BE628258A - - Google Patents

Info

Publication number

BE628258A

BE628258A BE628258DA BE628258A BE 628258 A BE628258 A BE 628258A BE 628258D A BE628258D A BE 628258DA BE 628258 A BE628258 A BE 628258A

Authority

BE

Belgium

Prior art keywords

filtered

broth

precipitated

tetracycline

base

Prior art date

Links

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• MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 24
• QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 12
• 235000006408 oxalic acid Nutrition 0.000 claims description 7
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 5
• 229910052791 calcium Inorganic materials 0.000 claims description 5
• 239000011575 calcium Substances 0.000 claims description 5
• 230000020477 pH reduction Effects 0.000 claims description 4
• 238000000034 method Methods 0.000 claims description 3
• 235000010633 broth Nutrition 0.000 description 16
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 8
• 239000004098 Tetracycline Substances 0.000 description 8
• 229960002180 tetracycline Drugs 0.000 description 8
• 229930101283 tetracycline Natural products 0.000 description 8
• 235000019364 tetracycline Nutrition 0.000 description 8
• 150000003522 tetracyclines Chemical class 0.000 description 8
• 239000000706 filtrate Substances 0.000 description 7
• 238000001556 precipitation Methods 0.000 description 5
• QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
• CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 4
• 238000000605 extraction Methods 0.000 description 4
• 238000003756 stirring Methods 0.000 description 4
• QXDMQSPYEZFLGF-UHFFFAOYSA-L calcium oxalate Chemical compound [Ca+2].[O-]C(=O)C([O-])=O QXDMQSPYEZFLGF-UHFFFAOYSA-L 0.000 description 3
• 238000001914 filtration Methods 0.000 description 3
• 238000004519 manufacturing process Methods 0.000 description 3
• 239000000203 mixture Substances 0.000 description 3
• 239000000047 product Substances 0.000 description 3
• 150000003839 salts Chemical class 0.000 description 3
• 235000011121 sodium hydroxide Nutrition 0.000 description 3
• 239000002904 solvent Substances 0.000 description 3
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
• 229910021529 ammonia Inorganic materials 0.000 description 2
• 239000002244 precipitate Substances 0.000 description 2
• 125000001453 quaternary ammonium group Chemical group 0.000 description 2
• 150000003242 quaternary ammonium salts Chemical class 0.000 description 2
• 229910000029 sodium carbonate Inorganic materials 0.000 description 2
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
• DEXFNLNNUZKHNO-UHFFFAOYSA-N 6-[3-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperidin-1-yl]-3-oxopropyl]-3H-1,3-benzoxazol-2-one Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C1CCN(CC1)C(CCC1=CC2=C(NC(O2)=O)C=C1)=O DEXFNLNNUZKHNO-UHFFFAOYSA-N 0.000 description 1
• QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
• BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
• 241000282341 Mustela putorius furo Species 0.000 description 1
• VCUFZILGIRCDQQ-KRWDZBQOSA-N N-[[(5S)-2-oxo-3-(2-oxo-3H-1,3-benzoxazol-6-yl)-1,3-oxazolidin-5-yl]methyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C1O[C@H](CN1C1=CC2=C(NC(O2)=O)C=C1)CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F VCUFZILGIRCDQQ-KRWDZBQOSA-N 0.000 description 1
• 239000002253 acid Substances 0.000 description 1
• 230000003115 biocidal effect Effects 0.000 description 1
• 230000015572 biosynthetic process Effects 0.000 description 1
• 229910052799 carbon Inorganic materials 0.000 description 1
• 239000003610 charcoal Substances 0.000 description 1
• 239000012043 crude product Substances 0.000 description 1
• 238000000855 fermentation Methods 0.000 description 1
• 230000004151 fermentation Effects 0.000 description 1
• 239000012065 filter cake Substances 0.000 description 1
• 239000012467 final product Substances 0.000 description 1
• 238000010438 heat treatment Methods 0.000 description 1
• 239000007791 liquid phase Substances 0.000 description 1
• 229910052749 magnesium Inorganic materials 0.000 description 1
• 239000011777 magnesium Substances 0.000 description 1
• 229910021645 metal ion Inorganic materials 0.000 description 1
• 210000003739 neck Anatomy 0.000 description 1
• 230000001376 precipitating effect Effects 0.000 description 1
• 238000000926 separation method Methods 0.000 description 1
• 238000005406 washing Methods 0.000 description 1