BG103338A - Нови производни на пиперидинкетокарбоксилни киселини, тяхното получаване и използването им - Google Patents
Нови производни на пиперидинкетокарбоксилни киселини, тяхното получаване и използването им Download PDFInfo
- Publication number
- BG103338A BG103338A BG103338A BG10333899A BG103338A BG 103338 A BG103338 A BG 103338A BG 103338 A BG103338 A BG 103338A BG 10333899 A BG10333899 A BG 10333899A BG 103338 A BG103338 A BG 103338A
- Authority
- BG
- Bulgaria
- Prior art keywords
- alkyl
- formula
- phenyl
- piperidine
- acid derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19642591A DE19642591A1 (de) | 1996-10-15 | 1996-10-15 | Neue Piperidin-Ketocarbonsäure-Derivate, deren Herstellung und Anwendung |
| PCT/EP1997/005202 WO1998016512A1 (fr) | 1996-10-15 | 1997-09-23 | Nouveaux derives de piperidine-cetoacide, leur preparation et leur utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG103338A true BG103338A (bg) | 2000-01-31 |
Family
ID=7808858
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG103338A BG103338A (bg) | 1996-10-15 | 1999-04-15 | Нови производни на пиперидинкетокарбоксилни киселини, тяхното получаване и използването им |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6380220B1 (fr) |
| EP (1) | EP0934273A1 (fr) |
| JP (1) | JP2001501955A (fr) |
| KR (1) | KR20000049130A (fr) |
| CN (1) | CN1239950A (fr) |
| AR (1) | AR009379A1 (fr) |
| AU (1) | AU736754B2 (fr) |
| BG (1) | BG103338A (fr) |
| BR (1) | BR9711908A (fr) |
| CA (1) | CA2268917A1 (fr) |
| CO (1) | CO4930264A1 (fr) |
| CZ (1) | CZ126899A3 (fr) |
| DE (1) | DE19642591A1 (fr) |
| HR (1) | HRP970549A2 (fr) |
| HU (1) | HUP9904104A3 (fr) |
| IL (1) | IL129089A0 (fr) |
| NO (1) | NO991761D0 (fr) |
| NZ (1) | NZ334979A (fr) |
| PL (1) | PL332720A1 (fr) |
| RU (1) | RU2189974C2 (fr) |
| SK (1) | SK38599A3 (fr) |
| TR (1) | TR199900819T2 (fr) |
| WO (1) | WO1998016512A1 (fr) |
| ZA (1) | ZA979175B (fr) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999054310A2 (fr) | 1998-04-20 | 1999-10-28 | Basf Aktiengesellschaft | Inhibiteurs de protease de cysteine |
| AU3818799A (en) * | 1998-04-20 | 1999-11-08 | Basf Aktiengesellschaft | Novel heterocyclically substituted amides with cysteine protease-inhibiting effect |
| ATE427300T1 (de) | 1998-04-20 | 2009-04-15 | Abbott Gmbh & Co Kg | Heterocyclisch substituierte amide als calpainhemmer |
| DE19817459A1 (de) * | 1998-04-20 | 1999-10-21 | Basf Ag | Neue heterozyklische substituierte Amide, Herstellung und Anwendung |
| US6117870A (en) * | 1998-11-12 | 2000-09-12 | Fujirebio Kabushiki Kaisha | Cyclic amide derivatives |
| WO2001014331A2 (fr) * | 1999-08-24 | 2001-03-01 | Regents Of The University Of California | Inhibiteurs exempts de quinoline de parasites du paludisme |
| CA2352957A1 (fr) | 1999-09-29 | 2001-04-05 | Ortho-Mcneil Pharmaceutical, Inc. | Isonipecotamides destinees au traitement de maladies provoquees par l'integrine |
| EP1295876A4 (fr) | 2000-06-30 | 2005-10-19 | Amides d'acide carboxylique, azides et amino-alcools et procedes de preparation de alpha-ceto amides a l'aide de ces derniers | |
| DE10114762A1 (de) * | 2001-03-26 | 2002-10-02 | Knoll Gmbh | Verwendung von Cysteinprotease-Inhibitoren |
| WO2002081467A1 (fr) | 2001-04-09 | 2002-10-17 | Ortho-Mcneil Pharmaceutical, Inc. | Quinazoline et composes similaires a la quinazoline pour traiter des troubles dus a l'integrine |
| CA2492035A1 (fr) | 2002-07-11 | 2004-01-15 | Vicuron Pharmaceuticals, Inc. | Derives de n-hydroxyamide ayant une activite anti-bacterienne |
| WO2005019177A1 (fr) * | 2003-08-14 | 2005-03-03 | Icos Corporation | Derives d'amide d'aminopiperidine utilises en tant qu'antagonistes d'integrine vla-1 et utilisations de ceux-ci |
| TWI405571B (zh) | 2006-12-29 | 2013-08-21 | Abbott Gmbh & Co Kg | 羰醯胺化合物及其作為鈣蛋白酶（ｃａｌｐａｉｎ）抑制劑之用途 |
| TWI453019B (zh) | 2007-12-28 | 2014-09-21 | Abbvie Deutschland | 甲醯胺化合物 |
| TWI519530B (zh) * | 2009-02-20 | 2016-02-01 | 艾伯維德國有限及兩合公司 | 羰醯胺化合物及其作為鈣蛋白酶（ｃａｌｐａｉｎ）抑制劑之用途 |
| US8236798B2 (en) | 2009-05-07 | 2012-08-07 | Abbott Gmbh & Co. Kg | Carboxamide compounds and their use as calpain inhibitors |
| US9051304B2 (en) | 2009-12-22 | 2015-06-09 | AbbVie Deutschland GmbH & Co. KG | Carboxamide compounds and their use as calpain inhibitors V |
| US8598211B2 (en) | 2009-12-22 | 2013-12-03 | Abbvie Inc. | Carboxamide compounds and their use as calpain inhibitors IV |
| MX2013006419A (es) | 2010-12-09 | 2013-12-16 | Abbvie Inc | Compuestos carboxamida y su uso como inhibidores de calpaina v. |
| US9150545B2 (en) | 2012-04-03 | 2015-10-06 | AbbVie Deutschland GmbH & Co. KG | Carboxamide compounds and their use as calpain inhibitors V |
| US10590084B2 (en) | 2016-03-09 | 2020-03-17 | Blade Therapeutics, Inc. | Cyclic keto-amide compounds as calpain modulators and methods of production and use thereof |
| EP3481835A4 (fr) | 2016-07-05 | 2020-02-26 | Blade Therapeutics, Inc. | Modulateurs de calpain et leurs utilisations thérapeutiques |
| PE20191153A1 (es) | 2016-09-28 | 2019-09-05 | Blade Therapeutics Inc | Moduladores de calpainas y usos terapeuticos de los mismos |
| US11484502B2 (en) | 2017-06-01 | 2022-11-01 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition comprising PDE9 inhibitor |
| IL270357B2 (en) | 2017-06-01 | 2024-02-01 | Eisai R&D Man Co Ltd | A therapeutic agent in Lewy body disease containing pyrazoloquinoline compounds |
| SG11202008750XA (en) * | 2018-03-28 | 2020-10-29 | Blade Therapeutics Inc | Calpain modulators and therapeutic uses thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06504061A (ja) | 1990-12-28 | 1994-05-12 | コーテックス ファーマシューティカルズ インコーポレイテッド | 神経変性の治療および予防におけるカルパイン阻害剤の使用 |
| EP0564561A4 (en) * | 1990-12-28 | 1994-08-10 | Georgia Tech Res Inst | Peptides ketoamides, ketoacids, and ketoesters |
| CA2071621C (fr) * | 1991-06-19 | 1996-08-06 | Ahihiko Hosoda | Derives d'aldehyde |
| JPH09500087A (ja) | 1992-06-24 | 1997-01-07 | コーテックス ファーマシューティカルズ インコーポレイテッド | カルパイン活性の増大に関連した健康障害の抑制及び処置におけるカルパイン阻害剤の使用法 |
| US5541290A (en) | 1993-06-24 | 1996-07-30 | Harbeson; Scott L. | Optically pure calpain inhibitor compounds |
-
1996
- 1996-10-15 DE DE19642591A patent/DE19642591A1/de not_active Withdrawn
-
1997
- 1997-09-23 JP JP10517955A patent/JP2001501955A/ja active Pending
- 1997-09-23 US US09/284,543 patent/US6380220B1/en not_active Expired - Fee Related
- 1997-09-23 SK SK385-99A patent/SK38599A3/sk unknown
- 1997-09-23 EP EP97910332A patent/EP0934273A1/fr not_active Withdrawn
- 1997-09-23 RU RU99109969/04A patent/RU2189974C2/ru active
- 1997-09-23 CN CN97180507A patent/CN1239950A/zh active Pending
- 1997-09-23 NZ NZ334979A patent/NZ334979A/en unknown
- 1997-09-23 BR BR9711908A patent/BR9711908A/pt unknown
- 1997-09-23 IL IL12908997A patent/IL129089A0/xx unknown
- 1997-09-23 AU AU47770/97A patent/AU736754B2/en not_active Ceased
- 1997-09-23 TR TR1999/00819T patent/TR199900819T2/xx unknown
- 1997-09-23 HU HU9904104A patent/HUP9904104A3/hu unknown
- 1997-09-23 KR KR1019990703216A patent/KR20000049130A/ko not_active Application Discontinuation
- 1997-09-23 PL PL97332720A patent/PL332720A1/xx unknown
- 1997-09-23 CZ CZ991268A patent/CZ126899A3/cs unknown
- 1997-09-23 CA CA002268917A patent/CA2268917A1/fr not_active Abandoned
- 1997-09-23 WO PCT/EP1997/005202 patent/WO1998016512A1/fr not_active Application Discontinuation
- 1997-10-14 HR HR19642591,3A patent/HRP970549A2/hr not_active Application Discontinuation
- 1997-10-14 AR ARP970104718A patent/AR009379A1/es not_active Application Discontinuation
- 1997-10-14 ZA ZA979175A patent/ZA979175B/xx unknown
- 1997-10-14 CO CO97060053A patent/CO4930264A1/es unknown
-
1999
- 1999-04-14 NO NO991761A patent/NO991761D0/no not_active Application Discontinuation
- 1999-04-15 BG BG103338A patent/BG103338A/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2189974C2 (ru) | 2002-09-27 |
| JP2001501955A (ja) | 2001-02-13 |
| US6380220B1 (en) | 2002-04-30 |
| CN1239950A (zh) | 1999-12-29 |
| IL129089A0 (en) | 2000-02-17 |
| KR20000049130A (ko) | 2000-07-25 |
| ZA979175B (en) | 1999-04-14 |
| SK38599A3 (en) | 2000-04-10 |
| TR199900819T2 (xx) | 1999-06-21 |
| NZ334979A (en) | 2001-02-23 |
| WO1998016512A1 (fr) | 1998-04-23 |
| AR009379A1 (es) | 2000-04-12 |
| BR9711908A (pt) | 1999-08-24 |
| DE19642591A1 (de) | 1998-04-16 |
| NO991761L (no) | 1999-04-14 |
| CZ126899A3 (cs) | 1999-07-14 |
| EP0934273A1 (fr) | 1999-08-11 |
| PL332720A1 (en) | 1999-10-11 |
| HRP970549A2 (en) | 1998-08-31 |
| AU736754B2 (en) | 2001-08-02 |
| HUP9904104A2 (hu) | 2000-05-28 |
| HUP9904104A3 (en) | 2001-01-29 |
| AU4777097A (en) | 1998-05-11 |
| CA2268917A1 (fr) | 1998-04-23 |
| NO991761D0 (no) | 1999-04-14 |
| CO4930264A1 (es) | 2000-06-27 |
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