SE439305B - Forfarande for framstellning av 5-halogenpyrimid-2-oner, vilka er metafasinhibitorer - Google Patents

Forfarande for framstellning av 5-halogenpyrimid-2-oner, vilka er metafasinhibitorer

Info

Publication number
SE439305B
SE439305B SE7611493A SE7611493A SE439305B SE 439305 B SE439305 B SE 439305B SE 7611493 A SE7611493 A SE 7611493A SE 7611493 A SE7611493 A SE 7611493A SE 439305 B SE439305 B SE 439305B
Authority
SE
Sweden
Prior art keywords
halogenypyrimid
ones
procedure
preparation
metaphase
Prior art date
Application number
SE7611493A
Other languages
English (en)
Swedish (sv)
Other versions
SE7611493L (sv
Inventor
K Undheim
S G M Laland
M J Gacek
R Oftebro
Original Assignee
Nyegaard & Co As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nyegaard & Co As filed Critical Nyegaard & Co As
Publication of SE7611493L publication Critical patent/SE7611493L/xx
Publication of SE439305B publication Critical patent/SE439305B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SE7611493A 1975-10-16 1976-10-15 Forfarande for framstellning av 5-halogenpyrimid-2-oner, vilka er metafasinhibitorer SE439305B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB42509/75A GB1561290A (en) 1975-10-16 1975-10-16 Pyrimid - 2 - ones

Publications (2)

Publication Number Publication Date
SE7611493L SE7611493L (sv) 1977-04-17
SE439305B true SE439305B (sv) 1985-06-10

Family

ID=10424751

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7611493A SE439305B (sv) 1975-10-16 1976-10-15 Forfarande for framstellning av 5-halogenpyrimid-2-oner, vilka er metafasinhibitorer

Country Status (14)

Country Link
US (1) US4395406A (xx)
JP (1) JPS5253869A (xx)
BE (1) BE847234A (xx)
CA (1) CA1086736A (xx)
CH (3) CH634308A5 (xx)
DE (1) DE2646676A1 (xx)
DK (1) DK144525C (xx)
FR (1) FR2327765A1 (xx)
GB (1) GB1561290A (xx)
IE (1) IE44431B1 (xx)
LU (1) LU75994A1 (xx)
NL (1) NL7611415A (xx)
NO (1) NO151040C (xx)
SE (1) SE439305B (xx)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1582884A (en) * 1977-05-19 1981-01-14 Beecham Group Ltd Clavulanic acid derivatives their preparation and use
DK330880A (da) * 1979-08-03 1981-02-04 Beecham Group Ltd Fremgangsmaade til fremstilling af clavulansyrederivater
ES498337A0 (es) * 1980-01-07 1982-06-01 Nyegaard & Co As Un procedimiento para la preparacion de 5-halo-pirimidin-2- onas
NZ195992A (en) * 1980-01-10 1983-11-30 Nyegaard & Co As 5-halopyrimidines;their 2-sulphides and s-oxides;pharmaceutical compositions
NZ197715A (en) * 1980-07-15 1984-12-14 Glaxo Group Ltd Substituted pyrimin-2-ones and pharmaceutical compositions
CA1160226A (en) * 1980-07-15 1984-01-10 Gordon H. Phillipps Substituted pyrimidin-2-ones, the salts thereof, processes for their preparation, pharmaceutical compositions containing them and a method therefor
EP0053893B1 (en) * 1980-12-09 1985-03-20 Beecham Group Plc Derivatives of clavulanic acid, their preparation and their use
US4562182A (en) * 1980-12-23 1985-12-31 Beecham Group P.L.C. Compounds containing beta-lactams
JPS57136575A (en) * 1981-01-09 1982-08-23 Nyegaard & Co As Substituted pyrimidine-2-one compound
DE3272892D1 (en) * 1981-09-11 1986-10-02 Nyegaard & Co As Substituted pyrimid-2-ones, the salts thereof, processes for their preparation and pharmaceutical compositions containing them
US4782142A (en) * 1982-01-05 1988-11-01 The Research Foundation Of State University Of New York Novel 5-substituted 2-pyrimidinone nucleosides and methods of use
DK83783A (da) * 1982-02-24 1983-08-25 Nyegaard & Co As Fremgangsmaade til fremstilling af substituerede pyrimidin-2-oner
NZ219299A (en) * 1986-03-14 1989-01-06 Squibb & Sons Inc Pyrimidine derivatives
GB8706176D0 (en) * 1987-03-16 1987-04-23 Wellcome Found Therapeutic nucleosides
EP0425669B1 (en) * 1988-07-18 1995-01-25 Yamasa Shoyu Kabushiki Kaisha also trading as Yamasa Corporation 1-amino-5-halogenouracils, process for their preparation, and central nervous system depressants containing same as active ingredient
GB9026114D0 (en) * 1990-11-30 1991-01-16 Norsk Hydro As New compounds
AU7286696A (en) * 1995-10-13 1997-05-07 F. Hoffmann-La Roche Ag Antisense oligomers
NZ330360A (en) * 1997-06-02 1999-03-29 Hoffmann La Roche 5'-deoxy-cytidine derivatives, their manufacture and use as antitumoral agents
EP0882734B1 (en) * 1997-06-02 2009-08-26 F. Hoffmann-La Roche Ag 5'-Deoxy-cytidine derivatives
US6005098A (en) * 1998-02-06 1999-12-21 Hoffmann-La Roche Inc. 5'deoxycytidine derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3317532A (en) * 1964-11-19 1967-05-02 Hoffmann La Roche Derivatives of pyrimidine
DE2032559A1 (de) * 1970-06-27 1972-01-13 Schering Ag Berlin Und Bergkamen, 1000 Berlin N-Substituierte Amide und Lactame
US3833586A (en) * 1971-03-25 1974-09-03 Morton Norwich Products Inc 1-(substituted benzyl)-2-(1h)pyrimidones and 1-(substituted benzyl)tetrahydro-2-(1h)pyrimidones
DE2440677A1 (de) * 1974-08-24 1976-03-04 Bayer Ag Pyrimidinylthionophosphonsaeureester, verfahren zu ihrer herstellung und ihre verwendung als insektizide, akarizide und nematizide
DE2450951A1 (de) * 1974-10-26 1976-05-06 Bayer Ag Pyrimidinyl(thiono)(thiol)phosphor (phosphon)-saeureester bzw. -esteramide, verfahren zu ihrer herstellung und ihre verwendung als insektizide, akarizide und nematizide
US4003900A (en) * 1976-03-11 1977-01-18 Morton-Norwich Products, Inc. 1-Benzyl-5-chloro-2-(1H)-pyrimidone

Also Published As

Publication number Publication date
NO763533L (xx) 1977-04-19
DE2646676C2 (xx) 1987-06-19
DK144525C (da) 1982-10-18
JPS5253869A (en) 1977-04-30
IE44431B1 (en) 1981-12-02
CH634310A5 (de) 1983-01-31
US4395406A (en) 1983-07-26
DK462376A (da) 1977-04-17
FR2327765A1 (fr) 1977-05-13
NO151040C (no) 1985-01-30
LU75994A1 (xx) 1977-05-11
CH634308A5 (de) 1983-01-31
GB1561290A (en) 1980-02-20
DE2646676A1 (de) 1977-04-28
SE7611493L (sv) 1977-04-17
NO151040B (no) 1984-10-22
BE847234A (fr) 1977-04-13
FR2327765B1 (xx) 1981-11-20
IE44431L (en) 1977-04-16
DK144525B (da) 1982-03-22
CH634309A5 (de) 1983-01-31
NL7611415A (nl) 1977-04-19
CA1086736A (en) 1980-09-30

Similar Documents

Publication Publication Date Title
SE433208B (sv) Forfarande for framstellning av fenoletrar
SE439305B (sv) Forfarande for framstellning av 5-halogenpyrimid-2-oner, vilka er metafasinhibitorer
SE7605139L (sv) Forfarande for framstellning av vattenupptagande cellulosaetrar
SE430336B (sv) Forbettrat forfarande for framstellning av amoxicillinfrihydrat
AR217629A1 (es) Procedimiento de preparacion de derivados de tienotetrahidropiridina
SE7604475L (sv) Forfarande for framstellning av 1,1,1-triaryl-alkylaminer
SE419983B (sv) Forfarande for framstellning av finkornig, fast cyanurklorid
DK137275C (da) Fremgangsmaade til fremstilling af 4-oxo-hexahydropyrazinoisoquinolinderivater
SE7606116L (sv) Forfarande for framstellning av 3-fenoxidbensaldehyder
SE428469B (sv) Forfarande for framstellning av tertiera aminer.
SE428922B (sv) Forfarande for framstellning av 13, 14-dihydro-11-dioxi-prostaglandiner
SE7604781L (sv) Forfarande for framstellning av diarylhydroxibutylaminer
NO142444C (no) Fremgangsmaate for fremstilling av foretrede melamin-formaldehydharpikser i vandig opploesning
SE7600847L (sv) Nytt forfarande for framstellning av 8-bromtienotriazolo-1,4-diazepiner
SE423814B (sv) Forfarande for framstellning av dibensofenazin- eller acenaftokinoxalinderivat
SE404186B (sv) Forfarande for framstellning av cyklopropanolderivat
SE421793B (sv) Analogiforfarande for framstellning naftyridinsubstituerade pyrrolderivat
NO143314C (no) Fremgangsmaate for fremstilling av akrylamid
IT1066001B (it) Procedimento per l esterificazione di clorosilani
SE446726B (sv) Forfarande for framstellning av 16-metoxiprostaglandiner
SE7610637L (sv) Forfarande for framstellning av 2-alkylindaner
SE7608589L (sv) Forfarande for framstellning av fortimicin c
SE7608453L (sv) Forfarande for framstellning av 1,2,3,4-tetrahydroisokinoliner
DK141532C (da) Fremgangsmaade til fremstilling af 21-hydroxy-16-pregnen-20-onderivater
SE7605427L (sv) Forfarande for framstellning av klorcyan

Legal Events

Date Code Title Description
NUG Patent has lapsed

Ref document number: 7611493-3

Effective date: 19880627

Format of ref document f/p: F