Prolineamide derivatives | |
WO2003053368A3 (en) | Chalcone derivatives and their use to treat diseases | |
GB9914486D0 (en) | Medicaments | |
BG106394A (en) | A medicament and method for the production thereof | |
YU69902A (sh) | Novi derivati piperazina | |
AU2323897A (en) | Cyclopropyl alkanoic acid derivatives | |
AU2002227931A1 (en) | Ortho-substituted and meta-substituted bis-aryl compounds, method for the production thereof, their use as medicament, and pharmaceutical preparations containing these compounds | |
IL160075A0 (en) | Histone deacetylase enzyme-inhibiting derivatives of hydroxamic acid as new cytokine synthesis-inhibiting anti-inflammatory drugs | |
BR0112591A (pt) | Derivados de acridina e sua aplicação como medicamento | |
AU2364600A (en) | Heteroroaromatic amides as inhibitor of factor xa | |
HUP0203437A3 (en) | Use of resorcinol derivatives for producing pharmaceutical compositions for treatment of immune diseases | |
WO2004026306A3 (en) | Pyrazole derivatives as transforming growth factor (tgf) inhibitors | |
IL148288A0 (en) | Indolealkanol ester and indolealkylamide derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same | |
AU4949800A (en) | 2-arylpurine-9-acetamide derivatives, process for the preparation thereof, medicinal compositions containing the same and intermediates of the derivatives | |
MY125428A (en) | ?-carboline drug products | |
GEP20053617B (en) | Bridged Piperazine Derivatives | |
CA2412047A1 (en) | Shortened synthesis of 3,3-diarylpropylamine derivatives | |
MY133112A (en) | 3-amino-3-arylpropan-1-ol derivatives, and their preparation and use | |
AU777185C (en) | Pharmaceutical form of administration for peptides, methods for its production and use | |
IL150528A0 (en) | Ibuprofen containing active agent preparation | |
ES2191449T3 (es) | Derivados de ciclopentabenzofurano y su uso. |