ES8205399A1 - Un procedimiento para la preparacion de 5-halo-pirimidin-2- onas - Google Patents
Un procedimiento para la preparacion de 5-halo-pirimidin-2- onasInfo
- Publication number
- ES8205399A1 ES8205399A1 ES498337A ES498337A ES8205399A1 ES 8205399 A1 ES8205399 A1 ES 8205399A1 ES 498337 A ES498337 A ES 498337A ES 498337 A ES498337 A ES 498337A ES 8205399 A1 ES8205399 A1 ES 8205399A1
- Authority
- ES
- Spain
- Prior art keywords
- ring
- groups
- heterocyclic
- saturated
- het
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/28—Halogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE 5-HALOPRIMIDIN-2-ONAS Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE X ES UN HALOGENO; R1 Y R2 SON HIDROGENO O ALCOHILO C1-4; ALC ES UN RADICAL HIDROCARBILO ALIFATICO, DIVALENTE, Y HET ES UN ANILLO HETEROCICLICO DE 3 A 9 ESLABONES. CONSISTE EN LA REACCION DE CONDENSACION DE UN COMPUESTO DE FORMULA (II), EN LA QUE X, R1 Y R2 SON LOS MISMOS QUE EN LA FORMULA (I), O UNA DE SUS SALES, CON UN AGENTE CAPAZ DE INTRODUCIR EL GRUPO HET-ALC-, TAL COMO UN DERIVADO HALOGENADO, O TIPO ESTER, DEL MISMO. LA REACCION SE LLEVA A CABO EN AUSENCIA DE AGUA, A PH ALCALINO Y EN PRESENCIA DE UN AGENTE DE CONDENSACION, TAL COMO UN ACETAL DE UNA DIALCOHILFORMAMIDA C1-5.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8000381 | 1980-01-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8205399A1 true ES8205399A1 (es) | 1982-06-01 |
ES498337A0 ES498337A0 (es) | 1982-06-01 |
Family
ID=10510470
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES498337A Granted ES498337A0 (es) | 1980-01-07 | 1981-01-05 | Un procedimiento para la preparacion de 5-halo-pirimidin-2- onas |
ES509219A Granted ES509219A0 (es) | 1980-01-07 | 1982-02-01 | "un procedimiento para la preparacion de 5-halopirimidin-2-onas". |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES509219A Granted ES509219A0 (es) | 1980-01-07 | 1982-02-01 | "un procedimiento para la preparacion de 5-halopirimidin-2-onas". |
Country Status (13)
Country | Link |
---|---|
US (1) | US4399140A (es) |
EP (1) | EP0032131B1 (es) |
JP (1) | JPS56150087A (es) |
AT (1) | ATE4715T1 (es) |
AU (1) | AU543939B2 (es) |
CA (1) | CA1168239A (es) |
DE (1) | DE3160886D1 (es) |
DK (1) | DK149892B (es) |
ES (2) | ES498337A0 (es) |
IE (1) | IE50765B1 (es) |
NO (1) | NO810024L (es) |
NZ (1) | NZ195947A (es) |
ZA (1) | ZA8164B (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ197715A (en) * | 1980-07-15 | 1984-12-14 | Glaxo Group Ltd | Substituted pyrimin-2-ones and pharmaceutical compositions |
CA1160226A (en) * | 1980-07-15 | 1984-01-10 | Gordon H. Phillipps | Substituted pyrimidin-2-ones, the salts thereof, processes for their preparation, pharmaceutical compositions containing them and a method therefor |
DE3270525D1 (en) * | 1981-01-09 | 1986-05-22 | Nyegaard & Co As | Substituted pyrimidin-2-ones and the salts thereof |
JPS58159479A (ja) * | 1982-02-24 | 1983-09-21 | ニユエガ−ド・アンド・コンパニ−・アクシエ/セルカペト | 置換されたピリミジン−2−オン化合物 |
SU1235864A1 (ru) * | 1983-03-11 | 1986-06-07 | Отделение ордена Ленина института химической физики АН СССР | Нитроксильные производные 5-фторурацила,обладающие противоопухолевой активностью |
CN103130732A (zh) * | 2011-11-22 | 2013-06-05 | 上海博康精细化工有限公司 | 3,5-二甲基-4-氯甲基异噁唑的制备方法 |
US20160002204A1 (en) * | 2014-07-03 | 2016-01-07 | Board Of Regents, The University Of Texas System | Gls1 inhibitors for treating disease |
PT3164394T (pt) | 2014-07-03 | 2020-05-08 | Univ Texas | Inibidores gls1 para o tratamento de doenças |
CN107921044B (zh) | 2015-06-30 | 2022-01-21 | 德州大学系统董事会 | 用于治疗疾病的gls1抑制剂 |
CA3009355A1 (en) | 2015-12-22 | 2017-06-29 | Board Of Regents, The University Of Texas System | Salt forms and polymorphs of (r)-1-(4-(6-(2-(4-(3,3-difluorocyclobutoxy)-6-methylpyridin-2-yl) acetamido) pyridazin-3-yl)-2-fluorobutyl)-n-methyl-1h-1,2,3-triazole-4-carboxamide |
RU2020112558A (ru) | 2017-10-18 | 2021-11-18 | Боард Оф Регентс, Зе Юниверсити Оф Тексас Систем | Терапия на основе ингибитора глутаминазы |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3833586A (en) * | 1971-03-25 | 1974-09-03 | Morton Norwich Products Inc | 1-(substituted benzyl)-2-(1h)pyrimidones and 1-(substituted benzyl)tetrahydro-2-(1h)pyrimidones |
GB1561290A (en) * | 1975-10-16 | 1980-02-20 | Nyegaard & Co As | Pyrimid - 2 - ones |
US4003900A (en) * | 1976-03-11 | 1977-01-18 | Morton-Norwich Products, Inc. | 1-Benzyl-5-chloro-2-(1H)-pyrimidone |
US4052399A (en) * | 1976-09-13 | 1977-10-04 | Morton-Norwich Products, Inc. | 1-[2-(Hexahydro-1H-azepino)ethyl]-2(1H)pyrimidone dihydrochloride |
US4052400A (en) * | 1976-10-29 | 1977-10-04 | Morton-Norwich Products, Inc. | Hypertensive 1-substituted 2(1h)-pyrimidones |
-
1981
- 1981-01-05 ES ES498337A patent/ES498337A0/es active Granted
- 1981-01-06 AT AT81300031T patent/ATE4715T1/de not_active IP Right Cessation
- 1981-01-06 NO NO810024A patent/NO810024L/no unknown
- 1981-01-06 JP JP63181A patent/JPS56150087A/ja active Pending
- 1981-01-06 CA CA000367958A patent/CA1168239A/en not_active Expired
- 1981-01-06 ZA ZA00810064A patent/ZA8164B/xx unknown
- 1981-01-06 EP EP81300031A patent/EP0032131B1/en not_active Expired
- 1981-01-06 NZ NZ195947A patent/NZ195947A/xx unknown
- 1981-01-06 US US06/222,959 patent/US4399140A/en not_active Expired - Fee Related
- 1981-01-06 AU AU66016/81A patent/AU543939B2/en not_active Ceased
- 1981-01-06 IE IE13/81A patent/IE50765B1/en unknown
- 1981-01-06 DE DE8181300031T patent/DE3160886D1/de not_active Expired
- 1981-01-06 DK DK003281AA patent/DK149892B/da unknown
-
1982
- 1982-02-01 ES ES509219A patent/ES509219A0/es active Granted
Also Published As
Publication number | Publication date |
---|---|
NO810024L (no) | 1981-07-08 |
NZ195947A (en) | 1983-09-02 |
DK3281A (da) | 1981-07-08 |
AU543939B2 (en) | 1985-05-09 |
DK149892B (da) | 1986-10-20 |
EP0032131A1 (en) | 1981-07-15 |
ATE4715T1 (de) | 1983-10-15 |
ZA8164B (en) | 1982-03-31 |
ES8304946A1 (es) | 1983-03-16 |
IE50765B1 (en) | 1986-07-09 |
IE810013L (en) | 1981-07-07 |
DE3160886D1 (en) | 1983-10-27 |
AU6601681A (en) | 1981-07-16 |
EP0032131B1 (en) | 1983-09-21 |
US4399140A (en) | 1983-08-16 |
JPS56150087A (en) | 1981-11-20 |
CA1168239A (en) | 1984-05-29 |
ES509219A0 (es) | 1983-03-16 |
ES498337A0 (es) | 1982-06-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19871118 |