BE748392A - Nouvelles phenylpyrrolidines, utiles notamment comme decontractants musculaires et anticonvulsifs, et leur procede de preparation - Google Patents
Nouvelles phenylpyrrolidines, utiles notamment comme decontractants musculaires et anticonvulsifs, et leur procede de preparationInfo
- Publication number
- BE748392A BE748392A BE748392DA BE748392A BE 748392 A BE748392 A BE 748392A BE 748392D A BE748392D A BE 748392DA BE 748392 A BE748392 A BE 748392A
- Authority
- BE
- Belgium
- Prior art keywords
- decontractants
- phenylpyrrolidines
- convulsive
- muscle
- useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81444269A | 1969-04-08 | 1969-04-08 | |
US81444369A | 1969-04-08 | 1969-04-08 | |
US81549269A | 1969-04-11 | 1969-04-11 | |
US81549569A | 1969-04-11 | 1969-04-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
BE748392A true BE748392A (fr) | 1970-09-16 |
Family
ID=27505843
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE748392D BE748392A (fr) | 1969-04-08 | 1970-04-02 | Nouvelles phenylpyrrolidines, utiles notamment comme decontractants musculaires et anticonvulsifs, et leur procede de preparation |
Country Status (10)
Country | Link |
---|---|
US (4) | US3635982A (fr) |
AT (1) | AT294815B (fr) |
BE (1) | BE748392A (fr) |
CA (1) | CA974995A (fr) |
CH (2) | CH556336A (fr) |
DE (2) | DE2017255A1 (fr) |
FR (2) | FR2042322B1 (fr) |
GB (2) | GB1299621A (fr) |
NL (1) | NL7005191A (fr) |
SE (1) | SE366040B (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5665754A (en) * | 1993-09-20 | 1997-09-09 | Glaxo Wellcome Inc. | Substituted pyrrolidines |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2541855A1 (de) * | 1975-09-18 | 1977-03-31 | Schering Ag | 4-(polyalkoxy-phenyl)-2-pyrrolidone ii |
US4066772A (en) * | 1975-07-21 | 1978-01-03 | Janssen Pharmaceutica N.V. | 1,3-Dihydro-1-[3-(1-piperidinyl)propyl]-2H-benzimidazol-2-ones and related compounds |
US4175129A (en) | 1975-07-21 | 1979-11-20 | Janssen Pharmaceutica N.V. | Antiemetic 1-(benzoxazolylalkyl)-piperidine derivatives |
US4035369A (en) * | 1975-10-08 | 1977-07-12 | Janssen Pharmaceutica N.V. | 1-Benzazolylalkyl-4-substituted-piperidines |
US4126687A (en) * | 1976-05-17 | 1978-11-21 | Janssen Pharmaceutica N.V. | Antiemetic, 1-(benzimidazolyl-alkyl)-piperidine derivatives |
LU75478A1 (fr) * | 1976-07-28 | 1978-02-08 | ||
US4241061A (en) * | 1979-05-21 | 1980-12-23 | International Minerals & Chemical Corp. | Oxazolidinyl-quinoxalines and use as growth promoters |
US4303667A (en) * | 1979-05-25 | 1981-12-01 | Nippon Soda Company Limited | Phenylprrole derivatives |
DE3070247D1 (en) * | 1979-12-05 | 1985-04-04 | Astra Laekemedel Ab | New phenyl-azacycloalkanes, processes for preparation and pharmaceutical preparations for such compounds |
US4661593A (en) * | 1980-08-07 | 1987-04-28 | Angus Chemcial Company | Quinoxaline adducts useful as anthelmintics |
US4720548A (en) * | 1980-08-07 | 1988-01-19 | Angus Chemical Company | Quinoxaline adducts useful as anthelmintics |
US4629790A (en) * | 1980-08-07 | 1986-12-16 | Angus Chemical Company | Quinoxaline adducts useful as anthelmintics |
US4658028A (en) * | 1980-08-07 | 1987-04-14 | Angus Chemical Company | Quinoxaline adducts useful as anthelmintics |
US4348389A (en) * | 1980-08-07 | 1982-09-07 | International Minerals & Chemical Corp. | Quinoxaline adducts useful as anthelmintics |
US4656276A (en) * | 1980-08-07 | 1987-04-07 | Angus Chemical Company | Quinoxaline adducts useful as anthelmintics |
DE3328643A1 (de) * | 1983-08-09 | 1985-02-21 | Gödecke AG, 1000 Berlin | 3-aryl-3-pyrrolin-derivate, verfahren zu deren herstellung sowie deren verwendung bei der bekaempfung von herz- und gefaesskrankheiten |
US5118816A (en) * | 1990-12-26 | 1992-06-02 | American Cyanamid Company | 2-aryl-5-(trifluoromethyl)-2-pyrroline compounds useful in the manufacture of insecticidal, nematocidal and acaricidal arylpyrroles |
US5514678A (en) * | 1992-03-26 | 1996-05-07 | E. I. Du Pont De Nemours And Company | Arthropodicidal 1,2,4-triazinyl amides |
US6355659B1 (en) | 1994-07-29 | 2002-03-12 | Laboratorios Del Dr. Esteve, S.A. | 4-(4-Chlorophenyl)-1236-tetrahydro-1(1H-124-triazol-1-yl)butty)pyrideine and salts thereof; pharmaceutical compositions and method of treating psychoses utilizing same |
FR2723091B1 (fr) * | 1994-07-29 | 1996-11-08 | Esteve Labor Dr | Tetrahydropyridine-(6,4-hydroxypiperidine) alkylazoles |
ES2201105T3 (es) * | 1994-08-05 | 2004-03-16 | Pfizer Inc. | Derivados del bencimidazol con actividad dopaminergica. |
US5883094A (en) * | 1995-04-24 | 1999-03-16 | Pfizer Inc. | Benzimidazolone derivatives with central dopaminergic activity |
US5889010A (en) * | 1995-05-18 | 1999-03-30 | Pfizer Inc. | Benzimidazole derivatives having dopaminergic activity |
DE19615232A1 (de) * | 1996-04-18 | 1997-10-23 | Merck Patent Gmbh | Neue Carbamoylderivate und deren Verwendung als 5-HT ¶1¶¶A¶-Antagonisten |
GB9801392D0 (en) * | 1998-01-22 | 1998-03-18 | Smithkline Beecham Plc | Novel compounds |
ES2282647T3 (es) * | 2002-06-14 | 2007-10-16 | MERCK & CO., INC. | Inhibidores de cinesina mitotica. |
JP4377323B2 (ja) * | 2002-06-14 | 2009-12-02 | メルク エンド カムパニー インコーポレーテッド | 有糸分裂キネシン阻害剤 |
WO2004037171A2 (fr) * | 2002-10-18 | 2004-05-06 | Merck & Co., Inc. | Inhibiteurs de kinesine mitotiques |
AU2004266629B2 (en) * | 2003-08-15 | 2009-11-26 | Merck Sharp & Dohme Corp. | Mitotic kinesin inhibitors |
WO2005017190A2 (fr) * | 2003-08-15 | 2005-02-24 | Merck & Co., Inc. | Inhibiteurs de kinesine mitotique |
PT1664026E (pt) * | 2003-08-15 | 2009-04-23 | Merck & Co Inc | Inibidores de cinesina mitótica |
JP2008545801A (ja) * | 2005-06-10 | 2008-12-18 | エリクシアー ファーマシューティカルズ, インコーポレイテッド | スルホンアミド化合物およびその使用 |
US7829589B2 (en) * | 2005-06-10 | 2010-11-09 | Elixir Pharmaceuticals, Inc. | Sulfonamide compounds and uses thereof |
FR2902790A1 (fr) * | 2006-06-27 | 2007-12-28 | Sanofi Aventis Sa | Derives d'urees de piperidine ou pyrrolidine,leur preparation et leur application en therapeutique |
RU2471781C2 (ru) * | 2007-06-05 | 2013-01-10 | НСАБ, Филиаль аф НьюроСёрч Свиден АБ, Сверийе | Новые двузамещенные фенилпирролидины в качестве модуляторов кортикальной катехоламинергической нейротрансмиссии |
JP2010529080A (ja) * | 2007-06-05 | 2010-08-26 | エヌエスエイビー、フィリアル アヴ ノイロサーチ スウェーデン エービー、スヴェーリエ | 皮質カテコールアミン作動性神経伝達の調節因子としての新規な二置換フェニルピロリジン |
TWI457122B (zh) | 2007-07-20 | 2014-10-21 | Orion Corp | 作為用於治療周邊和中央神經系統疾病之alpha2C拮抗劑的2,3-二氫苯並[1,4]戴奧辛-2-基甲基衍生物 |
MX2011005036A (es) | 2008-11-24 | 2011-06-16 | Nsab Af Neurosearch Sweden Ab | Derivados de 3-fenil-3metoxipirrolidina como moduladores de la neurotransmision catecolaminergia cortical. |
JOP20190050A1 (ar) * | 2016-09-23 | 2019-03-20 | Bial Portela & C? S A | مثبطات دوبامين-b-هيدروكسيلاز تخترق حاجز المخ الدموي |
CA3082337A1 (fr) | 2017-12-04 | 2019-06-13 | Bial - Portela & Ca, S.A. | Inhibiteurs de dopamine-b-hydroxylase |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3362956A (en) * | 1965-08-19 | 1968-01-09 | Sterling Drug Inc | 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines |
-
1969
- 1969-04-08 US US814443A patent/US3635982A/en not_active Expired - Lifetime
- 1969-04-08 US US814442A patent/US3647790A/en not_active Expired - Lifetime
- 1969-04-11 US US815492A patent/US3634441A/en not_active Expired - Lifetime
- 1969-04-11 US US815495A patent/US3644414A/en not_active Expired - Lifetime
-
1970
- 1970-02-20 CH CH250270A patent/CH556336A/xx not_active IP Right Cessation
- 1970-02-20 CH CH249470A patent/CH549038A/xx not_active IP Right Cessation
- 1970-03-24 GB GB04118/70A patent/GB1299621A/en not_active Expired
- 1970-04-02 BE BE748392D patent/BE748392A/fr unknown
- 1970-04-07 GB GB1289089D patent/GB1289089A/en not_active Expired
- 1970-04-09 AT AT325570A patent/AT294815B/de not_active IP Right Cessation
- 1970-04-09 SE SE04844/70A patent/SE366040B/xx unknown
- 1970-04-10 DE DE19702017255 patent/DE2017255A1/de active Pending
- 1970-04-10 FR FR707013078A patent/FR2042322B1/fr not_active Expired
- 1970-04-10 CA CA079,859A patent/CA974995A/en not_active Expired
- 1970-04-10 FR FR7013077A patent/FR2042321B1/fr not_active Expired
- 1970-04-10 NL NL7005191A patent/NL7005191A/xx unknown
- 1970-04-10 DE DE19702017265 patent/DE2017265A1/de active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5665754A (en) * | 1993-09-20 | 1997-09-09 | Glaxo Wellcome Inc. | Substituted pyrrolidines |
Also Published As
Publication number | Publication date |
---|---|
SE366040B (fr) | 1974-04-08 |
CA974995A (en) | 1975-09-23 |
CH549038A (de) | 1974-05-15 |
AT294815B (de) | 1971-12-10 |
FR2042322B1 (fr) | 1973-06-08 |
DE2017255A1 (de) | 1970-10-08 |
DE2017265A1 (de) | 1970-10-15 |
US3647790A (en) | 1972-03-07 |
FR2042321A1 (fr) | 1971-02-12 |
GB1289089A (fr) | 1972-09-13 |
GB1299621A (en) | 1972-12-13 |
US3644414A (en) | 1972-02-22 |
FR2042321B1 (fr) | 1974-03-22 |
FR2042322A1 (fr) | 1971-02-12 |
US3635982A (en) | 1972-01-18 |
NL7005191A (fr) | 1970-10-13 |
US3634441A (en) | 1972-01-11 |
CH556336A (de) | 1974-11-29 |
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