FR2636948A1 - N-(2-piperidylmethyl)benzamides substitues anti-arythmiques et composition pharmaceutique les contenant - Google Patents
N-(2-piperidylmethyl)benzamides substitues anti-arythmiques et composition pharmaceutique les contenantInfo
- Publication number
- FR2636948A1 FR2636948A1 FR8912527A FR8912527A FR2636948A1 FR 2636948 A1 FR2636948 A1 FR 2636948A1 FR 8912527 A FR8912527 A FR 8912527A FR 8912527 A FR8912527 A FR 8912527A FR 2636948 A1 FR2636948 A1 FR 2636948A1
- Authority
- FR
- France
- Prior art keywords
- piperidylmethyl
- benzamides
- substituted
- antiarrhythmic
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention concerne des N-(2-pipéridylméthyl)-benzamides substitués nouveaux. Les composés de l'invention répondent à la formule : (CF DESSIN DANS BOPI) dans laquelle Y est un radical organique. L'invention concerne également des compositions pharmaceutiques contenant ces composés nouveaux, qui y jouent le rôle d'agents anti-arythmiques.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/248,814 US4952574A (en) | 1988-09-26 | 1988-09-26 | Antiarrhythmic substituted N-(2-piperidylmethyl)benzamides |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2636948A1 true FR2636948A1 (fr) | 1990-03-30 |
FR2636948B1 FR2636948B1 (fr) | 1994-09-30 |
Family
ID=22940797
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR898912527A Expired - Fee Related FR2636948B1 (fr) | 1988-09-26 | 1989-09-25 | N-(2-piperidylmethyl)benzamides substitues anti-arythmiques et composition pharmaceutique les contenant |
Country Status (3)
Country | Link |
---|---|
US (1) | US4952574A (fr) |
DE (1) | DE3931954A1 (fr) |
FR (1) | FR2636948B1 (fr) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6316627B1 (en) | 1997-04-21 | 2001-11-13 | Fine Tech Ltd. | Process for the preparation of flecainide |
DE19982965B3 (de) * | 1998-12-25 | 2012-08-30 | Jnc Corporation | Flüssigkristalline Verbindung mit einem negativen Wert der dielektrischen Anisotropie |
DE10025700A1 (de) * | 2000-05-26 | 2001-11-29 | Merck Patent Gmbh | Verfahren zur Herstellung von trifluorethoxysubstituierten Benzoesäuren |
US20040220409A1 (en) * | 2001-02-20 | 2004-11-04 | Mcdaniel William C | Flecainide synthesis |
US7244865B2 (en) * | 2003-02-24 | 2007-07-17 | Mallinckrodt Inc. | Process for preparing benzhydrylthioacetamide |
CA2628635C (fr) * | 2005-11-08 | 2017-03-28 | Atheris Laboratories | Peptides de type mu-conotoxine et leur emploi en tant qu'anesthesique local |
LT2797416T (lt) | 2011-12-28 | 2017-10-25 | Global Blood Therapeutics, Inc. | Pakeistieji benzaldehido junginiai ir jų panaudojimo būdai, didinant audinių aprūpinimą deguonimi |
ES2790358T3 (es) | 2011-12-28 | 2020-10-27 | Global Blood Therapeutics Inc | Compuestos de heteroaril aldehído sustituido y métodos para su uso en el aumento de la oxigenación tisular |
MX2015011445A (es) | 2013-03-15 | 2016-04-20 | Global Blood Therapeutics Inc | Compuestos y usos de estos para la modulacion de la hemoglobina. |
KR20150132146A (ko) | 2013-03-15 | 2015-11-25 | 글로벌 블러드 테라퓨틱스, 인크. | 헤모글로빈 조정을 위한 화합물 및 이의 용도 |
WO2014145040A1 (fr) | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Composés aldéhydes substitués et leurs procédés d'utilisation pour accroître l'oxygénation tissulaire |
US10266551B2 (en) | 2013-03-15 | 2019-04-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US8952171B2 (en) | 2013-03-15 | 2015-02-10 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
AU2014237348C1 (en) | 2013-03-15 | 2019-02-07 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US20140274961A1 (en) | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US9802900B2 (en) | 2013-03-15 | 2017-10-31 | Global Blood Therapeutics, Inc. | Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin |
US9422279B2 (en) | 2013-03-15 | 2016-08-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US9458139B2 (en) | 2013-03-15 | 2016-10-04 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US9604999B2 (en) | 2013-03-15 | 2017-03-28 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
BR112015032160B1 (pt) | 2014-02-07 | 2021-11-30 | Global Blood Therapeutics, Inc | Ansolvato cristalino de composto, composição e composição farmacêutica |
MA41841A (fr) | 2015-03-30 | 2018-02-06 | Global Blood Therapeutics Inc | Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs |
MA43373A (fr) | 2015-12-04 | 2018-10-10 | Global Blood Therapeutics Inc | Régimes posologiques pour 2-hydroxy-6-((2- (1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)méthoxy)benzaldéhyde |
TWI663160B (zh) | 2016-05-12 | 2019-06-21 | 全球血液治療公司 | 用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法 |
TW202332423A (zh) | 2016-10-12 | 2023-08-16 | 美商全球血液治療公司 | 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑 |
WO2020072377A1 (fr) | 2018-10-01 | 2020-04-09 | Global Blood Therapeutics, Inc. | Modulateurs de l'hémoglobine pour le traitement de la drépanocytose |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3900481A (en) * | 1974-04-01 | 1975-08-19 | Riker Laboratories Inc | Derivatives of pyrrolidine and piperidine |
US4005209A (en) * | 1974-04-01 | 1977-01-25 | Riker Laboratories, Inc. | Antiarrhythmic method utilizing fluoroalkoxy-N-piperidyl and pyridyl benzamides |
US4013670A (en) * | 1974-04-01 | 1977-03-22 | Riker Laboratories, Inc. | Derivatives of pyrrolidine and piperidine |
US4097481A (en) * | 1976-11-08 | 1978-06-27 | Riker Laboratories, Inc. | Tertiary amide derivatives of pyrrolidine and piperidine |
US4339587A (en) * | 1981-06-08 | 1982-07-13 | Riker Laboratories, Inc. | 5-Benzyloxy or 5-hydroxy-2-(2,2,2-trifluoroethoxy)-N-(2-pyridylmethyl)benzamide |
US4452983A (en) * | 1981-06-08 | 1984-06-05 | Riker Laboratories, Inc. | Phenolic derivative |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3342826A (en) * | 1964-01-13 | 1967-09-19 | Ile De France | Heterocyclic aminoalkyl benzamides |
US4071524A (en) * | 1976-11-08 | 1978-01-31 | Riker Laboratories, Inc. | Derivatives of urea |
US4650873A (en) * | 1979-03-19 | 1987-03-17 | Riker Laboratories | Process for the preparation of a derivative of piperidine |
IT1171707B (it) * | 1983-09-30 | 1987-06-10 | Babcock Samifi Spa | Dispositivo per il raffreddamento dell'olio in una unita' di compressione e, particolarmente, di compressione a vite |
US4599434A (en) * | 1983-11-15 | 1986-07-08 | Riker Laboratories, Inc. | Cyclopentanone derivatives |
US4656285A (en) * | 1983-11-15 | 1987-04-07 | Riker Laboratories, Inc. | Compound 2-acetamidomethyl-6-methoxy-pyridine |
-
1988
- 1988-09-26 US US07/248,814 patent/US4952574A/en not_active Expired - Fee Related
-
1989
- 1989-09-25 DE DE3931954A patent/DE3931954A1/de not_active Withdrawn
- 1989-09-25 FR FR898912527A patent/FR2636948B1/fr not_active Expired - Fee Related
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3900481A (en) * | 1974-04-01 | 1975-08-19 | Riker Laboratories Inc | Derivatives of pyrrolidine and piperidine |
US4005209A (en) * | 1974-04-01 | 1977-01-25 | Riker Laboratories, Inc. | Antiarrhythmic method utilizing fluoroalkoxy-N-piperidyl and pyridyl benzamides |
US4013670A (en) * | 1974-04-01 | 1977-03-22 | Riker Laboratories, Inc. | Derivatives of pyrrolidine and piperidine |
US4097481A (en) * | 1976-11-08 | 1978-06-27 | Riker Laboratories, Inc. | Tertiary amide derivatives of pyrrolidine and piperidine |
US4339587A (en) * | 1981-06-08 | 1982-07-13 | Riker Laboratories, Inc. | 5-Benzyloxy or 5-hydroxy-2-(2,2,2-trifluoroethoxy)-N-(2-pyridylmethyl)benzamide |
US4452983A (en) * | 1981-06-08 | 1984-06-05 | Riker Laboratories, Inc. | Phenolic derivative |
Non-Patent Citations (1)
Title |
---|
JOURNAL OF MEDICINAL CHEMISTRY, vol. 20, no. 6, juin 1977, page 821; E.H. BANITT et al.: "Antiarrhythmics. 2. Synthesis and antiarrhythmic activity of N-(piperidylalkyl)trifluorothoxybenzamides" * |
Also Published As
Publication number | Publication date |
---|---|
DE3931954A1 (de) | 1990-03-29 |
US4952574A (en) | 1990-08-28 |
FR2636948B1 (fr) | 1994-09-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |