CH549038A - Verfahren zur herstellung von 1-((omega)-substituierten-alkyl)2-methylbenzimidazolen. - Google Patents

Verfahren zur herstellung von 1-((omega)-substituierten-alkyl)2-methylbenzimidazolen.

Info

Publication number
CH549038A
CH549038A CH249470A CH249470A CH549038A CH 549038 A CH549038 A CH 549038A CH 249470 A CH249470 A CH 249470A CH 249470 A CH249470 A CH 249470A CH 549038 A CH549038 A CH 549038A
Authority
CH
Switzerland
Prior art keywords
methylbenzimidazole
omega
preparation
substituted alkyl
substituted
Prior art date
Application number
CH249470A
Other languages
English (en)
Original Assignee
Robins Co Inc A H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robins Co Inc A H filed Critical Robins Co Inc A H
Publication of CH549038A publication Critical patent/CH549038A/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CH249470A 1969-04-08 1970-02-20 Verfahren zur herstellung von 1-((omega)-substituierten-alkyl)2-methylbenzimidazolen. CH549038A (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US81444269A 1969-04-08 1969-04-08
US81444369A 1969-04-08 1969-04-08
US81549569A 1969-04-11 1969-04-11
US81549269A 1969-04-11 1969-04-11

Publications (1)

Publication Number Publication Date
CH549038A true CH549038A (de) 1974-05-15

Family

ID=27505843

Family Applications (2)

Application Number Title Priority Date Filing Date
CH250270A CH556336A (de) 1969-04-08 1970-02-20 Verfahren zur herstellung von 1-acylierten 3-arylpyrrolidinen und 1-acylierten 3-arylpyrrolinen.
CH249470A CH549038A (de) 1969-04-08 1970-02-20 Verfahren zur herstellung von 1-((omega)-substituierten-alkyl)2-methylbenzimidazolen.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CH250270A CH556336A (de) 1969-04-08 1970-02-20 Verfahren zur herstellung von 1-acylierten 3-arylpyrrolidinen und 1-acylierten 3-arylpyrrolinen.

Country Status (10)

Country Link
US (4) US3635982A (de)
AT (1) AT294815B (de)
BE (1) BE748392A (de)
CA (1) CA974995A (de)
CH (2) CH556336A (de)
DE (2) DE2017265A1 (de)
FR (2) FR2042322B1 (de)
GB (2) GB1299621A (de)
NL (1) NL7005191A (de)
SE (1) SE366040B (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2541855A1 (de) * 1975-09-18 1977-03-31 Schering Ag 4-(polyalkoxy-phenyl)-2-pyrrolidone ii
US4066772A (en) * 1975-07-21 1978-01-03 Janssen Pharmaceutica N.V. 1,3-Dihydro-1-[3-(1-piperidinyl)propyl]-2H-benzimidazol-2-ones and related compounds
US4175129A (en) 1975-07-21 1979-11-20 Janssen Pharmaceutica N.V. Antiemetic 1-(benzoxazolylalkyl)-piperidine derivatives
US4035369A (en) * 1975-10-08 1977-07-12 Janssen Pharmaceutica N.V. 1-Benzazolylalkyl-4-substituted-piperidines
US4126688A (en) * 1976-05-17 1978-11-21 Janssen Pharmaceutica N.V. Antiemetic 1-(benzotriazolyl-alkyl)-piperidine derivatives
LU75478A1 (de) * 1976-07-28 1978-02-08
US4241061A (en) * 1979-05-21 1980-12-23 International Minerals & Chemical Corp. Oxazolidinyl-quinoxalines and use as growth promoters
US4303667A (en) * 1979-05-25 1981-12-01 Nippon Soda Company Limited Phenylprrole derivatives
IE50674B1 (en) * 1979-12-05 1986-06-11 Astra Laekemedel Ab Phenyl-azacycloakanes
US4720548A (en) * 1980-08-07 1988-01-19 Angus Chemical Company Quinoxaline adducts useful as anthelmintics
US4629790A (en) * 1980-08-07 1986-12-16 Angus Chemical Company Quinoxaline adducts useful as anthelmintics
US4348389A (en) * 1980-08-07 1982-09-07 International Minerals & Chemical Corp. Quinoxaline adducts useful as anthelmintics
US4661593A (en) * 1980-08-07 1987-04-28 Angus Chemcial Company Quinoxaline adducts useful as anthelmintics
US4656276A (en) * 1980-08-07 1987-04-07 Angus Chemical Company Quinoxaline adducts useful as anthelmintics
US4658028A (en) * 1980-08-07 1987-04-14 Angus Chemical Company Quinoxaline adducts useful as anthelmintics
DE3328643A1 (de) * 1983-08-09 1985-02-21 Gödecke AG, 1000 Berlin 3-aryl-3-pyrrolin-derivate, verfahren zu deren herstellung sowie deren verwendung bei der bekaempfung von herz- und gefaesskrankheiten
US5118816A (en) * 1990-12-26 1992-06-02 American Cyanamid Company 2-aryl-5-(trifluoromethyl)-2-pyrroline compounds useful in the manufacture of insecticidal, nematocidal and acaricidal arylpyrroles
US5514678A (en) * 1992-03-26 1996-05-07 E. I. Du Pont De Nemours And Company Arthropodicidal 1,2,4-triazinyl amides
US5665754A (en) * 1993-09-20 1997-09-09 Glaxo Wellcome Inc. Substituted pyrrolidines
US6355659B1 (en) 1994-07-29 2002-03-12 Laboratorios Del Dr. Esteve, S.A. 4-(4-Chlorophenyl)-1236-tetrahydro-1(1H-124-triazol-1-yl)butty)pyrideine and salts thereof; pharmaceutical compositions and method of treating psychoses utilizing same
FR2723091B1 (fr) * 1994-07-29 1996-11-08 Esteve Labor Dr Tetrahydropyridine-(6,4-hydroxypiperidine) alkylazoles
ES2201105T3 (es) * 1994-08-05 2004-03-16 Pfizer Inc. Derivados del bencimidazol con actividad dopaminergica.
US5883094A (en) * 1995-04-24 1999-03-16 Pfizer Inc. Benzimidazolone derivatives with central dopaminergic activity
US5889010A (en) * 1995-05-18 1999-03-30 Pfizer Inc. Benzimidazole derivatives having dopaminergic activity
DE19615232A1 (de) * 1996-04-18 1997-10-23 Merck Patent Gmbh Neue Carbamoylderivate und deren Verwendung als 5-HT ¶1¶¶A¶-Antagonisten
GB9801392D0 (en) * 1998-01-22 1998-03-18 Smithkline Beecham Plc Novel compounds
JP4463679B2 (ja) * 2002-06-14 2010-05-19 メルク エンド カムパニー インコーポレーテッド 有糸分裂キネシン阻害剤
PL374190A1 (en) * 2002-06-14 2005-10-03 Merck & Co, Inc. Mitotic kinesin inhibitors
US7235580B2 (en) * 2002-10-18 2007-06-26 Merck & Co., Inc. Mitotic kinesin inhibitors
US7465746B2 (en) * 2003-08-15 2008-12-16 Merck & Co., Inc. Fluorinated 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP
JP2007502773A (ja) * 2003-08-15 2007-02-15 メルク　エンド　カムパニー　インコーポレーテッド 有糸分裂キネシン阻害薬
CA2534729A1 (en) * 2003-08-15 2005-02-24 Merck & Co., Inc. Mitotic kinesin inhibitors
US20060293370A1 (en) * 2005-06-10 2006-12-28 Saunders Jeffrey O Sulfonamide compounds and uses thereof
US7829589B2 (en) * 2005-06-10 2010-11-09 Elixir Pharmaceuticals, Inc. Sulfonamide compounds and uses thereof
FR2902790A1 (fr) * 2006-06-27 2007-12-28 Sanofi Aventis Sa Derives d'urees de piperidine ou pyrrolidine,leur preparation et leur application en therapeutique
EP2155669B1 (de) * 2007-06-05 2011-05-04 NSAB, Filial af NeuroSearch Sweden AB, Sverige Neue disubstituierte phenylpyrrolidine als modulatoren der kortikalen katecholaminergen neurotransmission
KR20100038295A (ko) * 2007-06-05 2010-04-14 엔에스아베 필리알 아프 뉴로서치 스웨덴 아베 스베리게 피질 카테콜아민성 신경 전달의 조정자로서의 이치환된 페닐피롤리딘
TWI457122B (zh) * 2007-07-20 2014-10-21 Orion Corp 作為用於治療周邊和中央神經系統疾病之alpha2C拮抗劑的2,3－二氫苯並[1,4]戴奧辛－2－基甲基衍生物
AU2009317156B2 (en) * 2008-11-24 2015-12-03 Integrative Research Laboratories Sweden Ab 3-phenyl-3-methoxypyrrolidine derivatives as modulators of cortical catecholaminergic neurotransmission
JOP20190050A1 (ar) * 2016-09-23 2019-03-20 Bial Portela & C? S A مثبطات دوبامين-b-هيدروكسيلاز تخترق حاجز المخ الدموي
US11434242B2 (en) 2017-12-04 2022-09-06 Bial—Portela & Ca, S.A. Dopamine-b-hydroxylase inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3362956A (en) * 1965-08-19 1968-01-09 Sterling Drug Inc 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines

Also Published As

Publication number Publication date
DE2017265A1 (de) 1970-10-15
FR2042321A1 (de) 1971-02-12
CA974995A (en) 1975-09-23
US3647790A (en) 1972-03-07
GB1289089A (de) 1972-09-13
FR2042321B1 (de) 1974-03-22
NL7005191A (de) 1970-10-13
US3634441A (en) 1972-01-11
FR2042322A1 (de) 1971-02-12
FR2042322B1 (de) 1973-06-08
US3644414A (en) 1972-02-22
CH556336A (de) 1974-11-29
DE2017255A1 (de) 1970-10-08
US3635982A (en) 1972-01-18
SE366040B (de) 1974-04-08
GB1299621A (en) 1972-12-13
BE748392A (fr) 1970-09-16
AT294815B (de) 1971-12-10

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