BE1005236A3 - Compositions pharmaceutiques a base de cyclosporines. - Google Patents
Compositions pharmaceutiques a base de cyclosporines. Download PDFInfo
- Publication number
- BE1005236A3 BE1005236A3 BE9000181A BE9000181A BE1005236A3 BE 1005236 A3 BE1005236 A3 BE 1005236A3 BE 9000181 A BE9000181 A BE 9000181A BE 9000181 A BE9000181 A BE 9000181A BE 1005236 A3 BE1005236 A3 BE 1005236A3
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- Belgium
- Prior art keywords
- sep
- components
- fatty acids
- component
- acid
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 18
- 229960001265 ciclosporin Drugs 0.000 title claims description 99
- 108010036949 Cyclosporine Proteins 0.000 title claims description 92
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title claims description 91
- 229930182912 cyclosporin Natural products 0.000 title claims description 69
- 229930105110 Cyclosporin A Natural products 0.000 title description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 99
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- 239000000194 fatty acid Substances 0.000 claims abstract description 67
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898903804A GB8903804D0 (en) | 1989-02-20 | 1989-02-20 | Improvements in or relating to organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE1005236A3 true BE1005236A3 (fr) | 1993-06-08 |
Family
ID=10651981
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE9000181A BE1005236A3 (fr) | 1989-02-20 | 1990-02-19 | Compositions pharmaceutiques a base de cyclosporines. |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPH0611703B2 (cg-RX-API-DMAC7.html) |
| BE (1) | BE1005236A3 (cg-RX-API-DMAC7.html) |
| CH (1) | CH680650A5 (cg-RX-API-DMAC7.html) |
| CY (1) | CY1886A (cg-RX-API-DMAC7.html) |
| DE (1) | DE4005190A1 (cg-RX-API-DMAC7.html) |
| FR (1) | FR2643262B1 (cg-RX-API-DMAC7.html) |
| GB (2) | GB8903804D0 (cg-RX-API-DMAC7.html) |
| HK (1) | HK149595A (cg-RX-API-DMAC7.html) |
| IT (1) | IT1240765B (cg-RX-API-DMAC7.html) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5639724A (en) | 1984-07-24 | 1997-06-17 | Sandoz Ltd. | Cyclosporin galenic forms |
| GB8904182D0 (en) * | 1989-02-23 | 1989-04-05 | Glaxo Canada | Pharmaceutical compositions |
| HU208491B (en) * | 1990-11-27 | 1993-11-29 | Gyogyszerkutato Intezet | Process for producing oral pharmaceutical composition containing cyclosporin |
| IL102236A0 (en) * | 1991-06-27 | 1993-01-14 | Ltt Inst Co Ltd | Topical preparations containing cyclosporin |
| US6262022B1 (en) | 1992-06-25 | 2001-07-17 | Novartis Ag | Pharmaceutical compositions containing cyclosporin as the active agent |
| GB9113872D0 (en) * | 1991-06-27 | 1991-08-14 | Sandoz Ag | Improvements in or relating to organic compounds |
| AU688920B2 (en) * | 1991-06-27 | 1998-03-19 | Novartis Ag | Transesterified corn oil products |
| ES2098739T3 (es) | 1992-05-13 | 1997-05-01 | Sandoz Ltd | Composiciones oftalmicas conteniendo una cyclosporin. |
| US5759566A (en) * | 1992-07-28 | 1998-06-02 | Poli Industria Chimica Spa | Microemulsion pharmaceutical compositions for the delivery of pharmaceutically active agents |
| EP0589843B1 (en) * | 1992-09-25 | 2001-11-28 | Novartis AG | Pharmaceutical compositions containing cyclosporins |
| DE4310643A1 (de) * | 1993-04-01 | 1994-10-06 | Merck Patent Gmbh | Cyclische Adhäsionsinhibitoren |
| CZ291237B6 (cs) † | 1993-04-20 | 2003-01-15 | Novartis Ag | Farmaceutický přípravek pro orální podání obsahující cyklosporin A |
| DE4412201A1 (de) * | 1993-04-20 | 1994-11-10 | Rentschler Arzneimittel | Neue pharmazeutische Zubereitungen zur oralen Verabreichung enthaltend Cyclosporin |
| NZ247516A (en) * | 1993-04-28 | 1995-02-24 | Bernard Charles Sherman | Water dispersible pharmaceutical compositions comprising drug dissolved in solvent system comprising at least one alcohol and at least one surfactant |
| DE4322826A1 (de) * | 1993-07-08 | 1995-01-12 | Galenik Labor Freiburg Gmbh | Pharmazeutisches Präparat |
| DE4340781C3 (de) * | 1993-11-30 | 2000-01-27 | Novartis Ag | Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung |
| EP0694308A4 (en) * | 1994-02-17 | 1997-09-10 | Shiseido Co Ltd | CYCLOSPORIN EMULSION COMPOSITION |
| US5891846A (en) * | 1994-02-17 | 1999-04-06 | Shiseido Company, Ltd. | Cyclosporin-containing emulsion composition |
| GB9405304D0 (en) * | 1994-03-16 | 1994-04-27 | Scherer Ltd R P | Delivery systems for hydrophobic drugs |
| US5474979A (en) * | 1994-05-17 | 1995-12-12 | Allergan, Inc. | Nonirritating emulsions for sensitive tissue |
| US5739105A (en) * | 1994-06-01 | 1998-04-14 | Yuhan Corporation | Cyclosporin containing composition and process for the preparation thereof |
| ES2177652T3 (es) | 1994-11-03 | 2002-12-16 | Novartis Ag | Nuevas formas de preparacion de ciclosporina para la aplicacion oral con composicion simple y alta biodisponibilidad, y procedimiento para su obtencion. |
| US5603951A (en) * | 1994-11-09 | 1997-02-18 | Hanmi Pharm. Ind. Co., Ltd. | Cyclosporin-containing soft capsule compositions |
| KR0167613B1 (ko) * | 1994-12-28 | 1999-01-15 | 한스 루돌프 하우스, 니콜 케르커 | 사이클로스포린-함유 연질캅셀제 조성물 |
| US5834017A (en) * | 1995-08-25 | 1998-11-10 | Sangstat Medical Corporation | Oral cyclopsporin formulations |
| US5766629A (en) * | 1995-08-25 | 1998-06-16 | Sangstat Medical Corporation | Oral cyclosporin formulations |
| US5962019A (en) * | 1995-08-25 | 1999-10-05 | Sangstat Medical Corporation | Oral cyclosporin formulations |
| US5827822A (en) * | 1996-03-25 | 1998-10-27 | Sangstat Medical Corporation | Cyclosporin a formulations as nanoparticles |
| DE19544507B4 (de) | 1995-11-29 | 2007-11-15 | Novartis Ag | Cyclosporin enthaltende Präparate |
| CZ288631B6 (cs) * | 1996-01-18 | 2001-08-15 | Galena, A. S. | Léčivé přípravky s obsahem cyklosporinu |
| US5858401A (en) | 1996-01-22 | 1999-01-12 | Sidmak Laboratories, Inc. | Pharmaceutical composition for cyclosporines |
| EP1331002A3 (en) | 1997-01-30 | 2004-01-14 | Novartis AG | Oil-free pharmaceutical compositions containing cyclosporin A |
| PL193414B1 (pl) * | 1997-03-12 | 2007-02-28 | Abbott Lab | Dwuskładnikowa kompozycja farmaceutyczna do podawania cyklosporyny |
| JP2001515491A (ja) * | 1997-03-12 | 2001-09-18 | アボツト・ラボラトリーズ | 親油性化合物の投与のための親油性二成分系 |
| US6121313A (en) | 1997-07-29 | 2000-09-19 | Pharmacia & Upjohn Company | Pharmaceutical composition in a form of self-emulsifying formulation for lipophilic compounds |
| RU2202346C2 (ru) * | 1997-07-29 | 2003-04-20 | Фармация Энд Апджон Компани | Фармацевтическая композиция для кислотных липофильных соединений в форме самоэмульгирующейся композиции |
| US6346511B1 (en) | 1997-09-08 | 2002-02-12 | Panacea Biotec Limited | Pharmaceutical composition comprising cyclosporin |
| US6187747B1 (en) | 1997-09-08 | 2001-02-13 | Panacea Biotech Limited | Pharmaceutical composition comprising cyclosporin |
| US6008191A (en) * | 1997-09-08 | 1999-12-28 | Panacea Biotec Limited | Pharmaceutical compositions containing cyclosporin |
| US5981607A (en) * | 1998-01-20 | 1999-11-09 | Allergan | Emulsion eye drop for alleviation of dry eye related symptoms in dry eye patients and/or contact lens wearers |
| ID25908A (id) * | 1998-03-06 | 2000-11-09 | Novartis Ag | Prakonsentrat-prakonsentrat emulsi yang mengandung siklosporin atau makrolida |
| DE19859910C2 (de) * | 1998-12-23 | 2001-03-22 | Ratiopharm Gmbh | Orales Arzneimittel |
| US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| GB9912476D0 (en) | 1999-05-28 | 1999-07-28 | Novartis Ag | Organic compounds |
| WO2001032143A1 (en) * | 1999-11-02 | 2001-05-10 | Cipla Ltd. | A pharmaceutical composition for the administration of water-insoluble pharmaceutically active substances and a process for preparation thereof |
| GB2362573A (en) * | 2000-05-25 | 2001-11-28 | Cipla Ltd | Cyclosporin formulation |
| ATE290876T1 (de) * | 2000-05-04 | 2005-04-15 | Panacea Biotec Ltd | Pharmazeutische zusammensetzung enthaltend cyclosprin als aktiven bestandteil |
| DE10030378A1 (de) * | 2000-06-21 | 2002-03-14 | Audit Inst For Medical Service | Neue pharmazeutische Zusammensetzung zur topischen Anwendung von wasserunlöslichen und/oder schwer wasserlöslichen Wirkstoffen |
| DE60233150D1 (de) | 2001-10-19 | 2009-09-10 | Isotechnika Inc | Neue cyclosporin-analoge mikroemulsionsvorkonzentrate |
| US6979672B2 (en) | 2002-12-20 | 2005-12-27 | Polichem, S.A. | Cyclosporin-based pharmaceutical compositions |
| JP4381037B2 (ja) | 2003-06-04 | 2009-12-09 | 花王株式会社 | 油脂組成物 |
| WO2006102157A1 (en) * | 2005-03-21 | 2006-09-28 | Ivax Pharmaceuticals S.R.O. | Crystallization inhibitor and its use in gelatin capsules |
| US8492369B2 (en) | 2010-04-12 | 2013-07-23 | Clarus Therapeutics Inc | Oral testosterone ester formulations and methods of treating testosterone deficiency comprising same |
| AU2006236564B2 (en) | 2005-04-15 | 2011-02-17 | Besins Healthcare Luxembourg S.A.R.L. | Pharmaceutical delivery systems for hydrophobic drugs and compositions comprising same |
| FR2914188B1 (fr) * | 2007-03-28 | 2012-06-22 | Trophos | Nouvelle composition a base d'oxime de cholest-4-en-3-one |
| GB2451811A (en) | 2007-08-09 | 2009-02-18 | Ems Sa | Delivery composition for solubilising water-insoluble pharmaceutical active ingredients |
| US11304960B2 (en) | 2009-01-08 | 2022-04-19 | Chandrashekar Giliyar | Steroidal compositions |
| CA2690490C (en) * | 2010-01-19 | 2012-06-26 | Accucaps Industries Limited | Pharmaceutical formulations of loratadine for encapsulation and combinations thereof |
| US20180153904A1 (en) | 2010-11-30 | 2018-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
| US9358241B2 (en) | 2010-11-30 | 2016-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
| US9034858B2 (en) | 2010-11-30 | 2015-05-19 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
| US20120148675A1 (en) | 2010-12-10 | 2012-06-14 | Basawaraj Chickmath | Testosterone undecanoate compositions |
| WO2015108045A1 (ja) * | 2014-01-16 | 2015-07-23 | マルホ株式会社 | 経皮投与用外用剤 |
| US20170246187A1 (en) | 2014-08-28 | 2017-08-31 | Lipocine Inc. | (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE |
| US9498485B2 (en) | 2014-08-28 | 2016-11-22 | Lipocine Inc. | Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters |
| WO2016205423A2 (en) | 2015-06-15 | 2016-12-22 | Lipocine Inc. | Composition and method for oral delivery of androgen prodrugs |
| US11559530B2 (en) | 2016-11-28 | 2023-01-24 | Lipocine Inc. | Oral testosterone undecanoate therapy |
| JP2021531348A (ja) | 2018-07-20 | 2021-11-18 | リポシン，インク． | 肝臓病 |
| AU2020270985A1 (en) | 2019-04-11 | 2021-12-09 | Pfizer Ireland Pharmaceuticals | Formulation for oral delivery of proteins, peptides and small molecules with poor permeability |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4388307A (en) * | 1978-03-07 | 1983-06-14 | Sandoz Ltd. | Galenical compositions |
| BE895724A (fr) * | 1982-02-01 | 1983-07-28 | Sandoz Sa | Nouvelle utilisation therapeutique de la dihydrocyclosporine d |
| CH641356A5 (en) * | 1979-02-27 | 1984-02-29 | Sandoz Ag | Pharmaceutical compositions containing cyclosporin |
-
1989
- 1989-02-20 GB GB898903804A patent/GB8903804D0/en active Pending
-
1990
- 1990-02-16 GB GB9003616A patent/GB2228198B/en not_active Expired - Lifetime
- 1990-02-16 CH CH504/90A patent/CH680650A5/de not_active IP Right Cessation
- 1990-02-19 BE BE9000181A patent/BE1005236A3/fr not_active IP Right Cessation
- 1990-02-19 DE DE4005190A patent/DE4005190A1/de not_active Ceased
- 1990-02-19 JP JP2038168A patent/JPH0611703B2/ja not_active Expired - Lifetime
- 1990-02-19 FR FR9002086A patent/FR2643262B1/fr not_active Expired - Lifetime
- 1990-02-20 IT IT47650A patent/IT1240765B/it active IP Right Grant
-
1995
- 1995-09-21 HK HK149595A patent/HK149595A/xx not_active IP Right Cessation
-
1996
- 1996-04-05 CY CY188696A patent/CY1886A/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4388307A (en) * | 1978-03-07 | 1983-06-14 | Sandoz Ltd. | Galenical compositions |
| CH641356A5 (en) * | 1979-02-27 | 1984-02-29 | Sandoz Ag | Pharmaceutical compositions containing cyclosporin |
| BE895724A (fr) * | 1982-02-01 | 1983-07-28 | Sandoz Sa | Nouvelle utilisation therapeutique de la dihydrocyclosporine d |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0611703B2 (ja) | 1994-02-16 |
| GB2228198A (en) | 1990-08-22 |
| DE4005190A1 (de) | 1990-08-23 |
| IT9047650A1 (it) | 1990-08-21 |
| GB9003616D0 (en) | 1990-04-11 |
| JPH02255623A (ja) | 1990-10-16 |
| GB8903804D0 (en) | 1989-04-05 |
| FR2643262B1 (fr) | 1993-06-11 |
| CH680650A5 (cg-RX-API-DMAC7.html) | 1992-10-15 |
| IT9047650A0 (it) | 1990-02-20 |
| CY1886A (en) | 1996-04-05 |
| FR2643262A1 (fr) | 1990-08-24 |
| HK149595A (en) | 1995-09-29 |
| GB2228198B (en) | 1992-12-16 |
| IT1240765B (it) | 1993-12-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RE20 | Patent expired |
Owner name: *NOVARTIS A.G. Effective date: 20100219 |