BE897968A - Werkwijze voor het radio-afbeelden van het myocardium van zoogdieren onder gebruikmaking van radiogemerkte lipofiele kationen - Google Patents
Werkwijze voor het radio-afbeelden van het myocardium van zoogdieren onder gebruikmaking van radiogemerkte lipofiele kationen Download PDFInfo
- Publication number
- BE897968A BE897968A BE2/60226A BE2060226A BE897968A BE 897968 A BE897968 A BE 897968A BE 2/60226 A BE2/60226 A BE 2/60226A BE 2060226 A BE2060226 A BE 2060226A BE 897968 A BE897968 A BE 897968A
- Authority
- BE
- Belgium
- Prior art keywords
- sep
- quaternary compound
- halide
- quaternary
- bromide
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 33
- 150000001768 cations Chemical class 0.000 title claims description 20
- 210000004165 myocardium Anatomy 0.000 title claims description 14
- 150000001875 compounds Chemical class 0.000 claims description 56
- 238000003384 imaging method Methods 0.000 claims description 12
- 125000003118 aryl group Chemical group 0.000 claims description 9
- 150000004820 halides Chemical class 0.000 claims description 9
- -1 halo diaryl dialkylammonium halide Chemical class 0.000 claims description 7
- VUEDNLCYHKSELL-UHFFFAOYSA-N arsonium Chemical group [AsH4+] VUEDNLCYHKSELL-UHFFFAOYSA-N 0.000 claims description 6
- 125000005496 phosphonium group Chemical group 0.000 claims description 6
- 125000001453 quaternary ammonium group Chemical group 0.000 claims description 6
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 5
- 125000000217 alkyl group Chemical group 0.000 claims description 3
- 229910052785 arsenic Inorganic materials 0.000 claims description 3
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 claims description 3
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 2
- VQMRBJLNEVCKII-UHFFFAOYSA-M [Br-].C1(=CC=CC=C1)[P+](C1=CC=CC=C1)(C1=CC=CC=C1)C1=CC=CC=C1.[I] Chemical compound [Br-].C1(=CC=CC=C1)[P+](C1=CC=CC=C1)(C1=CC=CC=C1)C1=CC=CC=C1.[I] VQMRBJLNEVCKII-UHFFFAOYSA-M 0.000 claims description 2
- 238000001990 intravenous administration Methods 0.000 claims description 2
- 229910052698 phosphorus Inorganic materials 0.000 claims description 2
- 239000011574 phosphorus Substances 0.000 claims description 2
- CMSYDJVRTHCWFP-UHFFFAOYSA-N triphenylphosphane;hydrobromide Chemical compound Br.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 CMSYDJVRTHCWFP-UHFFFAOYSA-N 0.000 claims 2
- OFWYYLWAQSLIMC-UHFFFAOYSA-M [Br-].C(C1=CC=CC=C1)[N+](C)(C)CC1=CC=CC=C1.[I] Chemical compound [Br-].C(C1=CC=CC=C1)[N+](C)(C)CC1=CC=CC=C1.[I] OFWYYLWAQSLIMC-UHFFFAOYSA-M 0.000 claims 1
- QQCKHACFYAWLQY-UHFFFAOYSA-M [Cl-].C1(=CC=CC=C1)[As+](C1=CC=CC=C1)(C1=CC=CC=C1)C1=CC=CC=C1.[I] Chemical compound [Cl-].C1(=CC=CC=C1)[As+](C1=CC=CC=C1)(C1=CC=CC=C1)C1=CC=CC=C1.[I] QQCKHACFYAWLQY-UHFFFAOYSA-M 0.000 claims 1
- JCESMSFMLFOKHH-UHFFFAOYSA-M benzyl-(2-iodophenyl)-diphenylphosphanium;bromide Chemical compound [Br-].IC1=CC=CC=C1[P+](C=1C=CC=CC=1)(C=1C=CC=CC=1)CC1=CC=CC=C1 JCESMSFMLFOKHH-UHFFFAOYSA-M 0.000 claims 1
- XBKZMRKXDQBGOQ-UHFFFAOYSA-M benzyl-(2-iodophenyl)-diphenylphosphanium;chloride Chemical compound [Cl-].IC1=CC=CC=C1[P+](C=1C=CC=CC=1)(C=1C=CC=CC=1)CC1=CC=CC=C1 XBKZMRKXDQBGOQ-UHFFFAOYSA-M 0.000 claims 1
- XKLGFIGRQOUCJC-UHFFFAOYSA-M benzyl-(iodomethyl)-methyl-phenylazanium;bromide Chemical compound [Br-].C=1C=CC=CC=1[N+](CI)(C)CC1=CC=CC=C1 XKLGFIGRQOUCJC-UHFFFAOYSA-M 0.000 claims 1
- 125000006278 bromobenzyl group Chemical group 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 210000002216 heart Anatomy 0.000 description 26
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 19
- 230000002107 myocardial effect Effects 0.000 description 19
- 229910052716 thallium Inorganic materials 0.000 description 15
- BKVIYDNLLOSFOA-UHFFFAOYSA-N thallium Chemical compound [Tl] BKVIYDNLLOSFOA-UHFFFAOYSA-N 0.000 description 15
- 229910052740 iodine Inorganic materials 0.000 description 13
- 230000002285 radioactive effect Effects 0.000 description 12
- 239000008280 blood Substances 0.000 description 10
- 210000004369 blood Anatomy 0.000 description 10
- 210000004185 liver Anatomy 0.000 description 10
- 210000004072 lung Anatomy 0.000 description 10
- 239000000243 solution Substances 0.000 description 10
- 230000000747 cardiac effect Effects 0.000 description 8
- 210000000056 organ Anatomy 0.000 description 8
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 7
- 239000011630 iodine Substances 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- 241000700159 Rattus Species 0.000 description 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
- 229910052794 bromium Inorganic materials 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 5
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 5
- 239000012216 imaging agent Substances 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- JLTDJTHDQAWBAV-UHFFFAOYSA-N N,N-dimethylaniline Chemical compound CN(C)C1=CC=CC=C1 JLTDJTHDQAWBAV-UHFFFAOYSA-N 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 239000000835 fiber Substances 0.000 description 4
- 229910052736 halogen Inorganic materials 0.000 description 4
- 150000002367 halogens Chemical group 0.000 description 4
- 239000011541 reaction mixture Substances 0.000 description 4
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
- 238000009825 accumulation Methods 0.000 description 3
- 238000005984 hydrogenation reaction Methods 0.000 description 3
- 230000004807 localization Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- OIICUUGPVAEJSH-UHFFFAOYSA-M (2-bromophenyl)methyl-ethyl-dimethylazanium;bromide Chemical class [Br-].CC[N+](C)(C)CC1=CC=CC=C1Br OIICUUGPVAEJSH-UHFFFAOYSA-M 0.000 description 2
- IPJPTPFIJLFWLP-UHFFFAOYSA-M (4-nitrophenyl)methyl-triphenylphosphanium;bromide Chemical compound [Br-].C1=CC([N+](=O)[O-])=CC=C1C[P+](C=1C=CC=CC=1)(C=1C=CC=CC=1)C1=CC=CC=C1 IPJPTPFIJLFWLP-UHFFFAOYSA-M 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- AHFYYJLIKYKOEG-UHFFFAOYSA-N argon;toluene Chemical compound [Ar].CC1=CC=CC=C1 AHFYYJLIKYKOEG-UHFFFAOYSA-N 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- LNIYNESXCOYFPW-UHFFFAOYSA-N dibenzyl(dimethyl)azanium Chemical compound C=1C=CC=CC=1C[N+](C)(C)CC1=CC=CC=C1 LNIYNESXCOYFPW-UHFFFAOYSA-N 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 229910052731 fluorine Inorganic materials 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 230000002452 interceptive effect Effects 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 229910052759 nickel Inorganic materials 0.000 description 2
- 239000003208 petroleum Substances 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 125000001424 substituent group Chemical group 0.000 description 2
- AYNNSCRYTDRFCP-UHFFFAOYSA-N triazene Chemical compound NN=N AYNNSCRYTDRFCP-UHFFFAOYSA-N 0.000 description 2
- 229910052722 tritium Inorganic materials 0.000 description 2
- RCJCUXKRMJYUKN-UHFFFAOYSA-M (2-iodophenyl)methyl-triphenylphosphanium;chloride Chemical compound [Cl-].IC1=CC=CC=C1C[P+](C=1C=CC=CC=1)(C=1C=CC=CC=1)C1=CC=CC=C1 RCJCUXKRMJYUKN-UHFFFAOYSA-M 0.000 description 1
- FQJYKXVQABPCRA-UHFFFAOYSA-M (4-bromophenyl)methyl-triphenylphosphanium;bromide Chemical compound [Br-].C1=CC(Br)=CC=C1C[P+](C=1C=CC=CC=1)(C=1C=CC=CC=1)C1=CC=CC=C1 FQJYKXVQABPCRA-UHFFFAOYSA-M 0.000 description 1
- MORAZTHSCBMYRY-UHFFFAOYSA-M (4-iodophenyl)methyl-dimethyl-phenylazanium;bromide Chemical compound [Br-].C=1C=CC=CC=1[N+](C)(C)CC1=CC=C(I)C=C1 MORAZTHSCBMYRY-UHFFFAOYSA-M 0.000 description 1
- FTMNWZHKQGKKAU-UHFFFAOYSA-N 1-(chloromethyl)-2-iodobenzene Chemical compound ClCC1=CC=CC=C1I FTMNWZHKQGKKAU-UHFFFAOYSA-N 0.000 description 1
- YLRBJYMANQKEAW-UHFFFAOYSA-N 1-bromo-4-(bromomethyl)benzene Chemical compound BrCC1=CC=C(Br)C=C1 YLRBJYMANQKEAW-UHFFFAOYSA-N 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 239000007868 Raney catalyst Substances 0.000 description 1
- 229910000564 Raney nickel Inorganic materials 0.000 description 1
- 238000000297 Sandmeyer reaction Methods 0.000 description 1
- YZCKVEUIGOORGS-NJFSPNSNSA-N Tritium Chemical compound [3H] YZCKVEUIGOORGS-NJFSPNSNSA-N 0.000 description 1
- 230000009056 active transport Effects 0.000 description 1
- SWLVFNYSXGMGBS-UHFFFAOYSA-N ammonium bromide Chemical compound [NH4+].[Br-] SWLVFNYSXGMGBS-UHFFFAOYSA-N 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- AGEZXYOZHKGVCM-UHFFFAOYSA-N benzyl bromide Chemical compound BrCC1=CC=CC=C1 AGEZXYOZHKGVCM-UHFFFAOYSA-N 0.000 description 1
- WTEPWWCRWNCUNA-UHFFFAOYSA-M benzyl(triphenyl)phosphanium;bromide Chemical compound [Br-].C=1C=CC=CC=1[P+](C=1C=CC=CC=1)(C=1C=CC=CC=1)CC1=CC=CC=C1 WTEPWWCRWNCUNA-UHFFFAOYSA-M 0.000 description 1
- 238000002306 biochemical method Methods 0.000 description 1
- 239000000090 biomarker Substances 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- KVWNWTZZBKCOPM-UHFFFAOYSA-M bretylium tosylate Chemical class CC1=CC=C(S([O-])(=O)=O)C=C1.CC[N+](C)(C)CC1=CC=CC=C1Br KVWNWTZZBKCOPM-UHFFFAOYSA-M 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 210000005242 cardiac chamber Anatomy 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- VDQQXEISLMTGAB-UHFFFAOYSA-N chloramine T Chemical compound [Na+].CC1=CC=C(S(=O)(=O)[N-]Cl)C=C1 VDQQXEISLMTGAB-UHFFFAOYSA-N 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- IMKFYSIHWZULRD-UHFFFAOYSA-M dibenzyl(dimethyl)azanium;bromide Chemical compound [Br-].C=1C=CC=CC=1C[N+](C)(C)CC1=CC=CC=C1 IMKFYSIHWZULRD-UHFFFAOYSA-M 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000026045 iodination Effects 0.000 description 1
- 238000006192 iodination reaction Methods 0.000 description 1
- XMBWDFGMSWQBCA-RNFDNDRNSA-M iodine-131(1-) Chemical compound [131I-] XMBWDFGMSWQBCA-RNFDNDRNSA-M 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000005567 liquid scintillation counting Methods 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- AZFQCTBZOPUVOW-UHFFFAOYSA-N methyl(triphenyl)phosphanium Chemical class C=1C=CC=CC=1[P+](C=1C=CC=CC=1)(C)C1=CC=CC=C1 AZFQCTBZOPUVOW-UHFFFAOYSA-N 0.000 description 1
- LSEFCHWGJNHZNT-UHFFFAOYSA-M methyl(triphenyl)phosphanium;bromide Chemical compound [Br-].C=1C=CC=CC=1[P+](C=1C=CC=CC=1)(C)C1=CC=CC=C1 LSEFCHWGJNHZNT-UHFFFAOYSA-M 0.000 description 1
- 210000001700 mitochondrial membrane Anatomy 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- PMOIAJVKYNVHQE-UHFFFAOYSA-N phosphanium;bromide Chemical compound [PH4+].[Br-] PMOIAJVKYNVHQE-UHFFFAOYSA-N 0.000 description 1
- XYFCBTPGUUZFHI-UHFFFAOYSA-O phosphonium Chemical compound [PH4+] XYFCBTPGUUZFHI-UHFFFAOYSA-O 0.000 description 1
- 150000004714 phosphonium salts Chemical class 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000012217 radiopharmaceutical Substances 0.000 description 1
- 229940121896 radiopharmaceutical Drugs 0.000 description 1
- 230000002799 radiopharmaceutical effect Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 235000009518 sodium iodide Nutrition 0.000 description 1
- 229940001584 sodium metabisulfite Drugs 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- IUVXCVGGLRYGFE-UHFFFAOYSA-N tetraphenyl-lambda5-arsane hydrochloride Chemical compound C1=CC=C(C=C1)[AsH](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4.Cl IUVXCVGGLRYGFE-UHFFFAOYSA-N 0.000 description 1
- BRKFQVAOMSWFDU-UHFFFAOYSA-M tetraphenylphosphanium;bromide Chemical compound [Br-].C1=CC=CC=C1[P+](C=1C=CC=CC=1)(C=1C=CC=CC=1)C1=CC=CC=C1 BRKFQVAOMSWFDU-UHFFFAOYSA-M 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 229960001479 tosylchloramide sodium Drugs 0.000 description 1
- XREXPQGDOPQPAH-QKUPJAQQSA-K trisodium;[(z)-18-[1,3-bis[[(z)-12-sulfonatooxyoctadec-9-enoyl]oxy]propan-2-yloxy]-18-oxooctadec-9-en-7-yl] sulfate Chemical compound [Na+].[Na+].[Na+].CCCCCCC(OS([O-])(=O)=O)C\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CC(CCCCCC)OS([O-])(=O)=O)COC(=O)CCCCCCC\C=C/CC(CCCCCC)OS([O-])(=O)=O XREXPQGDOPQPAH-QKUPJAQQSA-K 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/433,871 US4446123A (en) | 1982-10-13 | 1982-10-13 | Process of radioimaging the myocardium of mammals utilizing radiolabeled lipophilic cations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE897968A true BE897968A (nl) | 1984-01-30 |
Family
ID=23721862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE2/60226A BE897968A (nl) | 1982-10-13 | 1983-10-12 | Werkwijze voor het radio-afbeelden van het myocardium van zoogdieren onder gebruikmaking van radiogemerkte lipofiele kationen |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4446123A (enExample) |
| JP (1) | JPS59139326A (enExample) |
| BE (1) | BE897968A (enExample) |
| CA (1) | CA1219207A (enExample) |
| DE (1) | DE3336748A1 (enExample) |
| FR (1) | FR2534576B1 (enExample) |
| GB (1) | GB2128191B (enExample) |
| IT (1) | IT1205396B (enExample) |
| LU (1) | LU85042A1 (enExample) |
| NL (1) | NL8303481A (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001271248A1 (en) * | 2000-04-28 | 2001-11-12 | Duke University | 18f-labeled choline analogs |
| US6548042B2 (en) * | 2000-08-07 | 2003-04-15 | Arstad Erik | Bis-phosphonate compounds |
| TWI266634B (en) * | 2002-02-06 | 2006-11-21 | Univ Johns Hopkins | Non-invasive diagnostic imaging technology for mitochondria dysfunction using radiolabeled lipophilic salts |
| AU2011203177B2 (en) * | 2004-02-24 | 2012-04-26 | The General Hospital Corporation | Catalytic radiofluorination |
| US9017724B2 (en) * | 2004-02-24 | 2015-04-28 | The General Hospital Corporation | Catalytic radiofluorination |
| US8257680B1 (en) | 2004-02-24 | 2012-09-04 | The General Hospital Corporation | Catalytic radiofluorination |
| EP2388017B1 (en) * | 2004-02-24 | 2014-12-24 | The General Hospital Corporation | Catalytic radiofluorination |
| US8388936B2 (en) * | 2008-02-22 | 2013-03-05 | Mcw Research Foundation, Inc. | In vivo mitochondrial labeling using positively-charged nitroxide enhanced and gadolinium chelate enhanced magnetic resonance imaging |
| MX375108B (es) | 2008-03-21 | 2025-03-06 | Massachusetts Gen Hospital | Compuestos y composiciones para la deteccion y el tratamiento de la enfermedad de alzheimer y trastornos relacionados. |
| US9205156B2 (en) * | 2010-05-27 | 2015-12-08 | Hadasit Medical Research Services & Development Limited | Molecular imaging agents |
| JP6285164B2 (ja) * | 2013-12-05 | 2018-02-28 | デクセリアルズ株式会社 | 化合物、熱硬化性樹脂組成物、及び熱硬化性シート |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4107283A (en) * | 1976-07-19 | 1978-08-15 | New England Nuclear Corporation | Tracer for circulation determinations |
| JPS5572640A (en) * | 1978-11-27 | 1980-05-31 | Automob Antipollut & Saf Res Center | Air-fuel ratio control device |
| DE2965469D1 (en) * | 1978-11-29 | 1983-07-07 | Hoffmann La Roche | Radioiodine containing amines, their preparation and their use as brain imaging agents |
| US4360511A (en) * | 1978-11-29 | 1982-11-23 | Medi-Physics, Inc. | Amines useful as brain imaging agents |
| NL7900964A (nl) * | 1979-02-07 | 1980-08-11 | Byk Mallinckrodt Cil Bv | Nieuwe radioactief gemerkte aminen, werkwijze ter bereiding van de nieuwe verbindingen, alsmede diagnostische preparaten op basis van de nieuwe verbindingen. |
| US4387087A (en) * | 1980-04-18 | 1983-06-07 | Research Corporation | Cationic lipophilic complexes of 99m Tc and their use for myocardial and hepatobiliary imaging |
-
1982
- 1982-10-13 US US06/433,871 patent/US4446123A/en not_active Expired - Fee Related
-
1983
- 1983-10-08 DE DE19833336748 patent/DE3336748A1/de not_active Withdrawn
- 1983-10-10 NL NL8303481A patent/NL8303481A/nl not_active Application Discontinuation
- 1983-10-12 LU LU85042A patent/LU85042A1/de unknown
- 1983-10-12 JP JP58189395A patent/JPS59139326A/ja active Granted
- 1983-10-12 BE BE2/60226A patent/BE897968A/nl not_active IP Right Cessation
- 1983-10-12 GB GB08327249A patent/GB2128191B/en not_active Expired
- 1983-10-12 IT IT68048/83A patent/IT1205396B/it active
- 1983-10-13 CA CA000438933A patent/CA1219207A/en not_active Expired
- 1983-10-13 FR FR8316263A patent/FR2534576B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| LU85042A1 (de) | 1984-04-02 |
| IT1205396B (it) | 1989-03-15 |
| GB2128191B (en) | 1986-05-08 |
| FR2534576A1 (fr) | 1984-04-20 |
| JPS6217974B2 (enExample) | 1987-04-21 |
| GB2128191A (en) | 1984-04-26 |
| IT8368048A0 (it) | 1983-10-12 |
| CA1219207A (en) | 1987-03-17 |
| US4446123A (en) | 1984-05-01 |
| DE3336748A1 (de) | 1984-07-05 |
| FR2534576B1 (fr) | 1986-09-19 |
| GB8327249D0 (en) | 1983-11-16 |
| JPS59139326A (ja) | 1984-08-10 |
| NL8303481A (nl) | 1984-05-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RE | Patent lapsed |
Owner name: HAHNEMANN UNIVERSITY Effective date: 19861031 |