BE558454A - - Google Patents
Info
- Publication number
- BE558454A BE558454A BE558454DA BE558454A BE 558454 A BE558454 A BE 558454A BE 558454D A BE558454D A BE 558454DA BE 558454 A BE558454 A BE 558454A
- Authority
- BE
- Belgium
- Prior art keywords
- solution
- monosodium
- enantiomorph
- glutamate
- optically active
- Prior art date
Links
- 239000000243 solution Substances 0.000 claims description 88
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 63
- LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 claims description 50
- 239000000203 mixture Substances 0.000 claims description 43
- 238000000034 method Methods 0.000 claims description 34
- 229960002989 Glutamic Acid Drugs 0.000 claims description 30
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims description 25
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 25
- 239000011780 sodium chloride Substances 0.000 claims description 21
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 20
- 235000013922 glutamic acid Nutrition 0.000 claims description 20
- 239000004220 glutamic acid Substances 0.000 claims description 20
- 150000003839 salts Chemical class 0.000 claims description 19
- 235000013923 monosodium glutamate Nutrition 0.000 claims description 17
- 238000000926 separation method Methods 0.000 claims description 14
- 239000002002 slurry Substances 0.000 claims description 13
- 239000007790 solid phase Substances 0.000 claims description 12
- LPUQAYUQRXPFSQ-AENDTGMFSA-M monosodium D-glutamate Chemical compound [Na+].[O-]C(=O)[C@H]([NH3+])CCC([O-])=O LPUQAYUQRXPFSQ-AENDTGMFSA-M 0.000 claims description 10
- 239000004223 monosodium glutamate Substances 0.000 claims description 10
- 239000007864 aqueous solution Substances 0.000 claims description 9
- PHKGGXPMPXXISP-DFWYDOINSA-N azanium;(4S)-4-amino-5-hydroxy-5-oxopentanoate Chemical class [NH4+].[O-]C(=O)[C@@H]([NH3+])CCC([O-])=O PHKGGXPMPXXISP-DFWYDOINSA-N 0.000 claims description 6
- 150000002307 glutamic acids Chemical class 0.000 claims description 5
- 230000000875 corresponding Effects 0.000 claims description 4
- 239000007787 solid Substances 0.000 claims description 4
- 238000001640 fractional crystallisation Methods 0.000 claims description 3
- 159000000000 sodium salts Chemical class 0.000 claims description 3
- 238000006243 chemical reaction Methods 0.000 claims description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-N hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 claims description 2
- 238000000746 purification Methods 0.000 claims 3
- 238000002156 mixing Methods 0.000 claims 2
- 239000003125 aqueous solvent Substances 0.000 claims 1
- 150000007514 bases Chemical class 0.000 claims 1
- 229920001098 polystyrene-block-poly(ethylene/propylene) Polymers 0.000 description 98
- 239000000047 product Substances 0.000 description 18
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 18
- WHUUTDBJXJRKMK-GSVOUGTGSA-N D-glutamic acid Chemical compound OC(=O)[C@H](N)CCC(O)=O WHUUTDBJXJRKMK-GSVOUGTGSA-N 0.000 description 15
- 239000000706 filtrate Substances 0.000 description 14
- 239000002253 acid Substances 0.000 description 10
- 230000005712 crystallization Effects 0.000 description 10
- 238000002425 crystallisation Methods 0.000 description 9
- 238000001914 filtration Methods 0.000 description 9
- RPAJSBKBKSSMLJ-DFWYDOINSA-N (2S)-2-aminopentanedioic acid;hydrochloride Chemical compound Cl.OC(=O)[C@@H](N)CCC(O)=O RPAJSBKBKSSMLJ-DFWYDOINSA-N 0.000 description 8
- 239000007858 starting material Substances 0.000 description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 235000011121 sodium hydroxide Nutrition 0.000 description 6
- 238000010956 selective crystallization Methods 0.000 description 5
- GJBHGUUFMNITCI-QTNFYWBSSA-M sodium;(2S)-2-aminopentanedioate;hydron;hydrate Chemical compound O.[Na+].OC(=O)[C@@H](N)CCC([O-])=O GJBHGUUFMNITCI-QTNFYWBSSA-M 0.000 description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- 238000010899 nucleation Methods 0.000 description 4
- RPAJSBKBKSSMLJ-AENDTGMFSA-N (2R)-2-aminopentanedioic acid;hydrochloride Chemical compound Cl.OC(=O)[C@H](N)CCC(O)=O RPAJSBKBKSSMLJ-AENDTGMFSA-N 0.000 description 3
- 229940049906 Glutamate Drugs 0.000 description 3
- 238000001704 evaporation Methods 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
- 239000007791 liquid phase Substances 0.000 description 3
- 150000004682 monohydrates Chemical class 0.000 description 3
- LPUQAYUQRXPFSQ-UHFFFAOYSA-M monosodium glutamate Chemical compound [Na+].[O-]C(=O)C(N)CCC(O)=O LPUQAYUQRXPFSQ-UHFFFAOYSA-M 0.000 description 3
- ZMCBEVWKPOJRPQ-QTNFYWBSSA-N (2S)-2-aminopentanedioic acid;azane;hydrate Chemical compound [NH4+].O.OC(=O)[C@@H](N)CCC([O-])=O ZMCBEVWKPOJRPQ-QTNFYWBSSA-N 0.000 description 2
- RPAJSBKBKSSMLJ-UHFFFAOYSA-N 2-aminopentanedioic acid;hydron;chloride Chemical compound Cl.OC(=O)C(N)CCC(O)=O RPAJSBKBKSSMLJ-UHFFFAOYSA-N 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-N Carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N DL-glutamic acid Chemical compound OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 239000008346 aqueous phase Substances 0.000 description 2
- 238000007865 diluting Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L na2so4 Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
- 239000012071 phase Substances 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 238000004064 recycling Methods 0.000 description 2
- 239000012047 saturated solution Substances 0.000 description 2
- 229910001415 sodium ion Inorganic materials 0.000 description 2
- 239000012265 solid product Substances 0.000 description 2
- 238000010189 synthetic method Methods 0.000 description 2
- WHUUTDBJXJRKMK-VKHMYHEASA-M L-glutamate(1-) Chemical compound [O-]C(=O)[C@@H]([NH3+])CCC([O-])=O WHUUTDBJXJRKMK-VKHMYHEASA-M 0.000 description 1
- 150000008539 L-glutamic acids Chemical class 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000002708 enhancing Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000019264 food flavour enhancer Nutrition 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-L glutamate(2-) Chemical compound [O-]C(=O)C(N)CCC([O-])=O WHUUTDBJXJRKMK-UHFFFAOYSA-L 0.000 description 1
- 229960003707 glutamic acid hydrochloride Drugs 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000006011 modification reaction Methods 0.000 description 1
- 239000010413 mother solution Substances 0.000 description 1
- 230000003287 optical Effects 0.000 description 1
- 230000000737 periodic Effects 0.000 description 1
- 239000011833 salt mixture Substances 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- WZWGGYFEOBVNLA-UHFFFAOYSA-N sodium;dihydrate Chemical compound O.O.[Na] WZWGGYFEOBVNLA-UHFFFAOYSA-N 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001131 transforming Effects 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE558454A true BE558454A (es) |
Family
ID=181510
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE558454D BE558454A (es) |
Country Status (1)
| Country | Link |
|---|---|
| BE (1) | BE558454A (es) |
-
0
- BE BE558454D patent/BE558454A/fr unknown
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