BE847234A - Nouveaux composes pour combattre les leucemies et les tumeurs malignes, - Google Patents
Nouveaux composes pour combattre les leucemies et les tumeurs malignes,Info
- Publication number
- BE847234A BE847234A BE171474A BE171474A BE847234A BE 847234 A BE847234 A BE 847234A BE 171474 A BE171474 A BE 171474A BE 171474 A BE171474 A BE 171474A BE 847234 A BE847234 A BE 847234A
- Authority
- BE
- Belgium
- Prior art keywords
- fight
- leukemia
- new compounds
- malignant tumors
- malignant
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 208000032839 leukemia Diseases 0.000 title 1
- 230000003211 malignant effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB42509/75A GB1561290A (en) | 1975-10-16 | 1975-10-16 | Pyrimid - 2 - ones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE847234A true BE847234A (fr) | 1977-04-13 |
Family
ID=10424751
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE171474A BE847234A (fr) | 1975-10-16 | 1976-10-13 | Nouveaux composes pour combattre les leucemies et les tumeurs malignes, |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4395406A (en:Method) |
| JP (1) | JPS5253869A (en:Method) |
| BE (1) | BE847234A (en:Method) |
| CA (1) | CA1086736A (en:Method) |
| CH (3) | CH634308A5 (en:Method) |
| DE (1) | DE2646676A1 (en:Method) |
| DK (1) | DK144525C (en:Method) |
| FR (1) | FR2327765A1 (en:Method) |
| GB (1) | GB1561290A (en:Method) |
| IE (1) | IE44431B1 (en:Method) |
| LU (1) | LU75994A1 (en:Method) |
| NL (1) | NL7611415A (en:Method) |
| NO (1) | NO151040C (en:Method) |
| SE (1) | SE439305B (en:Method) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1582884A (en) * | 1977-05-19 | 1981-01-14 | Beecham Group Ltd | Clavulanic acid derivatives their preparation and use |
| ZA804670B (en) * | 1979-08-03 | 1981-07-29 | Beecham Group Ltd | Derivatives of clavulanic acid, a process for their preparation and their use |
| ES8205399A1 (es) * | 1980-01-07 | 1982-06-01 | Nyegaard & Co As | Un procedimiento para la preparacion de 5-halo-pirimidin-2- onas |
| US4423047A (en) * | 1980-01-10 | 1983-12-27 | Nyegaard & Co. A/S | Pyrimidine-2-sulphides and their S-oxides for use in medicine and methods of use therefor, pharmaceutical compositions containing them, processes for their preparation and per se novel sulphides and S-oxides |
| CA1159830A (en) * | 1980-07-15 | 1984-01-03 | Gordon H. Phillipps | Substituted pyrimidin-2-ones, the salts thereof, processes for their preparation, pharmaceutical compositions containing them and a method therefor |
| CA1160226A (en) * | 1980-07-15 | 1984-01-10 | Gordon H. Phillipps | Substituted pyrimidin-2-ones, the salts thereof, processes for their preparation, pharmaceutical compositions containing them and a method therefor |
| EP0053893B1 (en) * | 1980-12-09 | 1985-03-20 | Beecham Group Plc | Derivatives of clavulanic acid, their preparation and their use |
| NZ199200A (en) * | 1980-12-23 | 1984-07-31 | Beecham Group Ltd | Clavulanic acid derivatives and pharmaceutical compositions |
| EP0056319B1 (en) * | 1981-01-09 | 1986-04-16 | NYEGAARD & CO. A/S | Substituted pyrimidin-2-ones and the salts thereof |
| JPS5857368A (ja) * | 1981-09-11 | 1983-04-05 | ニユエガ−ド・アンド・コンパニ−・アクシエ／セル・カペト | 置換ピリミド−２−オン化合物 |
| US4782142A (en) * | 1982-01-05 | 1988-11-01 | The Research Foundation Of State University Of New York | Novel 5-substituted 2-pyrimidinone nucleosides and methods of use |
| US4539324A (en) * | 1982-02-24 | 1985-09-03 | Nyegaard & Co. A/S | Substituted pyrimidin-2-ones and the salts thereof |
| CA1275410C (en) * | 1986-03-14 | 1990-10-23 | Karnail S. Atwal | 1,2,3,4-tetrahydro-6-substituted-4-aryl(or heterocyclo) -3-substituted-2-thioxo(or oxo)-5- pyrimidinecarboxylic acids and esters |
| GB8706176D0 (en) * | 1987-03-16 | 1987-04-23 | Wellcome Found | Therapeutic nucleosides |
| US5252576A (en) * | 1988-07-18 | 1993-10-12 | Yamasa Shoyu Kabushiki Kaisha | 1-amino-5-halogenouracils, process for their preparation, and central nervous system depressants containing same as active ingredient |
| GB9026114D0 (en) * | 1990-11-30 | 1991-01-16 | Norsk Hydro As | New compounds |
| AU7286696A (en) * | 1995-10-13 | 1997-05-07 | F. Hoffmann-La Roche Ag | Antisense oligomers |
| NZ330360A (en) * | 1997-06-02 | 1999-03-29 | Hoffmann La Roche | 5'-deoxy-cytidine derivatives, their manufacture and use as antitumoral agents |
| EP0882734B1 (en) * | 1997-06-02 | 2009-08-26 | F. Hoffmann-La Roche Ag | 5'-Deoxy-cytidine derivatives |
| US6005098A (en) * | 1998-02-06 | 1999-12-21 | Hoffmann-La Roche Inc. | 5'deoxycytidine derivatives |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3317532A (en) * | 1964-11-19 | 1967-05-02 | Hoffmann La Roche | Derivatives of pyrimidine |
| DE2032559A1 (de) * | 1970-06-27 | 1972-01-13 | Schering Ag Berlin Und Bergkamen, 1000 Berlin | N-Substituierte Amide und Lactame |
| US3833586A (en) * | 1971-03-25 | 1974-09-03 | Morton Norwich Products Inc | 1-(substituted benzyl)-2-(1h)pyrimidones and 1-(substituted benzyl)tetrahydro-2-(1h)pyrimidones |
| DE2440677A1 (de) * | 1974-08-24 | 1976-03-04 | Bayer Ag | Pyrimidinylthionophosphonsaeureester, verfahren zu ihrer herstellung und ihre verwendung als insektizide, akarizide und nematizide |
| DE2450951A1 (de) * | 1974-10-26 | 1976-05-06 | Bayer Ag | Pyrimidinyl(thiono)(thiol)phosphor (phosphon)-saeureester bzw. -esteramide, verfahren zu ihrer herstellung und ihre verwendung als insektizide, akarizide und nematizide |
| US4003900A (en) * | 1976-03-11 | 1977-01-18 | Morton-Norwich Products, Inc. | 1-Benzyl-5-chloro-2-(1H)-pyrimidone |
-
1975
- 1975-10-16 GB GB42509/75A patent/GB1561290A/en not_active Expired
-
1976
- 1976-10-13 BE BE171474A patent/BE847234A/xx not_active IP Right Cessation
- 1976-10-14 LU LU75994A patent/LU75994A1/xx unknown
- 1976-10-14 FR FR7630923A patent/FR2327765A1/fr active Granted
- 1976-10-14 DK DK462376A patent/DK144525C/da not_active IP Right Cessation
- 1976-10-15 CA CA263,452A patent/CA1086736A/en not_active Expired
- 1976-10-15 SE SE7611493A patent/SE439305B/xx not_active IP Right Cessation
- 1976-10-15 CH CH1310376A patent/CH634308A5/de not_active IP Right Cessation
- 1976-10-15 NL NL7611415A patent/NL7611415A/xx not_active Application Discontinuation
- 1976-10-15 NO NO763533A patent/NO151040C/no unknown
- 1976-10-15 DE DE19762646676 patent/DE2646676A1/de active Granted
- 1976-10-15 JP JP51123013A patent/JPS5253869A/ja active Pending
- 1976-10-15 IE IE2284/76A patent/IE44431B1/en unknown
-
1980
- 1980-07-07 US US06/166,600 patent/US4395406A/en not_active Expired - Lifetime
-
1981
- 1981-06-18 CH CH405581A patent/CH634310A5/de not_active IP Right Cessation
- 1981-06-18 CH CH405481A patent/CH634309A5/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5253869A (en) | 1977-04-30 |
| IE44431L (en) | 1977-04-16 |
| NO151040B (no) | 1984-10-22 |
| DE2646676A1 (de) | 1977-04-28 |
| US4395406A (en) | 1983-07-26 |
| CH634308A5 (de) | 1983-01-31 |
| LU75994A1 (en:Method) | 1977-05-11 |
| CH634309A5 (de) | 1983-01-31 |
| DE2646676C2 (en:Method) | 1987-06-19 |
| DK144525C (da) | 1982-10-18 |
| NO151040C (no) | 1985-01-30 |
| SE439305B (sv) | 1985-06-10 |
| CA1086736A (en) | 1980-09-30 |
| FR2327765B1 (en:Method) | 1981-11-20 |
| GB1561290A (en) | 1980-02-20 |
| NO763533L (en:Method) | 1977-04-19 |
| CH634310A5 (de) | 1983-01-31 |
| NL7611415A (nl) | 1977-04-19 |
| FR2327765A1 (fr) | 1977-05-13 |
| SE7611493L (sv) | 1977-04-17 |
| IE44431B1 (en) | 1981-12-02 |
| DK144525B (da) | 1982-03-22 |
| DK462376A (da) | 1977-04-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RE | Patent lapsed |
Owner name: NYEGAARD & CO. A/S Effective date: 19871031 |