AU7668696A - Methods and compositions for the reduction of xenotransplantation rejection - Google Patents

Methods and compositions for the reduction of xenotransplantation rejection

Info

Publication number
AU7668696A
AU7668696A AU76686/96A AU7668696A AU7668696A AU 7668696 A AU7668696 A AU 7668696A AU 76686/96 A AU76686/96 A AU 76686/96A AU 7668696 A AU7668696 A AU 7668696A AU 7668696 A AU7668696 A AU 7668696A
Authority
AU
Australia
Prior art keywords
transgenic
cells
cell
galactosidase
gal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU76686/96A
Other languages
English (en)
Inventor
Robert J Desnick
Yiannis Ioannou
Ian F.C. Mckenzie
Mauro S. Sandrin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Austin Research Institute
Mount Sinai Medical Center
Original Assignee
Austin Research Institute
Mount Sinai Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Austin Research Institute, Mount Sinai Medical Center filed Critical Austin Research Institute
Publication of AU7668696A publication Critical patent/AU7668696A/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • A01K67/0275Genetically modified vertebrates, e.g. transgenic
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/24Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2465Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1) acting on alpha-galactose-glycoside bonds, e.g. alpha-galactosidase (3.2.1.22)
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU76686/96A 1995-11-03 1996-11-01 Methods and compositions for the reduction of xenotransplantation rejection Abandoned AU7668696A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US620095P 1995-11-03 1995-11-03
US006200 1995-11-03
PCT/US1996/017695 WO1997016064A1 (fr) 1995-11-03 1996-11-01 Procedes et compositions de reduction du rejet de xenogreffe

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU69707/00A Division AU6970700A (en) 1995-11-03 2000-11-03 Method and compositions for the reduction of xenotransplantation rejection

Publications (1)

Publication Number Publication Date
AU7668696A true AU7668696A (en) 1997-05-22

Family

ID=21719767

Family Applications (1)

Application Number Title Priority Date Filing Date
AU76686/96A Abandoned AU7668696A (en) 1995-11-03 1996-11-01 Methods and compositions for the reduction of xenotransplantation rejection

Country Status (5)

Country Link
EP (1) EP0877549A4 (fr)
JP (1) JP2000514641A (fr)
AU (1) AU7668696A (fr)
IL (1) IL124293A0 (fr)
WO (1) WO1997016064A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999021415A1 (fr) * 1997-10-28 1999-05-06 Stem Cell Sciences Pty. Ltd. Transfert nucleaire pour la production d'un embryon d'animal transgenique
US6399578B1 (en) 1998-12-09 2002-06-04 La Jolla Pharmaceutical Company Conjugates comprising galactose α1,3 galactosyl epitopes and methods of using same
US7547522B2 (en) 2002-08-14 2009-06-16 Immerge Biotherapeutics, Inc. Method to enrich for α(1,3)-galactosyltransferase null pig cells
ES2338111T3 (es) 2002-08-21 2010-05-04 Revivicor, Inc. Animales porcinos que carecen de cualquier expresion de alfa 1,3 galactosiltransferasa funcional.
WO2005047469A2 (fr) 2003-11-05 2005-05-26 University Of Pittsburgh Proteine isogloboside 3 synthase porcine, adnc, organisation genomique, et region regulatrice
JP2007529278A (ja) 2004-03-17 2007-10-25 レビビコア, インコーポレイテッド 機能的α1,3ガラクトシルトランスフェラーゼを欠く動物に由来する組織生成物
AU2010278290A1 (en) 2009-07-30 2012-02-09 F. Hoffmann-La Roche Ag Enzymatic antibody processing
US9420770B2 (en) 2009-12-01 2016-08-23 Indiana University Research & Technology Corporation Methods of modulating thrombocytopenia and modified transgenic pigs
JP5941049B2 (ja) 2010-10-05 2016-06-29 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft ヒトtweakに対する抗体およびその使用
SG2014012470A (en) 2011-10-05 2014-06-27 Hoffmann La Roche Process for antibody g1 glycoform production

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5356804A (en) * 1990-10-24 1994-10-18 Mount Sinai School Of Medicine Of The City Of New York Cloning and expression of biologically active human α-galactosidase A
EP0755402B1 (fr) * 1994-04-13 2008-05-14 Biotransplant, Inc Porc negatif pour l'alpha(1,3) galactosyltranferase
JPH10504707A (ja) * 1994-06-15 1998-05-12 アレクション・ファーマシューティカル・インク 異種移植片の超急性拒否反応を減少させる方法

Also Published As

Publication number Publication date
JP2000514641A (ja) 2000-11-07
EP0877549A1 (fr) 1998-11-18
WO1997016064A1 (fr) 1997-05-09
IL124293A0 (en) 1998-12-06
EP0877549A4 (fr) 2002-01-02

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Legal Events

Date Code Title Description
MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted