AU750701C - Alpha-O-linked glycoconjugates, methods of preparation and uses thereof - Google Patents

Alpha-O-linked glycoconjugates, methods of preparation and uses thereof

Info

Publication number
AU750701C
AU750701C AU67792/98A AU6779298A AU750701C AU 750701 C AU750701 C AU 750701C AU 67792/98 A AU67792/98 A AU 67792/98A AU 6779298 A AU6779298 A AU 6779298A AU 750701 C AU750701 C AU 750701C
Authority
AU
Australia
Prior art keywords
branched chain
glycoconjugate
independently
linear
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU67792/98A
Other languages
English (en)
Other versions
AU6779298A (en
AU750701B2 (en
Inventor
Xiao-Tao Chen
Samuel J. Danishefsky
Peter Glunz
Samuel Hintermann
Scott Kuduk
Philip O. Livingston
Govindaswami Ragupathi
Dalibor Sames
Jacob B. Schwarz
Lawrence Williams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Memorial Sloan Kettering Cancer Center
Original Assignee
Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memorial Sloan Kettering Cancer Center filed Critical Memorial Sloan Kettering Cancer Center
Publication of AU6779298A publication Critical patent/AU6779298A/en
Application granted granted Critical
Publication of AU750701B2 publication Critical patent/AU750701B2/en
Publication of AU750701C publication Critical patent/AU750701C/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4727—Mucins, e.g. human intestinal mucin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
AU67792/98A 1997-04-16 1998-03-25 Alpha-O-linked glycoconjugates, methods of preparation and uses thereof Expired AU750701C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4371397P 1997-04-16 1997-04-16
US60/043713 1997-04-16
PCT/US1998/006035 WO1998046246A1 (en) 1997-04-16 1998-03-25 α-O-LINKED GLYCOCONJUGATES WITH CLUSTERED (2,6)-ST EPITOPES, METHODS OF PREPARATION AND USES THEREOF

Publications (3)

Publication Number Publication Date
AU6779298A AU6779298A (en) 1998-11-11
AU750701B2 AU750701B2 (en) 2002-07-25
AU750701C true AU750701C (en) 2003-03-20

Family

ID=21928513

Family Applications (1)

Application Number Title Priority Date Filing Date
AU67792/98A Expired AU750701C (en) 1997-04-16 1998-03-25 Alpha-O-linked glycoconjugates, methods of preparation and uses thereof

Country Status (6)

Country Link
US (2) US6660714B1 (enExample)
EP (1) EP0996455B1 (enExample)
JP (1) JP4308918B2 (enExample)
AU (1) AU750701C (enExample)
CA (1) CA2286798C (enExample)
WO (1) WO1998046246A1 (enExample)

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US7550146B2 (en) * 1997-04-16 2009-06-23 Sloan-Kettering Institute For Cancer Research Glycopeptide conjugates and uses thereof
EP0996455B1 (en) * 1997-04-16 2009-12-16 Sloan-Kettering Institute For Cancer Research Alpha-o-linked glycoconjugates with clustered (2,6)-st epitopes, methods of preparation and uses thereof
EP1091751A4 (en) * 1998-03-25 2005-01-19 Sloan Kettering Institutefor C TRIMERIC OXYGENIC BINDING GLYCOPEPTIDE CONJUGATES, METHODS OF PREPARATION AND USE THEREOF
ATE325803T1 (de) * 1999-08-20 2006-06-15 Sloan Kettering Inst Cancer Glycokonjugate, glycoaminosäure, deren zwischenprodukte, und ihre verwendung
US7854934B2 (en) 1999-08-20 2010-12-21 Sloan-Kettering Institute For Cancer Research Glycoconjugates, glycoamino acids, intermediates thereto, and uses thereof
US7824687B2 (en) * 1999-08-20 2010-11-02 Sloan-Kettering Institute For Cancer Research Clustered multi-antigenic carbohydrate constructs, methods for their preparation, and uses thereof
WO2003003985A2 (en) 2001-07-06 2003-01-16 Sloan-Kettering Institute For Cancer Research Polyvalent conjugate vaccine for cancer
US7504364B2 (en) * 2002-03-01 2009-03-17 Receptors Llc Methods of making arrays and artificial receptors
CA2486881A1 (en) * 2002-05-20 2003-11-27 Chemstop Pty Ltd Process for the preparation and activation of substances and a means of producing same
US20050037381A1 (en) * 2002-09-16 2005-02-17 Receptors Llc Artificial receptors, building blocks, and methods
US20040137481A1 (en) * 2002-09-16 2004-07-15 Receptors Llc Artificial receptor building blocks, components, and kits
US20050037429A1 (en) * 2003-03-28 2005-02-17 Receptors Llc Artificial receptors including reversibly immobilized building blocks and methods
US20060057625A1 (en) * 2002-09-16 2006-03-16 Carlson Robert E Scaffold-based artificial receptors and methods
US20060051802A1 (en) * 2002-09-16 2006-03-09 Receptors Llc Artificial receptors, building blocks, and methods
US7469076B2 (en) * 2003-09-03 2008-12-23 Receptors Llc Sensors employing combinatorial artificial receptors
US20050136483A1 (en) * 2003-09-03 2005-06-23 Receptors Llc Nanodevices employing combinatorial artificial receptors
EP1613737A4 (en) * 2003-03-28 2008-12-03 Receptors Llc ARTIFICIAL RECEPTORS COMPRISING REVERSIBLE IMMOBILIZED CONSTRUCTION BLOCKS AND METHODS
US20060035267A1 (en) * 2003-04-09 2006-02-16 Livingston Philip O Optimal polyvalent vaccine for cancer
JP2007527864A (ja) * 2003-09-05 2007-10-04 スローン − ケッタリング インスティチュート フォー キャンサー リサーチ 自然に起こる化学的連結による、多官能化ペプチドおよび／またはタンパク質の調製方法
US7504365B2 (en) * 2004-09-03 2009-03-17 Receptors Llc Combinatorial artificial receptors including tether building blocks
US7985715B2 (en) 2004-09-11 2011-07-26 Receptors Llc Combinatorial artificial receptors including peptide building blocks
JP4942014B2 (ja) * 2004-09-14 2012-05-30 独立行政法人産業技術総合研究所 Ｏ−結合型糖アミノ酸
ATE509027T1 (de) 2006-01-13 2011-05-15 Pasteur Institut Enzymatische synthese von grossen mengen von mucin glyconjugaten und deren immunogenische anwendungen
EP2010556B1 (en) 2006-04-11 2015-09-23 Sloan-Kettering Institute for Cancer Research Homogeneous erythropoietin and method for their preparation
MX2010013931A (es) 2008-06-16 2011-06-01 Academia Sinica Diagnosis de cancer basada en niveles de anticuerpos contra globo h y sus fragmentos.
JP2011524375A (ja) * 2008-06-16 2011-09-01 アカデミア シニカ ＧｌｏｂｏＨおよびＳＳＥＡ３に特異的な免疫反応を誘起する組成物および癌治療におけるその使用
WO2010006343A2 (en) 2008-07-11 2010-01-14 Sloan-Kettering Institute For Cancer Research Glycopeptide constructs and uses thereof
CN102215862B (zh) * 2009-06-16 2016-04-06 中央研究院 Globo h及含新颖糖脂质佐剂的相关抗癌疫苗
CA2801922A1 (en) 2010-06-11 2011-12-15 Sloan-Kettering Institute For Cancer Research Multivalent glycopeptide constructs and uses thereof
EP2500033A1 (en) * 2011-03-17 2012-09-19 Institut Pasteur Method for preparing muliple antigen glycopeptide carbohydrate conjugates
AU2013340414B2 (en) 2012-10-23 2019-05-02 Caris Science, Inc. Aptamers and uses thereof
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
AU2013361323B2 (en) 2012-12-19 2018-09-06 Caris Science, Inc. Compositions and methods for aptamer screening
KR102003138B1 (ko) * 2014-08-22 2019-07-23 아카데미아 시니카 신규한 글리칸 접합체 및 그의 용도
PT110526B (pt) 2018-01-26 2021-02-04 Univ Nova De Lisboa Anticorpo, fragmento funcional ou sonda do mesmo contra antigénios tumorais
CN111303112A (zh) * 2020-02-28 2020-06-19 南京工业大学 一种固定二氧化碳的方法

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CA1339204C (en) 1987-01-07 1997-08-05 Joyce Taylor-Papadimitriou Mucin core polypeptide, antibodies and probes
US5683674A (en) 1987-01-07 1997-11-04 Imperial Cancer Research Technology Ltd. Antibody against human mucin core protein and method of preparing and using same
US6222020B1 (en) 1987-01-07 2001-04-24 Imperial Cancer Research Technology Limited Antigens derived from the core protein of the human mammary epithelial mucin
US5053489A (en) 1988-01-29 1991-10-01 Dana-Farber Cancer Institute, Inc. Genetically engineered polypeptides with determinants of the human DF3 breast carcinoma-associated antigen
US5660834A (en) 1988-03-11 1997-08-26 The Biomembrane Institute Monoclonal antibodies and vaccine development directed to human cancer-associated antigens by immunization with carbohydrate-carrier conjugates
US5229289A (en) 1988-03-11 1993-07-20 The Biomembrane Institute Monoclonal antibodies and vaccine development directed to human cancer-associated antigens by immunization with animal and human and with synthetic carbohydrate-carrier conjugates
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IL94872A (en) 1989-06-30 1995-03-30 Oncogen Monoclonal or chimeric antibodies reactive with human carcinomas, recombinant proteins comprising their antigen binding region, pharmaceutical compositions and kits comprising said antibodies and methods for imaging human carcinoma using same
US5280113A (en) 1989-08-16 1994-01-18 Monsanto Company Method for producing synthetic N-linked glycoconjugates
US5212298A (en) 1989-08-16 1993-05-18 Monsanto Company Method for producing synthetic N-linked glycoconjugates
IL105503A (en) 1992-04-28 1999-05-09 Astra Ab Carbon peptide couplets capable of eliciting an immune response of T cells
US5376531A (en) 1992-09-03 1994-12-27 Northwestern University Method of detecting cancer
WO1995018781A1 (en) 1994-01-06 1995-07-13 Metabolix, Inc. Methods for synthesizing oligomers containing hydroxy acid units
US5679769A (en) * 1994-03-15 1997-10-21 Sloan-Kettering Institute For Cancer Research Synthesis of asparagine-linked glycopeptides on a polymeric solid support
US6303120B1 (en) * 1994-03-15 2001-10-16 Memorial Sloan-Kettering Institute For Cancer Research Synthesis of glycoconjugates of the lewis y epitope and uses thereof
US5708163A (en) 1994-03-15 1998-01-13 Sloan-Kettering Institute Of Cancer Research Synthesis of the breast tumor-associated antigen defined by monoclonalantibody MBRL and uses thereof
WO1995029927A2 (en) 1994-05-02 1995-11-09 Biomira, Inc. Process for preparation of glycosides of tumor-associated carbohydrate antigens
DE4436164A1 (de) 1994-10-10 1996-04-11 Hoechst Ag Neue Kohlenhydratkonjugate als Inhibitoren der Zelladhäsion
JP3139957B2 (ja) 1995-03-17 2001-03-05 財団法人神奈川科学技術アカデミー レクチンの固定化法及びそれを用いた細胞用基材
US5871990A (en) 1996-05-15 1999-02-16 Clausen; Henrik UDP-N-acetyl-α-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase, gAlnAc-T3
CA2277867A1 (en) 1997-01-13 1998-07-16 Sloan-Kettering Institute For Cancer Research Colon cancer kh-1 and n3 antigens
US7550146B2 (en) 1997-04-16 2009-06-23 Sloan-Kettering Institute For Cancer Research Glycopeptide conjugates and uses thereof
EP0996455B1 (en) 1997-04-16 2009-12-16 Sloan-Kettering Institute For Cancer Research Alpha-o-linked glycoconjugates with clustered (2,6)-st epitopes, methods of preparation and uses thereof
AU745555B2 (en) 1997-09-25 2002-03-21 Sloan-Kettering Institute For Cancer Research Fucosyl GM1-KLH conjugate vaccine against small cell lung cancer
EP1091751A4 (en) 1998-03-25 2005-01-19 Sloan Kettering Institutefor C TRIMERIC OXYGENIC BINDING GLYCOPEPTIDE CONJUGATES, METHODS OF PREPARATION AND USE THEREOF
ATE325803T1 (de) 1999-08-20 2006-06-15 Sloan Kettering Inst Cancer Glycokonjugate, glycoaminosäure, deren zwischenprodukte, und ihre verwendung
US7824687B2 (en) 1999-08-20 2010-11-02 Sloan-Kettering Institute For Cancer Research Clustered multi-antigenic carbohydrate constructs, methods for their preparation, and uses thereof
US7854934B2 (en) 1999-08-20 2010-12-21 Sloan-Kettering Institute For Cancer Research Glycoconjugates, glycoamino acids, intermediates thereto, and uses thereof

Also Published As

Publication number Publication date
US20030083235A1 (en) 2003-05-01
AU6779298A (en) 1998-11-11
CA2286798A1 (en) 1998-10-22
WO1998046246A1 (en) 1998-10-22
AU750701B2 (en) 2002-07-25
EP0996455A1 (en) 2000-05-03
US6660714B1 (en) 2003-12-09
JP4308918B2 (ja) 2009-08-05
JP2002515060A (ja) 2002-05-21
CA2286798C (en) 2014-01-07
EP0996455B1 (en) 2009-12-16
EP0996455A4 (en) 2005-06-08
US7160856B2 (en) 2007-01-09

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Legal Events

Date Code Title Description
DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE PROPOSED AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 20020830

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS WAS NOTIFIED IN THE OFFICIAL JOURNAL DATED 20021017