BE902450A - Ethers aminocyclopentyliques leur preparation et compositions pharmaceutiques les contenant. - Google Patents
Ethers aminocyclopentyliques leur preparation et compositions pharmaceutiques les contenant.Info
- Publication number
- BE902450A BE902450A BE0/215034A BE215034A BE902450A BE 902450 A BE902450 A BE 902450A BE 0/215034 A BE0/215034 A BE 0/215034A BE 215034 A BE215034 A BE 215034A BE 902450 A BE902450 A BE 902450A
- Authority
- BE
- Belgium
- Prior art keywords
- aminocyclopentyl
- ethers
- preparation
- same
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Des éthers aminocyclopentyliques répondant à la formule (1) dans laquelle R1 est -H ou -CH3; n est 1, m est 2-4 et X est -CH=CH- ou -CH2CH2-; ou n est 3, m est O est X est trans -CH=CH-; Y est un groupe aminohétérocyclique saturé; R2 est (1) naphtylalkyle, thiénylalkyle, phénylalkyle, substitué ou non, ou (2) cinnamyle; ainsi que les sels et solvates de ces composés. Ces substances inhibent la thrombo-agglutination, la bronchoconstriction et la vasoconstriction.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB848412774A GB8412774D0 (en) | 1984-05-18 | 1984-05-18 | Carbocyclic compounds |
GB848423083A GB8423083D0 (en) | 1984-09-12 | 1984-09-12 | Carbocyclic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
BE902450A true BE902450A (fr) | 1985-11-18 |
Family
ID=26287761
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE0/215034A BE902450A (fr) | 1984-05-18 | 1985-05-17 | Ethers aminocyclopentyliques leur preparation et compositions pharmaceutiques les contenant. |
Country Status (14)
Country | Link |
---|---|
US (1) | US4880800A (fr) |
AU (1) | AU580777B2 (fr) |
BE (1) | BE902450A (fr) |
CA (1) | CA1243020A (fr) |
CH (1) | CH667646A5 (fr) |
DE (1) | DE3517901A1 (fr) |
DK (1) | DK218985A (fr) |
FR (1) | FR2564464B1 (fr) |
GB (1) | GB2159816B (fr) |
IL (1) | IL75230A (fr) |
IT (1) | IT1180748B (fr) |
NL (1) | NL8501429A (fr) |
NZ (1) | NZ212108A (fr) |
SE (1) | SE8502455L (fr) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5039673A (en) * | 1987-06-22 | 1991-08-13 | Glaxo Group Limited | Aminocyclopentyl ethers and their preparation and pharmaceutical formulation |
PT87776B (pt) * | 1987-06-22 | 1992-10-30 | Glaxo Group Ltd | Processo para a preparacao de eteres aminociclopentilicos e composicoes farmaceuticas que os contem |
AU751772C (en) | 1998-04-01 | 2006-09-07 | Correvio International Sàrl | Aminocyclohexyl ether compounds and uses thereof |
US6979685B1 (en) | 1999-02-12 | 2005-12-27 | Cardiome Pharma Corp. | Cycloalkyl amine compounds and uses thereof |
AU2528900A (en) * | 1999-02-12 | 2000-08-29 | Nortran Pharmaceuticals Inc. | Cycloalkyl amine compounds and uses thereof |
US7507545B2 (en) | 1999-03-31 | 2009-03-24 | Cardiome Pharma Corp. | Ion channel modulating activity method |
US7057053B2 (en) | 2000-10-06 | 2006-06-06 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
US7524879B2 (en) | 2000-10-06 | 2009-04-28 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
US20070099983A1 (en) * | 2003-05-02 | 2007-05-03 | Cardiome Pharma Corp. | Aminocyclohexyl ether compounds and uses thereof |
US7345086B2 (en) | 2003-05-02 | 2008-03-18 | Cardiome Pharma Corp. | Uses of ion channel modulating compounds |
US20090041841A1 (en) * | 2003-05-02 | 2009-02-12 | Cardiome Pharma Corp. | Controlled release tablet formulations for the prevention of arrhythmias |
WO2005018635A2 (fr) | 2003-08-07 | 2005-03-03 | Cardiome Pharma Corp. | Activite i modulant des canaux ioniques |
US7345087B2 (en) | 2003-10-31 | 2008-03-18 | Cardiome Pharma Corp. | Aminocyclohexyl ether compounds and uses thereof |
US8058304B2 (en) | 2004-04-01 | 2011-11-15 | Cardiome Pharma Corp. | Merged ion channel modulating compounds and uses thereof |
WO2005113011A2 (fr) | 2004-04-01 | 2005-12-01 | Cardiome Pharma Corp. | Promedicaments de composes modulant les canaux ioniques et leurs utilisations |
EP1868598B1 (fr) | 2004-11-08 | 2014-04-23 | Cardiome Pharma Corp. | Schemas posologiques pour modulateurs de canaux ioniques pour le traitement de la fibrillation auriculaire aigue chez l'homme |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2658401A1 (de) * | 1976-12-23 | 1978-07-06 | Merck Patent Gmbh | Cyclopentan-1-amine, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel |
DK290079A (da) * | 1978-07-11 | 1980-01-12 | Glaxo Group Ltd | Fremgangsmaade til fremstilling af prostanoidforbindelser |
AU542949B2 (en) * | 1980-01-09 | 1985-03-28 | Glaxo Group Limited | Prostanoid compounds |
US4345984A (en) * | 1981-03-02 | 1982-08-24 | The Procter & Gamble Company | Novel prostaglandin analogues and process for making same |
GB8307099D0 (en) * | 1983-03-15 | 1983-04-20 | Glaxo Group Ltd | Carbocyclic compounds |
NO843529L (no) * | 1983-09-06 | 1985-03-07 | Glaxo Group Ltd | Fremgangsmaate for fremstilling av aminocyklopentaner |
-
1985
- 1985-05-17 DK DK218985A patent/DK218985A/da not_active Application Discontinuation
- 1985-05-17 SE SE8502455A patent/SE8502455L/xx not_active Application Discontinuation
- 1985-05-17 NL NL8501429A patent/NL8501429A/nl not_active Application Discontinuation
- 1985-05-17 NZ NZ212108A patent/NZ212108A/xx unknown
- 1985-05-17 BE BE0/215034A patent/BE902450A/fr not_active IP Right Cessation
- 1985-05-17 FR FR8507483A patent/FR2564464B1/fr not_active Expired
- 1985-05-17 CH CH2125/85A patent/CH667646A5/de not_active IP Right Cessation
- 1985-05-17 AU AU42625/85A patent/AU580777B2/en not_active Ceased
- 1985-05-17 IT IT48093/85A patent/IT1180748B/it active
- 1985-05-17 CA CA000481809A patent/CA1243020A/fr not_active Expired
- 1985-05-17 GB GB8512591A patent/GB2159816B/en not_active Expired
- 1985-05-17 IL IL75230A patent/IL75230A/xx unknown
- 1985-05-17 DE DE19853517901 patent/DE3517901A1/de not_active Withdrawn
-
1987
- 1987-09-15 US US07/096,755 patent/US4880800A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
IL75230A (en) | 1989-07-31 |
IT1180748B (it) | 1987-09-23 |
FR2564464A1 (fr) | 1985-11-22 |
SE8502455D0 (sv) | 1985-05-17 |
GB8512591D0 (en) | 1985-06-19 |
AU4262585A (en) | 1985-11-21 |
AU580777B2 (en) | 1989-02-02 |
DE3517901A1 (de) | 1985-12-12 |
SE8502455L (sv) | 1985-11-19 |
GB2159816A (en) | 1985-12-11 |
GB2159816B (en) | 1989-05-24 |
US4880800A (en) | 1989-11-14 |
CH667646A5 (de) | 1988-10-31 |
CA1243020A (fr) | 1988-10-11 |
DK218985D0 (da) | 1985-05-17 |
NL8501429A (nl) | 1985-12-16 |
FR2564464B1 (fr) | 1988-09-02 |
DK218985A (da) | 1985-11-19 |
IT8548093A1 (it) | 1986-11-17 |
IT8548093A0 (it) | 1985-05-17 |
IL75230A0 (en) | 1985-09-29 |
NZ212108A (en) | 1988-10-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RE | Patent lapsed |
Owner name: GLAXO GROUP LTD Effective date: 19900531 |