BE905801A - Carbapenemes portant en position 2 un substituant heterothioalcoylthio quaternise. - Google Patents

Carbapenemes portant en position 2 un substituant heterothioalcoylthio quaternise.

Info

Publication number
BE905801A
BE905801A BE0/217447A BE217447A BE905801A BE 905801 A BE905801 A BE 905801A BE 0/217447 A BE0/217447 A BE 0/217447A BE 217447 A BE217447 A BE 217447A BE 905801 A BE905801 A BE 905801A
Authority
BE
Belgium
Prior art keywords
carrying
carbapenems
heterothioalcoylthio
substitute
cycloaliphatic
Prior art date
Application number
BE0/217447A
Other languages
English (en)
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of BE905801A publication Critical patent/BE905801A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Nouveaux carbapénèmes portant en position 2 un substituant de formule I, où n représente 1, 2 ou 3, R5 représente un radical aliphatique, cycloaliphatique, cycloaliphatique-aliphatique, araliphatique, hétéroaraliphatique, hétérocyclyle ou hétérocyclylaliphatique éventuellement substitue, et représente un hétérocycle aromatique azoté quaternisé uni à -S-(CH2)n-S- par un atome de carbone du cycle.
BE0/217447A 1985-11-22 1986-11-21 Carbapenemes portant en position 2 un substituant heterothioalcoylthio quaternise. BE905801A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/800,867 US4880922A (en) 1985-11-22 1985-11-22 Carbapenems with quaternized heterothioalkylthio substitution at position 2

Publications (1)

Publication Number Publication Date
BE905801A true BE905801A (fr) 1987-05-21

Family

ID=25179586

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/217447A BE905801A (fr) 1985-11-22 1986-11-21 Carbapenemes portant en position 2 un substituant heterothioalcoylthio quaternise.

Country Status (35)

Country Link
US (1) US4880922A (fr)
JP (1) JPS62195382A (fr)
KR (1) KR870004985A (fr)
CN (1) CN86107742A (fr)
AR (1) AR242209A1 (fr)
AT (1) AT397090B (fr)
AU (1) AU598767B2 (fr)
BE (1) BE905801A (fr)
CA (1) CA1273015A (fr)
CH (1) CH671020A5 (fr)
CS (1) CS259895B2 (fr)
DD (1) DD250710A5 (fr)
DE (1) DE3639762A1 (fr)
DK (1) DK560886A (fr)
EG (1) EG18111A (fr)
ES (1) ES2002914A6 (fr)
FI (1) FI83323C (fr)
FR (1) FR2590574B1 (fr)
GB (1) GB2183237B (fr)
GR (1) GR862786B (fr)
HU (1) HU197748B (fr)
IL (1) IL80694A0 (fr)
IT (1) IT1199669B (fr)
LU (1) LU86678A1 (fr)
MY (1) MY102954A (fr)
NL (1) NL8602964A (fr)
NO (1) NO164239C (fr)
NZ (1) NZ218296A (fr)
OA (1) OA08488A (fr)
PT (1) PT83797B (fr)
SE (1) SE469631B (fr)
SU (1) SU1614763A3 (fr)
YU (1) YU46030B (fr)
ZA (1) ZA868829B (fr)
ZW (1) ZW23486A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ219892A (en) * 1986-04-15 1991-02-26 Merck & Co Inc N-amino quaternised heteroarylium carbapenem derivatives and pharmaceutical compositions thereof
US5116833A (en) * 1990-10-19 1992-05-26 Bristol-Myers Squibb Company Antibiotic c-3 dithioacetal-substituted carbapenem compounds, compositions, and methods of use thereof
EP0507313A1 (fr) * 1991-04-05 1992-10-07 Takeda Chemical Industries, Ltd. Composés polycycliques de carbapénèmes, leur préparation et leur utilisation
FR2920778B1 (fr) 2007-09-11 2009-10-30 Oreal Composes quinoliniums azoiques a motif disulfure/thiol, compositions les comprenant, procede de coloration de fibres keratiniques et dispositif.
FR2921382B1 (fr) 2007-09-21 2009-10-30 Oreal Colorant derive de phenyl-pyridol[1,2-a]indolium thiol-disulfure, composition tinctoriale comprenant ce colorant, procede d'eclaircissement des matieres keratiniques a partir de ce colorant
FR2921258A1 (fr) 2007-09-24 2009-03-27 Oreal Composition tinctoriale comprenant au moins un precurseur incolore disulfures/thiol, proced de coloration a partir de la composition

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4376774A (en) * 1979-05-29 1983-03-15 Merck & Co., Inc. Antibiotic N-heterocyclyl thienamycin
US4552696A (en) * 1982-04-09 1985-11-12 Bristol-Myers Company Carbapenem antibiotics
US4536335A (en) * 1982-06-18 1985-08-20 Bristol-Myers Company Carbapenem antibiotics
CA1269978A (fr) * 1982-09-28 1990-06-05 Choung U. Kim Antibiotiques a base de carbapenemes
AR241016A1 (es) * 1983-03-08 1991-04-30 Bristol Myeres Squibb Company "derivados de aminotiol cuaternario, procedimiento para prepararlos y procedimiento para preparar compuestos de carbapenem a partir de dichos derivados".
CA1273011A (fr) * 1984-07-02 1990-08-21 Susan M. Schmitt Carbapenems a substituant mono- ou bicyclique de type heteroarylalkythio 2-quaternaire, exterieurement aklyle
CA1273012A (fr) * 1984-07-02 1990-08-21 Burton G. Christensen Carbapenems a substituant mono- ou bicyclique de type heteroarylalkythio 2-quaternaire, extrerieurement alkyle
NZ219892A (en) * 1986-04-15 1991-02-26 Merck & Co Inc N-amino quaternised heteroarylium carbapenem derivatives and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
PT83797A (en) 1986-12-01
FI83323B (fi) 1991-03-15
SU1614763A3 (ru) 1990-12-15
FR2590574B1 (fr) 1989-07-28
EG18111A (en) 1992-09-30
GR862786B (en) 1987-03-24
NO864669D0 (no) 1986-11-21
SE8604990L (sv) 1987-05-23
CS259895B2 (en) 1988-11-15
IT8622426A0 (it) 1986-11-21
GB2183237A (en) 1987-06-03
ES2002914A6 (es) 1988-10-01
YU46030B (sh) 1992-12-21
SE8604990D0 (sv) 1986-11-21
FI864714A (fi) 1987-05-23
CS843186A2 (en) 1988-03-15
ATA313686A (de) 1993-06-15
US4880922A (en) 1989-11-14
NO164239B (no) 1990-06-05
FI864714A0 (fi) 1986-11-19
LU86678A1 (fr) 1987-06-26
AR242209A1 (es) 1993-03-31
CH671020A5 (fr) 1989-07-31
NO164239C (no) 1990-09-12
IL80694A0 (en) 1987-02-27
AT397090B (de) 1994-01-25
DK560886D0 (da) 1986-11-21
CN86107742A (zh) 1987-08-12
SE469631B (sv) 1993-08-09
GB8627913D0 (en) 1986-12-31
FI83323C (fi) 1991-06-25
CA1273015A (fr) 1990-08-21
NO864669L (no) 1987-05-25
ZW23486A1 (en) 1987-04-29
ZA868829B (en) 1987-08-26
MY102954A (en) 1993-03-31
OA08488A (fr) 1988-07-29
AU6534386A (en) 1987-05-28
HU197748B (en) 1989-05-29
DK560886A (da) 1987-05-23
JPS62195382A (ja) 1987-08-28
GB2183237B (en) 1989-11-08
FR2590574A1 (fr) 1987-05-29
IT1199669B (it) 1988-12-30
NL8602964A (nl) 1987-06-16
NZ218296A (en) 1990-04-26
DD250710A5 (de) 1987-10-21
HUT42486A (en) 1987-07-28
AU598767B2 (en) 1990-07-05
YU199486A (en) 1988-02-29
PT83797B (pt) 1989-06-30
DE3639762A1 (de) 1987-06-04
IT8622426A1 (it) 1988-05-21
KR870004985A (ko) 1987-06-04

Similar Documents

Publication Publication Date Title
ATE67493T1 (de) Heterocyclische verbindungen.
DK426289D0 (da) Spiroforbindelser og farmaceutisk praeparat indeholdende en saadan forbindelse
ATE12224T1 (de) Verbindungen mit antifibrinolytischer wirksamkeit.
DK234885A (da) Cephalosporinderivater
BE905801A (fr) Carbapenemes portant en position 2 un substituant heterothioalcoylthio quaternise.
IE822182L (en) Dipeptide derivatives
GR3003327T3 (en) Substituted 1,8-naphthyridine derivatives and fungicides containing them
GB1507032A (en) 2-thiol-4,5-diphenyloxazole s-derivatives
FI864836A (fi) Kefalosporinfoereningar.
DK7286A (da) Octahydroindoliziner
FI870460A (fi) Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 5-substituerade oktahydroindolizinderivat och vid foerfarandet anvaendbara mellanprodukter.
ES464764A1 (es) Un procedimiento para preparar un compuesto de indol-dihi- droindoldionadimerico
BE898927A (fr) 22-ethers d'hexanor-brassinolide, leur procede de preparation et leur utilisation
FR2144705A1 (en) N-substd trichloracetamides - useful as soil nitrification inhibitors
PL324070A1 (en) Novel compounds of ellipticin, method of obtaining them and pharmaceutical preparations containing such compounds
GR3005034T3 (fr)

Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: BRISTOL-MYERS CY

Effective date: 19941130