BE890962R - Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique - Google Patents

Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique

Info

Publication number
BE890962R
BE890962R BE0/206420A BE206420A BE890962R BE 890962 R BE890962 R BE 890962R BE 0/206420 A BE0/206420 A BE 0/206420A BE 206420 A BE206420 A BE 206420A BE 890962 R BE890962 R BE 890962R
Authority
BE
Belgium
Prior art keywords
new
preparation process
therapeutic application
tropane derivatives
tropane
Prior art date
Application number
BE0/206420A
Other languages
English (en)
French (fr)
Inventor
P Dostert
T Imbert
B Bucher
Original Assignee
Delalande Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande Sa filed Critical Delalande Sa
Application granted granted Critical
Publication of BE890962R publication Critical patent/BE890962R/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
    • C07C65/40—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BE0/206420A 1980-11-07 1981-11-03 Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique BE890962R (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8023785A FR2493848B2 (fr) 1980-11-07 1980-11-07 Nouveaux derives des nor-tropane et granatane, leur procede de preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
BE890962R true BE890962R (fr) 1982-05-03

Family

ID=9247763

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/206420A BE890962R (fr) 1980-11-07 1981-11-03 Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique

Country Status (15)

Country Link
US (1) US4434170A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS57108090A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BE (1) BE890962R (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1209574A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (1) CH651561A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3144183A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES507394A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2493848B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB2088364B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR75112B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IT (1) IT1140040B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
LU (1) LU83737A7 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL8105042A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SE (1) SE448457B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA817675B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0189002A3 (en) * 1984-12-20 1990-01-31 Sandoz Ag Treatment of gastrointestinal disorders using 5-ht3 antagonists
EP0201165A3 (en) * 1985-03-14 1990-08-16 Beecham Group Plc Medicaments for the treatment of emesis, anxiety and irritable bowel syndrome
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2440946A2 (fr) * 1978-01-20 1980-06-06 Ile De France Nouveaux benzamides heterocycliques substitues, leurs procedes de preparation et leur application comme modificateurs du comportement
DE3268378D1 (en) * 1981-06-17 1986-02-20 Beecham Group Plc Alkylthio derivatives of azabicyclobenzamides, their preparation and pharmaceutical compositions
DE3275296D1 (en) * 1981-10-01 1987-03-05 Beecham Group Plc Azabicyclo-(3,3,1)-nonylbenzamide derivatives, processes for their preparation, and pharmaceutical compositions containing them
EP0083737A1 (en) * 1981-12-15 1983-07-20 Beecham Group Plc N-azabicycloalkane benzamides, process for their preparation and pharmaceutical compositions containing them
FR2531083B1 (fr) * 1982-06-29 1986-11-28 Sandoz Sa Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments
CA1244028A (en) * 1983-04-14 1988-11-01 Hans Maag Pyrimidine derivatives
FR2546169B1 (fr) * 1983-05-20 1986-03-21 Delalande Sa N-oxydes de derives aminocycliques, leur procede de preparation et leur application en therapeutique
FR2548666A1 (fr) * 1983-07-08 1985-01-11 Delalande Sa Nouveaux derives du nor-tropane et du granatane, leur procede de preparation et leur application en therapeutique
WO1985001048A1 (en) * 1983-08-26 1985-03-14 Sandoz Ag Aromatic esters or amides of carboxylic acid and sulfonic acid
FR2557110B1 (fr) * 1983-12-23 1989-11-24 Sandoz Sa Nouveaux derives d'amines cycliques, leur preparation et leur utilisation comme medicaments
GB8516371D0 (en) * 1985-06-28 1985-07-31 Beecham Group Plc Compounds
HU895334D0 (en) * 1986-07-30 1990-01-28 Sandoz Ag Process for the preparation of nasal pharmaceutical compositions
GB9005014D0 (en) * 1990-03-06 1990-05-02 Janssen Pharmaceutica Nv N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives
GB9027098D0 (en) * 1990-12-13 1991-02-06 Beecham Group Plc Pharmaceuticals
ES2118842T3 (es) * 1992-02-04 1998-10-01 Eisai Co Ltd Derivados del acido aminobenzoico.
SE0102764D0 (sv) * 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
GB0226930D0 (en) 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
JP2007523905A (ja) * 2004-02-18 2007-08-23 アストラゼネカ アクチボラグ 化合物
ATE426597T1 (de) * 2004-02-18 2009-04-15 Astrazeneca Ab Benzamidderivate und deren verwendung als glucokinaseaktivierende mittel
TW200600086A (en) * 2004-06-05 2006-01-01 Astrazeneca Ab Chemical compound
GB0423043D0 (en) * 2004-10-16 2004-11-17 Astrazeneca Ab Compounds
GB0423044D0 (en) * 2004-10-16 2004-11-17 Astrazeneca Ab Compounds
EP1802570A1 (en) 2004-10-16 2007-07-04 AstraZeneca AB Process for making phenoxy benzamide compounds
USD554516S1 (en) * 2004-11-22 2007-11-06 Saverglass Inc. Carafe
USD550564S1 (en) * 2005-03-04 2007-09-11 Partida Tequila, Llc Bottle
JP2008542247A (ja) * 2005-05-24 2008-11-27 アストラゼネカ アクチボラグ グルコキナーゼモジュレーターとしての２−フェニル置換イミダゾール［４，５ｂ］ピリジン／ピラジンおよびプリン誘導体
TW200714597A (en) * 2005-05-27 2007-04-16 Astrazeneca Ab Chemical compounds
US20110053910A1 (en) * 2005-07-09 2011-03-03 Mckerrecher Darren 2 -heterocyclyloxybenzoyl amino heterocyclyl compounds as modulators of glucokinase for the treatment of type 2 diabetes
EP2301935A1 (en) * 2005-07-09 2011-03-30 AstraZeneca AB (Publ) Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes
US20080234273A1 (en) * 2005-07-09 2008-09-25 Mckerrecher Darren Heteroaryl Benzamide Derivatives for Use as Glk Activators in the Treatment of Diabetes
US9202182B2 (en) * 2005-08-11 2015-12-01 International Business Machines Corporation Method and system for analyzing business architecture
TW200738621A (en) * 2005-11-28 2007-10-16 Astrazeneca Ab Chemical process
TW200825063A (en) * 2006-10-23 2008-06-16 Astrazeneca Ab Chemical compounds
TW200825060A (en) * 2006-10-26 2008-06-16 Astrazeneca Ab Chemical compounds
UY30822A1 (es) * 2006-12-21 2008-07-31 Astrazeneca Ab Fnueva forma cristalina de 3-{[5-azetidin-1-ylcabonyl)pyrazin-2-yl]oxy}-5-[1-methylethyloxy]-n-1h-pyrazol-3-ylbenzamida, composiciones conteniéndola, procesos de preparacion y aplicaciones
AU2009278929B2 (en) * 2008-08-04 2012-07-05 Astrazeneca Ab Pyrazolo [3,4] pyrimidin-4-yl derivatives and their uses to treat diabetes and obesity
GB0902434D0 (en) * 2009-02-13 2009-04-01 Astrazeneca Ab Chemical process
GB0902406D0 (en) * 2009-02-13 2009-04-01 Astrazeneca Ab Crystalline polymorphic form
WO2010116177A1 (en) 2009-04-09 2010-10-14 Astrazeneca Ab A pyrazolo [4,5-e] pyrimidine derivative and its use to treat diabetes and obesity
WO2010116176A1 (en) * 2009-04-09 2010-10-14 Astrazeneca Ab Pyrazolo [4, 5-e] pyrimidine derivative and its use to treat diabetes and obesity

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3134782A (en) 1964-05-26 Chjxch-
GB774858A (en) 1954-10-20 1957-05-15 Sandoz Ltd Tropane and -Î-tropane derivatives and process for preparation thereof
FR1162129A (fr) * 1954-10-20 1958-09-09 Sandoz Ag Dérivés amidés du tropane et leur préparation
CH374679A (de) 1958-11-26 1964-01-31 Sandoz Ag Verfahren zur Herstellung von neuen Tropan-Derivaten
US4179567A (en) 1978-04-10 1979-12-18 Sterling Drug Inc. 2-Aryltropane compounds
IL59004A0 (en) * 1978-12-30 1980-03-31 Beecham Group Ltd Substituted benzamides their preparation and pharmaceutical compositions containing them
JPS5592384A (en) * 1978-12-30 1980-07-12 Beecham Group Ltd Compound having pharmacological activity
FR2446823A1 (fr) * 1979-01-16 1980-08-14 Delalande Sa Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique
FR2476088A2 (fr) * 1979-01-16 1981-08-21 Delalande Sa Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0189002A3 (en) * 1984-12-20 1990-01-31 Sandoz Ag Treatment of gastrointestinal disorders using 5-ht3 antagonists
EP0201165A3 (en) * 1985-03-14 1990-08-16 Beecham Group Plc Medicaments for the treatment of emesis, anxiety and irritable bowel syndrome
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
US5576448A (en) * 1989-03-22 1996-11-19 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl) (dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives

Also Published As

Publication number Publication date
FR2493848A2 (fr) 1982-05-14
JPS57108090A (en) 1982-07-05
ZA817675B (en) 1982-10-27
ES8301979A2 (es) 1983-02-01
NL8105042A (nl) 1982-06-01
US4434170A (en) 1984-02-28
CH651561A5 (fr) 1985-09-30
ES507394A0 (es) 1983-02-01
GB2088364B (en) 1984-10-31
SE448457B (sv) 1987-02-23
FR2493848B2 (fr) 1986-05-16
GB2088364A (en) 1982-06-09
DE3144183C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1992-01-23
DE3144183A1 (de) 1982-08-12
JPS6344753B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1988-09-06
CA1209574A (en) 1986-08-12
LU83737A7 (fr) 1983-09-01
SE8106425L (sv) 1982-05-08
IT1140040B (it) 1986-09-24
GR75112B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1984-07-13
IT8124835A0 (it) 1981-11-03

Similar Documents

Publication Publication Date Title
BE890962R (fr) Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique
BE892270A (fr) Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique
BE892758A (fr) Derives phenylcyclobutyliques, leur procede de preparation et leur application therapeutique
FR2504920B1 (fr) Derives phenylcyclobutyliques, leur procede de preparation et leur application therapeutique
BE881134A (fr) Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique
BE875174A (fr) Nouveaux derives de carbostyrile, leur procede de preparation et leurs applications en therapeutique
BE878723A (fr) Derives de 4-anilinoquinazoline, leur procede de preparation et leur application en therapeutique
BE865632A (fr) Nouveaux derives de cephalosporine, leur procede de preparation et leur application en therapeutique
FR2383157B1 (fr) Derives de chalcone, leur procede de preparation et leur application en therapeutique
FR2532648B1 (fr) Derives de carbostyrile, leur procede de preparation et leur application en therapeutique
LU76848A1 (fr) Nouveaux hydroxymethyl-5 oxazolidinone-2, leur procede de preparation et leur application therapeutique
BE864312A (fr) Nouveaux derives de la pyrrolidine, leur procede de preparation et leur application en therapeutique
FR2506306B1 (fr) Nouveaux derives de l&#39;amidinopiperidine, leur procede de preparation et leur application en therapeutique
MA19331A1 (fr) Derives de la thieno - pyridinone , leur procede de preparation et leur application therapeutique .
BE883124A (fr) Nouveaux derives de la 5h-furanone-2 et de la 3h-dihydro-furanone-2, leur procede de preparation et leur application en therapeutique
FR2315925A1 (fr) Nouveaux derives de 5-benzyle-2-oxazolidone, leur procede de preparation et leur application en therapeutique
BE891526A (fr) Nouveaux derives aminoalcoyl heterocycliques, leur procede de preparation et leur application en therapeutique
FR2477536B1 (fr) Nouveaux derives acyles de carnitine, procede de preparation de ces derives et leur utilisation therapeutique
BE883713A (fr) Nouveau derives de carbostyrile, leur procede de preparation et leur application en therapeutique
BE888417A (fr) Nouveaux derives de theophyllinylmethyldioxolane, leur procedes de preparation et leur application en therapeutique,
FR2349587A1 (fr) 1,3-dihydro-heteroarylspiro(isobenzofurannes), leur procede de preparation et leur application therapeutique
LU79606A1 (fr) Derives de bisamidine,leur procede de preparation et leur application therapeutique
BE854812A (fr) Benzenesulfonylurees, leur procede de preparation et leur application therapeutique
FR2520739B1 (fr) Nouveaux derives d&#39;ester indoleacetique, leur procede de preparation et leur application en therapeutique
BE844229A (fr) Nouveaux derives d&#39;apovincaminol leur procede de preparation et leur application

Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: DELALANDE S.A.

Effective date: 20000114