FR2327765A1 - Nouveaux composes pour combattre les leucemies et les tumeurs malignes - Google Patents

Nouveaux composes pour combattre les leucemies et les tumeurs malignes

Info

Publication number
FR2327765A1
FR2327765A1 FR7630923A FR7630923A FR2327765A1 FR 2327765 A1 FR2327765 A1 FR 2327765A1 FR 7630923 A FR7630923 A FR 7630923A FR 7630923 A FR7630923 A FR 7630923A FR 2327765 A1 FR2327765 A1 FR 2327765A1
Authority
FR
France
Prior art keywords
fight
leukemia
new compounds
malignant tumors
malignant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7630923A
Other languages
English (en)
Other versions
FR2327765B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nyegaard and Co AS
Original Assignee
Nyegaard and Co AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nyegaard and Co AS filed Critical Nyegaard and Co AS
Publication of FR2327765A1 publication Critical patent/FR2327765A1/fr
Application granted granted Critical
Publication of FR2327765B1 publication Critical patent/FR2327765B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR7630923A 1975-10-16 1976-10-14 Nouveaux composes pour combattre les leucemies et les tumeurs malignes Granted FR2327765A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB42509/75A GB1561290A (en) 1975-10-16 1975-10-16 Pyrimid - 2 - ones

Publications (2)

Publication Number Publication Date
FR2327765A1 true FR2327765A1 (fr) 1977-05-13
FR2327765B1 FR2327765B1 (fr) 1981-11-20

Family

ID=10424751

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7630923A Granted FR2327765A1 (fr) 1975-10-16 1976-10-14 Nouveaux composes pour combattre les leucemies et les tumeurs malignes

Country Status (14)

Country Link
US (1) US4395406A (fr)
JP (1) JPS5253869A (fr)
BE (1) BE847234A (fr)
CA (1) CA1086736A (fr)
CH (3) CH634308A5 (fr)
DE (1) DE2646676A1 (fr)
DK (1) DK144525C (fr)
FR (1) FR2327765A1 (fr)
GB (1) GB1561290A (fr)
IE (1) IE44431B1 (fr)
LU (1) LU75994A1 (fr)
NL (1) NL7611415A (fr)
NO (1) NO151040C (fr)
SE (1) SE439305B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1582884A (en) * 1977-05-19 1981-01-14 Beecham Group Ltd Clavulanic acid derivatives their preparation and use
DK330880A (da) * 1979-08-03 1981-02-04 Beecham Group Ltd Fremgangsmaade til fremstilling af clavulansyrederivater
ES498337A0 (es) * 1980-01-07 1982-06-01 Nyegaard & Co As Un procedimiento para la preparacion de 5-halo-pirimidin-2- onas
ATE16799T1 (de) 1980-01-10 1985-12-15 Nyegaard & Co As Pyrimidin-2-sulfide und ihre s-oxide zur verwendung in der medizin, die verbindungen enthaltende pharmazeutische zusammensetzungen, verfahren zu ihrer herstellung und die verbindungen an sich, sofern sie neu sind.
NZ197715A (en) * 1980-07-15 1984-12-14 Glaxo Group Ltd Substituted pyrimin-2-ones and pharmaceutical compositions
CA1160226A (fr) * 1980-07-15 1984-01-10 Gordon H. Phillipps Pyrimidine-2-ones substituees, leurs sels, procedes de preparation, composes pharmaceutiques les contenant et methodes
EP0053893B1 (fr) * 1980-12-09 1985-03-20 Beecham Group Plc Dérivés de l'acide clavulanique, leur préparation et leur application
US4562182A (en) * 1980-12-23 1985-12-31 Beecham Group P.L.C. Compounds containing beta-lactams
ZA82125B (en) * 1981-01-09 1982-12-29 Nyegaard & Co As Substituted pyrimidin-2-ones and the salts thereof
ZA826660B (en) * 1981-09-11 1983-08-31 Nyegaard & Co As Substituted pyrimid-2-ones,the salts thereof,processes for their preparation and pharmaceutical compositions containing them
US4782142A (en) * 1982-01-05 1988-11-01 The Research Foundation Of State University Of New York Novel 5-substituted 2-pyrimidinone nucleosides and methods of use
AU1179883A (en) * 1982-02-24 1983-09-01 Nyegaard & Co. A/S Pyrimidin-z-ones
CA1275410C (fr) * 1986-03-14 1990-10-23 Karnail S. Atwal Acides 1,2,3,4-tetrahydro-6-(substituant)-4-aryl (ou heterocyclo)-3-(substituant)-2-thioxo(ou oxo)-5-pyrimidinecarboxyliques et esters de ceux-ci
GB8706176D0 (en) * 1987-03-16 1987-04-23 Wellcome Found Therapeutic nucleosides
US5252576A (en) * 1988-07-18 1993-10-12 Yamasa Shoyu Kabushiki Kaisha 1-amino-5-halogenouracils, process for their preparation, and central nervous system depressants containing same as active ingredient
GB9026114D0 (en) * 1990-11-30 1991-01-16 Norsk Hydro As New compounds
WO1997014709A1 (fr) * 1995-10-13 1997-04-24 F. Hoffmann-La Roche Ag Oligomeres antisens
EP0882734B1 (fr) * 1997-06-02 2009-08-26 F. Hoffmann-La Roche Ag Dérivés de 5'-déoxy-cytidine
NZ330360A (en) * 1997-06-02 1999-03-29 Hoffmann La Roche 5'-deoxy-cytidine derivatives, their manufacture and use as antitumoral agents
US6005098A (en) * 1998-02-06 1999-12-21 Hoffmann-La Roche Inc. 5'deoxycytidine derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3317532A (en) * 1964-11-19 1967-05-02 Hoffmann La Roche Derivatives of pyrimidine
DE2032559A1 (de) * 1970-06-27 1972-01-13 Schering Ag Berlin Und Bergkamen, 1000 Berlin N-Substituierte Amide und Lactame
US3833586A (en) * 1971-03-25 1974-09-03 Morton Norwich Products Inc 1-(substituted benzyl)-2-(1h)pyrimidones and 1-(substituted benzyl)tetrahydro-2-(1h)pyrimidones
DE2440677A1 (de) * 1974-08-24 1976-03-04 Bayer Ag Pyrimidinylthionophosphonsaeureester, verfahren zu ihrer herstellung und ihre verwendung als insektizide, akarizide und nematizide
DE2450951A1 (de) * 1974-10-26 1976-05-06 Bayer Ag Pyrimidinyl(thiono)(thiol)phosphor (phosphon)-saeureester bzw. -esteramide, verfahren zu ihrer herstellung und ihre verwendung als insektizide, akarizide und nematizide
US4003900A (en) * 1976-03-11 1977-01-18 Morton-Norwich Products, Inc. 1-Benzyl-5-chloro-2-(1H)-pyrimidone

Also Published As

Publication number Publication date
DE2646676C2 (fr) 1987-06-19
DK144525C (da) 1982-10-18
DK144525B (da) 1982-03-22
BE847234A (fr) 1977-04-13
FR2327765B1 (fr) 1981-11-20
DE2646676A1 (de) 1977-04-28
SE7611493L (sv) 1977-04-17
US4395406A (en) 1983-07-26
NL7611415A (nl) 1977-04-19
CH634310A5 (de) 1983-01-31
SE439305B (sv) 1985-06-10
DK462376A (da) 1977-04-17
JPS5253869A (en) 1977-04-30
GB1561290A (en) 1980-02-20
CA1086736A (fr) 1980-09-30
CH634308A5 (de) 1983-01-31
NO763533L (fr) 1977-04-19
IE44431B1 (en) 1981-12-02
NO151040C (no) 1985-01-30
NO151040B (no) 1984-10-22
CH634309A5 (de) 1983-01-31
IE44431L (en) 1977-04-16
LU75994A1 (fr) 1977-05-11

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Legal Events

Date Code Title Description
TP Transmission of property
ST Notification of lapse