BE900425A - Nouveaux esters et amides aromatiques, leur preparation et leur utilisation comme medicaments. - Google Patents
Nouveaux esters et amides aromatiques, leur preparation et leur utilisation comme medicaments.Info
- Publication number
- BE900425A BE900425A BE1/11076A BE1011076A BE900425A BE 900425 A BE900425 A BE 900425A BE 1/11076 A BE1/11076 A BE 1/11076A BE 1011076 A BE1011076 A BE 1011076A BE 900425 A BE900425 A BE 900425A
- Authority
- BE
- Belgium
- Prior art keywords
- medicaments
- amides
- preparation
- aromatic esters
- novel aromatic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/24—Camphidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
L'invention concerne les composés de formule A-B-C-D dans laquelle A est un cycle hydrocarboné aromatique ou un hétérocycle aromatique éventuellement condensés, B signifie CO ou SO2, C signifie O ou NH et D un reste pipéridine ponté. Ces composés peuvent etre utilisés comme médicaments, présentant une action antagoniste sur les récepteurs sérotoninergiques M et par une activité anti-arythmique.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH467583 | 1983-08-26 | ||
CH593383 | 1983-11-03 | ||
CH687783 | 1983-12-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
BE900425A true BE900425A (fr) | 1985-02-25 |
Family
ID=27174937
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE1/11076A BE900425A (fr) | 1983-08-26 | 1984-08-24 | Nouveaux esters et amides aromatiques, leur preparation et leur utilisation comme medicaments. |
Country Status (8)
Country | Link |
---|---|
US (1) | US4797406A (fr) |
BE (1) | BE900425A (fr) |
CH (1) | CH664567A5 (fr) |
DE (1) | DE3429830A1 (fr) |
FR (1) | FR2551064B1 (fr) |
GB (1) | GB2145416B (fr) |
IT (1) | IT1175629B (fr) |
WO (1) | WO1985001048A1 (fr) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2602142A1 (fr) * | 1986-07-30 | 1988-02-05 | Sandoz Sa | Utilisation en therapeutique des antagonistes des recepteurs serotoninergiques 5ht3 |
FR2617713A1 (fr) * | 1987-07-11 | 1989-01-13 | Sandoz Sa | Nouvelle utilisation des antagonistes de 5ht-3 |
US4910193A (en) * | 1985-12-16 | 1990-03-20 | Sandoz Ltd. | Treatment of gastrointestinal disorders |
AU595172B2 (en) * | 1984-12-20 | 1990-03-29 | Novartis Ag | Treatment of gastrointestinal disorders |
EP0329932A3 (fr) * | 1988-02-23 | 1992-08-05 | Merrell Pharmaceuticals Inc. | Utilisation des dérivés de la quinolizine et de la quinolizinone pour la manufacture des médicaments |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4888353A (en) * | 1986-02-28 | 1989-12-19 | Erbamont, Inc. | Carboxamides useful as antiemetic or antipsychotic agents |
US5122528A (en) * | 1983-12-22 | 1992-06-16 | Erbamont, Inc. | Analgesic use of benzobicyclic carboxamides |
DE3445377A1 (de) * | 1983-12-23 | 1985-07-04 | Sandoz-Patent-GmbH, 7850 Lörrach | Carbocylische und heterocyclische carbonsaeureester und -amide von ueberbrueckten und nicht ueberbrueckten cyclischen stickstoffhaltigen aminen oder alkoholen |
GB8525913D0 (en) * | 1985-10-21 | 1985-11-27 | Beecham Group Plc | Compounds |
GB8623142D0 (en) * | 1986-09-26 | 1986-10-29 | Beecham Group Plc | Compounds |
DE3650772T2 (de) * | 1985-04-27 | 2003-04-03 | Hoffmann La Roche | Derivate von Indazole-3-carboxamide und -3-carboxylsäure |
US4937247A (en) * | 1985-04-27 | 1990-06-26 | Beecham Group P.L.C. | 1-acyl indazoles |
GB8516371D0 (en) * | 1985-06-28 | 1985-07-31 | Beecham Group Plc | Compounds |
ES2053451T3 (es) * | 1986-01-07 | 1994-08-01 | Beecham Group Plc | Un procedimiento para la preparacion de un compuesto que tiene propiedades farmacologicas utiles. |
US4717563A (en) * | 1986-03-05 | 1988-01-05 | A. H. Robins Company, Inc. | 2-alkoxy-N-(1-azabicyclo(2.2.2)oct-3-yl) benzamides and thiobenzamides in a method for alleviating emesis caused by non-platinum anticancer drugs |
DE3782107T2 (de) * | 1986-07-25 | 1993-04-01 | Beecham Group Plc | Azabicyclische verbindungen, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung. |
AT396870B (de) * | 1986-08-07 | 1993-12-27 | Sandoz Ag | Verfahren zur herstellung einer galenischen formulierung zur nasalen verabreichung von serotoninantagonisten |
ZA878096B (en) * | 1986-11-03 | 1988-04-26 | Merrell Dow Pharmaceuticals Inc. | Esters of hexahydro-8-hydroxy-2,6-methano-2h-quinolizin-3(4h)-one and related compounds |
EP0278173B1 (fr) * | 1986-12-17 | 1993-11-03 | Glaxo Group Limited | Emploi de dérivés hétérocycliques pour le traitement de la dépression |
GB8806990D0 (en) * | 1988-03-23 | 1988-04-27 | Beecham Group Plc | Novel compounds |
DE3827253A1 (de) * | 1987-08-20 | 1989-03-02 | Sandoz Ag | Ester und amide von cyclischen carbonsaeuren und cyclischen alkoholen und aminen sowie verfahren zu deren herstellung und sie enthaltende therapeutische zusammensetzungen |
US4883877A (en) * | 1987-11-13 | 1989-11-28 | Ciba-Geigy Corporation | Azabicycloheptanes and process for their preparation |
US5011846A (en) * | 1988-02-23 | 1991-04-30 | Merrell Dow Pharmaceuticals Inc. | Medicament compositions derived from quinolizine and quinolizinone and methods of use thereof |
IT1228293B (it) * | 1989-02-06 | 1991-06-07 | Angeli Inst Spa | Benzoderivati di composti eterociclici contenenti azoto. |
IT1230881B (it) * | 1989-06-20 | 1991-11-08 | Angeli Inst Spa | Derivati del r(-) 3-chinuclidinolo |
US5126343A (en) * | 1989-09-11 | 1992-06-30 | G. D. Searle & Co. | N-azabicyclo [3.3.0]octane amides of aromatic acids |
US5225419A (en) * | 1989-10-14 | 1993-07-06 | John Wyeth & Brother, Limited | Certain 1,8-ethano or propano-1,4-dihydro-4-oxo-quinoline-3-carboxamides and derivatives thereof |
GB2236751B (en) * | 1989-10-14 | 1993-04-28 | Wyeth John & Brother Ltd | Heterocyclic compounds |
US5223613A (en) * | 1990-04-27 | 1993-06-29 | G. D. Searle & Co. | Azatetracycle compounds and process of preparing same |
US5140023A (en) * | 1990-04-27 | 1992-08-18 | G. D. Searle & Co. | Azatetracycle compounds |
JP3122671B2 (ja) * | 1990-05-23 | 2001-01-09 | 協和醗酵工業株式会社 | 複素環式化合物 |
ES2080482T3 (es) * | 1990-12-28 | 1996-02-01 | Kyowa Hakko Kogyo Kk | Derivado de quinoleina. |
US5219850A (en) * | 1991-03-07 | 1993-06-15 | G. D. Searle & Co. | Pharmaceutically useful meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof |
US5137893A (en) * | 1991-03-07 | 1992-08-11 | G. D. Searle & Co. | Pharmaceutically useful meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof |
JPH05507942A (ja) * | 1991-03-07 | 1993-11-11 | ジー.ディー.サール アンド カンパニー | 新規セロトニン作動性剤としての新規なmeso―アザ環式芳香族酸アミド化合物およびエステル化合物 |
US5260303A (en) * | 1991-03-07 | 1993-11-09 | G. D. Searle & Co. | Imidazopyridines as serotonergic 5-HT3 antagonists |
US5227377A (en) * | 1991-03-07 | 1993-07-13 | G. D. Searle & Co. | Meso-azacyclic amides of certain bicyclic carboxylic acids |
US5516782A (en) * | 1991-03-07 | 1996-05-14 | G. D. Searle & Co. | New meso-azacyclic aromatic acid amides and esters as novel serotonergic agents |
US5234921A (en) * | 1991-03-07 | 1993-08-10 | G. D. Searle & Co. | Meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof as pharmaceuticals |
US5196547A (en) * | 1991-03-07 | 1993-03-23 | G. D. Searle & Co. | Meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof |
DE4126999A1 (de) * | 1991-08-16 | 1993-02-18 | Basf Ag | Herbizide mittel, enthaltend 3-aminobenzo(b)thiophene als antidots |
JP2699794B2 (ja) * | 1992-03-12 | 1998-01-19 | 三菱化学株式会社 | チエノ〔3,2−b〕ピリジン誘導体 |
GB9301660D0 (en) * | 1993-01-28 | 1993-03-17 | Smithkline Beecham Plc | Pharmaceuticals |
AR036041A1 (es) * | 2001-06-12 | 2004-08-04 | Upjohn Co | Compuestos aromaticos heterociclicos sustituidos con quinuclidina y composiciones farmaceuticas que los contienen |
AR036040A1 (es) | 2001-06-12 | 2004-08-04 | Upjohn Co | Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen |
BR0212477A (pt) * | 2001-09-12 | 2004-08-24 | Upjohn Co | 7-aza[2.2.1] bicicloheptanos substituìdos para o tratamento de doenças |
HUP0402289A2 (hu) | 2001-10-02 | 2005-02-28 | Pharmacia & Upjohn Company | Gyógyhatású azabiciklusos csoporttal helyettesített kondenzált heteroaril-származékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk |
US6849620B2 (en) | 2001-10-26 | 2005-02-01 | Pfizer Inc | N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease |
MXPA04004373A (es) | 2001-11-09 | 2004-08-11 | Upjohn Co | Compuestos heterociclicos condensados con fenilo azabiciclo para el tratamiento de enfermedades. |
DE10156719A1 (de) | 2001-11-19 | 2003-05-28 | Bayer Ag | Heteroarylcarbonsäureamide |
US6858613B2 (en) * | 2002-02-19 | 2005-02-22 | Pfizer Inc. | Fused bicyclic-N-bridged-heteroaromatic carboxamides for the treatment of disease |
EP1476448A2 (fr) * | 2002-02-19 | 2004-11-17 | PHARMACIA & UPJOHN COMPANY | Composes azabicycliques servant a traiter des maladies |
JP4890762B2 (ja) | 2002-09-25 | 2012-03-07 | メモリー・ファーマシューティカルズ・コーポレイション | インダゾール、ベンゾチアゾール、及びベンゾイソチアゾール、並びにそれらの調製及び使用 |
JP2006506395A (ja) * | 2002-11-01 | 2006-02-23 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | CNS疾患の治療のための、α7ニコチンアゴニスト活性及び5HT3アンタゴニスト活性を有する化合物 |
DE602004010299T2 (de) | 2003-12-22 | 2008-09-18 | Memory Pharmaceuticals Corp. | Indole, 1h-indazole, 1,2-benzisoxazole und 1,2-benzisothiazole und deren herstellung und anwendungen |
CN103724343A (zh) | 2004-03-25 | 2014-04-16 | 记忆药物公司 | 吲唑、苯并噻唑、苯并异噻唑、苯并异噁唑及其制备和用途 |
WO2006001894A1 (fr) | 2004-04-22 | 2006-01-05 | Memory Pharmaceutical Corporation | Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, leur preparation et leurs utilisations |
BRPI0510212A (pt) | 2004-05-07 | 2007-10-16 | Memory Pharm Corp | 1h-indazóis, benzotiazóis, 1,2 - benzoisoxazóis, 1,2-benzoisotiazóis, e cromonas e a preparação e usos dos mesmos |
US7524958B2 (en) | 2004-06-18 | 2009-04-28 | Neurosearch A/S | Certain 9-aza-bicyclo[3.3.1] nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
EP1761527A1 (fr) * | 2004-06-18 | 2007-03-14 | Neurosearch A/S | Nouveaux derives de 9-aza-bicyclo¬3.3.1|nonane et leur utilisation comme inhibiteurs du recaptage des neurotransmetteurs monoamines |
MX2007007328A (es) | 2004-12-22 | 2007-07-25 | Memory Pharm Corp | Ligandos del receptor alfa-7 nicotinico y preparacion y sus usos. |
US8106066B2 (en) | 2005-09-23 | 2012-01-31 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof |
CN104193741B (zh) * | 2007-10-01 | 2016-08-24 | 阿尔法梅根有限责任公司 | 作为α7-烟碱乙酰胆碱受体配体的奎宁环-4-基甲基1H-吲哚-3-甲酸酯衍生物 |
CN102532128B (zh) * | 2010-12-17 | 2014-11-12 | 北大方正集团有限公司 | 托烷司琼的合成方法以及盐酸托烷司琼的制备方法 |
CN102584815A (zh) * | 2011-01-14 | 2012-07-18 | 湖南康普医药研究院 | 一种规模化制备盐酸托烷司琼的方法 |
WO2016007630A1 (fr) | 2014-07-11 | 2016-01-14 | Alpharmagen, Llc | Composés de quinuclidine pour moduler l'activité du récepteur nicotinique alpha7 de l'acétylcholine |
CN110845493B (zh) * | 2019-11-04 | 2021-09-10 | 植恩生物技术股份有限公司 | 盐酸托烷司琼的制备方法 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3170927A (en) * | 1965-02-23 | O chzoh | ||
US2748134A (en) * | 1956-05-29 | Amide-like derivatives of piperidine | ||
GB774858A (en) * | 1954-10-20 | 1957-05-15 | Sandoz Ltd | Tropane and -Î-tropane derivatives and process for preparation thereof |
US3342826A (en) * | 1964-01-13 | 1967-09-19 | Ile De France | Heterocyclic aminoalkyl benzamides |
US3405134A (en) * | 1965-08-17 | 1968-10-08 | Colgate Palmolive Co | Quinuclidyl esters of aromatic acids |
SE331841B (fr) * | 1967-05-23 | 1971-01-18 | Astra Ab | |
US3740408A (en) * | 1967-09-11 | 1973-06-19 | Upjohn Co | Oxygenated 3-aza bicyclo(3,3,1)nonanes |
US3702324A (en) * | 1970-06-24 | 1972-11-07 | Stanford Research Inst | 3,4,5-trimethoxybenzamides of substituted anilines and of alkylpiperidines |
GB1293446A (en) * | 1970-07-23 | 1972-10-18 | Rech S Et D Applic Scient Soge | Quinuclidine derivatives, the preparation thereof and pharmaceutical compositions containing them |
CH614709A5 (fr) * | 1975-09-25 | 1979-12-14 | Ciba Geigy Ag | |
FI763021A (fr) * | 1975-11-03 | 1977-05-04 | Thomae Gmbh Dr K | |
GB1593146A (en) * | 1976-11-05 | 1981-07-15 | Beecham Group Ltd | Octahydro-quinolizinyl benzamide derivatives |
IL59004A0 (en) * | 1978-12-30 | 1980-03-31 | Beecham Group Ltd | Substituted benzamides their preparation and pharmaceutical compositions containing them |
FR2476088A2 (fr) * | 1979-01-16 | 1981-08-21 | Delalande Sa | Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique |
NZ197356A (en) * | 1980-06-18 | 1984-05-31 | Beecham Group Ltd | Ar-alkylsulphinyl-n-(azaicycloalkyl(alkyl)) benzamides |
FR2493848B2 (fr) * | 1980-11-07 | 1986-05-16 | Delalande Sa | Nouveaux derives des nor-tropane et granatane, leur procede de preparation et leur application en therapeutique |
FR2499570A1 (fr) * | 1981-02-11 | 1982-08-13 | Delalande Sa | Nouveaux derives du b-amino-3 nor-tropane et leur procede de preparation |
CA1220141A (fr) * | 1981-06-13 | 1987-04-07 | John R. Fozard | Traitement de la migraine avec des derives de benzoate de tropyle |
EP0067615B1 (fr) * | 1981-06-17 | 1986-01-08 | Beecham Group Plc | Dérivés thioalkyl d'azabicyclobenzamides, leur procédé de préparation et les compositions pharmaceutiques les contenant |
EP0069482A1 (fr) * | 1981-06-29 | 1983-01-12 | Beecham Group Plc | Azabicycloalkylenzamides, leur procédé de préparation et les compositions pharmaceutiques les contenant |
EP0068700A1 (fr) * | 1981-06-29 | 1983-01-05 | Beecham Group Plc | Azabicycloalkylbenzamides, leur procédé de préparation et les compositions pharmaceutiques les contenant |
EP0076592B1 (fr) * | 1981-10-01 | 1987-01-28 | Beecham Group Plc | Dérivés d'azabicyclo-(3,3,1)-nonylbenzamide, leur procédé de préparation et les compositions pharmaceutiques les contenant |
FR2531083B1 (fr) * | 1982-06-29 | 1986-11-28 | Sandoz Sa | Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments |
-
1984
- 1984-08-14 WO PCT/CH1984/000127 patent/WO1985001048A1/fr unknown
- 1984-08-14 DE DE19843429830 patent/DE3429830A1/de not_active Withdrawn
- 1984-08-14 CH CH1727/85A patent/CH664567A5/de not_active IP Right Cessation
- 1984-08-22 GB GB08421333A patent/GB2145416B/en not_active Expired
- 1984-08-23 FR FR848413239A patent/FR2551064B1/fr not_active Expired
- 1984-08-23 IT IT22397/84A patent/IT1175629B/it active
- 1984-08-24 BE BE1/11076A patent/BE900425A/fr not_active IP Right Cessation
-
1986
- 1986-06-16 US US06/874,756 patent/US4797406A/en not_active Expired - Fee Related
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU595172B2 (en) * | 1984-12-20 | 1990-03-29 | Novartis Ag | Treatment of gastrointestinal disorders |
US4910193A (en) * | 1985-12-16 | 1990-03-20 | Sandoz Ltd. | Treatment of gastrointestinal disorders |
FR2602142A1 (fr) * | 1986-07-30 | 1988-02-05 | Sandoz Sa | Utilisation en therapeutique des antagonistes des recepteurs serotoninergiques 5ht3 |
BE1005921A4 (fr) * | 1986-07-30 | 1994-03-15 | Sandoz Sa | Utilisation en therapeutique des antagonistes des recepteurs serotoninergiques 5ht3. |
FR2617713A1 (fr) * | 1987-07-11 | 1989-01-13 | Sandoz Sa | Nouvelle utilisation des antagonistes de 5ht-3 |
EP0329932A3 (fr) * | 1988-02-23 | 1992-08-05 | Merrell Pharmaceuticals Inc. | Utilisation des dérivés de la quinolizine et de la quinolizinone pour la manufacture des médicaments |
Also Published As
Publication number | Publication date |
---|---|
DE3429830A1 (de) | 1985-03-07 |
GB2145416B (en) | 1987-05-28 |
IT1175629B (it) | 1987-07-15 |
FR2551064B1 (fr) | 1989-12-01 |
GB2145416A (en) | 1985-03-27 |
CH664567A5 (de) | 1988-03-15 |
FR2551064A1 (fr) | 1985-03-01 |
IT8422397A0 (it) | 1984-08-23 |
US4797406A (en) | 1989-01-10 |
WO1985001048A1 (fr) | 1985-03-14 |
GB8421333D0 (en) | 1984-09-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BE900425A (fr) | Nouveaux esters et amides aromatiques, leur preparation et leur utilisation comme medicaments. | |
BE1002212A5 (fr) | Nouveaux derives peptidiques, leur preparation et leur utilisation comme medicaments. | |
FR2636948A1 (fr) | N-(2-piperidylmethyl)benzamides substitues anti-arythmiques et composition pharmaceutique les contenant | |
BE1002436A3 (fr) | Nouveaux benzo(b)pyrannes et pyrannopyridines, leur preparation et leur utilisation comme medicaments. | |
ATE44528T1 (de) | Arzneimittel mit antipsychotischer wirkung. | |
BE899073A (fr) | Nouveaux composes azoliques, leur preparation et leur utilisation comme antifongiques et fongicides | |
FR2603037B1 (fr) | (pentamethyl-1,2,2,6,6,6 piperidyl-4 amino)- triazines, leur application comme stabilisants de matieres organiques, et compositions qui en contiennent | |
BE900594A (fr) | Nouveaux composes azoliques, leur preparation et leur utilisation comme antifongiques et fongicides. | |
FR2444681A1 (fr) | Nouvelles 1,4-dihydropyridines, leur preparation et leur application comme medicaments | |
FR2388793A1 (fr) | Azetidinyl-acetonitriles et -acetamides, compositions antiarythmiques contenant ces composes et utilisation de ces compositions | |
FR2422624A1 (fr) | Nouveaux agents anticholinergiques doues d'activite antisecretoire, leur procede de preparation et leurs utilisations | |
FR2455572A1 (fr) | Derives de phenylethylamine, leur preparation et utilisation dans le traitement des affections cardiovasculaires, et compositions les contenant | |
EP0265186A3 (fr) | Compositions contre le tartre dentaire | |
FR2362822A1 (fr) | Diamines cycloaliphatiques et leur utilisation comme catalyseurs pour les reactions de polyaddition de polyisocyanate | |
FR2391191A1 (fr) | Nouveaux composes polypeptidiques, lyeptidiques, leur preparation et leur application comme medicaments | |
ATE69220T1 (de) | Sechsgliedrige heterocyclische derivate von n'substituiertenn,n'-diacylhydrazinen. | |
ATE83481T1 (de) | Fuenfgliedrige heterocyclische derivate von n'substituiertenn,n'-diacylhydrazinen. | |
NO157297C (no) | Analogifremgangsmaate ved fremstilling av terapeutisk aktive 7alfa-acylthio-15,16-methylen-3-oxo-17alfa-pregna-1,4-dien-21,17-carbolactoner. | |
FI871535A0 (fi) | Menetelmä terapeuttisesti aktiivisten tiasykloalkeno/3,2-b/pyridiinien valmistamiseksi | |
FR2359120A1 (fr) | Nouveaux composes polypeptidiques, leur preparation et leur application comme medicaments | |
BE903912A (fr) | Nouvelles alpha-acylaminoergolines, leur preparation, leur utilisation comme medicaments et les compositions pharmaceutiques les contenant. | |
FR2382431A1 (fr) | Nouvelles 2-hydroxy-propylamines, leur preparation et leur utilisation comme agents tensio-actifs | |
BE905397A (fr) | Nouveaux ethers allyliques bicycliques, leur preparation et leur utilisation comme anti-fongiques et fongicides. | |
BE903755A (fr) | Nouveaux derives de la 1,4-dihydropyridine, leur preparation et leur utilisation comme medicaments. | |
BE900718A (fr) | Nouveaux derives du carbapeneme, leur preparation et leur utilisation comme medicaments. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RE | Patent lapsed |
Owner name: SANDOZ S.A. Effective date: 19910831 |