AU782469B2 - Improved pharmaceutical compositions for poorly soluble drugs - Google Patents

Improved pharmaceutical compositions for poorly soluble drugs Download PDF

Info

Publication number
AU782469B2
AU782469B2 AU72529/00A AU7252900A AU782469B2 AU 782469 B2 AU782469 B2 AU 782469B2 AU 72529/00 A AU72529/00 A AU 72529/00A AU 7252900 A AU7252900 A AU 7252900A AU 782469 B2 AU782469 B2 AU 782469B2
Authority
AU
Australia
Prior art keywords
pharmaceutical composition
drug
composition according
suspension
polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU72529/00A
Other languages
English (en)
Other versions
AU7252900A (en
Inventor
David Hayes
Angelo Mario Morella
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mayne Pharma International Pty Ltd
Original Assignee
FH Faulding and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25646230&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU782469(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from AUPQ4854A external-priority patent/AUPQ485499A0/en
Priority claimed from AUPQ7450A external-priority patent/AUPQ745000A0/en
Application filed by FH Faulding and Co Ltd filed Critical FH Faulding and Co Ltd
Priority to AU72529/00A priority Critical patent/AU782469B2/en
Publication of AU7252900A publication Critical patent/AU7252900A/en
Application granted granted Critical
Publication of AU782469B2 publication Critical patent/AU782469B2/en
Assigned to MAYNE PHARMA INTERNATIONAL PTY LTD reassignment MAYNE PHARMA INTERNATIONAL PTY LTD Request to Amend Deed and Register Assignors: F.H. FAULDING & CO. LIMITED
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
AU72529/00A 1999-12-23 2000-12-22 Improved pharmaceutical compositions for poorly soluble drugs Expired AU782469B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU72529/00A AU782469B2 (en) 1999-12-23 2000-12-22 Improved pharmaceutical compositions for poorly soluble drugs

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AUPQ4854 1999-12-23
AUPQ4854A AUPQ485499A0 (en) 1999-12-23 1999-12-23 Improved pharmaceutical compositions for poorly soluble drugs
AUPQ7450 2000-05-12
AUPQ7450A AUPQ745000A0 (en) 2000-05-12 2000-05-12 Improved pharmaceutical compositions for poorly soluble drugs
AU72529/00A AU782469B2 (en) 1999-12-23 2000-12-22 Improved pharmaceutical compositions for poorly soluble drugs

Publications (2)

Publication Number Publication Date
AU7252900A AU7252900A (en) 2001-06-28
AU782469B2 true AU782469B2 (en) 2005-08-04

Family

ID=25646230

Family Applications (2)

Application Number Title Priority Date Filing Date
AU72529/00A Expired AU782469B2 (en) 1999-12-23 2000-12-22 Improved pharmaceutical compositions for poorly soluble drugs
AU23318/01A Abandoned AU2331801A (en) 1999-12-23 2000-12-22 Improved pharmaceutical compositions for poorly soluble drugs

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU23318/01A Abandoned AU2331801A (en) 1999-12-23 2000-12-22 Improved pharmaceutical compositions for poorly soluble drugs

Country Status (8)

Country Link
US (3) US20030086976A1 (enExample)
EP (2) EP1239831B1 (enExample)
JP (2) JP5159012B2 (enExample)
AU (2) AU782469B2 (enExample)
CA (1) CA2396380C (enExample)
ES (1) ES2398643T3 (enExample)
PT (1) PT1239831E (enExample)
WO (1) WO2001047492A1 (enExample)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US20030236236A1 (en) * 1999-06-30 2003-12-25 Feng-Jing Chen Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
EP1239831B1 (en) * 1999-12-23 2012-10-31 Mayne Pharma International Pty Ltd. Improved pharmaceutical compositions for poorly soluble drugs
GB0012448D0 (en) 2000-05-24 2000-07-12 Astrazeneca Ab New process
DE10026698A1 (de) 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
GB0015239D0 (en) * 2000-06-21 2000-08-16 Biochemie Gmbh Organic compounds
GB0104752D0 (en) * 2001-02-27 2001-04-18 Astrazeneca Ab Pharmaceutical compositions
MXPA03011935A (es) * 2001-06-22 2004-03-26 Pfizer Prod Inc Composiciones farmaceuticas que contienen conjuntos de polimero y farmaco.
KR100664822B1 (ko) 2002-02-01 2007-01-04 화이자 프로덕츠 인코포레이티드 변형된 분무-건조 장치를 이용한 균질한 분무-건조된 고체비결정성 약물 분산액의 제조 방법
US7259186B2 (en) * 2002-12-17 2007-08-21 Abbott Laboratories Salts of fenofibric acid and pharmaceutical formulations thereof
US20080051411A1 (en) * 2002-12-17 2008-02-28 Cink Russell D Salts of Fenofibric Acid and Pharmaceutical Formulations Thereof
ES2286486T3 (es) * 2002-12-17 2007-12-01 ABBOTT GMBH & CO. KG Formulacion que comprende acido fenofibrico, una sal o un derivado fisiologicamente aceptables del mismo.
US20040115287A1 (en) * 2002-12-17 2004-06-17 Lipocine, Inc. Hydrophobic active agent compositions and methods
CL2004001884A1 (es) * 2003-08-04 2005-06-03 Pfizer Prod Inc Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros.
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US8025899B2 (en) * 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
US20060003002A1 (en) * 2003-11-03 2006-01-05 Lipocine, Inc. Pharmaceutical compositions with synchronized solubilizer release
US7507823B2 (en) 2004-05-06 2009-03-24 Bristol-Myers Squibb Company Process of making aripiprazole particles
US20080152714A1 (en) * 2005-04-08 2008-06-26 Yi Gao Pharmaceutical Formulations
JP2007308480A (ja) * 2006-04-20 2007-11-29 Shin Etsu Chem Co Ltd 腸溶性固体分散体を含んでなる固形製剤
US20070275052A1 (en) * 2006-05-24 2007-11-29 Glenmark Pharmaceuticals Limited Pharmaceutical compositions containing sterol inhibitors
MX2009000035A (es) * 2006-06-26 2009-05-28 Mutual Pharmaceutical Co Formulaciones de agente activo, procedimientos de preparacion y procedimientos de uso.
US8946200B2 (en) * 2006-11-02 2015-02-03 Southwest Research Institute Pharmaceutically active nanosuspensions
KR100954828B1 (ko) * 2006-12-22 2010-04-27 주식회사유한양행 레바프라잔 함유 고체분산체 및 그의 제조방법
EP2134327A1 (en) * 2007-03-13 2009-12-23 Sandoz AG Pharmaceutical compositions of poorly soluble drugs
EP2257220B1 (en) * 2008-03-13 2017-06-14 Liebel-Flarsheim Company LLC Multi-function, foot-activated controller for imaging system
US8404850B2 (en) * 2008-03-13 2013-03-26 Southwest Research Institute Bis-quaternary pyridinium-aldoxime salts and treatment of exposure to cholinesterase inhibitors
AU2009236290A1 (en) * 2008-04-15 2009-10-22 Merck Sharp & Dohme Corp. Oral pharmaceutical compositions in a solid dispersion comprising preferably posaconazole and HPMCAS
CN104983701A (zh) * 2008-04-15 2015-10-21 默沙东公司 优选含有泊沙康唑和hpmcas的固体分散体形式的口服药物组合物
US8722706B2 (en) * 2008-08-15 2014-05-13 Southwest Research Institute Two phase bioactive formulations of bis-quaternary pyridinium oxime sulfonate salts
US8309134B2 (en) * 2008-10-03 2012-11-13 Southwest Research Institute Modified calcium phosphate nanoparticle formation
US20100159010A1 (en) * 2008-12-24 2010-06-24 Mutual Pharmaceutical Company, Inc. Active Agent Formulations, Methods of Making, and Methods of Use
US11304960B2 (en) 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
AR077975A1 (es) 2009-08-28 2011-10-05 Irm Llc Derivados de pirazol pirimidina y composiciones como inhibidores de cinasa de proteina
US9028873B2 (en) * 2010-02-08 2015-05-12 Southwest Research Institute Nanoparticles for drug delivery to the central nervous system
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
WO2013078264A1 (en) 2011-11-23 2013-05-30 Novartis Ag Pharmaceutical formulations
US9650851B2 (en) 2012-06-18 2017-05-16 Schlumberger Technology Corporation Autonomous untethered well object
WO2013192566A1 (en) 2012-06-21 2013-12-27 Mayne Pharma International Pty. Ltd. Itraconazole compositions and dosage forms, and methods of using the same
US9192609B2 (en) * 2013-04-17 2015-11-24 Hedgepath Pharmaceuticals, Inc. Treatment and prognostic monitoring of proliferation disorders using hedgehog pathway inhibitors
EP2837391B1 (en) 2013-08-12 2017-05-10 Shin-Etsu Chemical Co., Ltd. Hypromellose acetate succinate for use as hot-melt extrusion carrier, hot-melt extrusion composition, and method for producing hot-melt extrudate
CN104644557B (zh) * 2013-11-22 2017-10-31 上海宣泰医药科技有限公司 卟啉铁固体分散体及其制备方法
US20170246187A1 (en) 2014-08-28 2017-08-31 Lipocine Inc. (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
US9498485B2 (en) 2014-08-28 2016-11-22 Lipocine Inc. Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters
US12133911B2 (en) 2015-06-09 2024-11-05 Capsugel Belgium Nv Formulations to achieve rapid dissolution of drug from spray-dried dispersions in capsules
US20160361322A1 (en) 2015-06-15 2016-12-15 Lipocine Inc. Composition and method for oral delivery of androgen prodrugs
US20180147215A1 (en) 2016-11-28 2018-05-31 Lipocine Inc. Oral testosterone undecanoate therapy
JP2020506905A (ja) * 2017-01-20 2020-03-05 コンステレーション・ファーマシューティカルズ・インコーポレイテッドＣｏｎｓｔｅｌｌａｔｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． （ｒ）−ｎ−（（４−メトキシ−６−メチル−２−オキソ−１，２−ジヒドロピリジン−３−イル）メチル）−２−メチル−１−（１−（１−（２，２，２−トリフルオロエチル）ピペリジン−４−イル）エチル）−１ｈ−インドール−３−カルボキサミド固体分散液
CA3073228A1 (en) 2017-08-20 2019-02-28 University Of Connecticut Azole analogues and methods of use thereof
US12150945B2 (en) 2018-07-20 2024-11-26 Lipocine Inc. Liver disease
WO2020159562A1 (en) 2019-01-29 2020-08-06 Slayback Pharma Llc Pharmaceutical compositions of posaconazole
US11318107B2 (en) 2019-02-22 2022-05-03 Avior, Inc. Pharmaceutical active-containing film delivery device for oral transmucosal administration
WO2021030174A1 (en) 2019-08-09 2021-02-18 University Of Connecticut Truncated itraconazole analogues and methods of use thereof
PH12022550492A1 (en) * 2019-08-28 2022-12-19 Shenzhen Chipscreen Biosciences Co Ltd Chidamide pharmaceutical composition, preparation method therefor and application thereof
CN115768779A (zh) 2020-05-07 2023-03-07 上海偕怡医药科技有限公司 伊曲康唑前药及其用途
EP4452232A1 (en) * 2021-12-22 2024-10-30 Palau Pharma, S.L.U. Multiparticulate albaconazole composition

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5340591A (en) * 1992-01-24 1994-08-23 Fujisawa Pharmaceutical Co., Ltd. Method of producing a solid dispersion of the sparingly water-soluble drug, nilvadipine
WO1998000113A1 (en) * 1996-06-28 1998-01-08 Schering Corporation Solid solution of an antifungal agent with enhanced bioavailability

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02167219A (ja) * 1988-12-20 1990-06-27 Fujisawa Pharmaceut Co Ltd 固体分散体の製造方法
JP3110794B2 (ja) 1991-06-05 2000-11-20 ユーシービージャパン株式会社 １，４−ジヒドロピリジン誘導体を含有する製剤
PH30929A (en) * 1992-09-03 1997-12-23 Janssen Pharmaceutica Nv Beads having a core coated with an antifungal and a polymer.
WO1997004782A1 (en) * 1995-07-26 1997-02-13 Kyowa Hakko Kogyo Co., Ltd. Solid dispersion or solid dispersion preparation of xanthine derivatives
DK0904060T3 (da) * 1996-05-20 2004-04-13 Janssen Pharmaceutica Nv Antifungale præparater med forbedret biotilgængelighed
DK0901786T3 (da) * 1997-08-11 2007-10-08 Pfizer Prod Inc Faste farmaceutiske dispersioner med foröget biotilgængelighed
EP1039909B1 (en) * 1997-12-31 2002-10-09 Choongwae Pharma Corporation Method of production and composition of an oral preparation of itraconazole
KR100336090B1 (ko) * 1998-06-27 2002-05-27 윤승원 오일, 지방산 또는 이들의 혼합물을 함유한 난용성 약물의 고형분산제제
DE19843904A1 (de) * 1998-09-24 2000-03-30 Basf Ag Feste Dosierungsform mit polymerem Bindemittel
JP2002534371A (ja) * 1999-01-06 2002-10-15 コリア リサーチ インスティテュート オブ ケミカル テクノロジー 水不溶性薬物を含む医薬的活性成分の製造方法及びそれを含む経口投与用医薬組成物
EP1027886B1 (en) * 1999-02-10 2008-07-09 Pfizer Products Inc. Pharmaceutical solid dispersions
EP1239831B1 (en) * 1999-12-23 2012-10-31 Mayne Pharma International Pty Ltd. Improved pharmaceutical compositions for poorly soluble drugs

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5340591A (en) * 1992-01-24 1994-08-23 Fujisawa Pharmaceutical Co., Ltd. Method of producing a solid dispersion of the sparingly water-soluble drug, nilvadipine
WO1998000113A1 (en) * 1996-06-28 1998-01-08 Schering Corporation Solid solution of an antifungal agent with enhanced bioavailability

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KAI, T ET AL. CHEM. PHARM. BULL. VOL 44(3) (1996) PP 568-571 *

Also Published As

Publication number Publication date
CA2396380C (en) 2015-04-21
CA2396380A1 (en) 2001-07-05
US20080260835A1 (en) 2008-10-23
US20030086976A1 (en) 2003-05-08
PT1239831E (pt) 2013-01-23
EP1239831B1 (en) 2012-10-31
US20030225104A1 (en) 2003-12-04
ES2398643T3 (es) 2013-03-20
AU7252900A (en) 2001-06-28
EP1239831A1 (en) 2002-09-18
EP2415462A1 (en) 2012-02-08
JP2003518483A (ja) 2003-06-10
US6881745B2 (en) 2005-04-19
WO2001047492A1 (en) 2001-07-05
EP1239831A4 (en) 2009-07-22
US8771739B2 (en) 2014-07-08
JP2012236837A (ja) 2012-12-06
JP5159012B2 (ja) 2013-03-06
AU2331801A (en) 2001-07-09

Similar Documents

Publication Publication Date Title
CA2396380C (en) Improved pharmaceutical compositions for poorly soluble drugs
JP2003505509A (ja) β−カルボリン製薬組成物
AU2007338359B2 (en) Pharmaceutical formulation comprising neurokinin antagonist
BG106764A (bg) Фармацевтични състави, осигуряващи повишени концентрации на лекарственото средство
CA2393737A1 (en) Compositions containing itraconazole with improved bioavailability and narrow intra- and inter-individual variation of its absorption
AU2024203208B2 (en) Pharmaceutical compostion containing acetominophen and ibuprofen
JP2003516347A (ja) 時間療法用ジルチアゼム製剤およびその投与法
EP1154762A1 (en) Pharmaceutical capsule compositions containing loratadine and pseudoephedrine
PT1178780E (pt) Formulações de inibidores selectivos da reassimilação de serotonina, de libertação controlada e multiparticularidades
JP2018508501A (ja) タムスロシン塩酸塩含有徐放性顆粒を含む経口用薬剤学的製剤
TW202435886A (zh) 米爾維仙(milvexian)醫藥組合物
WO2025122074A1 (en) Low dose riociguat compositions
NZ788137A (en) A medicament and method for treating pain
BR112019000848B1 (pt) Formulações de gama-hidroxibutirato únicas noturnas

Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired