ES8304946A1 - "un procedimiento para la preparacion de 5-halopirimidin-2-onas". - Google Patents
"un procedimiento para la preparacion de 5-halopirimidin-2-onas".Info
- Publication number
- ES8304946A1 ES8304946A1 ES509219A ES509219A ES8304946A1 ES 8304946 A1 ES8304946 A1 ES 8304946A1 ES 509219 A ES509219 A ES 509219A ES 509219 A ES509219 A ES 509219A ES 8304946 A1 ES8304946 A1 ES 8304946A1
- Authority
- ES
- Spain
- Prior art keywords
- ring
- groups
- heterocyclic
- saturated
- het
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003839 salts Chemical class 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 4
- 230000002159 abnormal effect Effects 0.000 abstract 3
- 229920006395 saturated elastomer Polymers 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 238000006798 ring closing metathesis reaction Methods 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 230000022131 cell cycle Effects 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 239000002254 cytotoxic agent Substances 0.000 abstract 1
- 230000026030 halogenation Effects 0.000 abstract 1
- 238000005658 halogenation reaction Methods 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000031864 metaphase Effects 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/28—Halogen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE 5-HALOPIRIMIDIN-2-ONAS, DE FORMULA GENERAL (I), EN DONDE X REPRESENTA UN ATOMO DE HALOGENO; R Y R REPRESENTAN CADA UNO DE ELLOS UN ATOMO DE HIDROGENO O UN GRUPO ALCOHILO DE C <- ; ~AHET~B REPRESENTA UN ANILLO HETEROCICLICO SATURADO, INSATURADO O AROMATICO; Y ~AALC~B REPRESENTA UN GRUPO HIDROCARBILO ALIFATICO, DIVALENTE, DE CADENA NORMAL O RAMIFICADA, Y DE SUS SALES FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN CERRAR EL ANILLO DE UN COMPUESTO DE FORMULA (I), EN DONDE R , R , X Y ~AALC~B TIENEN LOS SIGNIFICADOS YA INDICADOS, Y Z REPRESENTA UN GRUPO CAPAZ DE CICLISACION PARA FORMAR EL GRUPO ~AHET~B, PARA OBTENER UN COMPUESTO DE FORMULA (I). DE APLICACION EN LA PREPARACION DE FARMACOS PARA COMBATIR LA PROLIFERACION CELULAR ANORMAL.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8000381 | 1980-01-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES509219A0 ES509219A0 (es) | 1983-03-16 |
| ES8304946A1 true ES8304946A1 (es) | 1983-03-16 |
Family
ID=10510470
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES498337A Expired ES8205399A1 (es) | 1980-01-07 | 1981-01-05 | Un procedimiento para la preparacion de 5-halo-pirimidin-2- onas |
| ES509219A Expired ES8304946A1 (es) | 1980-01-07 | 1982-02-01 | "un procedimiento para la preparacion de 5-halopirimidin-2-onas". |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES498337A Expired ES8205399A1 (es) | 1980-01-07 | 1981-01-05 | Un procedimiento para la preparacion de 5-halo-pirimidin-2- onas |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4399140A (es) |
| EP (1) | EP0032131B1 (es) |
| JP (1) | JPS56150087A (es) |
| AT (1) | ATE4715T1 (es) |
| AU (1) | AU543939B2 (es) |
| CA (1) | CA1168239A (es) |
| DE (1) | DE3160886D1 (es) |
| DK (1) | DK149892B (es) |
| ES (2) | ES8205399A1 (es) |
| IE (1) | IE50765B1 (es) |
| NO (1) | NO810024L (es) |
| NZ (1) | NZ195947A (es) |
| ZA (1) | ZA8164B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ197715A (en) * | 1980-07-15 | 1984-12-14 | Glaxo Group Ltd | Substituted pyrimin-2-ones and pharmaceutical compositions |
| NZ197714A (en) * | 1980-07-15 | 1984-11-09 | Glaxo Group Ltd | Substituted pyrimidin-2-ones and pharmaceutical compositions |
| CA1180710A (en) * | 1981-01-09 | 1985-01-08 | Tore Benneche | Substituted pyrimidin-2-ones and the salts thereof |
| EP0087326B1 (en) * | 1982-02-24 | 1987-05-13 | Nycomed As | Substituted pyrimidin-2-ones and the salts thereof |
| SU1235864A1 (ru) * | 1983-03-11 | 1986-06-07 | Отделение ордена Ленина института химической физики АН СССР | Нитроксильные производные 5-фторурацила,обладающие противоопухолевой активностью |
| CN103130732A (zh) * | 2011-11-22 | 2013-06-05 | 上海博康精细化工有限公司 | 3,5-二甲基-4-氯甲基异噁唑的制备方法 |
| US9809588B2 (en) | 2014-07-03 | 2017-11-07 | Board Of Regents, The University Of Texas System | GLS1 inhibitors for treating disease |
| WO2016004417A1 (en) * | 2014-07-03 | 2016-01-07 | Board Of Regents, University Of Texas System | Gls1 inhibitors for treating disease |
| CN107921044B (zh) | 2015-06-30 | 2022-01-21 | 德州大学系统董事会 | 用于治疗疾病的gls1抑制剂 |
| MX384732B (es) | 2015-12-22 | 2025-03-14 | Univ Texas | Formas de sales y polimorfos de (r)-1-(4-(6-(2-(4-(3,3-difluorociclobutoxi)-6-metilpiridin-2-il)acetamido)piridazin-3-il)-2-fluorobutil)-n-metil-1h-1,2,3-triazol-4-carboxamida. |
| EP3697764B1 (en) | 2017-10-18 | 2025-06-11 | Board Of Regents, The University Of Texas System | Gls-1 inhibitors for use in the treatment of cancer |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3833586A (en) * | 1971-03-25 | 1974-09-03 | Morton Norwich Products Inc | 1-(substituted benzyl)-2-(1h)pyrimidones and 1-(substituted benzyl)tetrahydro-2-(1h)pyrimidones |
| GB1561290A (en) * | 1975-10-16 | 1980-02-20 | Nyegaard & Co As | Pyrimid - 2 - ones |
| US4003900A (en) * | 1976-03-11 | 1977-01-18 | Morton-Norwich Products, Inc. | 1-Benzyl-5-chloro-2-(1H)-pyrimidone |
| US4052399A (en) * | 1976-09-13 | 1977-10-04 | Morton-Norwich Products, Inc. | 1-[2-(Hexahydro-1H-azepino)ethyl]-2(1H)pyrimidone dihydrochloride |
| US4052400A (en) * | 1976-10-29 | 1977-10-04 | Morton-Norwich Products, Inc. | Hypertensive 1-substituted 2(1h)-pyrimidones |
-
1981
- 1981-01-05 ES ES498337A patent/ES8205399A1/es not_active Expired
- 1981-01-06 ZA ZA00810064A patent/ZA8164B/xx unknown
- 1981-01-06 NZ NZ195947A patent/NZ195947A/xx unknown
- 1981-01-06 IE IE13/81A patent/IE50765B1/en unknown
- 1981-01-06 DK DK003281AA patent/DK149892B/da unknown
- 1981-01-06 EP EP81300031A patent/EP0032131B1/en not_active Expired
- 1981-01-06 CA CA000367958A patent/CA1168239A/en not_active Expired
- 1981-01-06 JP JP63181A patent/JPS56150087A/ja active Pending
- 1981-01-06 AT AT81300031T patent/ATE4715T1/de not_active IP Right Cessation
- 1981-01-06 DE DE8181300031T patent/DE3160886D1/de not_active Expired
- 1981-01-06 NO NO810024A patent/NO810024L/no unknown
- 1981-01-06 US US06/222,959 patent/US4399140A/en not_active Expired - Fee Related
- 1981-01-06 AU AU66016/81A patent/AU543939B2/en not_active Ceased
-
1982
- 1982-02-01 ES ES509219A patent/ES8304946A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DK149892B (da) | 1986-10-20 |
| ES509219A0 (es) | 1983-03-16 |
| ES498337A0 (es) | 1982-06-01 |
| EP0032131B1 (en) | 1983-09-21 |
| AU543939B2 (en) | 1985-05-09 |
| CA1168239A (en) | 1984-05-29 |
| IE810013L (en) | 1981-07-07 |
| AU6601681A (en) | 1981-07-16 |
| NZ195947A (en) | 1983-09-02 |
| JPS56150087A (en) | 1981-11-20 |
| DE3160886D1 (en) | 1983-10-27 |
| DK3281A (da) | 1981-07-08 |
| ATE4715T1 (de) | 1983-10-15 |
| US4399140A (en) | 1983-08-16 |
| NO810024L (no) | 1981-07-08 |
| ES8205399A1 (es) | 1982-06-01 |
| ZA8164B (en) | 1982-03-31 |
| EP0032131A1 (en) | 1981-07-15 |
| IE50765B1 (en) | 1986-07-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MY101359A (en) | 7-acylamino-3-vinylcephalosporanic acid derivatives, processes for their preparation, pharmaceutical compositions containing them, their starting compounds and their preparation | |
| ES8304947A1 (es) | "procedimiento para la preparacion de pirimidin-2-sulfuros y sus s-oxidos". | |
| NZ227436A (en) | Cell proliferation inhibiting composition comprising a substituted styrene derivative | |
| DE3160886D1 (en) | 5-halo-pyrimidin-2-ones, the salts thereof, processes for their preparation and pharmaceutical compositions containing them | |
| ES481729A1 (es) | Procedimiento para la preparacion de derivados de 1,2-dihi- droquinolein-2-onas. | |
| GB1184714A (en) | Di- and Tri-Phenylpropyl Piperazine Derivatives | |
| ES2000456A6 (es) | Procedimiento para preparar deirvados de acido eicosatriinoico-5,8,11 y utilizacion de estos en composiciones farmaceuticas y cosmeticas. | |
| ES8307758A1 (es) | "un procedimiento para la preparacion de pirimidin-2-onas sustituidas". | |
| ES8401755A1 (es) | Procedimiento para la preparacion de derivados de tiometilpiridina. | |
| DK661088A (da) | N-(23-vinblastinoyl)derivater af 1-aminomethylphosphonsyre, fremgangsmaade til deres fremstilling og farmaceutiske midelr indeholdende dem | |
| GB973882A (en) | Benzyl-guanidines,their preparation and pharmaceutical compositions containing them | |
| ES8308860A1 (es) | "un procedimiento para la preparacion de pirimid-2-onas". | |
| ES8300750A1 (es) | Un procedimiento para la preparacion de pirimidin-2-onas sustituidas | |
| HUP0203696A2 (hu) | Sejtburjánzásgátló hatású helyettesített bisz-indolil-maleimidek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
| ES8401461A1 (es) | Procedimiento para la preparacion de derivados de 2-pirrolin-3-carbonitrilo. | |
| GB1049285A (en) | Guanidine and dihydroimidazole derivatives | |
| ES428535A1 (es) | Un procedimiento para la preparacion de cicloserina n-sus- tituida. | |
| ES443559A1 (es) | Un procedimiento para la obtencion de derivados de alanina -n,n-disustituidos. | |
| ES450211A1 (es) | Procedimiento para la obtencion de nuevos derivados de la 1-hidroxi-benzo-2,3,1-diazaborina. | |
| ES356259A1 (es) | Un procedimiento para la preparacion de compuestos hetero- ciclicos de actividad terapeutica. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19971201 |