IL124293A0 - Method and compositions for the reduction of xenotransplantation rejection - Google Patents

Method and compositions for the reduction of xenotransplantation rejection

Info

Publication number
IL124293A0
IL124293A0 IL12429396A IL12429396A IL124293A0 IL 124293 A0 IL124293 A0 IL 124293A0 IL 12429396 A IL12429396 A IL 12429396A IL 12429396 A IL12429396 A IL 12429396A IL 124293 A0 IL124293 A0 IL 124293A0
Authority
IL
Israel
Prior art keywords
compositions
reduction
xenotransplantation rejection
xenotransplantation
rejection
Prior art date
Application number
IL12429396A
Other languages
English (en)
Original Assignee
Mount Sinai Medical Center
Austin Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mount Sinai Medical Center, Austin Research Inst filed Critical Mount Sinai Medical Center
Publication of IL124293A0 publication Critical patent/IL124293A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2465—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1) acting on alpha-galactose-glycoside bonds, e.g. alpha-galactosidase (3.2.1.22)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL12429396A 1995-11-03 1996-11-01 Method and compositions for the reduction of xenotransplantation rejection IL124293A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US620095P 1995-11-03 1995-11-03
PCT/US1996/017695 WO1997016064A1 (en) 1995-11-03 1996-11-01 Methods and compositions for the reduction of xenotransplantation rejection

Publications (1)

Publication Number Publication Date
IL124293A0 true IL124293A0 (en) 1998-12-06

Family

ID=21719767

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12429396A IL124293A0 (en) 1995-11-03 1996-11-01 Method and compositions for the reduction of xenotransplantation rejection

Country Status (5)

Country Link
EP (1) EP0877549A4 (xx)
JP (1) JP2000514641A (xx)
AU (1) AU7668696A (xx)
IL (1) IL124293A0 (xx)
WO (1) WO1997016064A1 (xx)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999021415A1 (en) * 1997-10-28 1999-05-06 Stem Cell Sciences Pty. Ltd. Nuclear transfer for production of transgenic animal embryo
US6399578B1 (en) 1998-12-09 2002-06-04 La Jolla Pharmaceutical Company Conjugates comprising galactose α1,3 galactosyl epitopes and methods of using same
WO2004016742A2 (en) 2002-08-14 2004-02-26 Immerge Biotherapeutics, Inc. α(1,3)-GALACTOSYLTRANSFERASE NULL CELLS, METHODS OF SELECTING AND α(1,3)-GALACTOSYLTRANSFERASE NULL SWINE PRODUCED THEREFROM
CA2496761C (en) 2002-08-21 2015-06-02 Revivicor, Inc. Porcine animals lacking any expression of functional alpha 1,3 galactosyltransferase
EP1685148A2 (en) 2003-11-05 2006-08-02 University Of Pittsburgh Of The Commonwealth System Of Higher Education PORCINE ISOGLOBOSIDE 3 SYNTHASE PROTEIN, cDNA, GENOMIC ORGANIZATION, AND REGULATORY REGION
CA2559720A1 (en) 2004-03-17 2005-09-29 Revivicor, Inc. Tissue products derived from animals lacking any expression of functional alpha 1,3 galactosyltransferase
CN102471376A (zh) 2009-07-30 2012-05-23 弗·哈夫曼-拉罗切有限公司 酶促抗体加工
US9420770B2 (en) 2009-12-01 2016-08-23 Indiana University Research & Technology Corporation Methods of modulating thrombocytopenia and modified transgenic pigs
EP2625200A1 (en) 2010-10-05 2013-08-14 F.Hoffmann-La Roche Ag Antibodies against human tweak and uses thereof
US9365881B2 (en) 2011-10-05 2016-06-14 Hoffmann-La Roche Inc. Process for antibody G1 glycoform production

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5356804A (en) * 1990-10-24 1994-10-18 Mount Sinai School Of Medicine Of The City Of New York Cloning and expression of biologically active human α-galactosidase A
DE69535752D1 (de) * 1994-04-13 2008-06-26 Biotransplant Inc Alpha(1,3)galactosyltransferase-negatives schwein
WO1995034202A1 (en) * 1994-06-15 1995-12-21 Alexion Pharmaceuticals, Inc. Methods for reducing hyperacute rejection of xenografts

Also Published As

Publication number Publication date
AU7668696A (en) 1997-05-22
WO1997016064A1 (en) 1997-05-09
EP0877549A1 (en) 1998-11-18
JP2000514641A (ja) 2000-11-07
EP0877549A4 (en) 2002-01-02

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