JP2000514641A - 異種移植拒絶を低減するための方法および組成物 - Google Patents

異種移植拒絶を低減するための方法および組成物

Info

Publication number
JP2000514641A
JP2000514641A JP09517615A JP51761597A JP2000514641A JP 2000514641 A JP2000514641 A JP 2000514641A JP 09517615 A JP09517615 A JP 09517615A JP 51761597 A JP51761597 A JP 51761597A JP 2000514641 A JP2000514641 A JP 2000514641A
Authority
JP
Japan
Prior art keywords
transgenic
cells
human
nucleic acid
organs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP09517615A
Other languages
English (en)
Japanese (ja)
Inventor
イオンヌ,ヤニス
デスニック,ロバート.ジェイ.
サンドリン,モロー,エス.
マッケンジー,イアン,エフ,シー.
Original Assignee
ザ マウント シナイ メディカル センター
ザ オースティン リサーチ インスティチュート
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ザ マウント シナイ メディカル センター, ザ オースティン リサーチ インスティチュート filed Critical ザ マウント シナイ メディカル センター
Publication of JP2000514641A publication Critical patent/JP2000514641A/ja
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • A01K67/0275Genetically modified vertebrates, e.g. transgenic
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/24Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2465Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1) acting on alpha-galactose-glycoside bonds, e.g. alpha-galactosidase (3.2.1.22)
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP09517615A 1995-11-03 1996-11-01 異種移植拒絶を低減するための方法および組成物 Pending JP2000514641A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US620095P 1995-11-03 1995-11-03
US60/006,200 1995-11-03
PCT/US1996/017695 WO1997016064A1 (fr) 1995-11-03 1996-11-01 Procedes et compositions de reduction du rejet de xenogreffe

Publications (1)

Publication Number Publication Date
JP2000514641A true JP2000514641A (ja) 2000-11-07

Family

ID=21719767

Family Applications (1)

Application Number Title Priority Date Filing Date
JP09517615A Pending JP2000514641A (ja) 1995-11-03 1996-11-01 異種移植拒絶を低減するための方法および組成物

Country Status (5)

Country Link
EP (1) EP0877549A4 (fr)
JP (1) JP2000514641A (fr)
AU (1) AU7668696A (fr)
IL (1) IL124293A0 (fr)
WO (1) WO1997016064A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1581899A (en) * 1997-10-28 1999-05-17 Biotransplant Incorporated Nuclear transfer for production of transgenic animal embryo
US6399578B1 (en) 1998-12-09 2002-06-04 La Jolla Pharmaceutical Company Conjugates comprising galactose α1,3 galactosyl epitopes and methods of using same
AU2003265415A1 (en) 2002-08-14 2004-03-03 Immerge Biotherapeutics, Inc. Alpha(1,3)-GALACTOSYLTRANSFERASE NULL CELLS, METHODS OF SELECTING AND Alpha(1,3)-GALACTOSYLTRANSFERASE NULL SWINE PRODUCED THEREFROM
US8106251B2 (en) 2002-08-21 2012-01-31 Revivicor, Inc. Tissue products derived from porcine animals lacking any expression of functional alpha 1,3 galactosyltransferase
EP1534819B1 (fr) 2002-08-21 2009-12-09 Revivicor, Inc. Porcins ne presentant aucune expression de l'alpha 1,3-galactosyltransferase fonctionnelle
EP1685148A2 (fr) 2003-11-05 2006-08-02 University Of Pittsburgh Of The Commonwealth System Of Higher Education Proteine isogloboside 3 synthase porcine, adnc, organisation genomique, et region regulatrice
ES2538819T3 (es) 2009-07-30 2015-06-24 F. Hoffmann-La Roche Ag Procesamiento enzimático de anticuerpos
US9420770B2 (en) 2009-12-01 2016-08-23 Indiana University Research & Technology Corporation Methods of modulating thrombocytopenia and modified transgenic pigs
CA2809632A1 (fr) 2010-10-05 2012-04-12 Monika Baehner Anticorps dirige contre le tweak humain et leurs utilisations
EP2764020B1 (fr) 2011-10-05 2015-08-12 F. Hoffmann-La Roche AG Procédé de production d'anticorps de glycoforme g1

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5356804A (en) * 1990-10-24 1994-10-18 Mount Sinai School Of Medicine Of The City Of New York Cloning and expression of biologically active human α-galactosidase A
AU2233295A (en) * 1994-04-13 1995-11-10 Biotransplant Incorporated Alpha(1,3) galactosyltransferase negative swine
CA2192660A1 (fr) * 1994-06-15 1995-12-21 Mauro S. Sandrin Procedes permettant de reduire le rejet suraigu d'heterogreffes

Also Published As

Publication number Publication date
WO1997016064A1 (fr) 1997-05-09
EP0877549A1 (fr) 1998-11-18
IL124293A0 (en) 1998-12-06
EP0877549A4 (fr) 2002-01-02
AU7668696A (en) 1997-05-22

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