BE896572A - Benzoazacycloalkyl-spiro-imidazolidines leur preparation et leur application en therapeutique - Google Patents

Benzoazacycloalkyl-spiro-imidazolidines leur preparation et leur application en therapeutique

Info

Publication number
BE896572A
BE896572A BE0/210633A BE210633A BE896572A BE 896572 A BE896572 A BE 896572A BE 0/210633 A BE0/210633 A BE 0/210633A BE 210633 A BE210633 A BE 210633A BE 896572 A BE896572 A BE 896572A
Authority
BE
Belgium
Prior art keywords
benzoazacycloalkyl
imidazolidines
spiro
therapeutics
preparation
Prior art date
Application number
BE0/210633A
Other languages
English (en)
French (fr)
Inventor
C Malen
J-L Peglion
J Duhault
M Boulanger
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Publication of BE896572A publication Critical patent/BE896572A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BE0/210633A 1982-04-27 1983-04-26 Benzoazacycloalkyl-spiro-imidazolidines leur preparation et leur application en therapeutique BE896572A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8207203A FR2525603A1 (fr) 1982-04-27 1982-04-27 Benzoazacycloalkyl-spiro-imidazolinines, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
BE896572A true BE896572A (fr) 1983-10-26

Family

ID=9273425

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/210633A BE896572A (fr) 1982-04-27 1983-04-26 Benzoazacycloalkyl-spiro-imidazolidines leur preparation et leur application en therapeutique

Country Status (22)

Country Link
JP (1) JPS5910584A (enrdf_load_stackoverflow)
KR (1) KR840004428A (enrdf_load_stackoverflow)
AT (1) ATA125383A (enrdf_load_stackoverflow)
AU (1) AU1395383A (enrdf_load_stackoverflow)
BE (1) BE896572A (enrdf_load_stackoverflow)
DD (1) DD209833A5 (enrdf_load_stackoverflow)
DE (1) DE3315106A1 (enrdf_load_stackoverflow)
DK (1) DK183583A (enrdf_load_stackoverflow)
ES (1) ES521895A0 (enrdf_load_stackoverflow)
FR (1) FR2525603A1 (enrdf_load_stackoverflow)
GB (1) GB2133401B (enrdf_load_stackoverflow)
GR (1) GR78481B (enrdf_load_stackoverflow)
IL (1) IL68497A0 (enrdf_load_stackoverflow)
IT (1) IT1167123B (enrdf_load_stackoverflow)
LU (1) LU84770A1 (enrdf_load_stackoverflow)
MA (1) MA19783A1 (enrdf_load_stackoverflow)
NL (1) NL8301476A (enrdf_load_stackoverflow)
NO (1) NO831473L (enrdf_load_stackoverflow)
OA (1) OA07412A (enrdf_load_stackoverflow)
PT (1) PT76595B (enrdf_load_stackoverflow)
SE (1) SE8302347L (enrdf_load_stackoverflow)
ZA (1) ZA832927B (enrdf_load_stackoverflow)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4927831A (en) * 1988-10-20 1990-05-22 American Home Products Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
AU617541B2 (en) * 1988-10-20 1991-11-28 Wyeth Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
CA2529320C (en) 2003-06-17 2013-03-05 Arena Pharmaceuticals, Inc. Benzazepine derivatives useful for the treatment of 5ht2c receptor associated diseases
EP1636191A2 (en) 2003-06-17 2006-03-22 Arena Pharmaceuticals, Inc. Benzazepine derivatives useful for the treatment of 5ht2c receptor associated diseases
EA017894B1 (ru) 2004-12-21 2013-04-30 Арена Фармасьютикалз, Инк. Кристаллические формы гидрохлорида (r)-8-хлор-1-метил-2,3,4,5-тетрагидро-1h-3-бензазепина
SI1833473T1 (sl) 2004-12-23 2010-01-29 Arena Pharm Inc Sestavki modulatorjev 5HT2C receptorjev in postopki uporabe
CN101466684B (zh) 2006-04-03 2012-06-20 艾尼纳制药公司 8-氯-1-甲基-2,3,4,5-四氢-1h-3-苯并氮杂卓的制备工艺和其相关中间体
SG177128A1 (en) 2006-12-05 2012-01-30 Arena Pharm Inc Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof
WO2009111004A1 (en) 2008-03-04 2009-09-11 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-ht2c agonist (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine
EP2443080A2 (en) 2009-06-18 2012-04-25 Arena Pharmaceuticals, Inc. Process for the preparation of 5-ht2c receptor agonists
KR20130112848A (ko) 2010-06-02 2013-10-14 아레나 파마슈티칼스, 인크. 5-ｈｔ2ｃ 수용체 아고니스트의 제조 방법
KR20180094131A (ko) 2010-09-01 2018-08-22 에자이 알앤드디 매니지먼트 가부시키가이샤 신장 손상을 갖는 개체에 대한 로카세린의 투여
SG10201506870PA (en) 2010-09-01 2015-10-29 Arena Pharm Inc Salts of lorcaserin with optically active acids
WO2012030957A2 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Non-hygroscopic salts of 5-ht2c agonists
CN103189053A (zh) 2010-09-01 2013-07-03 艾尼纳制药公司 用于体重控制的5-ht2c激动剂的调节释放剂型
UY34436A (es) 2012-10-09 2014-07-31 Arena Pharm Inc Metodo de control del peso

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4209630A (en) * 1976-10-18 1980-06-24 Pfizer Inc. Hydantoin derivatives as therapeutic agents
US4235911A (en) * 1979-06-13 1980-11-25 Pfizer Inc. Hydantoin derivatives

Also Published As

Publication number Publication date
SE8302347L (sv) 1983-10-28
DE3315106A1 (de) 1983-11-03
ATA125383A (de) 1986-05-15
KR840004428A (ko) 1984-10-15
OA07412A (fr) 1984-11-30
DK183583A (da) 1983-10-28
IT8348155A0 (it) 1983-04-26
NL8301476A (nl) 1983-11-16
ZA832927B (en) 1984-06-27
IL68497A0 (en) 1983-07-31
AU1395383A (en) 1983-11-03
JPS5910584A (ja) 1984-01-20
DK183583D0 (da) 1983-04-26
GB8311508D0 (en) 1983-06-02
MA19783A1 (fr) 1983-12-31
IT1167123B (it) 1987-05-13
GB2133401A (en) 1984-07-25
FR2525603B1 (enrdf_load_stackoverflow) 1984-09-14
GB2133401B (en) 1985-10-23
GR78481B (enrdf_load_stackoverflow) 1984-09-27
LU84770A1 (fr) 1984-11-28
ES8405796A1 (es) 1984-06-16
FR2525603A1 (fr) 1983-10-28
DD209833A5 (de) 1984-05-23
PT76595B (fr) 1986-01-21
PT76595A (fr) 1983-05-01
SE8302347D0 (sv) 1983-04-26
NO831473L (no) 1983-10-28
ES521895A0 (es) 1984-06-16

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: ADIR

Effective date: 19860430