AU758563B2 - Dicationic dibenzofuran and dibenzothiophene compounds and methods of use thereof - Google Patents

Dicationic dibenzofuran and dibenzothiophene compounds and methods of use thereof Download PDF

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Publication number
AU758563B2
AU758563B2 AU47152/99A AU4715299A AU758563B2 AU 758563 B2 AU758563 B2 AU 758563B2 AU 47152/99 A AU47152/99 A AU 47152/99A AU 4715299 A AU4715299 A AU 4715299A AU 758563 B2 AU758563 B2 AU 758563B2
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AU
Australia
Prior art keywords
loweralkyl
pharmaceutically acceptable
acceptable salts
alkylaryl
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU47152/99A
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English (en)
Other versions
AU4715299A (en
Inventor
James Edwin Hall
Richard R. Tidwell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of North Carolina at Chapel Hill
Original Assignee
University of North Carolina at Chapel Hill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of North Carolina at Chapel Hill filed Critical University of North Carolina at Chapel Hill
Publication of AU4715299A publication Critical patent/AU4715299A/en
Application granted granted Critical
Publication of AU758563B2 publication Critical patent/AU758563B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/08—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis for Pneumocystis carinii
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/76—Dibenzothiophenes

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
AU47152/99A 1998-08-20 1999-06-24 Dicationic dibenzofuran and dibenzothiophene compounds and methods of use thereof Ceased AU758563B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9727398P 1998-08-20 1998-08-20
US60/097273 1998-08-20
PCT/US1999/014313 WO2000010990A2 (en) 1998-08-20 1999-06-24 Dicationic dibenzofuran and dibenzothiophene compounds and methods of use thereof

Publications (2)

Publication Number Publication Date
AU4715299A AU4715299A (en) 2000-03-14
AU758563B2 true AU758563B2 (en) 2003-03-27

Family

ID=22262567

Family Applications (1)

Application Number Title Priority Date Filing Date
AU47152/99A Ceased AU758563B2 (en) 1998-08-20 1999-06-24 Dicationic dibenzofuran and dibenzothiophene compounds and methods of use thereof

Country Status (9)

Country Link
US (1) US6172104B1 (enExample)
EP (1) EP1105381B1 (enExample)
JP (1) JP2003523927A (enExample)
AT (1) ATE239003T1 (enExample)
AU (1) AU758563B2 (enExample)
CA (1) CA2340912C (enExample)
DE (1) DE69907476T2 (enExample)
ES (1) ES2198139T3 (enExample)
WO (1) WO2000010990A2 (enExample)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2784678B1 (fr) * 1998-09-23 2002-11-29 Sod Conseils Rech Applic Nouveaux derives de n-(iminomethyl)amines, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
US6569853B1 (en) * 2000-11-06 2003-05-27 Combinatorx, Incorporated Combinations of chlorpromazine and pentamidine for the treatment of neoplastic disorders
GB2380192B8 (en) * 2001-02-09 2005-09-14 Sumitomo Chemical Co Phenylacetylene compounds liquid crystal compositions polymers optically anisotropic products & optical & liquid crystal elements derived therefrom
JP2002255960A (ja) * 2001-02-27 2002-09-11 Sumitomo Chem Co Ltd ジベンゾチオフェン化合物、中間体およびその製造方法
US6825228B2 (en) 2001-06-13 2004-11-30 Genesoft Pharmaceuticals, Inc. Benzothiophene compounds having antiinfective activity
US20040006092A1 (en) * 2001-08-31 2004-01-08 Neurochem, Inc. Amidine derivatives for treating amyloidosis
SG124249A1 (en) * 2001-12-07 2006-08-30 Sumitomo Chemical Co New polymer and polymer light-emitting device using the same
JP4957669B2 (ja) * 2002-03-15 2012-06-20 住友化学株式会社 高分子化合物およびそれを用いた高分子発光素子
CA2494139A1 (en) 2002-08-02 2004-02-12 Genesoft Pharmaceuticals, Inc. Biaryl compounds having anti-infective activity
AU2003285958A1 (en) * 2002-10-25 2004-05-25 Genesoft Pharmaceuticals, Inc. Anti-infective biaryl compounds
US7129214B2 (en) * 2002-12-10 2006-10-31 Oscient Pharmaceuticals Corporation Antibacterial compounds having a (pyrrole carboxamide)-(benzamide)-(imidazole carboxamide) motif
US20050054708A1 (en) * 2003-07-28 2005-03-10 Nichols Matthew James Combinations of drugs for the treatment of neoplasms
US20050080075A1 (en) * 2003-08-25 2005-04-14 Nichols M. James Formulations, conjugates, and combinations of drugs for the treatment of neoplasms
US20050100508A1 (en) * 2003-11-12 2005-05-12 Nichols M. J. Methods for identifying drug combinations for the treatment of proliferative diseases
US20050158320A1 (en) * 2003-11-12 2005-07-21 Nichols M. J. Combinations for the treatment of proliferative diseases
CA2547972A1 (en) * 2003-11-24 2005-06-09 Georgia State University Research Foundation, Inc. Fused ring dicationic anti-protozoan agents and their prodrugs
US7262223B2 (en) * 2004-01-23 2007-08-28 Neurochem (International) Limited Amidine derivatives for treating amyloidosis
US7365193B2 (en) 2004-02-04 2008-04-29 Abbott Laboratories Amino-substituted tricyclic derivatives and methods of use
US7994225B2 (en) * 2004-03-17 2011-08-09 Rempex Pharmaceuticals, Inc. Bacterial efflux pump inhibitors for the treatment of ophthalmic and otic infections
CA2559208A1 (en) * 2004-03-17 2005-09-29 Mpex Pharmaceuticals, Inc. Use and administration of bacterial efflux pump inhibitors
DE102004031656A1 (de) * 2004-06-30 2006-01-19 Merck Patent Gmbh Tetrahydrochinoline
GB0619325D0 (en) * 2006-09-30 2006-11-08 Univ Strathclyde New compounds
US20090092574A1 (en) 2006-12-29 2009-04-09 Scott Richard W Ophthalmic And Otic Compositions Of Facially Amphiphilic Polymers And Oligomers And Uses Thereof
DE102007013856A1 (de) 2007-03-20 2008-09-25 Merck Patent Gmbh Substituierte Tetrahydropyrrolochinoline
DE102007013854A1 (de) 2007-03-20 2008-09-25 Merck Patent Gmbh Tetrahydrochinoline
DE102007013855A1 (de) 2007-03-20 2008-09-25 Merck Patent Gmbh Substituierte Tetrahydrochinoline
AU2009276744A1 (en) * 2008-07-28 2010-02-04 Polymedix, Inc. Anti-malarial compounds
TWI478915B (zh) 2008-10-27 2015-04-01 Cellceutix Corp 宿主防禦之合成模擬物及其用途
JP2013516470A (ja) * 2010-01-07 2013-05-13 ポリメディックス・インコーポレーテッド 抗ヘパリン化合物
DK2709619T3 (en) 2011-05-16 2018-01-15 Cellceutix Corp RELATIONSHIPS FOR USING THE TREATMENT OF MUCOSITIS
US11771694B2 (en) 2020-06-05 2023-10-03 Innovation Pharmaceuticals Inc. Arylamide compounds for treatment and prevention of viral infections

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2500734A (en) * 1946-06-13 1950-03-14 Gen Electric Process of preparing 2-ethyldibenzofuran
GB932813A (en) * 1960-12-01 1963-07-31 Monsanto Chemicals New heterocyclic chemical compounds
GB951797A (en) * 1960-12-20 1964-03-11 Monsanto Chemicals Heterocyclic compounds
US4362883A (en) * 1981-10-28 1982-12-07 The Halcon Sd Group, Inc. Preparation of dibenzofuran
AU626033B2 (en) * 1988-10-25 1992-07-23 Government Of The United States Of America, As Represented By The Secretary Of The Army, The Methods for the treatment and prophylaxis of pneumocystis carinii pneumonia and other diseases and compounds and formulations for use in said methods
IL115875A (en) 1994-11-14 2000-12-06 Univ Georgia State Res Found Methods of inhibiting pneumocystis carinii pneumonia giardia lamblia and cryptosporidium parvum in an animal subject and compounds useful therefor
JPH11506776A (ja) 1995-06-07 1999-06-15 ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル 微生物感染の治療方法
US5668167A (en) * 1995-06-07 1997-09-16 Duke University Methods of treating microbial infections
US5723495A (en) * 1995-11-16 1998-03-03 The University Of North Carolina At Chapel Hill Benzamidoxime prodrugs as antipneumocystic agents

Also Published As

Publication number Publication date
EP1105381B1 (en) 2003-05-02
AU4715299A (en) 2000-03-14
WO2000010990A2 (en) 2000-03-02
DE69907476T2 (de) 2004-04-15
EP1105381A1 (en) 2001-06-13
WO2000010990A3 (en) 2003-04-17
US6172104B1 (en) 2001-01-09
CA2340912C (en) 2008-11-18
CA2340912A1 (en) 2000-03-02
ATE239003T1 (de) 2003-05-15
JP2003523927A (ja) 2003-08-12
DE69907476D1 (de) 2003-06-05
ES2198139T3 (es) 2004-01-16

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