BG104644A - Нови макролиди - Google Patents

Нови макролиди

Info

Publication number
BG104644A
BG104644A BG104644A BG10464400A BG104644A BG 104644 A BG104644 A BG 104644A BG 104644 A BG104644 A BG 104644A BG 10464400 A BG10464400 A BG 10464400A BG 104644 A BG104644 A BG 104644A
Authority
BG
Bulgaria
Prior art keywords
compounds
relates
novel
methods
protozoa infections
Prior art date
Application number
BG104644A
Other languages
English (en)
Inventor
John Dirlam
Hamish Mcarthur
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of BG104644A publication Critical patent/BG104644A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Abstract

Изобретението се отнася до еритромицинови аналозии азалиди, по-специално такива с нови С-13 заместители, и до техни фармацевтично приемливи соли. Съединенията са антибактериални средства за лечение на различни бактериални и протозойни инфекции. Изобретението се отнася и до фармацевтични състави, съдържащи съединенията, и до метод за лечение на бактериални и протозойни инфекции, до методи и до междинни съединения за получаване на съединенията.
BG104644A 1998-01-02 2000-07-28 Нови макролиди BG104644A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7034398P 1998-01-02 1998-01-02
PCT/IB1998/002099 WO1999035156A1 (en) 1998-01-02 1998-12-21 Novel macrolides

Publications (1)

Publication Number Publication Date
BG104644A true BG104644A (bg) 2001-01-31

Family

ID=22094723

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104644A BG104644A (bg) 1998-01-02 2000-07-28 Нови макролиди

Country Status (34)

Country Link
US (2) US6472371B1 (bg)
EP (1) EP1044207A1 (bg)
JP (1) JP2002500230A (bg)
KR (1) KR100352809B1 (bg)
CN (1) CN1284081A (bg)
AP (1) AP9801420A0 (bg)
AR (4) AR014948A1 (bg)
AU (1) AU756409B2 (bg)
BG (1) BG104644A (bg)
BR (1) BR9814601A (bg)
CA (1) CA2316919C (bg)
CO (1) CO4970821A1 (bg)
CZ (1) CZ20002458A3 (bg)
DZ (1) DZ2698A1 (bg)
EA (1) EA200000594A1 (bg)
GT (1) GT199800206A (bg)
HR (1) HRP20000442A2 (bg)
HU (1) HUP0100420A3 (bg)
IL (1) IL137024A0 (bg)
IS (1) IS5528A (bg)
MA (1) MA24729A1 (bg)
NO (1) NO20003347L (bg)
NZ (1) NZ504986A (bg)
OA (1) OA11438A (bg)
PA (1) PA8465301A1 (bg)
PE (1) PE20000049A1 (bg)
PL (1) PL341642A1 (bg)
SK (1) SK9782000A3 (bg)
TN (1) TNSN98238A1 (bg)
TW (1) TW520374B (bg)
UY (2) UY25330A1 (bg)
WO (1) WO1999035156A1 (bg)
YU (1) YU41500A (bg)
ZA (1) ZA9811939B (bg)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP9801420A0 (en) 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
AP1060A (en) 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
EP1437360A3 (en) * 1998-08-19 2005-04-06 Pfizer Products Inc. C11 Carbamates of macrolide antibacterials
US6043227A (en) * 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
EP1754700A3 (en) 1999-01-27 2007-05-09 Kosan Biosciences, Inc. Synthesis of oligoketides
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
WO2000062783A2 (en) 1999-04-16 2000-10-26 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
IL145739A0 (en) 1999-05-24 2002-07-25 Pfizer Prod Inc 13-methyl-erythromycin derivatives
EP1479687A4 (en) * 2002-02-26 2006-01-04 Meiji Seika Kaisha A NEW LOW-GYLIC CYCLIC AZALIDE, A NEW 16-LOW CYCLIC DIAZALID DERIVATIVE AND METHOD FOR THE PRODUCTION THEREOF
JP4644254B2 (ja) 2004-09-23 2011-03-02 シェーリング−プラウ・リミテッド 新規トリフルオロメタンスルホンアニリドオキシムエーテル誘導体の使用による動物における寄生虫の制御
US7705038B2 (en) * 2004-11-19 2010-04-27 Intervet, Inc. Control of parasites in animals by the use of parasiticidal 2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives
DK1836211T3 (da) 2004-12-21 2010-05-17 Pfizer Prod Inc Makrolider
EP1890547A2 (en) * 2005-06-09 2008-02-27 Schering-Plough Ltd. Control of parasites in animals by n-[(phenyloxy)phenyl]-1,1,1-trifluoromethanesulfonamide and n-[(phenylsulfanyl)phenyl]-1,1,1-trifluoromethanesulfonamide derivatives
US8119667B2 (en) * 2005-12-29 2012-02-21 Schering-Plough Animal Health Corporation Carbonates of fenicol antibiotics
US20070238700A1 (en) * 2006-04-10 2007-10-11 Winzenberg Kevin N N-phenyl-1,1,1-trifluoromethanesulfonamide hydrazone derivative compounds and their usage in controlling parasites
US8044230B2 (en) * 2006-12-13 2011-10-25 Intervet Inc. Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof
CA2672586A1 (en) * 2006-12-13 2008-06-26 Schering-Plough Ltd. Water-soluble prodrugs of florfenicol and its analogs
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
KR101714291B1 (ko) 2007-06-27 2017-03-08 이 아이 듀폰 디 네모아 앤드 캄파니 동물 해충 방제 방법
WO2009064953A1 (en) * 2007-11-15 2009-05-22 Enanta Pharmaceuticals, Inc. Use of bridged macrolides or tylosin derivatives in treating inflammatory bowel diseases
TWI468407B (zh) 2008-02-06 2015-01-11 Du Pont 中離子農藥
WO2010014566A2 (en) * 2008-07-30 2010-02-04 Intervet International B.V. Process for preparing oxazoline-protected aminodiol compounds useful as intermediates to florfenicol
JP2013501059A (ja) 2009-08-05 2013-01-10 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー メソイオン性殺虫剤
UA107804C2 (en) 2009-08-05 2015-02-25 Du Pont Mixtures of pesticides mezoionnyh
MX2012001646A (es) 2009-08-05 2012-03-21 Du Pont Pesticidas mesoionicos.
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
DK2576523T3 (en) 2010-05-27 2016-04-18 Du Pont A crystalline form of 4- [5- [3-chloro-5- (trifluoromethyl) phenyl] -4,5-dihydro-5- (trifluoromethyl) -3-isoxazolyl] -N- [2-oxo-2 - [( 2,2,2-trifluoroethyl) amino] ethyl] - 1-naphthalenecarboxamide
WO2012087630A1 (en) 2010-12-20 2012-06-28 E.I. Du Pont De Nemours And Company Pyridine and pyrimidine compounds for controlling invertebrate
KR20140004187A (ko) * 2011-01-31 2014-01-10 메이지 세이카 파루마 가부시키가이샤 신규 마크로라이드 유도체
JP2014520151A (ja) 2011-06-20 2014-08-21 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 蠕虫感染を処置するためのヘテロ環式化合物
CN102260306B (zh) * 2011-07-22 2012-07-18 山东鲁抗舍里乐药业有限公司 一种制备泰拉霉素的方法
JP2015502936A (ja) 2011-11-28 2015-01-29 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ スルホンアミド駆虫薬
WO2013158422A1 (en) 2012-04-17 2013-10-24 E. I. Du Pont De Nemours And Company Heterocyclic compounds for controlling invertebrate pests
WO2014099837A1 (en) 2012-12-18 2014-06-26 E. I. Du Pont De Nemours And Company Sulfonamide anthelmintics
CN103965273B (zh) * 2013-08-23 2016-05-25 普莱柯生物工程股份有限公司 一种大环内酯类化合物
CN105669798B (zh) * 2013-08-23 2019-07-26 普莱柯生物工程股份有限公司 一种大环内酯类化合物

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3652537A (en) * 1969-11-21 1972-03-28 Lilly Co Eli Epierythromycylamine and epierythromycyl b amine
US3923784A (en) * 1973-09-10 1975-12-02 Hoffmann La Roche Erythromycin a derivatives
SI7910768A8 (en) * 1979-04-02 1996-06-30 Pliva Pharm & Chem Works Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
US4585759A (en) * 1985-01-22 1986-04-29 Pfizer Inc. Antibacterial derivatives of a neutral macrolide
EP0283055B1 (en) * 1987-09-03 1990-08-29 SOUR PLIVA farmaceutska, Kemijska prehrambena i kozmeticka industrija, n.sol.o. 10-dihydro-10-deoxo-11-azaerythronolide-a-compounds, methods and intermediates for the manufacture thereof and their use in pharmaceuticals and in the manufacture thereof
US5141926A (en) * 1990-04-18 1992-08-25 Abbott Laboratories Erythromycin derivatives
WO1993013663A1 (en) 1992-01-17 1993-07-22 Abbott Laboratories Method of directing biosynthesis of specific polyketides
US5824513A (en) * 1991-01-17 1998-10-20 Abbott Laboratories Recombinant DNA method for producing erythromycin analogs
US5985844A (en) * 1992-03-26 1999-11-16 Merck & Co., Inc. Homoerythromycin A derivatives modified at the 4"-and 8A-positions
CA2065218A1 (en) 1991-04-11 1992-10-12 Robert R. Wilkening Process for the preparation of 9-deoxo-8a-aza-8a-homoerythromycin a and its 8a-alkyl derivatives
US5523399A (en) * 1991-12-27 1996-06-04 Taisho Pharmaceutical Co., Ltd. 5-O-desosaminylerythronolide derivatives
FR2691464B1 (fr) * 1992-05-21 1995-06-02 Roussel Uclaf Nouveaux dérivés de la 1-oxa 6-azacyclopentadécane 13,15-dione, leur procédé de préparation et leur application comme médicaments.
US5332807A (en) * 1993-04-14 1994-07-26 Merck & Co., Inc. Process of producing 8A- and 9A-azalide antibiotics
US5441939A (en) * 1994-03-04 1995-08-15 Pfizer Inc. 3"-desmethoxy derivatives of erythromycin and azithromycin
US6271255B1 (en) * 1996-07-05 2001-08-07 Biotica Technology Limited Erythromycins and process for their preparation
US6162794A (en) * 1997-05-09 2000-12-19 Pfizer Inc. Erythromycin derivatives
HN1998000086A (es) * 1997-06-11 1999-03-08 Pfizer Prod Inc Derivados de 9 - desofo - 9 aza - 9a - homoeritromicina a - c - 4 sustituidos.
US20020025937A1 (en) * 2000-03-20 2002-02-28 Yong-Jin Wu 9-oxime erythromycin derivatives
HN1998000074A (es) * 1997-06-11 1999-01-08 Pfizer Prod Inc Derivados de macrolidos c-4 sustituidos
US6407074B1 (en) * 1997-06-11 2002-06-18 Pfizer Inc C-4″-substituted macrolide derivatives
WO1999000124A1 (en) 1997-06-26 1999-01-07 Merck & Co., Inc. 9a-azalides, compositions containing such compounds and methods of treatment
US6339063B1 (en) * 1997-09-10 2002-01-15 Merck & Co., Inc. 9a-azalides as veterinary antimicrobial agents
PA8461401A1 (es) * 1997-10-29 2000-05-24 Pfizer Prod Inc Derivados de eritromicina triciclicos
HN1998000159A (es) * 1997-10-29 1999-02-09 Monsanto Co Derivados de 9- amino - 3 ceto eritromicina
AP1060A (en) 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
AP9801420A0 (en) 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
ES2226282T3 (es) * 1998-03-03 2005-03-16 Pfizer Products Inc. Antibioticos macrilidos de 3,6-cetal.
US6248719B1 (en) * 1998-06-03 2001-06-19 Pfizer Inc Tricyclic 3-keto derivatives of 6-O-methylerthromycin
US6043227A (en) * 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
US6100240A (en) * 1998-10-09 2000-08-08 Pfizer Inc Macrolide derivatives
OA11670A (en) * 1998-11-03 2005-01-12 Pfizer Prod Inc Novel macrolide antibiotics.
UA70972C2 (uk) * 1998-11-20 2004-11-15 Пфайзер Продактс Інк. 13-членні азаліди і їх застосування як антибіотиків
IL145739A0 (en) 1999-05-24 2002-07-25 Pfizer Prod Inc 13-methyl-erythromycin derivatives
EP1101769A3 (en) * 1999-11-18 2001-10-24 Pfizer Products Inc. Nitrogen containing erythromycin derivatives
JP4311203B2 (ja) 2001-08-08 2009-08-12 大正製薬株式会社 １１ａ−アザライド化合物及びその製造方法

Also Published As

Publication number Publication date
US6472371B1 (en) 2002-10-29
DZ2698A1 (fr) 2003-03-29
AR019787A2 (es) 2002-03-13
CN1284081A (zh) 2001-02-14
AU756409B2 (en) 2003-01-09
ZA9811939B (en) 2000-06-30
HUP0100420A2 (hu) 2001-07-30
WO1999035156A1 (en) 1999-07-15
IS5528A (is) 2000-06-09
NO20003347D0 (no) 2000-06-27
CA2316919A1 (en) 1999-07-15
AR014948A1 (es) 2001-04-11
CA2316919C (en) 2004-10-26
SK9782000A3 (en) 2001-12-03
US7015203B2 (en) 2006-03-21
IL137024A0 (en) 2001-06-14
KR20010024818A (ko) 2001-03-26
AR020851A2 (es) 2002-05-29
TW520374B (en) 2003-02-11
CZ20002458A3 (cs) 2001-10-17
MA24729A1 (fr) 1999-07-01
PE20000049A1 (es) 2000-02-07
US20040092459A1 (en) 2004-05-13
JP2002500230A (ja) 2002-01-08
NZ504986A (en) 2003-03-28
WO1999035156B1 (en) 1999-10-21
HUP0100420A3 (en) 2003-07-28
HRP20000442A2 (en) 2001-04-30
UY25574A1 (es) 1999-09-27
AU1444799A (en) 1999-07-26
CO4970821A1 (es) 2000-11-07
UY25330A1 (es) 2000-12-29
YU41500A (sh) 2003-02-28
TNSN98238A1 (fr) 2005-03-15
OA11438A (en) 2004-04-30
PL341642A1 (en) 2001-04-23
BR9814601A (pt) 2000-10-17
PA8465301A1 (es) 2000-09-29
NO20003347L (no) 2000-08-28
EA200000594A1 (ru) 2001-04-23
AR020551A2 (es) 2002-05-15
EP1044207A1 (en) 2000-10-18
AP9801420A0 (en) 1998-12-31
KR100352809B1 (ko) 2002-11-01
GT199800206A (es) 2000-06-21

Similar Documents

Publication Publication Date Title
BG104644A (bg) Нови макролиди
UA70298A (uk) Похідні с-4"-заміщених макролідів, спосіб їх одержання, проміжні сполуки, фармацевтична композиція та спосіб лікування бактеріальної інфекції або протозойної інфекції
CA2292359A1 (en) Novel azalides and methods of making same
AP2001002142A0 (en) 13-membered azalides and their use as antibiotic agents.
YU40900A (sh) Novi derivati eritromicina
MY123354A (en) 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives
AP9801253A0 (en) 9-Oxime erythromycin derivatives.
AP2001002222A0 (en) Ketolide antibiotics.
BR9710768A (pt) Composto composi-Æo e processos para tratamento de infec-{es bacterianas em um mamifero hospedeiro com necessidade de tal tratamento e para prepara-Æo de 6-0-metileritromicina forma i
ATE344269T1 (de) Carbamat und carbazat ketolid antibiotika
AP2001002131A0 (en) Novel macrolide antibiotics.
BR9903737A (pt) Carbamatos em c-11 de macrólidos antibacterianos
EP1114826A3 (en) Novel antibacterial and prokinetic macrolides
CA2332686A1 (en) Novel 13 and 14-membered antibacterial and prokinetic macrolides and their intermediates
AP9801235A0 (en) Erythromycin derivatives.
YU64300A (sh) Derivati 2"-deoksi higromicina
EP1749832A3 (en) Carbamate and carbazate ketolide antibiotics