BE505771A - - Google Patents
Info
- Publication number
- BE505771A BE505771A BE505771DA BE505771A BE 505771 A BE505771 A BE 505771A BE 505771D A BE505771D A BE 505771DA BE 505771 A BE505771 A BE 505771A
- Authority
- BE
- Belgium
- Prior art keywords
- vitamins
- solution
- column
- vitamin
- ion exchange
- Prior art date
Links
- 239000000243 solution Substances 0.000 claims description 34
- 229940045999 Vitamin B 12 Drugs 0.000 claims description 33
- RMRCNWBMXRMIRW-WYVZQNDMSA-L Vitamin B12 Chemical compound N([C@@H]([C@@]1(C)[C@@](C)(CC(N)=O)[C@H](CCC(N)=O)\C(N1[Co+]C#N)=C(/C)\C1=N\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NCC(C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO RMRCNWBMXRMIRW-WYVZQNDMSA-L 0.000 claims description 33
- 235000013343 vitamin Nutrition 0.000 claims description 33
- 239000011782 vitamin Substances 0.000 claims description 33
- 229930003231 vitamins Natural products 0.000 claims description 33
- 238000000034 method Methods 0.000 claims description 32
- 239000011347 resin Substances 0.000 claims description 32
- 229920005989 resin Polymers 0.000 claims description 32
- 239000012141 concentrate Substances 0.000 claims description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- 229940088594 Vitamin Drugs 0.000 claims description 17
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 17
- 229940029983 VITAMINS Drugs 0.000 claims description 16
- 229940021016 Vitamin IV solution additives Drugs 0.000 claims description 15
- 238000002360 preparation method Methods 0.000 claims description 15
- 239000003456 ion exchange resin Substances 0.000 claims description 14
- 229920003303 ion-exchange polymer Polymers 0.000 claims description 14
- 235000019156 vitamin B Nutrition 0.000 claims description 10
- 239000011720 vitamin B Substances 0.000 claims description 10
- 238000005406 washing Methods 0.000 claims description 9
- 239000003513 alkali Substances 0.000 claims description 8
- CSCPPACGZOOCGX-UHFFFAOYSA-N acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 6
- 239000007864 aqueous solution Substances 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 5
- 125000003277 amino group Chemical group 0.000 claims description 4
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 claims description 2
- 125000001453 quaternary ammonium group Chemical group 0.000 claims description 2
- 230000008929 regeneration Effects 0.000 claims 2
- 238000011069 regeneration method Methods 0.000 claims 2
- 230000001172 regenerating Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 description 18
- 239000000463 material Substances 0.000 description 16
- 239000000047 product Substances 0.000 description 16
- 239000007788 liquid Substances 0.000 description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 8
- 229920001429 Chelating resin Polymers 0.000 description 7
- 238000000746 purification Methods 0.000 description 7
- 239000002994 raw material Substances 0.000 description 7
- 241000152160 Ira Species 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- 239000012535 impurity Substances 0.000 description 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 4
- 238000011084 recovery Methods 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 3
- 238000000862 absorption spectrum Methods 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 3
- 239000001569 carbon dioxide Substances 0.000 description 3
- 229910002092 carbon dioxide Inorganic materials 0.000 description 3
- 238000004587 chromatography analysis Methods 0.000 description 3
- 238000007710 freezing Methods 0.000 description 3
- 230000001264 neutralization Effects 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- 235000011121 sodium hydroxide Nutrition 0.000 description 3
- 239000003463 adsorbent Substances 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 2
- 150000003863 ammonium salts Chemical class 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000012045 crude solution Substances 0.000 description 2
- 230000002349 favourable Effects 0.000 description 2
- 238000005755 formation reaction Methods 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000003472 neutralizing Effects 0.000 description 2
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 2
- 150000004760 silicates Chemical class 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- PRKQVKDSMLBJBJ-UHFFFAOYSA-N Ammonium carbonate Chemical compound N.N.OC(O)=O PRKQVKDSMLBJBJ-UHFFFAOYSA-N 0.000 description 1
- 102000037197 Anion exchangers Human genes 0.000 description 1
- 108091006437 Anion exchangers Proteins 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N Carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 210000001072 Colon Anatomy 0.000 description 1
- 238000010306 acid treatment Methods 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 239000001099 ammonium carbonate Substances 0.000 description 1
- 235000012501 ammonium carbonate Nutrition 0.000 description 1
- 235000019728 animal nutrition Nutrition 0.000 description 1
- 239000003957 anion exchange resin Substances 0.000 description 1
- YOZNUFWCRFCGIH-WZHZPDAFSA-L aquacob(III)alamin Chemical compound C([C@@]1(C)C=2N3[C@H]([C@@H]1CC(N)=O)[C@]1(C)[N+]4=C(C(=C5[N+]6=C([C@H]([C@]5(C)CC(N)=O)CCC(N)=O)C=C5[N+]([Co-3]4363[OH2+])=C([C@H](C5(C)C)CCC(N)=O)C=2C)C)[C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)CC(=O)NC[C@@H](C)OP(=O)([O-])O[C@@H]([C@H]1O)[C@@H](CO)O[C@@H]1N1C2=CC(C)=C(C)C=C2[N+]3=C1 YOZNUFWCRFCGIH-WZHZPDAFSA-L 0.000 description 1
- 229960000074 biopharmaceuticals Drugs 0.000 description 1
- 235000010633 broth Nutrition 0.000 description 1
- 238000005039 chemical industry Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- YOZNUFWCRFCGIH-WZHZPDAFSA-K cobalt(3+);[(2R,3S,4R,5S)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2R)-1-[3-[(1R,2R,3R,4Z,7S,9Z,12S,13S,14Z,17S,18S,19R)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound C([C@@]1(C)C=2N3[C@H]([C@@H]1CC(N)=O)[C@]1(C)[N+]4=C(C(=C5[N+]6=C([C@H]([C@]5(C)CC(N)=O)CCC(N)=O)C=C5[N+]([Co-3]4363O)=C([C@H](C5(C)C)CCC(N)=O)C=2C)C)[C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)CC(=O)NC[C@@H](C)OP(=O)([O-])O[C@@H]([C@H]1O)[C@@H](CO)O[C@@H]1N1C2=CC(C)=C(C)C=C2[N+]3=C1 YOZNUFWCRFCGIH-WZHZPDAFSA-K 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000005712 crystallization Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 239000011147 inorganic material Substances 0.000 description 1
- 239000002198 insoluble material Substances 0.000 description 1
- 230000002906 microbiologic Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000020477 pH reduction Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 235000011118 potassium hydroxide Nutrition 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000012264 purified product Substances 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 239000012260 resinous material Substances 0.000 description 1
- 239000012262 resinous product Substances 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 210000001519 tissues Anatomy 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J47/00—Ion-exchange processes in general; Apparatus therefor
- B01J47/014—Ion-exchange processes in general; Apparatus therefor in which the adsorbent properties of the ion-exchanger are involved, e.g. recovery of proteins or other high-molecular compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE505771A true BE505771A (nl) |
Family
ID=146219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE505771D BE505771A (nl) |
Country Status (1)
| Country | Link |
|---|---|
| BE (1) | BE505771A (nl) |
-
0
- BE BE505771D patent/BE505771A/fr unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0663909B1 (fr) | Procede d'obtention de la desacetyl-10 baccatine iii | |
| FR2538394A1 (fr) | Procede pour la purification de glycosides anthracyclinoniques par adsorption selective sur des resines | |
| WO2004078105A2 (fr) | Composition de fondaparinux sodique de haute purete | |
| CH642947A5 (fr) | Procede de preparation enzymatique du l-tryptophane. | |
| JPH026443A (ja) | Ｌ―リジンのイオン交換回収 | |
| BE505771A (nl) | ||
| FR2624881A1 (fr) | Procede de traitement des minerais, en particulier pour l'extraction du tungstene, tungstene et articles en tungstene obtenus a l'aide de ce procede | |
| BE442963A (nl) | ||
| BE506950A (nl) | ||
| EP2921471A1 (fr) | Procédé d'extraction de l'acide aconitique à partir de produits issus de l'industrie de la canne à sucre | |
| EP0822250B1 (fr) | Procédé d'extraction du 2-phényl éthanol | |
| FR2596756A1 (fr) | Procede de purification de la carnitine | |
| BE544884A (nl) | ||
| EP0296937B1 (fr) | Procédé de séparation d'acides aminés | |
| FR2576589A1 (fr) | Procede de fabrication de carbonate de sodium anhydre dense et carbonate de sodium anhydre dense obtenu par ce procede | |
| FR2541289A1 (fr) | Procede de purification de liquides de fermentation contenant de la vitamine b12 et d'autres corrinoides pour preparer des concentres de vitamine b12 ou la vitamine b12 cristalline | |
| CH277822A (fr) | Procédé pour l'obtention de solutions concentrées de sels de la streptomycine, à partir de solutions diluées de la streptomycine. | |
| BE505856A (nl) | ||
| CH432478A (fr) | Procédé de séparation de composés amino d'un mélange | |
| BE480678A (nl) | ||
| FR2538381A1 (fr) | Procede de recuperation de l'inositol et eventuellement du sorbitol a partir d'extraits aqueux d'enveloppes d'amandes | |
| EP4217110A1 (fr) | Procede de purification avec recyclage des effluents | |
| KR790001457B1 (ko) | 불순물을 함유하는 티오 시안산염 수용액의 정제방법 | |
| BE498533A (nl) | ||
| BE512762A (nl) |