FR2053005A1 - Substituted guanidines in cardiac treatment - Google Patents

Substituted guanidines in cardiac treatment

Info

Publication number
FR2053005A1
FR2053005A1 FR7023109A FR7023109A FR2053005A1 FR 2053005 A1 FR2053005 A1 FR 2053005A1 FR 7023109 A FR7023109 A FR 7023109A FR 7023109 A FR7023109 A FR 7023109A FR 2053005 A1 FR2053005 A1 FR 2053005A1
Authority
FR
France
Prior art keywords
cardiac treatment
substituted guanidines
prepared
treatment
sulphonate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7023109A
Other languages
French (fr)
Other versions
FR2053005B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of FR2053005A1 publication Critical patent/FR2053005A1/en
Application granted granted Critical
Publication of FR2053005B1 publication Critical patent/FR2053005B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Acid addition salts of N-p-methylbenzyl-N'-N"-dimethylguanidine or of N-p-methoxybenzyl-N'-N=-dimethlguanidine are useful for the treatment of fibrillation of the auricles and ventricles of the heart. The prepared salts are chlorides, sulphates and sulphonates such as p-toluene sulphonate. They may be prepared by reacting guanidine with a benzyl- or methyl-containing compound e.g. sulphonate.
FR7023109A 1969-06-23 1970-06-23 Substituted guanidines in cardiac treatment Granted FR2053005A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB3168469 1969-06-23
GB5923269 1969-12-04

Publications (2)

Publication Number Publication Date
FR2053005A1 true FR2053005A1 (en) 1971-04-16
FR2053005B1 FR2053005B1 (en) 1978-03-24

Family

ID=26261037

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7023109A Granted FR2053005A1 (en) 1969-06-23 1970-06-23 Substituted guanidines in cardiac treatment

Country Status (13)

Country Link
JP (1) JPS532848B1 (en)
BE (1) BE752414A (en)
CA (1) CA974254A (en)
CH (3) CH546233A (en)
DE (1) DE2030693C3 (en)
DK (1) DK134172B (en)
ES (1) ES381018A1 (en)
FI (1) FI52853C (en)
FR (1) FR2053005A1 (en)
IL (1) IL34764A (en)
IT (1) IT8047875A0 (en)
NL (1) NL163776C (en)
SE (1) SE375096B (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB973882A (en) * 1959-12-23 1964-10-28 Wellcome Found Benzyl-guanidines,their preparation and pharmaceutical compositions containing them

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK106141C (en) * 1959-12-23 1966-12-27 Wellcome Found Process for the preparation of benzylguanidines or acid addition salts thereof.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB973882A (en) * 1959-12-23 1964-10-28 Wellcome Found Benzyl-guanidines,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
DE2030693C3 (en) 1982-04-29
CH545773A (en) 1974-02-15
CH553169A (en) 1974-08-30
IL34764A (en) 1973-07-30
IL34764A0 (en) 1970-08-19
DK134172B (en) 1976-09-27
FI52853B (en) 1977-08-31
CA974254A (en) 1975-09-09
NL163776C (en) 1980-10-15
DK134172C (en) 1977-02-21
DE2030693A1 (en) 1971-01-21
SE375096B (en) 1975-04-07
FR2053005B1 (en) 1978-03-24
CH546233A (en) 1974-02-28
ES381018A1 (en) 1972-10-16
JPS532848B1 (en) 1978-02-01
FI52853C (en) 1977-12-12
NL163776B (en) 1980-05-16
BE752414A (en) 1970-12-23
IT8047875A0 (en) 1980-02-12
DE2030693B2 (en) 1981-07-16
NL7009194A (en) 1970-12-28

Similar Documents

Publication Publication Date Title
CH550821A (en) PROCESS FOR THE PREPARATION OF 1,2,3,11B-TETRAHYDROPYRIDO (3,4,5: M, N) THIOXANTHENES AND THEIR ACID ADDITION SALTS.
FR2053005A1 (en) Substituted guanidines in cardiac treatment
DK137382B (en) Analogous process for the preparation of 2,2-diaryl-4- (4'-aryl-4'-hydroxy-piperidine) butyramides or acid addition salts thereof.
SE8700555D0 (en) PURINE DERIVATIVES, THEIR PRODUCTION AND MEDICAMENTS CONTAINING THEM
CA936533A (en) 5-aryl-2,3-dihydro-2,2(or 3,3) dimethyl-5h-imidazo(2,1-a) isoindol-5-ols and 2(4,4(5,5) dimethyl-2-imidazolin-2-yl) bensophenone acid addition salts and processes for their preparation
AT299968B (en) Process for the preparation of new 5-imino-1,2,4-triazine derivatives
AT295495B (en) Process for the preparation of new N, N'-bis (diphenylalkyl) alkylenediamines and their acid addition salts
GB1272606A (en) Imidazolinyl benzalhydrazone and a process for its preparation
CA982125A (en) 4,4'-diaminostilbene-2,2'-disulfonic acid derivatives and use thereof
FR2123632A6 (en) Prepn of 5-azacytosines and 5-azacytidines - from bis trimethylsilyl-5-azacytosine
CH555367A (en) PROCESS FOR THE PREPARATION OF 0,0-DISUBSTITUTED THIONOPHOSPHORIC ACID CHLORIDES.
AU6359769A (en) Acid addition salts of n4, n4' - decamethylene-bis-aminoquinaldine with microbiocidal and fungicidal actions
GB1313585A (en) Fungicidally and fungistatically active thiocarbonates
AT320661B (en) Process for the preparation of new 2-acylamino-1,2,3,4-tetrahydronaphthalenesulfonyl ureas or 2-acylamino-1,2,3,4-tetrahydronaphthalenesulfonyl semicarbazides and their physiologically harmless salts
FR2154574A1 (en) Chondroitin sulphate salts
Koda Experimental Studies in Traumatic Dislocation of the Hip
AT306701B (en) Process for the preparation of new racemic or optically active 1- (2'-cyano-5'-methylphenoxy) -2-hydroxy-3-sec. alkylaminopropanes, as well as their acid addition salts
SU660914A1 (en) Suction gripper
CA991174A (en) Crystalline forms of 4,4'-bis((4,6-dianilino-1,3,5-triazin-2-yl)-amino)-stilbene-2,2'-disulfonic acid
DK135576B (en) Analogous process for the preparation of 1,4-methano- or 1,4-ethano-tetrahydronaphthyloxyaminopropanols or acid addition salts thereof.
DK125593B (en) Analogous process for the preparation of 7-acyl-1,2,4,5-tetrahydro- (3H) -3-benzazepines or acid addition salts thereof.
DK137925B (en) Analogous process for the preparation of 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine compounds or acid addition salts thereof.
CH550204A (en) PROCESS FOR THE PREPARATION OF MIXTURES OF SALT CONTAINING THE ALKALINE SALT OF 0,0-DIALKYLDITHIOPHOSPHORIC ACID.
AT294836B (en) Process for the preparation of new 1,2,3,4-tetrahydroisoquinoline derivatives or their acid addition salts
BE780081A (en) ALIPHATIC SULPHONATES, ARYL-SUFONATES AND CYANOALKYL THIOPHENESULPHONATES AS FUNGICIDAL AGENTS IN THE CONTROL OF MUSHROOM GROWTH

Legal Events

Date Code Title Description
ST Notification of lapse