BE901703A - Procede d'activation de la production de proteines par des cultures cellulaires. - Google Patents
Procede d'activation de la production de proteines par des cultures cellulaires.Info
- Publication number
- BE901703A BE901703A BE0/214492A BE214492A BE901703A BE 901703 A BE901703 A BE 901703A BE 0/214492 A BE0/214492 A BE 0/214492A BE 214492 A BE214492 A BE 214492A BE 901703 A BE901703 A BE 901703A
- Authority
- BE
- Belgium
- Prior art keywords
- activation
- cell cultures
- protein production
- production
- antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
- C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
Abstract
Procédé de production de protéines et notamment d'anticorps,selon lequel, le milieu de culture utilisé est un milieu hypertonique, dont hypertonicité est obtenue par doublement de la quantité d'amino-acides par rapport à un milieu normal de culture. La production des cellules peut alors etre multipliée par un facteur élevé, par exemple égal à quatre. Application à la fabrication d'anticorps.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/579,492 US4724206A (en) | 1984-02-13 | 1984-02-13 | Protein production using hypertonic media |
Publications (1)
Publication Number | Publication Date |
---|---|
BE901703A true BE901703A (fr) | 1985-05-29 |
Family
ID=24317115
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE0/214492A BE901703A (fr) | 1984-02-13 | 1985-02-11 | Procede d'activation de la production de proteines par des cultures cellulaires. |
Country Status (12)
Country | Link |
---|---|
US (1) | US4724206A (fr) |
JP (1) | JPS60188062A (fr) |
AU (1) | AU3856985A (fr) |
BE (1) | BE901703A (fr) |
DE (1) | DE3504715A1 (fr) |
DK (1) | DK65185A (fr) |
FR (1) | FR2559501B1 (fr) |
GB (1) | GB2153830B (fr) |
IT (1) | IT1184883B (fr) |
NL (1) | NL8500350A (fr) |
NO (1) | NO850533L (fr) |
SE (1) | SE8500621L (fr) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL8500351A (nl) * | 1984-02-13 | 1985-09-02 | Damon Biotech Inc | Kweken van cellen met behulp van inborrelen van gas. |
CA1312030C (fr) * | 1987-11-18 | 1992-12-29 | Brian Maiorella | Methode pour accroitre le titre d'anticorps |
US6238891B1 (en) | 1987-11-18 | 2001-05-29 | Cetus Oncology Corporation | Method of increasing product expression through solute stress |
US5151359A (en) * | 1988-05-19 | 1992-09-29 | Mitsui Toatsu Chemicals Incorporated | Method for producing of human tissue type plasminogen activator |
JP2648624B2 (ja) * | 1988-10-04 | 1997-09-03 | 三井東圧化学株式会社 | ヒト組織型プラスミノーゲン活性化因子の製造方法 |
US5183754A (en) * | 1988-10-04 | 1993-02-02 | Mitsui Toatsu Chemicals, Incorporated | Method for production of human tissue type plasminogen activator |
GB9004390D0 (en) * | 1990-02-27 | 1990-04-25 | Ici Plc | Process |
US5156964A (en) * | 1990-08-16 | 1992-10-20 | Cetus Corporation | Methods for adapting cells for increased product production through exposure to ammonia |
KR930006117B1 (ko) * | 1990-12-28 | 1993-07-07 | 재단법인 목암생명공학연구소 | 동물세포 배양용 고농도 배지 및 배양공정 |
US5506129A (en) * | 1991-05-24 | 1996-04-09 | Evans Medical Limited | Virus production |
US5856179A (en) | 1994-03-10 | 1999-01-05 | Genentech, Inc. | Polypeptide production in animal cell culture |
US6656466B1 (en) * | 1995-06-06 | 2003-12-02 | Genetech, Inc. | Human tumor necrosis factor—immunoglobulin(TNFR1-IgG1) chimera composition |
US5721121A (en) * | 1995-06-06 | 1998-02-24 | Genentech, Inc. | Mammalian cell culture process for producing a tumor necrosis factor receptor immunoglobulin chimeric protein |
US5705364A (en) | 1995-06-06 | 1998-01-06 | Genentech, Inc. | Mammalian cell culture process |
DE19637591A1 (de) * | 1996-09-13 | 1998-03-19 | Bayer Ag | Osmokontrolliertes Fermentationsverfahren zur Herstellung von Acarbose |
US20020012991A1 (en) * | 1997-04-07 | 2002-01-31 | Florence Chua Nee Ho Kit Fong | Cell culture media for enhanced protein production |
US7094601B2 (en) * | 2000-05-16 | 2006-08-22 | The General Hospital Corporation | Microinjection of cryoprotectants for preservation of cells |
US20020045156A1 (en) * | 2000-05-16 | 2002-04-18 | Mehmet Toner | Microinjection of cryoprotectants for preservation of cells |
US20030087372A1 (en) * | 2001-06-13 | 2003-05-08 | Genentech, Inc. | Methods of culturing animal cells and polypeptide production in animal cells |
WO2006019366A1 (fr) * | 2003-03-28 | 2006-02-23 | Wisconsin Alumni Research Foundation | Conditions physicochimiques de culture pour des cellules souches embryonnaires |
JPWO2012017925A1 (ja) | 2010-08-02 | 2013-10-03 | 協和発酵キリン株式会社 | 物質の製造方法 |
EP2686423A4 (fr) | 2011-03-14 | 2015-01-28 | Nat Res Council Canada | Procédé de production virale dans des cellules |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3039932A (en) * | 1958-01-07 | 1962-06-19 | Research Corp | Tissue culturing with arginine, citrulline or aspartic acids supplements to the media |
JPS536483A (en) * | 1976-07-02 | 1978-01-20 | Tanabe Seiyaku Co Ltd | Composition having enzymatic activity and its preparation |
US4342833A (en) * | 1977-05-31 | 1982-08-03 | Bethesda Research Laboratory | Immobilized restriction endonucleases |
US4352883A (en) * | 1979-03-28 | 1982-10-05 | Damon Corporation | Encapsulation of biological material |
US4409331A (en) * | 1979-03-28 | 1983-10-11 | Damon Corporation | Preparation of substances with encapsulated cells |
NL8500351A (nl) * | 1984-02-13 | 1985-09-02 | Damon Biotech Inc | Kweken van cellen met behulp van inborrelen van gas. |
JPH11384A (ja) * | 1997-06-11 | 1999-01-06 | Okawara Mfg Co Ltd | 粉粒体の殺菌方法 |
-
1984
- 1984-02-13 US US06/579,492 patent/US4724206A/en not_active Expired - Fee Related
-
1985
- 1985-02-07 NL NL8500350A patent/NL8500350A/nl not_active Application Discontinuation
- 1985-02-08 AU AU38569/85A patent/AU3856985A/en not_active Abandoned
- 1985-02-08 GB GB08503249A patent/GB2153830B/en not_active Expired
- 1985-02-11 BE BE0/214492A patent/BE901703A/fr not_active IP Right Cessation
- 1985-02-12 FR FR8501964A patent/FR2559501B1/fr not_active Expired
- 1985-02-12 DK DK65185A patent/DK65185A/da not_active Application Discontinuation
- 1985-02-12 IT IT67140/85A patent/IT1184883B/it active
- 1985-02-12 SE SE8500621A patent/SE8500621L/xx not_active Application Discontinuation
- 1985-02-12 DE DE19853504715 patent/DE3504715A1/de active Granted
- 1985-02-12 NO NO850533A patent/NO850533L/no unknown
- 1985-02-13 JP JP60026133A patent/JPS60188062A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
NL8500350A (nl) | 1985-09-02 |
IT8567140A1 (it) | 1986-08-12 |
FR2559501A1 (fr) | 1985-08-16 |
AU3856985A (en) | 1985-08-22 |
FR2559501B1 (fr) | 1987-09-18 |
SE8500621D0 (sv) | 1985-02-12 |
NO850533L (no) | 1985-08-14 |
IT1184883B (it) | 1987-10-28 |
GB8503249D0 (en) | 1985-03-13 |
US4724206A (en) | 1988-02-09 |
GB2153830B (en) | 1987-08-12 |
IT8567140A0 (it) | 1985-02-12 |
DK65185D0 (da) | 1985-02-12 |
DE3504715A1 (de) | 1985-09-05 |
JPS60188062A (ja) | 1985-09-25 |
DK65185A (da) | 1985-08-14 |
SE8500621L (sv) | 1985-08-14 |
GB2153830A (en) | 1985-08-29 |
DE3504715C2 (fr) | 1987-08-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BE901703A (fr) | Procede d'activation de la production de proteines par des cultures cellulaires. | |
DK0403139T3 (da) | Celledyrkningssystemer og -medier | |
JPS6427485A (en) | Production of l-2-amino-4-(hydroxymethylphosphinyl)-butyric acid | |
US5324658A (en) | Media for cell growth and method for making them | |
ATE79900T1 (de) | Tierzellenkultur. | |
Soda et al. | Crystalline amino acid racemase with low substrate specificity | |
ES8403524A1 (es) | Un procedimiento para obtener s-adenosil-metionina. | |
ATE29387T1 (de) | Aus hefepilzen jeder art erhaltene stoffwechsel aktivierende praeparationen. | |
Cowman et al. | Caseinolytic and glyoprotein hydrolase activity of Streptococcus mutans | |
JPS60217894A (ja) | 新規プロテア−ゼ及びその製造方法 | |
Qureshi et al. | The isolation of acyl carrier protein from the pigeon liver fatty acid synthetase complex II | |
DK243589A (da) | Fremgangsmaade til fremstilling af human-vaevstypeplasminogenaktivator | |
Morihara | Studies on the Protease of Pseudomonas: Part IV. Factors Affecting the Enzyme Production, Especially on the Effect of Calcium Part V. On the Role of Calcium in the Enzyme Production | |
KR920012425A (ko) | 동물세포 배양용 고농도 배지 및 배양공정 | |
FR2434200A1 (fr) | Preparation d'acyl-coa synthetase lcf-18 a partir de micro-organismes | |
ATE97958T1 (de) | Zellenzuchtverfahren fuer die produktion von aktiviertem protein-c. | |
JPS557015A (en) | Proline acylase, its preparation and preparation of l-proline | |
Haars et al. | Regulation of proteolytic enzymes in axenically grown myxamoebae of Physarum polycephalum | |
SU1168597A1 (ru) | Способ получени питательной среды дл выращивани хлебопекарных дрожжей | |
Freyssinet et al. | Growth of Euglena gracilis on whey | |
SU565935A1 (ru) | Способ получени уратоксидазы | |
SU602542A1 (ru) | Способ выращивани спиртовых дрожжей | |
SU448219A1 (ru) | Способ получени биомассы | |
SU839254A1 (ru) | Питательна среда дл выращивани микробактерий туберкулеза | |
Hagiwara et al. | Fibrin membrane endowed with biological function VII. An approach to an artificial liver; Conversion of ammonia to urea invitro |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RE | Patent lapsed |
Owner name: DAMON BIOTECH INC. Effective date: 19880228 |