BE902124A - Nouveaux phosphonites cycliques, leur preparation et applications. - Google Patents
Nouveaux phosphonites cycliques, leur preparation et applications.Info
- Publication number
- BE902124A BE902124A BE0/214797A BE214797A BE902124A BE 902124 A BE902124 A BE 902124A BE 0/214797 A BE0/214797 A BE 0/214797A BE 214797 A BE214797 A BE 214797A BE 902124 A BE902124 A BE 902124A
- Authority
- BE
- Belgium
- Prior art keywords
- phosphonites
- preparation
- applications
- new cyclic
- new
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
- C07F9/65719—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonous acid derivative
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids R2P(=O)(OH); Thiophosphinic acids, i.e. R2P(=X)(XH) (X = S, Se)
- C07F9/32—Esters thereof
- C07F9/3258—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/3264—Esters with hydroxyalkyl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids R2P(=O)(OH); Thiophosphinic acids, i.e. R2P(=X)(XH) (X = S, Se)
- C07F9/32—Esters thereof
- C07F9/3258—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/3276—Esters with cycloaliphatic alcohols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
- C07F9/5325—Aromatic phosphine oxides or thioxides (P-C aromatic linkage)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
- C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
Abstract
Nouveaux phosphonites cycliques, dont un des atomes d'oxygène du cycle peut etre remplacé par un atome de soufre ou d'azote ; leur molécule présente une dissymétrie due à au moins 2 atomes de carbone, à un ou plusieurs atomes d'azote ou/et d'oxygène, ou bien à quelques uns de ces éléments à la fois. Préparation de ces phosphonites par la réaction d'une dihalogéno-phosphine avec un composé ayant deux H actifs, en présence d'un accepteur d'hydracide. Application des nouveaux phosphonites à la production de phosphinates et d'oxydes de phosphine correspondants.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8405622A FR2562543B1 (fr) | 1984-04-10 | 1984-04-10 | Nouveaux phosphonites cycliques, leur preparation et applications |
Publications (1)
Publication Number | Publication Date |
---|---|
BE902124A true BE902124A (fr) | 1985-10-04 |
Family
ID=9303009
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE0/214797A BE902124A (fr) | 1984-04-10 | 1985-04-04 | Nouveaux phosphonites cycliques, leur preparation et applications. |
Country Status (10)
Country | Link |
---|---|
US (1) | US4952740A (fr) |
JP (1) | JPH0662649B2 (fr) |
BE (1) | BE902124A (fr) |
CA (1) | CA1258266A (fr) |
CH (1) | CH665644A5 (fr) |
DE (1) | DE3512781C2 (fr) |
FR (1) | FR2562543B1 (fr) |
GB (1) | GB2158441B (fr) |
IT (1) | IT1201414B (fr) |
NL (1) | NL8501030A (fr) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2562543B1 (fr) * | 1984-04-10 | 1987-09-25 | Elf Aquitaine | Nouveaux phosphonites cycliques, leur preparation et applications |
FR2603286B1 (fr) * | 1986-08-27 | 1988-12-09 | Elf Aquitaine | Procede de preparation de derives de l'acide phosphineux et produit intermediaire utilise a cet effet |
DE3923492A1 (de) * | 1989-05-20 | 1991-02-07 | Hoechst Ag | Kunststoff-formmasse |
AU635537B2 (en) * | 1989-05-20 | 1993-03-25 | Clariant Gmbh | Arylesters of phosphonous acid, process for preparing them and their use to stabilize plastics, in particular polyolefin moulding materials |
FR2649109B1 (fr) * | 1989-06-30 | 1991-09-13 | Elf Aquitaine | Composes organiques du phosphore complexes par du bore, leur preparation et applications |
WO1997013763A1 (fr) * | 1995-10-13 | 1997-04-17 | The Penn State Research Foundation | Synthese asymetrique catalysee par des complexes de metaux de transition associes a de nouveaux ligands chiraux |
DE19608006A1 (de) * | 1996-03-04 | 1997-09-11 | Hoechst Ag | Salze von phosphonigen Säuren und deren Verwendung als Flammschutzmittel in Kunststoffen |
US5962440A (en) * | 1996-05-09 | 1999-10-05 | Bristol-Myers Squibb Company | Cyclic phosphonate ester inhibitors of microsomal triglyceride transfer protein and method |
CA2307889A1 (fr) * | 1997-10-28 | 1999-05-06 | Bristol-Myers Squibb Company | Inhibiteurs phosphonate ester cyclique de proteine microsomale de transfert des triglycerides et procede associe |
US6312662B1 (en) | 1998-03-06 | 2001-11-06 | Metabasis Therapeutics, Inc. | Prodrugs phosphorus-containing compounds |
US7205404B1 (en) | 1999-03-05 | 2007-04-17 | Metabasis Therapeutics, Inc. | Phosphorus-containing prodrugs |
CN1321999C (zh) | 1999-03-05 | 2007-06-20 | 症变治疗公司 | 新的含磷前药 |
JP4979866B2 (ja) | 1999-09-08 | 2012-07-18 | リガンド・ファーマシューティカルズ・インコーポレイテッド | 肝臓に特異的なドラッグデリバリーのためのプロドラッグ |
MY164523A (en) * | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
CN1315862C (zh) | 2000-05-26 | 2007-05-16 | 艾登尼科斯(开曼)有限公司 | 处理黄病毒和瘟病毒的方法和组合物 |
US7138376B2 (en) | 2001-09-28 | 2006-11-21 | Idenix Pharmaceuticals, Inc. | Methods and compositions for treating hepatitis C virus using 4'-modified nucleosides |
US7214668B2 (en) * | 2002-05-13 | 2007-05-08 | Metabasis Therapeutics, Inc. | Phosphonic acid based prodrugs of PMEA and its analogues |
WO2003095665A2 (fr) | 2002-05-13 | 2003-11-20 | Metabasis Therapeutics, Inc. | Procede d'elaboration de promedicaments cycliques de pmea et de pmpa |
NZ537662A (en) | 2002-06-28 | 2007-10-26 | Idenix Cayman Ltd | 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
US7456155B2 (en) | 2002-06-28 | 2008-11-25 | Idenix Pharmaceuticals, Inc. | 2′-C-methyl-3′-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
CN103319554A (zh) | 2002-06-28 | 2013-09-25 | 埃迪尼克斯医药公司 | 用于治疗黄病毒感染的修饰的2’和3’-核苷前药 |
US7608600B2 (en) | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
ATE442375T1 (de) * | 2002-10-31 | 2009-09-15 | Metabasis Therapeutics Inc | Cytarabin-monophosphate prodrugs |
EP1576138B1 (fr) | 2002-11-15 | 2017-02-01 | Idenix Pharmaceuticals LLC. | 2'-MÉTHYL-NUCLEOSIDES EN COMBInaISON AVEC l'INTERFÉRON ET MUTATION DE FLAVIVIRIDAE |
KR20050109918A (ko) | 2002-12-12 | 2005-11-22 | 이데닉스 (케이만) 리미티드 | 2'-분지형 뉴클레오시드의 제조 방법 |
WO2004058792A1 (fr) * | 2002-12-23 | 2004-07-15 | Idenix (Cayman) Limited | Procede de production de promedicaments a base de 3'-nucleosides |
ES2726998T3 (es) | 2003-05-30 | 2019-10-11 | Gilead Pharmasset Llc | Análogos de nucleósidos fluorados modificados |
BRPI0418133A2 (pt) * | 2003-12-23 | 2009-03-24 | Schering Plough Ltd | pró-fármaco de florfenicol tendo solubilidade em água melhorada |
CA2565966A1 (fr) * | 2004-06-08 | 2005-12-29 | Metabasis Therapeutics, Inc. | Synthese d'esters cycliques induite par l'acide de lewis |
BRPI0512360A (pt) * | 2004-06-23 | 2008-03-11 | Idenix Cayman Ltd | derivados de 5-aza-7-deazapurina para o tratamento de flaviviridae |
JP4516863B2 (ja) * | 2005-03-11 | 2010-08-04 | 株式会社ケンウッド | 音声合成装置、音声合成方法及びプログラム |
EP1976382B1 (fr) | 2005-12-23 | 2013-04-24 | IDENIX Pharmaceuticals, Inc. | Procede pour la preparation d'un intermediaire synthetique pour la preparation de nucleosides ramifies |
EP3042660A3 (fr) | 2008-04-15 | 2016-10-26 | RFS Pharma, LLC. | Dérivés de nucléosides pour le traitement d'infections de caliciviridae, y compris des infections de norovirus |
CA2819548C (fr) | 2010-12-10 | 2019-04-09 | Sigmapharm Laboratories, Llc | Compositions tres stables d'analogues nucleotidiques actifs par voie orale ou de promedicaments sous forme d'analogues nucleotidiques actifs par voie orale |
CN106061984A (zh) | 2014-02-13 | 2016-10-26 | 配体药物公司 | 前药化合物及其用途 |
EP3164136A4 (fr) | 2014-07-02 | 2018-04-04 | Ligand Pharmaceuticals, Inc. | Composés de promédicaments et leurs utilisations |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3297631A (en) * | 1965-10-24 | 1967-01-10 | Exxon Research Engineering Co | Novel phenolic phosphorus stabilizers for polyolefins |
FR2518100A1 (fr) * | 1981-12-11 | 1983-06-17 | Elf Aquitaine | Procede de preparation de phosphinamides, applications et nouveaux produits |
FR2562543B1 (fr) * | 1984-04-10 | 1987-09-25 | Elf Aquitaine | Nouveaux phosphonites cycliques, leur preparation et applications |
-
1984
- 1984-04-10 FR FR8405622A patent/FR2562543B1/fr not_active Expired
-
1985
- 1985-04-03 GB GB08508730A patent/GB2158441B/en not_active Expired
- 1985-04-04 CH CH1476/85A patent/CH665644A5/fr not_active IP Right Cessation
- 1985-04-04 BE BE0/214797A patent/BE902124A/fr not_active IP Right Cessation
- 1985-04-09 CA CA000478571A patent/CA1258266A/fr not_active Expired
- 1985-04-09 NL NL8501030A patent/NL8501030A/nl not_active Application Discontinuation
- 1985-04-09 IT IT20279/85A patent/IT1201414B/it active
- 1985-04-10 DE DE3512781A patent/DE3512781C2/de not_active Expired - Fee Related
- 1985-04-10 JP JP60074524A patent/JPH0662649B2/ja not_active Expired - Lifetime
-
1989
- 1989-09-12 US US07/407,702 patent/US4952740A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
GB8508730D0 (en) | 1985-05-09 |
GB2158441A (en) | 1985-11-13 |
DE3512781C2 (de) | 1995-07-27 |
IT1201414B (it) | 1989-02-02 |
US4952740A (en) | 1990-08-28 |
CH665644A5 (fr) | 1988-05-31 |
DE3512781A1 (de) | 1985-10-17 |
CA1258266A (fr) | 1989-08-08 |
JPH0662649B2 (ja) | 1994-08-17 |
IT8520279A0 (it) | 1985-04-09 |
JPS60228492A (ja) | 1985-11-13 |
FR2562543B1 (fr) | 1987-09-25 |
FR2562543A1 (fr) | 1985-10-11 |
NL8501030A (nl) | 1985-11-01 |
GB2158441B (en) | 1988-08-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RE | Patent lapsed |
Owner name: SOC. NATIONALE ELF AQUITAINE Effective date: 19990430 |