GB973882A - Benzyl-guanidines,their preparation and pharmaceutical compositions containing them - Google Patents

Benzyl-guanidines,their preparation and pharmaceutical compositions containing them

Info

Publication number
GB973882A
GB973882A GB43702/59A GB4370259A GB973882A GB 973882 A GB973882 A GB 973882A GB 43702/59 A GB43702/59 A GB 43702/59A GB 4370259 A GB4370259 A GB 4370259A GB 973882 A GB973882 A GB 973882A
Authority
GB
United Kingdom
Prior art keywords
benzyl
hydrogen atom
group
salt
atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB43702/59A
Inventor
Eric Walton
Graham Keith Ruffell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Priority to GB43702/59A priority Critical patent/GB973882A/en
Priority to US77032A priority patent/US3168562A/en
Priority to CA813,371A priority patent/CA940537A/en
Priority to DK507460AA priority patent/DK106141C/en
Priority to LU39574A priority patent/LU39574A1/en
Priority to CS7672A priority patent/CS149570B2/cs
Priority to DEW29144A priority patent/DE1288591B/en
Priority to CH1428160A priority patent/CH410905A/en
Priority to CH214466A priority patent/CH486430A/en
Priority to NL259381A priority patent/NL128795C/en
Priority to FR855866A priority patent/FR1019M/en
Publication of GB973882A publication Critical patent/GB973882A/en
Priority to MY1966101A priority patent/MY6600101A/en
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/155Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises compounds of general formula <FORM:0973882/C1/1> wherein Z1 is a hydrogen atom or a substituent halogen atom or alkyl or nitro group in the 2 or 3 position, Z2 is a hydrogen atom or a substituent halogen atom or alkyl group in the 4, 5 or 6 position, and R1, R2, R3 and R4 are the same or different and each is a hydrogen atom or a substituent alkyl group, provided that when Z1 is a hydrogen atom at least two of Z2, R1, R2, R3 and R4 are not hydrogen but are substituents as defined; acid addition salts thereof; and their preparation by (1) reacting a guanidine R5N=C(NR6R7)(NR8R9) or a salt thereo with a compound R10X where R5, R6, R7, R8, R9 and R10 are each as appropriate, and not as respective, a benzyl, R1, R2, R3 and R4 group and a hydrogen atom, and X is a reactive proton accepting atom or group, and (2) reacting ammonia or an ammonia derivative or a salt thereof with an S-substituted isothiourea or a salt thereof, or with a cyanamide. N-Benzyl-S-methylisothiourea hydriodides are prepared by treating with methyl iodide corresponding benzyl-thioureas obtained from ammonia derivatives and isothiocyanates. N-Benzyl-N1-methylguanidine is prepared from methylamine and N-benzyl-S-methylisothiourea hydriodide. Pharmaceutical compositions comprise Compounds I or their acid addition salts together with acceptable carriers. Forms mentioned are powders, granules, capsules, cachets, tablets (oral administration), solutions and suspensions (oral and parenteral), suppositories and pessaries. The compounds depress sympathetic function and may be used to treat hypertension.
GB43702/59A 1959-12-23 1959-12-23 Benzyl-guanidines,their preparation and pharmaceutical compositions containing them Expired GB973882A (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
GB43702/59A GB973882A (en) 1959-12-23 1959-12-23 Benzyl-guanidines,their preparation and pharmaceutical compositions containing them
US77032A US3168562A (en) 1959-12-23 1960-12-20 Substituted benzylguanidines
CA813,371A CA940537A (en) 1959-12-23 1960-12-20 Benzyl guanidines, and a process of production
CS7672A CS149570B2 (en) 1959-12-23 1960-12-22
LU39574A LU39574A1 (en) 1959-12-23 1960-12-22 Chemical compounds, processes and pharmaceutical preparations
DK507460AA DK106141C (en) 1959-12-23 1960-12-22 Process for the preparation of benzylguanidines or acid addition salts thereof.
DEW29144A DE1288591B (en) 1959-12-23 1960-12-22 Process for the preparation of benzylguanidines
CH1428160A CH410905A (en) 1959-12-23 1960-12-22 Process for the preparation of benzylguanidines
CH214466A CH486430A (en) 1959-12-23 1960-12-22 Process for the preparation of benzylguanidines
NL259381A NL128795C (en) 1959-12-23 1960-12-23 Process for the preparation of benzylguanidine derivatives and their acid addition salts
FR855866A FR1019M (en) 1959-12-23 1961-03-16 Hypotensive drug based on benzylguanidines.
MY1966101A MY6600101A (en) 1959-12-23 1966-12-31 Benzyl-guanidines, their preparation and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB43702/59A GB973882A (en) 1959-12-23 1959-12-23 Benzyl-guanidines,their preparation and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
GB973882A true GB973882A (en) 1964-10-28

Family

ID=10429933

Family Applications (1)

Application Number Title Priority Date Filing Date
GB43702/59A Expired GB973882A (en) 1959-12-23 1959-12-23 Benzyl-guanidines,their preparation and pharmaceutical compositions containing them

Country Status (1)

Country Link
GB (1) GB973882A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3352878A (en) * 1965-03-18 1967-11-14 Bristol Myers Co Certain pyridylmethyl guanidine derivatives
FR2053005A1 (en) * 1969-06-23 1971-04-16 Wellcome Found Substituted guanidines in cardiac treatment
DE1518230B1 (en) * 1964-08-05 1972-10-26 Wellcome Found Process for the preparation of N-benzyl-N ', N "-dimethylguanidine
NL7806526A (en) * 1977-06-17 1978-12-19 Gea As PROCESS FOR PREPARING SUBSTITUTED GUANIDINS.
DE3312516A1 (en) * 1983-04-07 1984-10-11 Brigitte Dr. 7400 Tübingen Pfeiffer Nuclear-substituted phenylalkyleneguanidine derivatives, process for their preparation and pharmaceuticals containing them
EP1962892A2 (en) * 2005-11-22 2008-09-03 University of South Florida Inhibition of cell proliferation
JP2017513948A (en) * 2014-04-17 2017-06-01 イミューノメット セラピューティクス インコーポレイテッド Guanidine compounds and uses thereof

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1518230B1 (en) * 1964-08-05 1972-10-26 Wellcome Found Process for the preparation of N-benzyl-N ', N "-dimethylguanidine
US3352878A (en) * 1965-03-18 1967-11-14 Bristol Myers Co Certain pyridylmethyl guanidine derivatives
FR2053005A1 (en) * 1969-06-23 1971-04-16 Wellcome Found Substituted guanidines in cardiac treatment
NL7806526A (en) * 1977-06-17 1978-12-19 Gea As PROCESS FOR PREPARING SUBSTITUTED GUANIDINS.
DE3312516A1 (en) * 1983-04-07 1984-10-11 Brigitte Dr. 7400 Tübingen Pfeiffer Nuclear-substituted phenylalkyleneguanidine derivatives, process for their preparation and pharmaceuticals containing them
EP1962892A2 (en) * 2005-11-22 2008-09-03 University of South Florida Inhibition of cell proliferation
EP1962892A4 (en) * 2005-11-22 2011-10-12 Univ South Florida Inhibition of cell proliferation
US8642278B2 (en) 2005-11-22 2014-02-04 University Of South Florida Inhibition of cell proliferation
US9656953B2 (en) 2005-11-22 2017-05-23 University Of South Florida Inhibition of cell proliferation
JP2017513948A (en) * 2014-04-17 2017-06-01 イミューノメット セラピューティクス インコーポレイテッド Guanidine compounds and uses thereof
US11465989B2 (en) 2014-04-17 2022-10-11 ImmunoMet Therapeutics, Inc. Guanidine compounds and use thereof

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