ES498337A0 - Un procedimiento para la preparacion de 5-halo-pirimidin-2- onas - Google Patents
Un procedimiento para la preparacion de 5-halo-pirimidin-2- onasInfo
- Publication number
- ES498337A0 ES498337A0 ES498337A ES498337A ES498337A0 ES 498337 A0 ES498337 A0 ES 498337A0 ES 498337 A ES498337 A ES 498337A ES 498337 A ES498337 A ES 498337A ES 498337 A0 ES498337 A0 ES 498337A0
- Authority
- ES
- Spain
- Prior art keywords
- ring
- groups
- heterocyclic
- saturated
- het
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/28—Halogen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8000381 | 1980-01-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8205399A1 ES8205399A1 (es) | 1982-06-01 |
ES498337A0 true ES498337A0 (es) | 1982-06-01 |
Family
ID=10510470
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES498337A Granted ES498337A0 (es) | 1980-01-07 | 1981-01-05 | Un procedimiento para la preparacion de 5-halo-pirimidin-2- onas |
ES509219A Granted ES509219A0 (es) | 1980-01-07 | 1982-02-01 | "un procedimiento para la preparacion de 5-halopirimidin-2-onas". |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES509219A Granted ES509219A0 (es) | 1980-01-07 | 1982-02-01 | "un procedimiento para la preparacion de 5-halopirimidin-2-onas". |
Country Status (13)
Country | Link |
---|---|
US (1) | US4399140A (es) |
EP (1) | EP0032131B1 (es) |
JP (1) | JPS56150087A (es) |
AT (1) | ATE4715T1 (es) |
AU (1) | AU543939B2 (es) |
CA (1) | CA1168239A (es) |
DE (1) | DE3160886D1 (es) |
DK (1) | DK149892B (es) |
ES (2) | ES498337A0 (es) |
IE (1) | IE50765B1 (es) |
NO (1) | NO810024L (es) |
NZ (1) | NZ195947A (es) |
ZA (1) | ZA8164B (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ197715A (en) * | 1980-07-15 | 1984-12-14 | Glaxo Group Ltd | Substituted pyrimin-2-ones and pharmaceutical compositions |
NZ197714A (en) * | 1980-07-15 | 1984-11-09 | Glaxo Group Ltd | Substituted pyrimidin-2-ones and pharmaceutical compositions |
US4596870A (en) * | 1981-01-09 | 1986-06-24 | Nyegaard & Co. A.S. | Substituted pyrimidin-2-ones and the salts thereof |
NO161440C (no) * | 1982-02-24 | 1989-08-16 | Nyegaard & Co As | Analogifremgangsmaate for fremstilling av fysiologisk aktive pyrimidin-2-oner. |
SU1235864A1 (ru) * | 1983-03-11 | 1986-06-07 | Отделение ордена Ленина института химической физики АН СССР | Нитроксильные производные 5-фторурацила,обладающие противоопухолевой активностью |
CN103130732A (zh) * | 2011-11-22 | 2013-06-05 | 上海博康精细化工有限公司 | 3,5-二甲基-4-氯甲基异噁唑的制备方法 |
SI3164394T1 (sl) | 2014-07-03 | 2020-08-31 | Board Of Regents, The University Of Texas System | GLS1 inhibitorji za zdravljenje bolezni |
US20160002204A1 (en) * | 2014-07-03 | 2016-01-07 | Board Of Regents, The University Of Texas System | Gls1 inhibitors for treating disease |
ES2794868T3 (es) | 2015-06-30 | 2020-11-19 | Univ Texas | Inhibidores de GLS1 para el tratamiento de enfermedades |
KR20180095677A (ko) | 2015-12-22 | 2018-08-27 | 보드 오브 리전츠 더 유니버시티 오브 텍사스 시스템 | (r)-1-(4-(6-(2-(4-(3,3-디플루오로시클로부톡시)-6-메틸피리딘-2-일)아세트아미도)피리다진-3-일)-2-플루오로부틸)-n-메틸-1h-1,2,3-트리아졸-4-카르복사미드의 염 형태 및 다형체 |
CN111225903A (zh) | 2017-10-18 | 2020-06-02 | 德州大学系统董事会 | 谷氨酰胺酶抑制剂疗法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3833586A (en) * | 1971-03-25 | 1974-09-03 | Morton Norwich Products Inc | 1-(substituted benzyl)-2-(1h)pyrimidones and 1-(substituted benzyl)tetrahydro-2-(1h)pyrimidones |
GB1561290A (en) * | 1975-10-16 | 1980-02-20 | Nyegaard & Co As | Pyrimid - 2 - ones |
US4003900A (en) * | 1976-03-11 | 1977-01-18 | Morton-Norwich Products, Inc. | 1-Benzyl-5-chloro-2-(1H)-pyrimidone |
US4052399A (en) * | 1976-09-13 | 1977-10-04 | Morton-Norwich Products, Inc. | 1-[2-(Hexahydro-1H-azepino)ethyl]-2(1H)pyrimidone dihydrochloride |
US4052400A (en) * | 1976-10-29 | 1977-10-04 | Morton-Norwich Products, Inc. | Hypertensive 1-substituted 2(1h)-pyrimidones |
-
1981
- 1981-01-05 ES ES498337A patent/ES498337A0/es active Granted
- 1981-01-06 ZA ZA00810064A patent/ZA8164B/xx unknown
- 1981-01-06 DK DK003281AA patent/DK149892B/da unknown
- 1981-01-06 EP EP81300031A patent/EP0032131B1/en not_active Expired
- 1981-01-06 NZ NZ195947A patent/NZ195947A/xx unknown
- 1981-01-06 CA CA000367958A patent/CA1168239A/en not_active Expired
- 1981-01-06 IE IE13/81A patent/IE50765B1/en unknown
- 1981-01-06 AU AU66016/81A patent/AU543939B2/en not_active Ceased
- 1981-01-06 DE DE8181300031T patent/DE3160886D1/de not_active Expired
- 1981-01-06 NO NO810024A patent/NO810024L/no unknown
- 1981-01-06 AT AT81300031T patent/ATE4715T1/de not_active IP Right Cessation
- 1981-01-06 JP JP63181A patent/JPS56150087A/ja active Pending
- 1981-01-06 US US06/222,959 patent/US4399140A/en not_active Expired - Fee Related
-
1982
- 1982-02-01 ES ES509219A patent/ES509219A0/es active Granted
Also Published As
Publication number | Publication date |
---|---|
US4399140A (en) | 1983-08-16 |
EP0032131B1 (en) | 1983-09-21 |
IE50765B1 (en) | 1986-07-09 |
ES8205399A1 (es) | 1982-06-01 |
AU543939B2 (en) | 1985-05-09 |
ZA8164B (en) | 1982-03-31 |
IE810013L (en) | 1981-07-07 |
NO810024L (no) | 1981-07-08 |
CA1168239A (en) | 1984-05-29 |
EP0032131A1 (en) | 1981-07-15 |
ES8304946A1 (es) | 1983-03-16 |
AU6601681A (en) | 1981-07-16 |
NZ195947A (en) | 1983-09-02 |
ATE4715T1 (de) | 1983-10-15 |
JPS56150087A (en) | 1981-11-20 |
DK149892B (da) | 1986-10-20 |
DE3160886D1 (en) | 1983-10-27 |
ES509219A0 (es) | 1983-03-16 |
DK3281A (da) | 1981-07-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19871118 |